Integration of knowledge and biobank resources in comprehensive translational approach for personalized prevention and treatment of metabolic disorders

Informazioni relative al progetto

INTEGROMED

ID dell’accordo di sovvenzione: 857572

DOI

10.3030/857572

Progetto chiuso

Data della firma CE 18 Giugno 2019

Data di avvio 1 Ottobre 2019

Data di completamento 31 Marzo 2023

Finanziato da

• Twinning of research institutions

Costo totale

€ 800 000,00

Contributo UE

€ 800 000,00

Coordinato da

LATVIJAS BIOMEDICINAS PETIJUMU UN STUDIJU CENTRS
Latvia

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (1)

Brochures describing the available biobank resource and its application in clinical studies

Websites, patent fillings, videos etc. (3)

Guidelines for the maintenance of efficient biobank, health register and research associated data management

Guidelines for the maintenance of efficient biobank health register and research associated data management

Creation of INTEGROMED website, including monthly website updates
Recommendations for LBMC scientists on design creation and conducting of academic clinical trials

Recommendations for LBMC scientists on design creation and conducting of academicclinical trials

Pubblicazioni

Peer reviewed articles (24)

Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients

Autori: Elbere I, Silamikelis I, Dindune II, Kalnina I, Ustinova M, Zaharenko L, Silamikele L, Rovite V, Gudra D, Konrade I, Sokolovska J, Pirags V, Klovins J.
Pubblicato in: PLoS One, Numero 15(10), 2020, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0241338

First Report on the Latvian SARS-CoV-2 Isolate Genetic Diversity

Autori: Zrelovs N, Ustinova M, Silamikelis I, Birzniece L, Megnis K, Rovite V, Freimane L, Silamikele L, Ansone L, Pjalkovskis J, Fridmanis D, Vilne B, Priedite M, Caica A, Gavars M, Perminov D, Storozenko J, Savicka O, Dimina E, Dumpis U, Klovins J.
Pubblicato in: Frontiers in Medicine (Lausanne), Numero 8:626000, 2021, ISSN 2296-858X
Editore: Frontiers Media S.A., Lausanne
DOI: 10.3389/fmed.2021.626000

Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues

Autori: Zake DM, Kurlovics J, Zaharenko L, Komasilovs V, Klovins J, Stalidzans E.
Pubblicato in: PLoS One, Numero 16/4, 2021, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0249594

Metformin Strongly Affects Gut Microbiome Composition in High-Fat Diet-Induced Type 2 Diabetes Mouse Model of Both Sexes

Autori: Silamiķele L, Silamiķelis I, Ustinova M, Kalniņa Z, Elbere I, Petrovska R, Kalniņa I, Kloviņš J.
Pubblicato in: Front Endocrinol (Lausanne), Numero 12:626359, 2021, ISSN 1664-2392
Editore: Frontiers Media S.A., Lausanne
DOI: 10.3389/fendo.2021.626359

Whole-blood transcriptome profiling reveals signatures of metformin and its therapeutic response

Autori: Ustinova M, Ansone L, Silamikelis I, Rovite V, Elbere I, Silamikele L, Kalnina I, Fridmanis D, Sokolovska J, Konrade I, Pirags V, Klovins J.
Pubblicato in: PLoS One, Numero 15/8, 2020, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0237400

Replication of LZTFL1 Gene Region as a Susceptibility Locus for COVID-19 in Latvian Population. Virol Sin

Autori: Rescenko R, Peculis R, Briviba M, Ansone L, Terentjeva A, Litvina HD, Birzniece L, Megnis K, Kolesova O, Rozentale B, Viksna L, Rovite V, Klovins J.
Pubblicato in: Virologica Sinica, Numero 36(5), 2021, Pagina/e 1241-1244, ISSN 1674-0769
Editore: Wuhan Institute of Virology, Chinese Academy of Sciences
DOI: 10.1007/s12250-021-00448-x

Toll-Like Receptor 1 Locus Re-examined in a Genome-Wide Association Study Update on Anti-Helicobacter pylori IgG Titers

Autori: Lam SY, Mommersteeg MC, Yu B, Broer L, Spaander MCW, Frost F, Weiss S, Völzke H, Lerch MM, Schöttker B, Zhang Y, Stocker H, Brenner H, Levy D, Hwang SJ, Wood AC, Rich SS, Rotter JI, Taylor KD, Tracy RP, Kabagambe EK, Leja M, Klovins J, Peculis R, Rudzite D, Nikitina-Zake L, Skenders G, Rovite V, Uitterlinden A, Kuipers EJ, Fuhler GM, Homuth G, Peppelenbosch MP.
Pubblicato in: Gastroenterology, Numero 162(6), 2022, Pagina/e 1705-1715, ISSN 0346-251X
Editore: Pergamon Press Ltd.
DOI: 10.1053/j.gastro.2022.01.011

