TRANSTEM: ERA Chair in Translational Stem Cell Biology

Informations projet

TRANSTEM

N° de convention de subvention: 856871

DOI

10.3030/856871

Projet clôturé

Date de signature de la CE 8 Juillet 2019

Date de début 1 Octobre 2019

Date de fin 31 Juillet 2025

Financé au titre de

• Establishing ‚ERA Chairs’

Coût total

€ 2 499 978,75

Contribution de l’UE

€ 2 499 978,75

Coordonné par

Medical University Of Varna
Bulgaria

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (1)

Project Website

D7.1. will report the creation of Project Website

Documents, reports (9)

Published Job Position Advertisement

D1.3. will report the published Job Position Advertisement

Paper: “Stem Cell Research Department: Vision and Strategy”

D15 will report the publishment of the paper Stem Cell Research Department Vision and Strategy

Report on synergies M36

D76 will report synergies

Newly created department of Stem Cell Biology in RI-MUV

D1.1. will report the creation of the new department of Stem Cell Biology in RI-MUV

10 Published Job Position Advertisements

D22 will report 10 Published Job Position Advertisements

5 academic publications M36

D48 will report 5 academic publications

5 visiting researchers in MUV and SCBD M36

D43 will report 5 visits of researchers in MUV and SCBD

20 co-funded outgoing researcher exchanges carried out M36

D41 will report 20 cofunded outgoing researcher exchanges

Report of ERA Chair-led trainings M36

D45 will report ERA Chairled trainings

Open Research Data Pilot (1)

DMP Submission

D88 DMP Submission will report Data Management Plan

Publications

Peer reviewed articles (30)

<scp>GDF11</scp> inhibits adipogenesis and improves mature adipocytes metabolic function via <scp>WNT</scp> /β‐catenin and <scp>ALK5</scp> / <scp>SMAD2</scp> /3 pathways

Auteurs: Jan Frohlich; Kristina Kovacovicova; Marco Raffaele; Tereza Virglova; Eliska Cizkova; Jan Kucera; Julie Bienertova‐Vasku; Martin Wabitsch; Marion Peyrou; Francesca Bonomini; Rita Rezzani; George N. Chaldakov; Anton B. Tonchev; Michelino Di Rosa; Nicolas Blavet; Vaclav Hejret; Manlio Vinciguerra
Publié dans: Crossref, Numéro 13652184, 2022, ISSN 1365-2184
Éditeur: Cell Proliferation
DOI: 10.1111/cpr.13310

Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin

Auteurs: Marco Raffaele; Kristina Kovacovicova; Jan Frohlich; Oriana Lo Re; Sebastiano Giallongo; Jude A. Oben; Martin Faldyna; Lenka Leva; Antonino Giulio Giannone; Daniela Cabibi; Manlio Vinciguerra; Manlio Vinciguerra
Publié dans: Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-9 (2021), Numéro 1478811X, 2021, ISSN 1478-811X
Éditeur: BioMed Central
DOI: 10.1186/s12964-021-00731-0

Integrative CUT&amp;Tag-RNA-Seq Analysis of Histone Variant MacroH2A1-Dependent Orchestration of Human Induced Pluripotent Stem Cell Reprogramming

Auteurs: Niccolò Liorni, Alessandro Napoli, Stefano Castellana, Sebastiano Giallongo, Daniela Řeháková, Oriana Lo Re, Irena Koutná, Tommaso Mazza, Manlio Vinciguerra
Publié dans: Epigenomics, Numéro 15, 2024, Page(s) 863-877, ISSN 1750-1911
Éditeur: Future Medicine Ltd.
DOI: 10.2217/epi-2023-0267

Evolution, trends, outcomes, and economics of hematopoietic stem cell transplantation in severe autoimmune diseases

Auteurs: John A. Snowden,corresponding author, Manuela Badoglio, Myriam Labopin, Sebastian Giebel, Eoin McGrath, Zora Marjanovic, Joachim Burman, John Moore, Montserrat Rovira,Nico M. Wulffraat, Majid Kazmi, Raffaella Greco, Emilian Snarski, Tomas Kozak, Kirill Kirgizov, Tobias Alexander,Peter Bader, Riccardo Saccardi, and Dominique Farge
Publié dans: Blood Adv., Numéro 1(27), 2017, Page(s) 2742–2755, ISSN 2473-9537
Éditeur: Bloodadvances
DOI: 10.1182/bloodadvances.2017010041

Zbtb20 Regulates Developmental Neurogenesis in the Olfactory Bulb and Gliogenesis After Adult Brain Injury

Auteurs: Thorsten R Doeppner, Josephine Herz, Mathias Bähr, Anton B Tonchev, Anastassia Stoykova
Publié dans: Molecular Neurobiology, Numéro 56, 2019, Page(s) 567–582, ISSN 0893-7648
Éditeur: Humana Press, Inc.
DOI: 10.1007/s12035-018-1104-y

