Hyperpolarised MR technologies and molecular probes as alternatives for conventional metal-containing contrast agents for MRI examinations

Informations projet

AlternativesToGd

N° de convention de subvention: 858149

DOI 10.3030/858149

Projet clôturé

Date de signature de la CE 24 Septembre 2019

Date de début 1 Octobre 2019

Date de fin 30 Septembre 2023

Financé au titre de

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coût total € 3 065 956,25

Contribution de l’UE € 3 065 956,25

Coordonné par

HADASSAH MEDICAL ORGANIZATION
Israel

Livrables

Documents, reports (10)

Report comparing perfusion and tissue- retention imaging with HP water vs. GBCA in a pig model of coronary artery disease

Report comparing perfusion and tissueretention imaging with HP water vs GBCA in a pig model of coronary artery disease

Report on encapsulation of new and unconventional dDNP agents
Interim progress report on 13C hyperpolarisation in ensembles of nano-diamonds
Interim progress report on the safety of nitrate intravenous injection
Report on dual tuned coils installed at partners' sites

Report on dual tuned coils installed at partners sites

Interim progress report on 13C labelled agents for PHIP-SAH
Interim progress report on the design of a 15N/1H coil operating at 1.5T and 7T

Interim progress report on the design of a 15N1H coil operating at 15T and 7T

Interim progress report on 1H relaxation times of HOD in micro-emulsions and 1H hyperpolarisation

Interim progress report on 1H relaxation times of HOD in microemulsions and 1H hyperpolarisation

Interim progress report on the design of efficient sampling strategies and motion compensation and a plan for implementation on the partners' MRI scanners
Report on polarisation transfer protocols for imaging

Open Research Data Pilot (2)

First Version of Data Management Plan
Final Data Management Plan

Websites, patent fillings, videos etc. (1)

Project Website and Corporate Identity

Other (1)

End user workshop

Publications

Peer reviewed articles (29)

Real-time influence of intracellular acidification and Na+/H+ exchanger inhibition on in-cell pyruvate metabolism in the perfused mouse heart: A 31P-NMR and hyperpolarized 13C-NMR study

Auteurs: David Shaul, Naama Lev-Cohain, Gal Sapir, Jacob Sosna, J. Moshe Gomori, Leo Joskowicz, Rachel Katz-Brull
Publié dans: NMR in biomedicine, 2023, ISSN 0952-3480
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4993

Mechanistic Insights of Seeded Diamond Growth from Molecular Precursors

Auteurs: Christopher P. Ender; Jiaxu Liang; Jonas Friebel; Todd Zapata; Manfred Wagner; Anna Ermakova; Tanja Weil
Publié dans: Diamond and Related Materials, Numéro Vol 122, 2022, Page(s) 108796, ISSN 0925-9635
Éditeur: Elsevier BV
DOI: 10.1016/j.diamond.2021.108796

Hyperpolarized Carbon-13 MRI in Breast Cancer

Auteurs: Ramona Woitek, Kevin M. Brindle
Publié dans: Diagnostics, 2023, ISSN 2075-4418
Éditeur: MDPI
DOI: 10.3390/diagnostics13132311

Accumulation of 3-aminopropylphosphonate in the ex vivo brain observed by phosphorus-31 nuclear magnetic resonance

Auteurs: David Shaul, Benjamin Grieb, Naama Lev-Cohain, Jacob Sosna, J. Moshe Gomori, Rachel Katz-Brull
Publié dans: NMR in Biomedicine, 2022, Page(s) e4721, ISSN 0952-3480
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4721

ParaHydrogen Polarized Ethyl-[1-13 C]pyruvate in Water, a Key Substrate for Fostering the PHIP-SAH Approach to Metabolic Imaging.

Auteurs: Carla Carrera; Eleonora Cavallari; Giuseppe Digilio; Oksana Bondar; Silvio Aime; Francesca Reineri
Publié dans: Chemphyschem, Numéro Vol 22, Iss 11, 2021, Page(s) 1042-1048, ISSN 1439-4235
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cphc.202100062

Genetic algorithm‐based optimization of pulse sequences

Auteurs: Vencel Somai; Felix Kreis; Adam Gaunt; Anastasia Tsyben; Ming Li Chia; Friederike Hesse; Alan J. Wright; Kevin M. Brindle
Publié dans: Magnetic Resonance in Medicine, Numéro Vol 87, Iss 5, 2022, Page(s) 2130–2144, ISSN 0740-3194
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/mrm.29110

