Integration of knowledge and biobank resources in comprehensive translational approach for personalized prevention and treatment of metabolic disorders

Project Information

INTEGROMED

Grant agreement ID: 857572

DOI

10.3030/857572

Project closed

EC signature date 18 June 2019

Start date 1 October 2019

End date 31 March 2023

Funded under

• Twinning of research institutions

Total cost

€ 800 000,00

EU contribution

€ 800 000,00

Coordinated by

LATVIJAS BIOMEDICINAS PETIJUMU UN STUDIJU CENTRS
Latvia

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (1)

Brochures describing the available biobank resource and its application in clinical studies

Websites, patent fillings, videos etc. (3)

Guidelines for the maintenance of efficient biobank, health register and research associated data management

Guidelines for the maintenance of efficient biobank health register and research associated data management

Creation of INTEGROMED website, including monthly website updates
Recommendations for LBMC scientists on design creation and conducting of academic clinical trials

Recommendations for LBMC scientists on design creation and conducting of academicclinical trials

Publications

Peer reviewed articles (24)

Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients

Author(s): Elbere I, Silamikelis I, Dindune II, Kalnina I, Ustinova M, Zaharenko L, Silamikele L, Rovite V, Gudra D, Konrade I, Sokolovska J, Pirags V, Klovins J.
Published in: PLoS One, Issue 15(10), 2020, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0241338

First Report on the Latvian SARS-CoV-2 Isolate Genetic Diversity

Author(s): Zrelovs N, Ustinova M, Silamikelis I, Birzniece L, Megnis K, Rovite V, Freimane L, Silamikele L, Ansone L, Pjalkovskis J, Fridmanis D, Vilne B, Priedite M, Caica A, Gavars M, Perminov D, Storozenko J, Savicka O, Dimina E, Dumpis U, Klovins J.
Published in: Frontiers in Medicine (Lausanne), Issue 8:626000, 2021, ISSN 2296-858X
Publisher: Frontiers Media S.A., Lausanne
DOI: 10.3389/fmed.2021.626000

Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues

Author(s): Zake DM, Kurlovics J, Zaharenko L, Komasilovs V, Klovins J, Stalidzans E.
Published in: PLoS One, Issue 16/4, 2021, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0249594

Metformin Strongly Affects Gut Microbiome Composition in High-Fat Diet-Induced Type 2 Diabetes Mouse Model of Both Sexes

Author(s): Silamiķele L, Silamiķelis I, Ustinova M, Kalniņa Z, Elbere I, Petrovska R, Kalniņa I, Kloviņš J.
Published in: Front Endocrinol (Lausanne), Issue 12:626359, 2021, ISSN 1664-2392
Publisher: Frontiers Media S.A., Lausanne
DOI: 10.3389/fendo.2021.626359

Whole-blood transcriptome profiling reveals signatures of metformin and its therapeutic response

Author(s): Ustinova M, Ansone L, Silamikelis I, Rovite V, Elbere I, Silamikele L, Kalnina I, Fridmanis D, Sokolovska J, Konrade I, Pirags V, Klovins J.
Published in: PLoS One, Issue 15/8, 2020, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0237400

Replication of LZTFL1 Gene Region as a Susceptibility Locus for COVID-19 in Latvian Population. Virol Sin

Author(s): Rescenko R, Peculis R, Briviba M, Ansone L, Terentjeva A, Litvina HD, Birzniece L, Megnis K, Kolesova O, Rozentale B, Viksna L, Rovite V, Klovins J.
Published in: Virologica Sinica, Issue 36(5), 2021, Page(s) 1241-1244, ISSN 1674-0769
Publisher: Wuhan Institute of Virology, Chinese Academy of Sciences
DOI: 10.1007/s12250-021-00448-x

Toll-Like Receptor 1 Locus Re-examined in a Genome-Wide Association Study Update on Anti-Helicobacter pylori IgG Titers

Author(s): Lam SY, Mommersteeg MC, Yu B, Broer L, Spaander MCW, Frost F, Weiss S, Völzke H, Lerch MM, Schöttker B, Zhang Y, Stocker H, Brenner H, Levy D, Hwang SJ, Wood AC, Rich SS, Rotter JI, Taylor KD, Tracy RP, Kabagambe EK, Leja M, Klovins J, Peculis R, Rudzite D, Nikitina-Zake L, Skenders G, Rovite V, Uitterlinden A, Kuipers EJ, Fuhler GM, Homuth G, Peppelenbosch MP.
Published in: Gastroenterology, Issue 162(6), 2022, Page(s) 1705-1715, ISSN 0346-251X
Publisher: Pergamon Press Ltd.
DOI: 10.1053/j.gastro.2022.01.011

