TRANSTEM: ERA Chair in Translational Stem Cell Biology

Livrables

Project Website

D7.1. will report the creation of Project Website

Published Job Position Advertisement

D1.3. will report the published Job Position Advertisement

Paper: “Stem Cell Research Department: Vision and Strategy”

D15 will report the publishment of the paper Stem Cell Research Department Vision and Strategy

Report on synergies M36

D76 will report synergies

Newly created department of Stem Cell Biology in RI-MUV

D1.1. will report the creation of the new department of Stem Cell Biology in RI-MUV

10 Published Job Position Advertisements

D22 will report 10 Published Job Position Advertisements

5 academic publications M36

D48 will report 5 academic publications

5 visiting researchers in MUV and SCBD M36

D43 will report 5 visits of researchers in MUV and SCBD

20 co-funded outgoing researcher exchanges carried out M36

D41 will report 20 cofunded outgoing researcher exchanges

Report of ERA Chair-led trainings M36

D45 will report ERA Chairled trainings

DMP Submission

D88 DMP Submission will report Data Management Plan

Publications

<scp>GDF11</scp> inhibits adipogenesis and improves mature adipocytes metabolic function via <scp>WNT</scp> /β‐catenin and <scp>ALK5</scp> / <scp>SMAD2</scp> /3 pathways

Auteurs: Jan Frohlich; Kristina Kovacovicova; Marco Raffaele; Tereza Virglova; Eliska Cizkova; Jan Kucera; Julie Bienertova‐Vasku; Martin Wabitsch; Marion Peyrou; Francesca Bonomini; Rita Rezzani; George N. Chaldakov; Anton B. Tonchev; Michelino Di Rosa; Nicolas Blavet; Vaclav Hejret; Manlio Vinciguerra
Publié dans: Crossref, Numéro 13652184, 2022, ISSN 1365-2184
Éditeur: Cell Proliferation
DOI: 10.1111/cpr.13310

Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin

Auteurs: Marco Raffaele; Kristina Kovacovicova; Jan Frohlich; Oriana Lo Re; Sebastiano Giallongo; Jude A. Oben; Martin Faldyna; Lenka Leva; Antonino Giulio Giannone; Daniela Cabibi; Manlio Vinciguerra; Manlio Vinciguerra
Publié dans: Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-9 (2021), Numéro 1478811X, 2021, ISSN 1478-811X
Éditeur: BioMed Central
DOI: 10.1186/s12964-021-00731-0

Evolution, trends, outcomes, and economics of hematopoietic stem cell transplantation in severe autoimmune diseases

Auteurs: John A. Snowden,corresponding author, Manuela Badoglio, Myriam Labopin, Sebastian Giebel, Eoin McGrath, Zora Marjanovic, Joachim Burman, John Moore, Montserrat Rovira,Nico M. Wulffraat, Majid Kazmi, Raffaella Greco, Emilian Snarski, Tomas Kozak, Kirill Kirgizov, Tobias Alexander,Peter Bader, Riccardo Saccardi, and Dominique Farge
Publié dans: Blood Adv., Numéro 1(27), 2017, Page(s) 2742–2755, ISSN 2473-9537
Éditeur: Bloodadvances
DOI: 10.1182/bloodadvances.2017010041

Zbtb20 Regulates Developmental Neurogenesis in the Olfactory Bulb and Gliogenesis After Adult Brain Injury

Auteurs: Thorsten R Doeppner, Josephine Herz, Mathias Bähr, Anton B Tonchev, Anastassia Stoykova
Publié dans: Molecular Neurobiology, Numéro 56, 2019, Page(s) 567–582, ISSN 0893-7648
Éditeur: Humana Press, Inc.
DOI: 10.1007/s12035-018-1104-y

Implication of GPR40 Signaling in the Subventricular Zone Neurogenesis after Ischemia via Cross-Talk between Neural Progenitors and Microglia

Auteurs: Maryia Y Dazortsava, Ilya V Pyko, Nadezhda B Boneva, Anton B Tonchev, Zhu H, Sawamoto K, Minabe Y and Yamashima T
Publié dans: Journal of Alzheimers Disease & Parkinsonism, Numéro 8(6), 2018, Page(s) 454, ISSN 2161-0460
Éditeur: Journal of Alzheimers Disease & Parkinsonism
DOI: 10.4172/2161-0460.1000454

Active acute leukaemia: should transplant be offered to all patients?

Auteurs: Batia Avni, Michael Y Shapira, Igor B Resnick, Polina Stepensky, Reuven Or, Sigal Grisariu
Publié dans: Hematological oncology, 2016, ISSN 1099-1069
Éditeur: Wiley
DOI: 10.1002/hon.2308

Ablation of BAF170 in Developing and Postnatal Dentate Gyrus Affects Neural Stem Cell Proliferation, Differentiation, and Learning.

Auteurs: Tuoc T, Dere E, Radyushkin K, Pham L, Nguyen H, Tonchev A, Sun G, Ronnenberg A, Shi Y, Staiger J, Ehrenreich H, Stoykova A.
Publié dans: MOLECULAR NEUROBIOLOGY., Numéro Aug;54(6), 2017, Page(s) 4618–35, ISSN 1559-1182
Éditeur: Springer
DOI: 10.1007/s12035-016-9948-5

Systemic depletion of histone macroH2A1.1 boosts hippocampal synaptic plasticity and social behavior in mice.

