Integration of knowledge and biobank resources in comprehensive translational approach for personalized prevention and treatment of metabolic disorders

Deliverables

Documents, reports (1)

Brochures describing the available biobank resource and its application in clinical studies

Websites, patent fillings, videos etc. (1)

Creation of INTEGROMED website, including monthly website updates

Publications

Peer reviewed articles (7)

A widely used sampling device in colorectal cancer screening programmes allows for large-scale microbiome studies

Author(s): Dita Gudra, Saeed Shoaie, Davids Fridmanis, Janis Klovins, Hugo Wefer, Ivars Silamikelis, Raitis Peculis, Ineta Kalnina, Ilze Elbere, Ilze Radovica-Spalvina, Rolf Hultcrantz, Ģirts Šķenders, Marcis Leja, Lars Engstrand
Published in: Gut, 68/9, 2019, Page(s) 1723-1725, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-316225

Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals

Author(s): Monta Ustinova, Ivars Silamikelis, Ineta Kalnina, Laura Ansone, Vita Rovite, Ilze Elbere, Ilze Radovica-Spalvina, Davids Fridmanis, Jekaterina Aladyeva, Ilze Konrade, Valdis Pirags, Janis Klovins
Published in: PLOS ONE, 14/11, 2019, Page(s) e0224835, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0224835

Genome Database of the Latvian Population (LGDB): Design, Goals, and Primary Results

Author(s): Vita Rovite, Yael Wolff-Sagi, Linda Zaharenko, Liene Nikitina-Zake, Elmars Grens, Janis Klovins
Published in: Journal of Epidemiology, 28/8, 2018, Page(s) 353-360, ISSN 0917-5040
Publisher: Tokyo University of Agriculture
DOI: 10.2188/jea.je20170079

Association of metformin administration with gut microbiome dysbiosis in healthy volunteers

Author(s): Ilze Elbere, Ineta Kalnina, Ivars Silamikelis, Ilze Konrade, Linda Zaharenko, Kristine Sekace, Ilze Radovica-Spalvina, Davids Fridmanis, Dita Gudra, Valdis Pirags, Janis Klovins
Published in: PLOS ONE, 13/9, 2018, Page(s) e0204317, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0204317

Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients

Author(s): Linda Zaharenko, Ineta Kalnina, Kristine Geldnere, Ilze Konrade, Solveiga Grinberga, Jozef Židzik, Martin Javorský, Aivars Lejnieks, Liene Nikitina-Zake, Davids Fridmanis, Raitis Peculis, Ilze Radovica-Spalvina, Dace Hartmane, Osvalds Pugovics, Ivan Tkáč, Lucia Klimčáková, Valdis Pīrāgs, Janis Klovins
Published in: European Journal of Endocrinology, 175/6, 2016, Page(s) 531-540, ISSN 0804-4643
Publisher: BioScientifica Ltd.
DOI: 10.1530/eje-16-0347

DNA methylation of the Oct4A enhancers in embryonal carcinoma cells after etoposide treatment is associated with alternative splicing and altered pluripotency in reversibly senescent cells

Author(s): Mikhail Baryshev, Inna Inashkina, Kristine Salmina, Anda Huna, Thomas R Jackson, Jekaterina Erenpreisa
Published in: Cell Cycle, 17/3, 2018, Page(s) 362-366, ISSN 1538-4101
Publisher: Landes Bioscience
DOI: 10.1080/15384101.2018.1426412

Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals

Author(s): Ilze Elbere, Ivars Silamikelis, Monta Ustinova, Ineta Kalnina, Linda Zaharenko, Raitis Peculis, Ilze Konrade, Diana Maria Ciuculete, Christina Zhukovsky, Dita Gudra, Ilze Radovica-Spalvina, Davids Fridmanis, Valdis Pirags, Helgi B. Schiöth, Janis Klovins
Published in: Clinical Epigenetics, 10/1, 2018, ISSN 1868-7075
Publisher: Springer Verlag
DOI: 10.1186/s13148-018-0593-x