Germanium iodide mediated synthesis of nanodiamonds from adamantane “seeds” under moderate high-pressure high-temperature conditions

Auteurs: Jiaxu Liang, Christopher P. Ender, Todd Zapata, Anna Ermakova, Manfred Wagner, Tanja Weil
Publié dans: Diamond and Related Materials, Numéro 108, 2020, Page(s) 108000, ISSN 0925-9635
Éditeur: Elsevier BV
DOI: 10.1016/j.diamond.2020.108000

Directly Bound Deuterons Increase X-Nuclei Hyperpolarization using Dynamic Nuclear Polarization

Auteurs: Catriona H. E. Rooney, Dr. Ayelet Gamliel, David Shaul, Prof. Damian J. Tyler, Dr. James T. Grist, Prof. Rachel Katz-Brull
Publié dans: ChemPhysChem, 2023, ISSN 1439-4235
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/cphc.202300144

RF coil design for accurate parallel imaging on 13C MRSI using 23Na sensitivity profiles

Auteurs: Juan D. Sanchez-Heredia, Rie B. Olin, James T. Grist, Wenjun Wang, Nikolaj Bøgh, Vitaliy Zhurbenko, Esben S. Hansen, Rolf F. Schulte, Damian Tyler, Christoffer Laustsen, Jan H. Ardenkjær-Larsen
Publié dans: Magnetic Resonance in Medicine, 2022, ISSN 0740-3194
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/mrm.29259

Hydrogenative-PHIP polarized metabolites for biological studies

Auteurs: Francesca Reineri, Eleonora Cavallari, Carla Carrera, Silvio Aime
Publié dans: Magnetic Resonance Materials in Physics, Biology and Medicine, Numéro Vol 34, Iss 1, 2021, Page(s) 25-47, ISSN 1352-8661
Éditeur: Springer Nature
DOI: 10.1007/s10334-020-00904-x

Tolerance of Rodents to an Intravenous Bolus Injection of Sodium Nitrate in a High Concentration

Auteurs: Rachel Katz-Brull
Publié dans: Biology, Numéro 11-5, 2022, Page(s) 794, ISSN 2079-7737
Éditeur: MDPI
DOI: 10.3390/biology11050794

Fluorescent Nanodiamond–Nanogels for Nanoscale Sensing and Photodynamic Applications

Auteurs: Yingke Wu, Md Noor A Alam, Priyadharshini Balasubramanian, Pia Winterwerber, Anna Ermakova, Michael Müller, Manfred Wagner, Fedor Jelezko, Marco Raabe, Tanja Weil
Publié dans: Advanced NanoBiomed Research, Numéro Vol 1, Iss 7, 2021, Page(s) 2000101, ISSN 2699-9307
Éditeur: Wiley-VCH GmbH
DOI: 10.1002/anbr.202000101

Effect of the hydrogenation solvent in the PHIP-SAH hyperpolarization of [1-13C]pyruvate

Auteurs: O.Bondar, E.Cavallari, C.Carrera, S.Aime, F.Reineri
Publié dans: Catalysis Today, 2021, ISSN 0920-5861
Éditeur: Elsevier BV
DOI: 10.1016/j.cattod.2021.11.030

Design and Analysis of Field-of-View Independent k-Space Trajectories for Magnetic Resonance Imaging

Auteurs: Tobias Speidel, Patrick Metze, Kilian Stumpf, Thomas Hüfken, Volker Rasche
Publié dans: Sec. Medical Physics and Imaging, 2022, ISSN 2296-424X
Éditeur: Frontiers
DOI: 10.3389/fphy.2022.867676

Hyperpolarized 13 C magnetic resonance imaging for noninvasive assessment of tissue inflammation.

Auteurs: Stephanie Anderson; James T. Grist; James T. Grist; Andrew Lewis; Damian J. Tyler
Publié dans: Nmr in Biomedicine, Numéro 3, 2021, Page(s) e4460, ISSN 0952-3480
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4460

Singlet-Contrast Magnetic Resonance Imaging: Unlocking Hyperpolarization with Metabolism**

Auteurs: Dr. J. Eills, Dr. E. Cavallari, R. Kircher, G. Di Matteo, Dr. C. Carrera, Dr. L. Dagys, Prof. M. H. Levitt, K. L. Ivanov, Prof. S. Aime, Dr. F. Reineri, Dr. K. Münnemann, Prof. D. Budker, Prof. G. Buntkowsky, Dr. S. Knecht
Publié dans: Angewandte Chemie, 2021, ISSN 1433-7851
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202014933

Design and Testing of Diagnostic MRI/MRS Applications Based On Signal Enhancement by Parahydrogen-Induced Polarization

Auteurs: Francesca Reineri
Publié dans: Analysis & Sensing, 2022, ISSN 2629-2742
Éditeur: Wiley-VCH GmbH
DOI: 10.1002/anse.202200028

Rapid hyperpolarization and purification of the metabolite fumarate in aqueous solution.