Novel susceptibility loci identified in a genome-wide association study of type 2 diabetes complications in population of Latvia

Author(s): Ustinova M, Peculis R, Rescenko R, Rovite V, Zaharenko L, Elbere I, Silamikele L, Konrade I, Sokolovska J, Pirags V, Klovins J.
Published in: Med Genomics, Issue 14(1), 2021, ISSN 1755-8794
Publisher: BioMed Central
DOI: 10.1186/s12920-020-00860-4

COVID-19 Host Genetics Initiative. Mapping the human genetic architecture of COVID-19

Author(s): -
Published in: Nature, Issue 608, 2021, Page(s) 472-477, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03767-x

Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas

Author(s): Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A,Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC,Mercader JM, Kaur V, Witte JS, Lee MTM, Kamatani Y, Momozawa Y, Kubo M, PalmerCNA, Florez JC, Hedderson MM, 't Hart LM, Giacomini KM, Pearson ER; for MetGenPlus, for the DIRECT Consortium; MetGen Plus investigators
Published in: Diabetes Care, Issue 44(12), 2021, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc21-1152

A widely used sampling device in colorectal cancer screening programmes allows for large-scale microbiome studies

Author(s): Dita Gudra, Saeed Shoaie, Davids Fridmanis, Janis Klovins, Hugo Wefer, Ivars Silamikelis, Raitis Peculis, Ineta Kalnina, Ilze Elbere, Ilze Radovica-Spalvina, Rolf Hultcrantz, Ģirts Šķenders, Marcis Leja, Lars Engstrand
Published in: Gut, Issue 68/9, 2019, Page(s) 1723-1725, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-316225

Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals

Author(s): Monta Ustinova, Ivars Silamikelis, Ineta Kalnina, Laura Ansone, Vita Rovite, Ilze Elbere, Ilze Radovica-Spalvina, Davids Fridmanis, Jekaterina Aladyeva, Ilze Konrade, Valdis Pirags, Janis Klovins
Published in: PLOS ONE, Issue 14/11, 2019, Page(s) e0224835, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0224835

Genome Database of the Latvian Population (LGDB): Design, Goals, and Primary Results

Author(s): Vita Rovite, Yael Wolff-Sagi, Linda Zaharenko, Liene Nikitina-Zake, Elmars Grens, Janis Klovins
Published in: Journal of Epidemiology, Issue 28/8, 2018, Page(s) 353-360, ISSN 0917-5040
Publisher: Tokyo University of Agriculture
DOI: 10.2188/jea.je20170079

Association of metformin administration with gut microbiome dysbiosis in healthy volunteers

Author(s): Ilze Elbere, Ineta Kalnina, Ivars Silamikelis, Ilze Konrade, Linda Zaharenko, Kristine Sekace, Ilze Radovica-Spalvina, Davids Fridmanis, Dita Gudra, Valdis Pirags, Janis Klovins
Published in: PLOS ONE, Issue 13/9, 2018, Page(s) e0204317, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0204317

Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients

Author(s): Linda Zaharenko, Ineta Kalnina, Kristine Geldnere, Ilze Konrade, Solveiga Grinberga, Jozef Židzik, Martin Javorský, Aivars Lejnieks, Liene Nikitina-Zake, Davids Fridmanis, Raitis Peculis, Ilze Radovica-Spalvina, Dace Hartmane, Osvalds Pugovics, Ivan Tkáč, Lucia Klimčáková, Valdis Pīrāgs, Janis Klovins
Published in: European Journal of Endocrinology, Issue 175/6, 2016, Page(s) 531-540, ISSN 0804-4643
Publisher: BioScientifica Ltd.
DOI: 10.1530/eje-16-0347

DNA methylation of the Oct4A enhancers in embryonal carcinoma cells after etoposide treatment is associated with alternative splicing and altered pluripotency in reversibly senescent cells

Author(s): Mikhail Baryshev, Inna Inashkina, Kristine Salmina, Anda Huna, Thomas R Jackson, Jekaterina Erenpreisa
Published in: Cell Cycle, Issue 17/3, 2018, Page(s) 362-366, ISSN 1538-4101
Publisher: Landes Bioscience
DOI: 10.1080/15384101.2018.1426412

Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals

Author(s): Ilze Elbere, Ivars Silamikelis, Monta Ustinova, Ineta Kalnina, Linda Zaharenko, Raitis Peculis, Ilze Konrade, Diana Maria Ciuculete, Christina Zhukovsky, Dita Gudra, Ilze Radovica-Spalvina, Davids Fridmanis, Valdis Pirags, Helgi B. Schiöth, Janis Klovins
Published in: Clinical Epigenetics, Issue 10/1, 2018, ISSN 1868-7075
Publisher: Springer Verlag
DOI: 10.1186/s13148-018-0593-x

Metabolomic Fingerprints in Large Population Cohorts: Impact of Preanalytical Heterogeneity

Author(s): Ghini V, Abuja PM, Polasek O, Kozera L, Laiho P, Anton G, Zins M, Klovins J, Metspalu A, Wichmann HE, Gieger C, Luchinat C, Zatloukal K, Turano P.
Published in: Clinical Chemistry, Issue 67(8), 2021, Page(s) 133-142, ISSN 0009-9147
Publisher: American Association for Clinical Chemistry, Inc.
DOI: 10.1093/clinchem/hvab092

Metformin Transport Rates Between Plasma and Red Blood Cells in Humans.

Author(s): Kurlovics J, Zake DM, Zaharenko L, Berzins K, Klovins J, Stalidzans E.
Published in: Clinical Pharmacokinetics, Issue 61(1), 2021, Page(s) 133-142, ISSN 0312-5963
Publisher: Adis International Ltd.
DOI: 10.1007/s40262-021-01058-2

Amino Acid Metabolism is Significantly Altered at the Time of Admission in Hospital for Severe COVID-19 Patients: Findings from Longitudinal Targeted Metabolomics Analysis. Microbiol Spectr.

Author(s): Ansone L, Briviba M, Silamikelis I, Terentjeva A, Perkons I, Birzniece L, Rovite V, Rozentale B, Viksna L, Kolesova O, Klavins K, Klovins J.
Published in: Microbiology Spectrum, Issue 9(3), 2021, ISSN 2165-0497
Publisher: American Society for Microbiology
DOI: 10.1128/spectrum.00338-21

Whole exome sequencing reveals novel risk genes of pituitary neuroendocrine tumors

Author(s): Peculis R, Rovite V, Megnis K, Balcere I, Breiksa A, Nazarovs J, Stukens J, Konrade I, Sokolovska J, Pirags V, Klovins J.
Published in: PLoS One, Issue 17(8), 2022, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0265306

Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes

Author(s): García-Calzón S, Perfilyev A, Martinell M, Ustinova M, Kalamajski S, Franks PW, Bacos K, Elbere I, Pihlajamäki J, Volkov P, Vaag A, Groop L, Maziarz M, Klovins J, Ahlqvist E, Ling C.
Published in: SCIENCE TRANSLATIONAL MEDICINE, Issue 12(561), 2020, ISSN 1946-6234
Publisher: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aaz1803

Spatial variation of the gut microbiome in response to long-term metformin treatment in high-fat diet-induced type 2 diabetes mouse model of both sexes

Author(s): Silamiķele L, Saksis R, Silamiķelis I, Kotoviča PP, Brīvība M, Kalniņa I, Kalniņa Z, Fridmanis D, Kloviņš J.
Published in: Gut Microbes., Issue 15(1), 2023, ISSN 1949-0976
Publisher: Landes Bioscience
DOI: 10.1080/19490976.2023.2188663

Statistical and Machine Learning Techniques in Human Microbiome Studies: Contemporary Challenges and Solutions

Author(s): Moreno-Indias I, Lahti L, Nedyalkova M, Elbere I, Roshchupkin G, Adilovic M, Aydemir O, Bakir-Gungor B, Santa Pau EC, D’Elia D, Desai MS, Falquet L, Gundogdu A, Hron K, Klammsteiner T, Lopes MB, Marcos-Zambrano LJ, Marques C, Mason M, May P, Pašić L, Pio G, Pongor S, Promponas VJ, Przymus P, Saez-Rodriguez J, Sampri A, Shigdel R, Stres B, Suharoschi R, Truu J, Truică C-O, Vilne B, Vlachakis D
Published in: Frontiers in Microbiology, Issue 12/2021, 2021, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2021.635781