Integration of knowledge and biobank resources in comprehensive translational approach for personalized prevention and treatment of metabolic disorders

Información del proyecto

INTEGROMED

Identificador del acuerdo de subvención: 857572

DOI

10.3030/857572

Proyecto cerrado

Fecha de la firma de la CE 18 Junio 2019

Fecha de inicio 1 Octubre 2019

Fecha de finalización 31 Marzo 2023

Financiado con arreglo a

• Twinning of research institutions

Coste total

€ 800 000,00

Aportación de la UE

€ 800 000,00

Coordinado por

LATVIJAS BIOMEDICINAS PETIJUMU UN STUDIJU CENTRS
Latvia

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (1)

Brochures describing the available biobank resource and its application in clinical studies

Websites, patent fillings, videos etc. (3)

Guidelines for the maintenance of efficient biobank, health register and research associated data management

Guidelines for the maintenance of efficient biobank health register and research associated data management

Creation of INTEGROMED website, including monthly website updates
Recommendations for LBMC scientists on design creation and conducting of academic clinical trials

Recommendations for LBMC scientists on design creation and conducting of academicclinical trials

Publicaciones

Peer reviewed articles (24)

Baseline gut microbiome composition predicts metformin therapy short-term efficacy in newly diagnosed type 2 diabetes patients

Autores: Elbere I, Silamikelis I, Dindune II, Kalnina I, Ustinova M, Zaharenko L, Silamikele L, Rovite V, Gudra D, Konrade I, Sokolovska J, Pirags V, Klovins J.
Publicado en: PLoS One, Edición 15(10), 2020, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0241338

First Report on the Latvian SARS-CoV-2 Isolate Genetic Diversity

Autores: Zrelovs N, Ustinova M, Silamikelis I, Birzniece L, Megnis K, Rovite V, Freimane L, Silamikele L, Ansone L, Pjalkovskis J, Fridmanis D, Vilne B, Priedite M, Caica A, Gavars M, Perminov D, Storozenko J, Savicka O, Dimina E, Dumpis U, Klovins J.
Publicado en: Frontiers in Medicine (Lausanne), Edición 8:626000, 2021, ISSN 2296-858X
Editor: Frontiers Media S.A., Lausanne
DOI: 10.3389/fmed.2021.626000

Physiologically based metformin pharmacokinetics model of mice and scale-up to humans for the estimation of concentrations in various tissues

Autores: Zake DM, Kurlovics J, Zaharenko L, Komasilovs V, Klovins J, Stalidzans E.
Publicado en: PLoS One, Edición 16/4, 2021, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0249594

Metformin Strongly Affects Gut Microbiome Composition in High-Fat Diet-Induced Type 2 Diabetes Mouse Model of Both Sexes

Autores: Silamiķele L, Silamiķelis I, Ustinova M, Kalniņa Z, Elbere I, Petrovska R, Kalniņa I, Kloviņš J.
Publicado en: Front Endocrinol (Lausanne), Edición 12:626359, 2021, ISSN 1664-2392
Editor: Frontiers Media S.A., Lausanne
DOI: 10.3389/fendo.2021.626359

Whole-blood transcriptome profiling reveals signatures of metformin and its therapeutic response

Autores: Ustinova M, Ansone L, Silamikelis I, Rovite V, Elbere I, Silamikele L, Kalnina I, Fridmanis D, Sokolovska J, Konrade I, Pirags V, Klovins J.
Publicado en: PLoS One, Edición 15/8, 2020, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0237400

Replication of LZTFL1 Gene Region as a Susceptibility Locus for COVID-19 in Latvian Population. Virol Sin

Autores: Rescenko R, Peculis R, Briviba M, Ansone L, Terentjeva A, Litvina HD, Birzniece L, Megnis K, Kolesova O, Rozentale B, Viksna L, Rovite V, Klovins J.
Publicado en: Virologica Sinica, Edición 36(5), 2021, Página(s) 1241-1244, ISSN 1674-0769
Editor: Wuhan Institute of Virology, Chinese Academy of Sciences
DOI: 10.1007/s12250-021-00448-x

Toll-Like Receptor 1 Locus Re-examined in a Genome-Wide Association Study Update on Anti-Helicobacter pylori IgG Titers

Autores: Lam SY, Mommersteeg MC, Yu B, Broer L, Spaander MCW, Frost F, Weiss S, Völzke H, Lerch MM, Schöttker B, Zhang Y, Stocker H, Brenner H, Levy D, Hwang SJ, Wood AC, Rich SS, Rotter JI, Taylor KD, Tracy RP, Kabagambe EK, Leja M, Klovins J, Peculis R, Rudzite D, Nikitina-Zake L, Skenders G, Rovite V, Uitterlinden A, Kuipers EJ, Fuhler GM, Homuth G, Peppelenbosch MP.
Publicado en: Gastroenterology, Edición 162(6), 2022, Página(s) 1705-1715, ISSN 0346-251X
Editor: Pergamon Press Ltd.
DOI: 10.1053/j.gastro.2022.01.011