Epigenetic and transcriptional control of adipocyte function by centenarian-associated SIRT6 N308K/A313S mutant

Auteurs: Jan Frohlich, Niccolò Liorni, Manuel Mangoni, Gabriela Lochmanová, Pavlína Pírek, Nikola Kaštánková, Pille Pata, Jan Kucera, George N. Chaldakov, Anton B. Tonchev, Illar Pata, Vera Gorbunova, Eric Leire, Zbyněk Zdráhal, Tommaso Mazza, Manlio Vinciguerra
Publié dans: Clinical Epigenetics, Numéro 16, 2024, ISSN 1868-7083
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/s13148-024-01710-1

Implication of GPR40 Signaling in the Subventricular Zone Neurogenesis after Ischemia via Cross-Talk between Neural Progenitors and Microglia

Auteurs: Maryia Y Dazortsava, Ilya V Pyko, Nadezhda B Boneva, Anton B Tonchev, Zhu H, Sawamoto K, Minabe Y and Yamashima T
Publié dans: Journal of Alzheimers Disease & Parkinsonism, Numéro 8(6), 2018, Page(s) 454, ISSN 2161-0460
Éditeur: Journal of Alzheimers Disease & Parkinsonism
DOI: 10.4172/2161-0460.1000454

3D visualization of human colon tissue using a modified CUBIC-based tissue-clearing technique

Auteurs: Pavel Pavlov, Andreas Kontny, Neele Wagner, Nikola Kolev, Alexander Zlatarov, Turgay Kalinov, Anton B. Tonchev
Publié dans: Journal of Biological Methods, Numéro 12, 2025, Page(s) e99010052, ISSN 2326-9901
Éditeur: Journal of Biological Methods
DOI: 10.14440/jbm.2025.0101

The costs and benefits of senotherapeutics for human health

Auteurs: Marco Raffaele, Manlio Vinciguerra
Publié dans: The Lancet Healthy Longevity, Numéro 3, 2022, Page(s) e67-e77, ISSN 2666-7568
Éditeur: Elsevier BV
DOI: 10.1016/s2666-7568(21)00300-7

Active acute leukaemia: should transplant be offered to all patients?

Auteurs: Batia Avni, Michael Y Shapira, Igor B Resnick, Polina Stepensky, Reuven Or, Sigal Grisariu
Publié dans: Hematological oncology, 2016, ISSN 1099-1069
Éditeur: Wiley
DOI: 10.1002/hon.2308

Ablation of BAF170 in Developing and Postnatal Dentate Gyrus Affects Neural Stem Cell Proliferation, Differentiation, and Learning.

Auteurs: Tuoc T, Dere E, Radyushkin K, Pham L, Nguyen H, Tonchev A, Sun G, Ronnenberg A, Shi Y, Staiger J, Ehrenreich H, Stoykova A.
Publié dans: MOLECULAR NEUROBIOLOGY., Numéro Aug;54(6), 2017, Page(s) 4618–35, ISSN 1559-1182
Éditeur: Springer
DOI: 10.1007/s12035-016-9948-5

Systemic depletion of histone macroH2A1.1 boosts hippocampal synaptic plasticity and social behavior in mice.

Auteurs: Valentina Chiodi; Maria Rosaria Domenici; Tommaso Biagini; Roberta De Simone; Anna Maria Tartaglione; Michelino Di Rosa; Oriana Lo Re; Tommaso Mazza; Vincenzo Micale; Vincenzo Micale; Manlio Vinciguerra; Manlio Vinciguerra
Publié dans: The FASEB Journal, Numéro 08926638, 2021, ISSN 0892-6638
Éditeur: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202100569r

Distribution, Function, and Expression of the Apelinergic System in the Healthy and Diseased Mammalian Brain

Auteurs: Martin N. Ivanov, Dimo S. Stoyanov, Stoyan P. Pavlov, Anton. B. Tonchev
Publié dans: Genes, Numéro 13, 2025, Page(s) 2172, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes13112172

Histone Variant macroH2A1.1 Enhances Nonhomologous End Joining-dependent DNA Double-strand-break Repair and Reprogramming Efficiency of Human iPSCs

Auteurs: Sebastiano Giallongo, Daniela Řeháková, Tommaso Biagini, Oriana Lo Re, Priyanka Raina, Gabriela Lochmanová, Zbyněk Zdráhal, Igor Resnick, Pille Pata, Illar Pata, Martin Mistrík, João Pedro de Magalhães, Tommaso Mazza, Irena Koutná, Manlio Vinciguerra
Publié dans: Stem Cells, Numéro 10665099, 2022, ISSN 1066-5099
Éditeur: AlphaMed Press Inc
DOI: 10.1093/stmcls/sxab004