Auteurs: Stephan Knecht; John W. Blanchard; Danila A. Barskiy; Eleonora Cavallari; Laurynas Dagys; Erik van Dyke; Maksim Tsukanov; Bea Bliemel; Kerstin Münnemann; Silvio Aime; Francesca Reineri; Malcolm H. Levitt; Gerd Buntkowsky; Alexander Pines; Peter Blümler; Dmitry Budker; James Eills
Publié dans: Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 13, Numéro 9, 2021, ISSN 1091-6490
Éditeur: National Academy of Sciences
DOI: 10.15120/gsi-2021-01203

Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques

Auteurs: Andreas B. Schmidt, C. Russell Bowers, Kai Buckenmaier, Eduard Y. Chekmenev, Henri de Maissin, James Eills, Frowin Ellermann, Stefan Glöggler, Jeremy W. Gordon, Stephan Knecht, Igor V. Koptyug, Jule Kuhn, Andrey N. Pravdivtsev, Francesca Reineri, Thomas Theis, Kolja Them, and Jan-Bernd Hövener
Publié dans: Analytical Chemistry, Numéro Vol 94, Iss 1, 2022, Page(s) 479-502, ISSN 0003-2700
Éditeur: American Chemical Society
DOI: 10.1021/acs.analchem.1c04863

Laser-Synthesis of NV-Centers-Enriched Nanodiamonds: Effect of Different Nitrogen Sources

Auteurs: Luca Basso, Mirko Sacco, Nicola Bazzanella, Massimo Cazzanelli, Alessandro Barge, Michele Orlandi, Angelo Bifone, Antonio Miotello
Publié dans: Micromachines, Numéro 11/6, 2020, Page(s) 579, ISSN 2072-666X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi11060579

Increasing the sensitivity of hyperpolarized [ 15 N 2 ]urea detection by serial transfer of polarization to spin‐coupled protons

Auteurs: Felix Kreis, Alan J. Wright, Vencel Somai, Rachel Katz‐Brull, Kevin M. Brindle
Publié dans: Magnetic Resonance in Medicine, Numéro 84/4, 2020, Page(s) 1844-1856, ISSN 0740-3194
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/mrm.28241

Hyperpolarized water through dissolution dynamic nuclear polarization with UV-generated radicals

Auteurs: Arthur C. Pinon, Andrea Capozzi, Jan Henrik Ardenkjær-Larsen
Publié dans: Communications Chemistry, Numéro 3/1, 2020, ISSN 2399-3669
Éditeur: Springer Nature Limited
DOI: 10.1038/s42004-020-0301-6

Signal enhancement of hyperpolarized 15N sites in solution—increase in solid-state polarization at 3.35 T and prolongation of relaxation in deuterated water mixtures

Auteurs: Ayelet Gamliel, David Shaul, J. Moshe Gomori, Rachel Katz-Brull
Publié dans: NMR in biomedicine, 2022, ISSN 0952-3480
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4787

Advances in Stabilization and Enrichment of Shallow Nitrogen-Vacancy Centers in Diamond for Biosensing and Spin-Polarization Transfer

Auteurs: Federico Gorrini, Angelo Bifone
Publié dans: Biosensors, 2023, ISSN 2079-6374
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/bios13070691

Developing a metabolic clearance rate framework as a translational analysis approach for hyperpolarized 13C magnetic resonance imaging

Auteurs: James T. Grist, Nikolaj Bøgh, Esben Søvsø Hansen, Anna M. Schneider, Richard Healicon, Vicky Ball, Jack J. J. J. Miller, Sean Smart, Yvonne Couch, Alastair M. Buchan, Damian J. Tyler & Christoffer Laustsen
Publié dans: Nature Scientific Reports, 2023, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-28643-8

Assessing the effect of anesthetic gas mixtures on hyperpolarized 13C pyruvate metabolism in the rat brain

Auteurs: Richard Healicon, Catriona H. E. Rooney, Vicky Ball, Ayaka Shinozaki, Jack J. Miller, Sean Smart, Daniel Radford-Smith, Daniel Anthony, Damian J. Tyler, James T. Grist
Publié dans: Magnetic Resonance in Medicine, 2022, ISSN 0740-3194
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/mrm.29274

Nanodiamond Theranostic for Light-Controlled Intracellular Heating and Nanoscale Temperature Sensing.

