Project description
Zooming in on protein structures could significantly expand treatment opportunities for dysfunction
Proteins including antibodies, enzymes and hormones are large, complex molecules required for most cell functions. Not surprisingly, protein dysfunction is at the root of numerous diseases and conditions. A characteristic mechanism of protein activity is binding with other molecules at specific sites via conformational changes. Precise characterisation of the detailed 3D structure underlying specific functions is critical to advancing understanding. Nobel-winning cryo-electron microscopy enables imaging of frozen hydrated specimens in their native state without dyes or fixatives. It has opened a new window on fine cellular structures at molecular resolution. IMpaCT is using this revolutionary technique to visualise proteins related to human health while raising the visibility of the coordinating university.
Fields of science
Programme(s)
- H2020-EU.4.b. - Twinning of research institutions Main Programme
Topic(s)
Funding Scheme
CSA - Coordination and support action
Coordinator
1099 085 Lisboa
Portugal
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Participants (3)
28006 Madrid
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00014 Helsingin Yliopisto
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7610001 Rehovot
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