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Integration of knowledge and biobank resources in comprehensive translational approach for personalized prevention and treatment of metabolic disorders


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A widely used sampling device in colorectal cancer screening programmes allows for large-scale microbiome studies

Author(s): Dita Gudra, Saeed Shoaie, Davids Fridmanis, Janis Klovins, Hugo Wefer, Ivars Silamikelis, Raitis Peculis, Ineta Kalnina, Ilze Elbere, Ilze Radovica-Spalvina, Rolf Hultcrantz, Ģirts Šķenders, Marcis Leja, Lars Engstrand
Published in: Gut, 68/9, 2019, Page(s) 1723-1725, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-316225

Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals

Author(s): Monta Ustinova, Ivars Silamikelis, Ineta Kalnina, Laura Ansone, Vita Rovite, Ilze Elbere, Ilze Radovica-Spalvina, Davids Fridmanis, Jekaterina Aladyeva, Ilze Konrade, Valdis Pirags, Janis Klovins
Published in: PLOS ONE, 14/11, 2019, Page(s) e0224835, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0224835

Genome Database of the Latvian Population (LGDB): Design, Goals, and Primary Results

Author(s): Vita Rovite, Yael Wolff-Sagi, Linda Zaharenko, Liene Nikitina-Zake, Elmars Grens, Janis Klovins
Published in: Journal of Epidemiology, 28/8, 2018, Page(s) 353-360, ISSN 0917-5040
Publisher: Tokyo University of Agriculture
DOI: 10.2188/jea.je20170079

Association of metformin administration with gut microbiome dysbiosis in healthy volunteers

Author(s): Ilze Elbere, Ineta Kalnina, Ivars Silamikelis, Ilze Konrade, Linda Zaharenko, Kristine Sekace, Ilze Radovica-Spalvina, Davids Fridmanis, Dita Gudra, Valdis Pirags, Janis Klovins
Published in: PLOS ONE, 13/9, 2018, Page(s) e0204317, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0204317

Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients

Author(s): Linda Zaharenko, Ineta Kalnina, Kristine Geldnere, Ilze Konrade, Solveiga Grinberga, Jozef Židzik, Martin Javorský, Aivars Lejnieks, Liene Nikitina-Zake, Davids Fridmanis, Raitis Peculis, Ilze Radovica-Spalvina, Dace Hartmane, Osvalds Pugovics, Ivan Tkáč, Lucia Klimčáková, Valdis Pīrāgs, Janis Klovins
Published in: European Journal of Endocrinology, 175/6, 2016, Page(s) 531-540, ISSN 0804-4643
Publisher: BioScientifica Ltd.
DOI: 10.1530/eje-16-0347

DNA methylation of the Oct4A enhancers in embryonal carcinoma cells after etoposide treatment is associated with alternative splicing and altered pluripotency in reversibly senescent cells

Author(s): Mikhail Baryshev, Inna Inashkina, Kristine Salmina, Anda Huna, Thomas R Jackson, Jekaterina Erenpreisa
Published in: Cell Cycle, 17/3, 2018, Page(s) 362-366, ISSN 1538-4101
Publisher: Landes Bioscience
DOI: 10.1080/15384101.2018.1426412

Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals

Author(s): Ilze Elbere, Ivars Silamikelis, Monta Ustinova, Ineta Kalnina, Linda Zaharenko, Raitis Peculis, Ilze Konrade, Diana Maria Ciuculete, Christina Zhukovsky, Dita Gudra, Ilze Radovica-Spalvina, Davids Fridmanis, Valdis Pirags, Helgi B. Schiöth, Janis Klovins
Published in: Clinical Epigenetics, 10/1, 2018, ISSN 1868-7075
Publisher: Springer Verlag
DOI: 10.1186/s13148-018-0593-x