Cardio- and Neurometabolic Adipobiology: Consequences and Implications for Therapy

Auteurs: Frohlich J, Chaldakov GN, Vinciguerra M.
Publié dans: International Journal of Molecular Sciences, Numéro 14220067, 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22084137

Reduced neuroinflammation and enhanced neurogenesis following chronic agomelatine treatment in rats undergoing chronic constant light

Auteurs: Atanasova D, Lazarov N, Stoyanov DS, Spassov RH, Tonchev AB, Tchekalarova J
Publié dans: Neuropharmacology, Numéro 00283908, 2021, ISSN 0028-3908
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2021.108706

Tracking cell turnover in human brain using 15N-thymidine imaging mass spectrometry

Auteurs: Sebastian S. Roeder, Elisa A. Bonnin, Ting-Di Wu, Jean-Luc Guerquin-Kern, Samir Jabari, Sebastian Brandner, Ilker Y. Eyüpoglu, Stephanie Gollwitzer, Hajo M. Hamer, Stefan T. Gerner, Thorsten R. Doeppner, Christoph Rummel, Elisabet Englund, Ralph Heimke-Brinck, Tobias Borst, Christoph Daniel, Kerstin Amann, Ursula Schlötzer-Schrehardt, Anton B. Tonchev, Karl Roessler, Stefan Schwab, Olaf Bergmann
Publié dans: Frontiers in Neuroscience, Numéro 17, 2024, ISSN 1662-453X
Éditeur: Frontiers Media SA
DOI: 10.3389/fnins.2023.1274607

Expression of Transcription Factor ZBTB20 in the Adult Primate Neurogenic Niche under Physiological Conditions or after Ischemia

Auteurs: Dimo S. Stoyanov, Martin N. Ivanov, Tetsumori Yamashima, Anton B. Tonchev
Publié dans: Genes, Numéro 20734425, 2022, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes13091559

Downregulation of Aging-Associated Gene SUCLG1 Marks the Aggressiveness of Liver Disease

Auteurs: Desislava K. Tsoneva, Alessandro Napoli, Mariya Teneva, Tommaso Mazza, Manlio Vinciguerra
Publié dans: Cancers, Numéro 17, 2025, Page(s) 339, ISSN 2072-6694
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers17030339

Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects.

Auteurs: Marco Raffaele; Kristina Kovacovicova; Tommaso Biagini; Oriana Lo Re; Jan Frohlich; Sebastiano Giallongo; James D. Nhan; Antonino Giulio Giannone; Daniela Cabibi; Martin Ivanov; Anton B. Tonchev; Martin Mistrik; Matthew Lacey; Petr Dzubak; Sona Gurska; Marian Hajduch; Jiri Bartek; Jiri Bartek; Tommaso Mazza; Vincenzo Micale; Sean P. Curran; Manlio Vinciguerra
Publié dans: GeroScience, Numéro 25092723, 2021, ISSN 2509-2723
Éditeur: Springer
DOI: 10.1007/s11357-021-00487-y

Quantity, distribution and phenotype of newly generated cells in the intact spinal cord of adult macaque monkeys

Auteurs: D. Marinova, M.N. Ivanov, T. Yamashima, A.B. Tonchev
Publié dans: Heliyon, Numéro 10, 2025, Page(s) e28856, ISSN 2405-8440
Éditeur: Elsevier BV
DOI: 10.1016/j.heliyon.2024.e28856

Deficiency of histone variant macroH2A1.1 is associated with sexually dimorphic obesity in mice

Auteurs: Valentina Chiodi, Francesca Rappa, Oriana Lo Re, George N. Chaldakov, Benjamin Lelouvier, Vincenzo Micale, Maria Rosaria Domenici, Manlio Vinciguerra
Publié dans: Scientific Reports, Numéro 13, 2024, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-46304-8

Ghrelin Regulates Expression of the Transcription Factor Pax6 in Hypoxic Brain Progenitor Cells and Neurons

Auteurs: Irina I. Stoyanova, Andrii Klymenko, Jeannette Willms, Thorsten R. Doeppner, Anton B. Tonchev, David Lutz
Publié dans: Cells, Numéro 20734409, 2022, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells11050782

Simple limbal epithelial transplantation: a review on current approach and future directions

Auteurs: Davide Borroni, Bogumil Wowra, Vito Romano, Maria Boyadzhieva, Diego Ponzin, Stefano Ferrari, Sajjad Ahmad, Mohit Parekh
Publié dans: Survey of Ophthalmology, Numéro 63(6), 2018, Page(s) 869-874, ISSN 1879-3304
Éditeur: Science direct
DOI: 10.1016/j.survophthal.2018.05.003