Auteurs: Yingke Wu; Noor A Alam; Noor A Alam; Priyadharshini Balasubramanian; Anna Ermakova; Anna Ermakova; Stephan Fischer; Holger Barth; Manfred Wagner; Marco Raabe; Marco Raabe; Fedor Jelezko; Tanja Weil; Tanja Weil
Publié dans: Nano Letters, Numéro Vol 21, Iss 9, 2021, Page(s) 3780-3788, ISSN 1530-6984
Éditeur: American Chemical Society
DOI: 10.1021/acs.nanolett.1c00043

Long-Lived Ensembles of Shallow NV- Centers in Flat and Nanostructured Diamonds by Photoconversion.

Auteurs: Federico Gorrini; Federico Gorrini; C. Dorigoni; Domingo Olivares-Postigo; Domingo Olivares-Postigo; Rakshyakar Giri; Pietro Aprà; Federico Picollo; Angelo Bifone; Angelo Bifone
Publié dans: ACS Applied Materials & Interfaces, Numéro Vol 13, Iss 36, 2021, Page(s) 43221-43232, ISSN 1944-8244
Éditeur: American Chemical Society
DOI: 10.1021/acsami.1c09825

Metabolic imaging with deuterium labeled substrates

Auteurs: Jacob Chen Ming Low, Alan J Wright, Friederike Hesse, Jianbo Cao, Kevin M Brindle
Publié dans: Progress in Nuclear Magnetic Resonance Spectroscopy, 2023, ISSN 0079-6565
Éditeur: Elsevier BV
DOI: 10.1016/j.pnmrs.2023.02.002

Other (2)

Photoconversion of shallow nitrogen-vacancy centers in flat and nanostructured diamond under high-power laser irradiation

Auteurs: Federico Gorrini, Carla Dorigoni, Domingo Olivares-Postigo, Rakshyakar Giri, Pietro Aprà, Federico Picollo, Angelo Bifone
Publié dans: 2021
Éditeur: arXiv
DOI: 10.48550/arxiv.2105.04939

Divergent effects of laser irradiation on ensembles of nitrogen-vacancy centers in bulk and nano-diamonds: implications for biosensing

Auteurs: Domingo Olivares-Postigo, Federico Gorrini, Valeria Bitonto, Johannes Ackermann, Rakshyakar Giri, Anke Krueger, Angelo Bifone
Publié dans: 2021
Éditeur: arXiv
DOI: 10.48550/arxiv.2110.02955

Non-peer reviewed articles (2)

Metabolic Reactions Studied by Zero- and Low-Field Nuclear Magnetic Resonance

Auteurs: James Eills, Román Picazo-Frutos, Oksana Bondar, Eleonora Cavallari, Carla Carrera, Sylwia J. Barker, Marcel Utz, Silvio Aime, Francesca Reineri, Dmitry Budker, John W. Blanchard
Publié dans: arXiv, 2022, ISSN 2331-8422
Éditeur: arXiv
DOI: 10.48550/arxiv.2205.12380

High Pressure Induced Formation of Carbon Nanorods from Tetracosane

Auteurs: Jiaxu Liang, Christopher P. Ender, Pascal Rohrbeck, Robert Graf, Ingo Lieberwirth, Manfred Wagner, Stefan A. L. Weber, Klaus Müllen and Tanja Weil
Publié dans: ChemRxiv: Nanoscience, 2022, ISSN 2573-2293
Éditeur: ChemRxiv
DOI: 10.26434/chemrxiv-2022-2g6dl

Droits de propriété intellectuelle

Other (1)

SYSTEM AND METHOD FOR ACQUISITION OF A MAGNETIC RESONANCE IMAGE AS WELL AS DEVICE FOR DETERMINING A TRAJECTORY FOR ACQUISITION OF A MAGNETIC RESONANCE IMAGE

Numéro de demande/publication: WO 2022184808A1
Date: 2022-08-05
Demandeur(s): UNIVERSITAET ULM