TRANSTEM: ERA Chair in Translational Stem Cell Biology

Información del proyecto

TRANSTEM

Identificador del acuerdo de subvención: 856871

DOI

10.3030/856871

Proyecto cerrado

Fecha de la firma de la CE 8 Julio 2019

Fecha de inicio 1 Octubre 2019

Fecha de finalización 31 Julio 2025

Financiado con arreglo a

• Establishing ‚ERA Chairs’

Coste total

€ 2 499 978,75

Aportación de la UE

€ 2 499 978,75

Coordinado por

Medical University Of Varna
Bulgaria

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

Project Website

D7.1. will report the creation of Project Website

Documents, reports (9)

Published Job Position Advertisement

D1.3. will report the published Job Position Advertisement

Paper: “Stem Cell Research Department: Vision and Strategy”

D15 will report the publishment of the paper Stem Cell Research Department Vision and Strategy

Report on synergies M36

D76 will report synergies

Newly created department of Stem Cell Biology in RI-MUV

D1.1. will report the creation of the new department of Stem Cell Biology in RI-MUV

10 Published Job Position Advertisements

D22 will report 10 Published Job Position Advertisements

5 academic publications M36

D48 will report 5 academic publications

5 visiting researchers in MUV and SCBD M36

D43 will report 5 visits of researchers in MUV and SCBD

20 co-funded outgoing researcher exchanges carried out M36

D41 will report 20 cofunded outgoing researcher exchanges

Report of ERA Chair-led trainings M36

D45 will report ERA Chairled trainings

Publicaciones

Peer reviewed articles (30)

<scp>GDF11</scp> inhibits adipogenesis and improves mature adipocytes metabolic function via <scp>WNT</scp> /β‐catenin and <scp>ALK5</scp> / <scp>SMAD2</scp> /3 pathways

Autores: Jan Frohlich; Kristina Kovacovicova; Marco Raffaele; Tereza Virglova; Eliska Cizkova; Jan Kucera; Julie Bienertova‐Vasku; Martin Wabitsch; Marion Peyrou; Francesca Bonomini; Rita Rezzani; George N. Chaldakov; Anton B. Tonchev; Michelino Di Rosa; Nicolas Blavet; Vaclav Hejret; Manlio Vinciguerra
Publicado en: Crossref, Edición 13652184, 2022, ISSN 1365-2184
Editor: Cell Proliferation
DOI: 10.1111/cpr.13310

Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin

Autores: Marco Raffaele; Kristina Kovacovicova; Jan Frohlich; Oriana Lo Re; Sebastiano Giallongo; Jude A. Oben; Martin Faldyna; Lenka Leva; Antonino Giulio Giannone; Daniela Cabibi; Manlio Vinciguerra; Manlio Vinciguerra
Publicado en: Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-9 (2021), Edición 1478811X, 2021, ISSN 1478-811X
Editor: BioMed Central
DOI: 10.1186/s12964-021-00731-0

Integrative CUT&amp;Tag-RNA-Seq Analysis of Histone Variant MacroH2A1-Dependent Orchestration of Human Induced Pluripotent Stem Cell Reprogramming

Autores: Niccolò Liorni, Alessandro Napoli, Stefano Castellana, Sebastiano Giallongo, Daniela Řeháková, Oriana Lo Re, Irena Koutná, Tommaso Mazza, Manlio Vinciguerra
Publicado en: Epigenomics, Edición 15, 2024, Página(s) 863-877, ISSN 1750-1911
Editor: Future Medicine Ltd.
DOI: 10.2217/epi-2023-0267

Evolution, trends, outcomes, and economics of hematopoietic stem cell transplantation in severe autoimmune diseases

Autores: John A. Snowden,corresponding author, Manuela Badoglio, Myriam Labopin, Sebastian Giebel, Eoin McGrath, Zora Marjanovic, Joachim Burman, John Moore, Montserrat Rovira,Nico M. Wulffraat, Majid Kazmi, Raffaella Greco, Emilian Snarski, Tomas Kozak, Kirill Kirgizov, Tobias Alexander,Peter Bader, Riccardo Saccardi, and Dominique Farge
Publicado en: Blood Adv., Edición 1(27), 2017, Página(s) 2742–2755, ISSN 2473-9537
Editor: Bloodadvances
DOI: 10.1182/bloodadvances.2017010041

Zbtb20 Regulates Developmental Neurogenesis in the Olfactory Bulb and Gliogenesis After Adult Brain Injury

Autores: Thorsten R Doeppner, Josephine Herz, Mathias Bähr, Anton B Tonchev, Anastassia Stoykova
Publicado en: Molecular Neurobiology, Edición 56, 2019, Página(s) 567–582, ISSN 0893-7648
Editor: Humana Press, Inc.
DOI: 10.1007/s12035-018-1104-y

Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant

Autores: Jan Frohlich, Niccolò Liorni, Manuel Mangoni, Gabriela Lochmanová, Pavlína Pírek, Nikola Kaštánková, Pille Pata, Jan Kucera, George N. Chaldakov, Anton B. Tonchev, Illar Pata, Vera Gorbunova, Eric Leire, Zbyněk Zdráhal, Tommaso Mazza, Manlio Vinciguerra
Publicado en: Clinical Epigenetics, Edición 16, 2024, ISSN 1868-7083
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s13148-024-01710-1

Implication of GPR40 Signaling in the Subventricular Zone Neurogenesis after Ischemia via Cross-Talk between Neural Progenitors and Microglia

Autores: Maryia Y Dazortsava, Ilya V Pyko, Nadezhda B Boneva, Anton B Tonchev, Zhu H, Sawamoto K, Minabe Y and Yamashima T
Publicado en: Journal of Alzheimers Disease & Parkinsonism, Edición 8(6), 2018, Página(s) 454, ISSN 2161-0460
Editor: Journal of Alzheimers Disease & Parkinsonism
DOI: 10.4172/2161-0460.1000454

3D visualization of human colon tissue using a modified CUBIC-based tissue-clearing technique

Autores: Pavel Pavlov, Andreas Kontny, Neele Wagner, Nikola Kolev, Alexander Zlatarov, Turgay Kalinov, Anton B. Tonchev
Publicado en: Journal of Biological Methods, Edición 12, 2025, Página(s) e99010052, ISSN 2326-9901
Editor: Journal of Biological Methods
DOI: 10.14440/jbm.2025.0101

The costs and benefits of senotherapeutics for human health

Autores: Marco Raffaele, Manlio Vinciguerra
Publicado en: The Lancet Healthy Longevity, Edición 3, 2022, Página(s) e67-e77, ISSN 2666-7568
Editor: Elsevier BV
DOI: 10.1016/s2666-7568(21)00300-7

Active acute leukaemia: should transplant be offered to all patients?

Autores: Batia Avni, Michael Y Shapira, Igor B Resnick, Polina Stepensky, Reuven Or, Sigal Grisariu
Publicado en: Hematological oncology, 2016, ISSN 1099-1069
Editor: Wiley
DOI: 10.1002/hon.2308

Ablation of BAF170 in Developing and Postnatal Dentate Gyrus Affects Neural Stem Cell Proliferation, Differentiation, and Learning.

Autores: Tuoc T, Dere E, Radyushkin K, Pham L, Nguyen H, Tonchev A, Sun G, Ronnenberg A, Shi Y, Staiger J, Ehrenreich H, Stoykova A.
Publicado en: MOLECULAR NEUROBIOLOGY., Edición Aug;54(6), 2017, Página(s) 4618–35, ISSN 1559-1182
Editor: Springer
DOI: 10.1007/s12035-016-9948-5

Systemic depletion of histone macroH2A1.1 boosts hippocampal synaptic plasticity and social behavior in mice.

Autores: Valentina Chiodi; Maria Rosaria Domenici; Tommaso Biagini; Roberta De Simone; Anna Maria Tartaglione; Michelino Di Rosa; Oriana Lo Re; Tommaso Mazza; Vincenzo Micale; Vincenzo Micale; Manlio Vinciguerra; Manlio Vinciguerra
Publicado en: The FASEB Journal, Edición 08926638, 2021, ISSN 0892-6638
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202100569r

Distribution, Function, and Expression of the Apelinergic System in the Healthy and Diseased Mammalian Brain

Autores: Martin N. Ivanov, Dimo S. Stoyanov, Stoyan P. Pavlov, Anton. B. Tonchev
Publicado en: Genes, Edición 13, 2025, Página(s) 2172, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes13112172

Histone Variant macroH2A1.1 Enhances Nonhomologous End Joining-dependent DNA Double-strand-break Repair and Reprogramming Efficiency of Human iPSCs

Autores: Sebastiano Giallongo, Daniela Řeháková, Tommaso Biagini, Oriana Lo Re, Priyanka Raina, Gabriela Lochmanová, Zbyněk Zdráhal, Igor Resnick, Pille Pata, Illar Pata, Martin Mistrík, João Pedro de Magalhães, Tommaso Mazza, Irena Koutná, Manlio Vinciguerra
Publicado en: Stem Cells, Edición 10665099, 2022, ISSN 1066-5099
Editor: AlphaMed Press Inc
DOI: 10.1093/stmcls/sxab004

Cardio- and Neurometabolic Adipobiology: Consequences and Implications for Therapy