Auteurs: Valentina Chiodi; Maria Rosaria Domenici; Tommaso Biagini; Roberta De Simone; Anna Maria Tartaglione; Michelino Di Rosa; Oriana Lo Re; Tommaso Mazza; Vincenzo Micale; Vincenzo Micale; Manlio Vinciguerra; Manlio Vinciguerra
Publié dans: The FASEB Journal, Numéro 08926638, 2021, ISSN 0892-6638
Éditeur: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202100569r

Histone Variant macroH2A1.1 Enhances Nonhomologous End Joining-dependent DNA Double-strand-break Repair and Reprogramming Efficiency of Human iPSCs

Auteurs: Sebastiano Giallongo, Daniela Řeháková, Tommaso Biagini, Oriana Lo Re, Priyanka Raina, Gabriela Lochmanová, Zbyněk Zdráhal, Igor Resnick, Pille Pata, Illar Pata, Martin Mistrík, João Pedro de Magalhães, Tommaso Mazza, Irena Koutná, Manlio Vinciguerra
Publié dans: Stem Cells, Numéro 10665099, 2022, ISSN 1066-5099
Éditeur: AlphaMed Press Inc
DOI: 10.1093/stmcls/sxab004

Cardio- and Neurometabolic Adipobiology: Consequences and Implications for Therapy

Auteurs: Frohlich J, Chaldakov GN, Vinciguerra M.
Publié dans: International Journal of Molecular Sciences, Numéro 14220067, 2021, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22084137

Reduced neuroinflammation and enhanced neurogenesis following chronic agomelatine treatment in rats undergoing chronic constant light

Auteurs: Atanasova D, Lazarov N, Stoyanov DS, Spassov RH, Tonchev AB, Tchekalarova J
Publié dans: Neuropharmacology, Numéro 00283908, 2021, ISSN 0028-3908
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.neuropharm.2021.108706

Expression of Transcription Factor ZBTB20 in the Adult Primate Neurogenic Niche under Physiological Conditions or after Ischemia

Auteurs: Dimo S. Stoyanov, Martin N. Ivanov, Tetsumori Yamashima, Anton B. Tonchev
Publié dans: Genes, Numéro 20734425, 2022, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes13091559

Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects.

Auteurs: Marco Raffaele; Kristina Kovacovicova; Tommaso Biagini; Oriana Lo Re; Jan Frohlich; Sebastiano Giallongo; James D. Nhan; Antonino Giulio Giannone; Daniela Cabibi; Martin Ivanov; Anton B. Tonchev; Martin Mistrik; Matthew Lacey; Petr Dzubak; Sona Gurska; Marian Hajduch; Jiri Bartek; Jiri Bartek; Tommaso Mazza; Vincenzo Micale; Sean P. Curran; Manlio Vinciguerra
Publié dans: GeroScience, Numéro 25092723, 2021, ISSN 2509-2723
Éditeur: Springer
DOI: 10.1007/s11357-021-00487-y

Ghrelin Regulates Expression of the Transcription Factor Pax6 in Hypoxic Brain Progenitor Cells and Neurons

Auteurs: Irina I. Stoyanova, Andrii Klymenko, Jeannette Willms, Thorsten R. Doeppner, Anton B. Tonchev, David Lutz
Publié dans: Cells, Numéro 20734409, 2022, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells11050782

Transcriptome Response and Spatial Pattern of Gene Expression in the Primate Subventricular Zone Neurogenic Niche After Cerebral Ischemia

Auteurs: Monika C Chongtham, Haifang Wang, Christina Thaller, Nai-Hua Hsiao, Ivan H Vachkov, Stoyan P Pavlov, Lorenz H Williamson, Tetsumori Yamashima, Anastassia Stoykova, Jun Yan, Gregor Eichele, Anton B Tonchev
Publié dans: Frontiers in Cell and Developmental Biology, 2020, ISSN 2296-634X
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fcell.2020.584314

Phosphorylation within Intrinsic Disordered Region Discriminates Histone Variant macroH2A1 Splicing Isoforms—macroH2A1.1 and macroH2A1.2

Auteurs: Sebastiano Giallongo, Oriana Lo Re, Gabriela Lochmanová, Luca Parca, Francesco Petrizzelli, Zbyněk Zdráhal, Tommaso Mazza, Manlio Vinciguerra
Publié dans: Biology, Numéro 20797737, 2021, ISSN 2079-7737
Éditeur: MDPI
DOI: 10.3390/biology10070659

Mesenchymal Stromal Cell-Derived Exosomes Affect mRNA Expression and Function of B-Lymphocytes

Auteurs: Drirh Khare, Reuven Or, Igor Resnick, Claudine Barkatz, Osnat Almogi-Hazan and Batia Avni
Publié dans: Front. Immunol., Sec. B Cell Biology, Numéro 9, 2018, ISSN 1664-3224
Éditeur: Frontiers in immunology
DOI: 10.3389/fimmu.2018.03053

Effectiveness of chemo-G-CSF protocols for mobilization of peripheral stem cells in patients with non-hodgkin lymphomas and hodgkin disease-single center experience

Auteurs: Micheva I, Dimitrova S, Gerov V, Chervenkov T, Gercheva L, Reznik I.
Publié dans: Bone Marrow Transplantation, Numéro 54, 2019, Page(s) 144–619
Éditeur: Nature
DOI: 10.1038/s41409-019-0559-4

Additional file of Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin

Auteurs: Raffaele, Marco; Kovacovicova, Kristina; Frohlich, Jan; Re, Oriana Lo; Giallongo, Sebastiano; Oben, Jude A.; Faldyna, Martin; Leva, Lenka; Giannone, Antonino Giulio; Cabibi, Daniela; Vinciguerra, Manlio
Publié dans: Numéro 1, 2021
Éditeur: Springer Nature
DOI: 10.6084/m9.figshare.14431610.v1

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