Epigenetic remodelling in human hepatocellular carcinoma

Auteurs: Maria Rita Braghini, Oriana Lo Re, Ilaria Romito, Maite G. Fernandez-Barrena, Barbara Barbaro, Silvia Pomella, Rossella Rota, Manlio Vinciguerra, Matias A. Avila, Anna Alisi
Publié dans: Journal of Experimental &amp; Clinical Cancer Research, Numéro 41, 2022, ISSN 1756-9966
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/s13046-022-02297-2

Transcriptome Response and Spatial Pattern of Gene Expression in the Primate Subventricular Zone Neurogenic Niche After Cerebral Ischemia

Auteurs: Monika C Chongtham, Haifang Wang, Christina Thaller, Nai-Hua Hsiao, Ivan H Vachkov, Stoyan P Pavlov, Lorenz H Williamson, Tetsumori Yamashima, Anastassia Stoykova, Jun Yan, Gregor Eichele, Anton B Tonchev
Publié dans: Frontiers in Cell and Developmental Biology, 2020, ISSN 2296-634X
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fcell.2020.584314

TNC and GJA1 Are Putative Progenitor Markers That Are Localized in the Perivascular Adventitia of the Adult Monkey Brain Subventricular Niche

Auteurs: Martin N. Ivanov, Dimo S. Stoyanov, Lora V. Veleva, Andon M. Mladenov, Stoyan P. Pavlov, Tetsumori Yamashima, Anton B. Tonchev
Publié dans: International Journal of Molecular Sciences, Numéro 26, 2025, Page(s) 1397, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26041397

Phosphorylation within Intrinsic Disordered Region Discriminates Histone Variant macroH2A1 Splicing Isoforms—macroH2A1.1 and macroH2A1.2

Auteurs: Sebastiano Giallongo, Oriana Lo Re, Gabriela Lochmanová, Luca Parca, Francesco Petrizzelli, Zbyněk Zdráhal, Tommaso Mazza, Manlio Vinciguerra
Publié dans: Biology, Numéro 20797737, 2021, ISSN 2079-7737
Éditeur: MDPI
DOI: 10.3390/biology10070659

Mesenchymal Stromal Cell-Derived Exosomes Affect mRNA Expression and Function of B-Lymphocytes

Auteurs: Drirh Khare, Reuven Or, Igor Resnick, Claudine Barkatz, Osnat Almogi-Hazan and Batia Avni
Publié dans: Front. Immunol., Sec. B Cell Biology, Numéro 9, 2018, ISSN 1664-3224
Éditeur: Frontiers in immunology
DOI: 10.3389/fimmu.2018.03053

Glial Populations in the Human Brain Following Ischemic Injury

Auteurs: Victoria Mihailova, Irina I. Stoyanova, Anton B. Tonchev
Publié dans: Biomedicines, Numéro 11, 2023, Page(s) 2332, ISSN 2227-9059
Éditeur: MDPI AG
DOI: 10.3390/biomedicines11092332

Other (2)

Effectiveness of chemo-G-CSF protocols for mobilization of peripheral stem cells in patients with non-hodgkin lymphomas and hodgkin disease-single center experience

Auteurs: Micheva I, Dimitrova S, Gerov V, Chervenkov T, Gercheva L, Reznik I.
Publié dans: Bone Marrow Transplantation, Numéro 54, 2019, Page(s) 144–619
Éditeur: Nature
DOI: 10.1038/s41409-019-0559-4

Additional file of Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin

Auteurs: Raffaele, Marco; Kovacovicova, Kristina; Frohlich, Jan; Re, Oriana Lo; Giallongo, Sebastiano; Oben, Jude A.; Faldyna, Martin; Leva, Lenka; Giannone, Antonino Giulio; Cabibi, Daniela; Vinciguerra, Manlio
Publié dans: Numéro 1, 2021
Éditeur: Springer Nature
DOI: 10.6084/m9.figshare.14431610.v1

Book chapters (2)

Gene Editing and Human iPSCs in Cardiovascular and Metabolic Diseases

Auteurs: Sebastiano Giallongo, Oriana Lo Re, Igor Resnick, Marco Raffaele, Manlio Vinciguerra
Publié dans: Advances in Experimental Medicine and Biology, Genome Editing in Cardiovascular and Metabolic Diseases, 2023, Page(s) 275-298
Éditeur: Springer Nature Singapore
DOI: 10.1007/978-981-19-5642-3_18

Integrative Analysis of CUT&amp;Tag and RNA-Seq Data Through Bioinformatics: A Unified Workflow for Enhanced Insights

Auteurs: Niccolò Liorni, Alessandro Napoli, Marta Adinolfi, Manlio Vinciguerra, Tommaso Mazza
Publié dans: Methods in Molecular Biology, Chromatin Immunoprecipitation, 2024, Page(s) 191-213
Éditeur: Springer US
DOI: 10.1007/978-1-0716-4071-5_13