Autores: Frohlich J, Chaldakov GN, Vinciguerra M.
Publicado en: International Journal of Molecular Sciences, Edición 14220067, 2021, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22084137

Reduced neuroinflammation and enhanced neurogenesis following chronic agomelatine treatment in rats undergoing chronic constant light

Autores: Atanasova D, Lazarov N, Stoyanov DS, Spassov RH, Tonchev AB, Tchekalarova J
Publicado en: Neuropharmacology, Edición 00283908, 2021, ISSN 0028-3908
Editor: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2021.108706

Tracking cell turnover in human brain using 15N-thymidine imaging mass spectrometry

Autores: Sebastian S. Roeder, Elisa A. Bonnin, Ting-Di Wu, Jean-Luc Guerquin-Kern, Samir Jabari, Sebastian Brandner, Ilker Y. Eyüpoglu, Stephanie Gollwitzer, Hajo M. Hamer, Stefan T. Gerner, Thorsten R. Doeppner, Christoph Rummel, Elisabet Englund, Ralph Heimke-Brinck, Tobias Borst, Christoph Daniel, Kerstin Amann, Ursula Schlötzer-Schrehardt, Anton B. Tonchev, Karl Roessler, Stefan Schwab, Olaf Bergmann
Publicado en: Frontiers in Neuroscience, Edición 17, 2024, ISSN 1662-453X
Editor: Frontiers Media SA
DOI: 10.3389/fnins.2023.1274607

Expression of Transcription Factor ZBTB20 in the Adult Primate Neurogenic Niche under Physiological Conditions or after Ischemia

Autores: Dimo S. Stoyanov, Martin N. Ivanov, Tetsumori Yamashima, Anton B. Tonchev
Publicado en: Genes, Edición 20734425, 2022, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes13091559

Downregulation of Aging-Associated Gene SUCLG1 Marks the Aggressiveness of Liver Disease

Autores: Desislava K. Tsoneva, Alessandro Napoli, Mariya Teneva, Tommaso Mazza, Manlio Vinciguerra
Publicado en: Cancers, Edición 17, 2025, Página(s) 339, ISSN 2072-6694
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers17030339

Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects.

Autores: Marco Raffaele; Kristina Kovacovicova; Tommaso Biagini; Oriana Lo Re; Jan Frohlich; Sebastiano Giallongo; James D. Nhan; Antonino Giulio Giannone; Daniela Cabibi; Martin Ivanov; Anton B. Tonchev; Martin Mistrik; Matthew Lacey; Petr Dzubak; Sona Gurska; Marian Hajduch; Jiri Bartek; Jiri Bartek; Tommaso Mazza; Vincenzo Micale; Sean P. Curran; Manlio Vinciguerra
Publicado en: GeroScience, Edición 25092723, 2021, ISSN 2509-2723
Editor: Springer
DOI: 10.1007/s11357-021-00487-y

Quantity, distribution and phenotype of newly generated cells in the intact spinal cord of adult macaque monkeys

Autores: D. Marinova, M.N. Ivanov, T. Yamashima, A.B. Tonchev
Publicado en: Heliyon, Edición 10, 2025, Página(s) e28856, ISSN 2405-8440
Editor: Elsevier BV
DOI: 10.1016/j.heliyon.2024.e28856

Deficiency of histone variant macroH2A1.1 is associated with sexually dimorphic obesity in mice

Autores: Valentina Chiodi, Francesca Rappa, Oriana Lo Re, George N. Chaldakov, Benjamin Lelouvier, Vincenzo Micale, Maria Rosaria Domenici, Manlio Vinciguerra
Publicado en: Scientific Reports, Edición 13, 2024, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-023-46304-8

Ghrelin Regulates Expression of the Transcription Factor Pax6 in Hypoxic Brain Progenitor Cells and Neurons

Autores: Irina I. Stoyanova, Andrii Klymenko, Jeannette Willms, Thorsten R. Doeppner, Anton B. Tonchev, David Lutz
Publicado en: Cells, Edición 20734409, 2022, ISSN 2073-4409
Editor: MDPI
DOI: 10.3390/cells11050782

Simple limbal epithelial transplantation: a review on current approach and future directions

Autores: Davide Borroni, Bogumil Wowra, Vito Romano, Maria Boyadzhieva, Diego Ponzin, Stefano Ferrari, Sajjad Ahmad, Mohit Parekh
Publicado en: Survey of Ophthalmology, Edición 63(6), 2018, Página(s) 869-874, ISSN 1879-3304
Editor: Science direct
DOI: 10.1016/j.survophthal.2018.05.003