Novel susceptibility loci identified in a genome-wide association study of type 2 diabetes complications in population of Latvia

Autores: Ustinova M, Peculis R, Rescenko R, Rovite V, Zaharenko L, Elbere I, Silamikele L, Konrade I, Sokolovska J, Pirags V, Klovins J.
Publicado en: Med Genomics, Edición 14(1), 2021, ISSN 1755-8794
Editor: BioMed Central
DOI: 10.1186/s12920-020-00860-4

COVID-19 Host Genetics Initiative. Mapping the human genetic architecture of COVID-19

Autores: -
Publicado en: Nature, Edición 608, 2021, Página(s) 472-477, ISSN 0028-0836
Editor: Nature Publishing Group
DOI: 10.1038/s41586-021-03767-x

Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas

Autores: Dawed AY, Yee SW, Zhou K, van Leeuwen N, Zhang Y, Siddiqui MK, Etheridge A,Innocenti F, Xu F, Li JH, Beulens JW, van der Heijden AA, Slieker RC, Chang YC,Mercader JM, Kaur V, Witte JS, Lee MTM, Kamatani Y, Momozawa Y, Kubo M, PalmerCNA, Florez JC, Hedderson MM, 't Hart LM, Giacomini KM, Pearson ER; for MetGenPlus, for the DIRECT Consortium; MetGen Plus investigators
Publicado en: Diabetes Care, Edición 44(12), 2021, ISSN 0149-5992
Editor: American Diabetes Association
DOI: 10.2337/dc21-1152

A widely used sampling device in colorectal cancer screening programmes allows for large-scale microbiome studies

Autores: Dita Gudra, Saeed Shoaie, Davids Fridmanis, Janis Klovins, Hugo Wefer, Ivars Silamikelis, Raitis Peculis, Ineta Kalnina, Ilze Elbere, Ilze Radovica-Spalvina, Rolf Hultcrantz, Ģirts Šķenders, Marcis Leja, Lars Engstrand
Publicado en: Gut, Edición 68/9, 2019, Página(s) 1723-1725, ISSN 0017-5749
Editor: BMJ Publishing Group
DOI: 10.1136/gutjnl-2018-316225

Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals

Autores: Monta Ustinova, Ivars Silamikelis, Ineta Kalnina, Laura Ansone, Vita Rovite, Ilze Elbere, Ilze Radovica-Spalvina, Davids Fridmanis, Jekaterina Aladyeva, Ilze Konrade, Valdis Pirags, Janis Klovins
Publicado en: PLOS ONE, Edición 14/11, 2019, Página(s) e0224835, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0224835

Genome Database of the Latvian Population (LGDB): Design, Goals, and Primary Results

Autores: Vita Rovite, Yael Wolff-Sagi, Linda Zaharenko, Liene Nikitina-Zake, Elmars Grens, Janis Klovins
Publicado en: Journal of Epidemiology, Edición 28/8, 2018, Página(s) 353-360, ISSN 0917-5040
Editor: Tokyo University of Agriculture
DOI: 10.2188/jea.je20170079

Association of metformin administration with gut microbiome dysbiosis in healthy volunteers

Autores: Ilze Elbere, Ineta Kalnina, Ivars Silamikelis, Ilze Konrade, Linda Zaharenko, Kristine Sekace, Ilze Radovica-Spalvina, Davids Fridmanis, Dita Gudra, Valdis Pirags, Janis Klovins
Publicado en: PLOS ONE, Edición 13/9, 2018, Página(s) e0204317, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0204317

Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients

Autores: Linda Zaharenko, Ineta Kalnina, Kristine Geldnere, Ilze Konrade, Solveiga Grinberga, Jozef Židzik, Martin Javorský, Aivars Lejnieks, Liene Nikitina-Zake, Davids Fridmanis, Raitis Peculis, Ilze Radovica-Spalvina, Dace Hartmane, Osvalds Pugovics, Ivan Tkáč, Lucia Klimčáková, Valdis Pīrāgs, Janis Klovins
Publicado en: European Journal of Endocrinology, Edición 175/6, 2016, Página(s) 531-540, ISSN 0804-4643
Editor: BioScientifica Ltd.
DOI: 10.1530/eje-16-0347

DNA methylation of the Oct4A enhancers in embryonal carcinoma cells after etoposide treatment is associated with alternative splicing and altered pluripotency in reversibly senescent cells

