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Imaging life from Molecules to cells - building knowledge on Cryo-electron microscopy methodologies

Project description

Zooming in on protein structures could significantly expand treatment opportunities for dysfunction

Proteins including antibodies, enzymes and hormones are large, complex molecules required for most cell functions. Not surprisingly, protein dysfunction is at the root of numerous diseases and conditions. A characteristic mechanism of protein activity is binding with other molecules at specific sites via conformational changes. Precise characterisation of the detailed 3D structure underlying specific functions is critical to advancing understanding. Nobel-winning cryo-electron microscopy enables imaging of frozen hydrated specimens in their native state without dyes or fixatives. It has opened a new window on fine cellular structures at molecular resolution. IMpaCT is using this revolutionary technique to visualise proteins related to human health while raising the visibility of the coordinating university.

Call for proposal

H2020-WIDESPREAD-2018-2020

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Sub call

H2020-WIDESPREAD-2018-03

Coordinator

UNIVERSIDADE NOVA DE LISBOA
Net EU contribution
€ 412 616,25
Address
Campus De Campolide
1099 085 Lisboa
Portugal

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Region
Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (3)

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Net EU contribution
€ 100 023,75
Address
Calle Serrano 117
28006 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Other funding
€ 0,00
HELSINGIN YLIOPISTO
Finland
Net EU contribution
€ 146 316,25
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto

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Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
WEIZMANN INSTITUTE OF SCIENCE
Israel
Net EU contribution
€ 141 043,75
Address
Herzl Street 234
7610001 Rehovot

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Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00