Epigenetic remodelling in human hepatocellular carcinoma

Autores: Maria Rita Braghini, Oriana Lo Re, Ilaria Romito, Maite G. Fernandez-Barrena, Barbara Barbaro, Silvia Pomella, Rossella Rota, Manlio Vinciguerra, Matias A. Avila, Anna Alisi
Publicado en: Journal of Experimental &amp; Clinical Cancer Research, Edición 41, 2022, ISSN 1756-9966
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s13046-022-02297-2

Transcriptome Response and Spatial Pattern of Gene Expression in the Primate Subventricular Zone Neurogenic Niche After Cerebral Ischemia

Autores: Monika C Chongtham, Haifang Wang, Christina Thaller, Nai-Hua Hsiao, Ivan H Vachkov, Stoyan P Pavlov, Lorenz H Williamson, Tetsumori Yamashima, Anastassia Stoykova, Jun Yan, Gregor Eichele, Anton B Tonchev
Publicado en: Frontiers in Cell and Developmental Biology, 2020, ISSN 2296-634X
Editor: Frontiers Media S.A.
DOI: 10.3389/fcell.2020.584314

TNC and GJA1 Are Putative Progenitor Markers That Are Localized in the Perivascular Adventitia of the Adult Monkey Brain Subventricular Niche

Autores: Martin N. Ivanov, Dimo S. Stoyanov, Lora V. Veleva, Andon M. Mladenov, Stoyan P. Pavlov, Tetsumori Yamashima, Anton B. Tonchev
Publicado en: International Journal of Molecular Sciences, Edición 26, 2025, Página(s) 1397, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26041397

Phosphorylation within Intrinsic Disordered Region Discriminates Histone Variant macroH2A1 Splicing Isoforms—macroH2A1.1 and macroH2A1.2

Autores: Sebastiano Giallongo, Oriana Lo Re, Gabriela Lochmanová, Luca Parca, Francesco Petrizzelli, Zbyněk Zdráhal, Tommaso Mazza, Manlio Vinciguerra
Publicado en: Biology, Edición 20797737, 2021, ISSN 2079-7737
Editor: MDPI
DOI: 10.3390/biology10070659

Mesenchymal Stromal Cell-Derived Exosomes Affect mRNA Expression and Function of B-Lymphocytes

Autores: Drirh Khare, Reuven Or, Igor Resnick, Claudine Barkatz, Osnat Almogi-Hazan and Batia Avni
Publicado en: Front. Immunol., Sec. B Cell Biology, Edición 9, 2018, ISSN 1664-3224
Editor: Frontiers in immunology
DOI: 10.3389/fimmu.2018.03053

Glial Populations in the Human Brain Following Ischemic Injury

Autores: Victoria Mihailova, Irina I. Stoyanova, Anton B. Tonchev
Publicado en: Biomedicines, Edición 11, 2023, Página(s) 2332, ISSN 2227-9059
Editor: MDPI AG
DOI: 10.3390/biomedicines11092332

Other (2)

Effectiveness of chemo-G-CSF protocols for mobilization of peripheral stem cells in patients with non-hodgkin lymphomas and hodgkin disease-single center experience

Autores: Micheva I, Dimitrova S, Gerov V, Chervenkov T, Gercheva L, Reznik I.
Publicado en: Bone Marrow Transplantation, Edición 54, 2019, Página(s) 144–619
Editor: Nature
DOI: 10.1038/s41409-019-0559-4

Additional file of Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin

Autores: Raffaele, Marco; Kovacovicova, Kristina; Frohlich, Jan; Re, Oriana Lo; Giallongo, Sebastiano; Oben, Jude A.; Faldyna, Martin; Leva, Lenka; Giannone, Antonino Giulio; Cabibi, Daniela; Vinciguerra, Manlio
Publicado en: Edición 1, 2021
Editor: Springer Nature
DOI: 10.6084/m9.figshare.14431610.v1

Book chapters (2)

Gene Editing and Human iPSCs in Cardiovascular and Metabolic Diseases

Autores: Sebastiano Giallongo, Oriana Lo Re, Igor Resnick, Marco Raffaele, Manlio Vinciguerra
Publicado en: Advances in Experimental Medicine and Biology, Genome Editing in Cardiovascular and Metabolic Diseases, 2023, Página(s) 275-298
Editor: Springer Nature Singapore
DOI: 10.1007/978-981-19-5642-3_18

Integrative Analysis of CUT&amp;Tag and RNA-Seq Data Through Bioinformatics: A Unified Workflow for Enhanced Insights

Autores: Niccolò Liorni, Alessandro Napoli, Marta Adinolfi, Manlio Vinciguerra, Tommaso Mazza
Publicado en: Methods in Molecular Biology, Chromatin Immunoprecipitation, 2024, Página(s) 191-213
Editor: Springer US
DOI: 10.1007/978-1-0716-4071-5_13