Novel susceptibility loci identified in a genome-wide association study of type 2 diabetes complications in population of Latvia

Autori: Ustinova M, Peculis R, Rescenko R, Rovite V, Zaharenko L, Elbere I, Silamikele L, Konrade I, Sokolovska J, Pirags V, Klovins J.
Pubblicato in: Med Genomics, Numero 14(1), 2021, ISSN 1755-8794
Editore: BioMed Central
DOI: 10.1186/s12920-020-00860-4

COVID-19 Host Genetics Initiative. Mapping the human genetic architecture of COVID-19

Autori: -
Pubblicato in: Nature, Numero 608, 2021, Pagina/e 472-477, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-021-03767-x

Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas

Autori: Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A,Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC,Mercader JM, Kaur V, Witte JS, Lee MTM, Kamatani Y, Momozawa Y, Kubo M, PalmerCNA, Florez JC, Hedderson MM, 't Hart LM, Giacomini KM, Pearson ER; for MetGenPlus, for the DIRECT Consortium; MetGen Plus investigators
Pubblicato in: Diabetes Care, Numero 44(12), 2021, ISSN 0149-5992
Editore: American Diabetes Association
DOI: 10.2337/dc21-1152

A widely used sampling device in colorectal cancer screening programmes allows for large-scale microbiome studies

Autori: Dita Gudra, Saeed Shoaie, Davids Fridmanis, Janis Klovins, Hugo Wefer, Ivars Silamikelis, Raitis Peculis, Ineta Kalnina, Ilze Elbere, Ilze Radovica-Spalvina, Rolf Hultcrantz, Ģirts Šķenders, Marcis Leja, Lars Engstrand
Pubblicato in: Gut, Numero 68/9, 2019, Pagina/e 1723-1725, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-316225

Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals

Autori: Monta Ustinova, Ivars Silamikelis, Ineta Kalnina, Laura Ansone, Vita Rovite, Ilze Elbere, Ilze Radovica-Spalvina, Davids Fridmanis, Jekaterina Aladyeva, Ilze Konrade, Valdis Pirags, Janis Klovins
Pubblicato in: PLOS ONE, Numero 14/11, 2019, Pagina/e e0224835, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0224835

Genome Database of the Latvian Population (LGDB): Design, Goals, and Primary Results

Autori: Vita Rovite, Yael Wolff-Sagi, Linda Zaharenko, Liene Nikitina-Zake, Elmars Grens, Janis Klovins
Pubblicato in: Journal of Epidemiology, Numero 28/8, 2018, Pagina/e 353-360, ISSN 0917-5040
Editore: Tokyo University of Agriculture
DOI: 10.2188/jea.je20170079

Association of metformin administration with gut microbiome dysbiosis in healthy volunteers

Autori: Ilze Elbere, Ineta Kalnina, Ivars Silamikelis, Ilze Konrade, Linda Zaharenko, Kristine Sekace, Ilze Radovica-Spalvina, Davids Fridmanis, Dita Gudra, Valdis Pirags, Janis Klovins
Pubblicato in: PLOS ONE, Numero 13/9, 2018, Pagina/e e0204317, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0204317

Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients

Autori: Linda Zaharenko, Ineta Kalnina, Kristine Geldnere, Ilze Konrade, Solveiga Grinberga, Jozef Židzik, Martin Javorský, Aivars Lejnieks, Liene Nikitina-Zake, Davids Fridmanis, Raitis Peculis, Ilze Radovica-Spalvina, Dace Hartmane, Osvalds Pugovics, Ivan Tkáč, Lucia Klimčáková, Valdis Pīrāgs, Janis Klovins
Pubblicato in: European Journal of Endocrinology, Numero 175/6, 2016, Pagina/e 531-540, ISSN 0804-4643
Editore: BioScientifica Ltd.
DOI: 10.1530/eje-16-0347

DNA methylation of the Oct4A enhancers in embryonal carcinoma cells after etoposide treatment is associated with alternative splicing and altered pluripotency in reversibly senescent cells

Autori: Mikhail Baryshev, Inna Inashkina, Kristine Salmina, Anda Huna, Thomas R Jackson, Jekaterina Erenpreisa
Pubblicato in: Cell Cycle, Numero 17/3, 2018, Pagina/e 362-366, ISSN 1538-4101
Editore: Landes Bioscience
DOI: 10.1080/15384101.2018.1426412

Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals

Autori: Ilze Elbere, Ivars Silamikelis, Monta Ustinova, Ineta Kalnina, Linda Zaharenko, Raitis Peculis, Ilze Konrade, Diana Maria Ciuculete, Christina Zhukovsky, Dita Gudra, Ilze Radovica-Spalvina, Davids Fridmanis, Valdis Pirags, Helgi B. Schiöth, Janis Klovins
Pubblicato in: Clinical Epigenetics, Numero 10/1, 2018, ISSN 1868-7075
Editore: Springer Verlag
DOI: 10.1186/s13148-018-0593-x

Metabolomic Fingerprints in Large Population Cohorts: Impact of Preanalytical Heterogeneity

Autori: Ghini V, Abuja PM, Polasek O, Kozera L, Laiho P, Anton G, Zins M, Klovins J, Metspalu A, Wichmann HE, Gieger C, Luchinat C, Zatloukal K, Turano P.
Pubblicato in: Clinical Chemistry, Numero 67(8), 2021, Pagina/e 133-142, ISSN 0009-9147
Editore: American Association for Clinical Chemistry, Inc.
DOI: 10.1093/clinchem/hvab092

Metformin Transport Rates Between Plasma and Red Blood Cells in Humans.

Autori: Kurlovics J, Zake DM, Zaharenko L, Berzins K, Klovins J, Stalidzans E.
Pubblicato in: Clinical Pharmacokinetics, Numero 61(1), 2021, Pagina/e 133-142, ISSN 0312-5963
Editore: Adis International Ltd.
DOI: 10.1007/s40262-021-01058-2

Amino Acid Metabolism is Significantly Altered at the Time of Admission in Hospital for Severe COVID-19 Patients: Findings from Longitudinal Targeted Metabolomics Analysis. Microbiol Spectr.

Autori: Ansone L, Briviba M, Silamikelis I, Terentjeva A, Perkons I, Birzniece L, Rovite V, Rozentale B, Viksna L, Kolesova O, Klavins K, Klovins J.
Pubblicato in: Microbiology Spectrum, Numero 9(3), 2021, ISSN 2165-0497
Editore: American Society for Microbiology
DOI: 10.1128/spectrum.00338-21

Whole exome sequencing reveals novel risk genes of pituitary neuroendocrine tumors

Autori: Peculis R, Rovite V, Megnis K, Balcere I, Breiksa A, Nazarovs J, Stukens J, Konrade I, Sokolovska J, Pirags V, Klovins J.
Pubblicato in: PLoS One, Numero 17(8), 2022, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0265306

Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes

Autori: García-Calzón S, Perfilyev A, Martinell M, Ustinova M, Kalamajski S, Franks PW, Bacos K, Elbere I, Pihlajamäki J, Volkov P, Vaag A, Groop L, Maziarz M, Klovins J, Ahlqvist E, Ling C.
Pubblicato in: SCIENCE TRANSLATIONAL MEDICINE, Numero 12(561), 2020, ISSN 1946-6234
Editore: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aaz1803

Spatial variation of the gut microbiome in response to long-term metformin treatment in high-fat diet-induced type 2 diabetes mouse model of both sexes

Autori: Silamiķele L, Saksis R, Silamiķelis I, Kotoviča PP, Brīvība M, Kalniņa I, Kalniņa Z, Fridmanis D, Kloviņš J.
Pubblicato in: Gut Microbes., Numero 15(1), 2023, ISSN 1949-0976
Editore: Landes Bioscience
DOI: 10.1080/19490976.2023.2188663

Statistical and Machine Learning Techniques in Human Microbiome Studies: Contemporary Challenges and Solutions

Autori: Moreno-Indias I, Lahti L, Nedyalkova M, Elbere I, Roshchupkin G, Adilovic M, Aydemir O, Bakir-Gungor B, Santa Pau EC, D’Elia D, Desai MS, Falquet L, Gundogdu A, Hron K, Klammsteiner T, Lopes MB, Marcos-Zambrano LJ, Marques C, Mason M, May P, Pašić L, Pio G, Pongor S, Promponas VJ, Przymus P, Saez-Rodriguez J, Sampri A, Shigdel R, Stres B, Suharoschi R, Truu J, Truică C-O, Vilne B, Vlachakis D
Pubblicato in: Frontiers in Microbiology, Numero 12/2021, 2021, ISSN 1664-302X
Editore: Frontiers Media
DOI: 10.3389/fmicb.2021.635781