Autores: Mikhail Baryshev, Inna Inashkina, Kristine Salmina, Anda Huna, Thomas R Jackson, Jekaterina Erenpreisa
Publicado en: Cell Cycle, Edición 17/3, 2018, Página(s) 362-366, ISSN 1538-4101
Editor: Landes Bioscience
DOI: 10.1080/15384101.2018.1426412

Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals

Autores: Ilze Elbere, Ivars Silamikelis, Monta Ustinova, Ineta Kalnina, Linda Zaharenko, Raitis Peculis, Ilze Konrade, Diana Maria Ciuculete, Christina Zhukovsky, Dita Gudra, Ilze Radovica-Spalvina, Davids Fridmanis, Valdis Pirags, Helgi B. Schiöth, Janis Klovins
Publicado en: Clinical Epigenetics, Edición 10/1, 2018, ISSN 1868-7075
Editor: Springer Verlag
DOI: 10.1186/s13148-018-0593-x

Metabolomic Fingerprints in Large Population Cohorts: Impact of Preanalytical Heterogeneity

Autores: Ghini V, Abuja PM, Polasek O, Kozera L, Laiho P, Anton G, Zins M, Klovins J, Metspalu A, Wichmann HE, Gieger C, Luchinat C, Zatloukal K, Turano P.
Publicado en: Clinical Chemistry, Edición 67(8), 2021, Página(s) 133-142, ISSN 0009-9147
Editor: American Association for Clinical Chemistry, Inc.
DOI: 10.1093/clinchem/hvab092

Metformin Transport Rates Between Plasma and Red Blood Cells in Humans.

Autores: Kurlovics J, Zake DM, Zaharenko L, Berzins K, Klovins J, Stalidzans E.
Publicado en: Clinical Pharmacokinetics, Edición 61(1), 2021, Página(s) 133-142, ISSN 0312-5963
Editor: Adis International Ltd.
DOI: 10.1007/s40262-021-01058-2

Amino Acid Metabolism is Significantly Altered at the Time of Admission in Hospital for Severe COVID-19 Patients: Findings from Longitudinal Targeted Metabolomics Analysis. Microbiol Spectr.

Autores: Ansone L, Briviba M, Silamikelis I, Terentjeva A, Perkons I, Birzniece L, Rovite V, Rozentale B, Viksna L, Kolesova O, Klavins K, Klovins J.
Publicado en: Microbiology Spectrum, Edición 9(3), 2021, ISSN 2165-0497
Editor: American Society for Microbiology
DOI: 10.1128/spectrum.00338-21

Whole exome sequencing reveals novel risk genes of pituitary neuroendocrine tumors

Autores: Peculis R, Rovite V, Megnis K, Balcere I, Breiksa A, Nazarovs J, Stukens J, Konrade I, Sokolovska J, Pirags V, Klovins J.
Publicado en: PLoS One, Edición 17(8), 2022, ISSN 1932-6203
Editor: Public Library of Science
DOI: 10.1371/journal.pone.0265306

Epigenetic markers associated with metformin response and intolerance in drug-naïve patients with type 2 diabetes

Autores: García-Calzón S, Perfilyev A, Martinell M, Ustinova M, Kalamajski S, Franks PW, Bacos K, Elbere I, Pihlajamäki J, Volkov P, Vaag A, Groop L, Maziarz M, Klovins J, Ahlqvist E, Ling C.
Publicado en: SCIENCE TRANSLATIONAL MEDICINE, Edición 12(561), 2020, ISSN 1946-6234
Editor: American Association for the Advancement of Science
DOI: 10.1126/scitranslmed.aaz1803

Spatial variation of the gut microbiome in response to long-term metformin treatment in high-fat diet-induced type 2 diabetes mouse model of both sexes

Autores: Silamiķele L, Saksis R, Silamiķelis I, Kotoviča PP, Brīvība M, Kalniņa I, Kalniņa Z, Fridmanis D, Kloviņš J.
Publicado en: Gut Microbes., Edición 15(1), 2023, ISSN 1949-0976
Editor: Landes Bioscience
DOI: 10.1080/19490976.2023.2188663

Statistical and Machine Learning Techniques in Human Microbiome Studies: Contemporary Challenges and Solutions

Autores: Moreno-Indias I, Lahti L, Nedyalkova M, Elbere I, Roshchupkin G, Adilovic M, Aydemir O, Bakir-Gungor B, Santa Pau EC, D’Elia D, Desai MS, Falquet L, Gundogdu A, Hron K, Klammsteiner T, Lopes MB, Marcos-Zambrano LJ, Marques C, Mason M, May P, Pašić L, Pio G, Pongor S, Promponas VJ, Przymus P, Saez-Rodriguez J, Sampri A, Shigdel R, Stres B, Suharoschi R, Truu J, Truică C-O, Vilne B, Vlachakis D
Publicado en: Frontiers in Microbiology, Edición 12/2021, 2021, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2021.635781