Hyperpolarised MR technologies and molecular probes as alternatives for conventional metal-containing contrast agents for MRI examinations

Informacje na temat projektu

AlternativesToGd

Identyfikator umowy o grant: 858149

DOI 10.3030/858149

Projekt został zamknięty

Data podpisania przez KE 24 Września 2019

Data rozpoczęcia 1 Października 2019

Data zakończenia 30 Września 2023

Finansowanie w ramach

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Koszt całkowity € 3 065 956,25

Wkład UE € 3 065 956,25

Koordynowany przez

HADASSAH MEDICAL ORGANIZATION
Israel

Rezultaty

Documents, reports (10)

Report comparing perfusion and tissue- retention imaging with HP water vs. GBCA in a pig model of coronary artery disease

Report comparing perfusion and tissueretention imaging with HP water vs GBCA in a pig model of coronary artery disease

Report on encapsulation of new and unconventional dDNP agents
Interim progress report on 13C hyperpolarisation in ensembles of nano-diamonds
Interim progress report on the safety of nitrate intravenous injection
Report on dual tuned coils installed at partners' sites

Report on dual tuned coils installed at partners sites

Interim progress report on 13C labelled agents for PHIP-SAH
Interim progress report on the design of a 15N/1H coil operating at 1.5T and 7T

Interim progress report on the design of a 15N1H coil operating at 15T and 7T

Interim progress report on 1H relaxation times of HOD in micro-emulsions and 1H hyperpolarisation

Interim progress report on 1H relaxation times of HOD in microemulsions and 1H hyperpolarisation

Interim progress report on the design of efficient sampling strategies and motion compensation and a plan for implementation on the partners' MRI scanners
Report on polarisation transfer protocols for imaging

Open Research Data Pilot (2)

First Version of Data Management Plan
Final Data Management Plan

Websites, patent fillings, videos etc. (1)

Project Website and Corporate Identity

Publikacje

Peer reviewed articles (29)

Real-time influence of intracellular acidification and Na+/H+ exchanger inhibition on in-cell pyruvate metabolism in the perfused mouse heart: A 31P-NMR and hyperpolarized 13C-NMR study

Autorzy: David Shaul, Naama Lev-Cohain, Gal Sapir, Jacob Sosna, J. Moshe Gomori, Leo Joskowicz, Rachel Katz-Brull
Opublikowane w: NMR in biomedicine, 2023, ISSN 0952-3480
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4993

Mechanistic Insights of Seeded Diamond Growth from Molecular Precursors

Autorzy: Christopher P. Ender; Jiaxu Liang; Jonas Friebel; Todd Zapata; Manfred Wagner; Anna Ermakova; Tanja Weil
Opublikowane w: Diamond and Related Materials, Numer Vol 122, 2022, Strona(/y) 108796, ISSN 0925-9635
Wydawca: Elsevier BV
DOI: 10.1016/j.diamond.2021.108796

Hyperpolarized Carbon-13 MRI in Breast Cancer

Autorzy: Ramona Woitek, Kevin M. Brindle
Opublikowane w: Diagnostics, 2023, ISSN 2075-4418
Wydawca: MDPI
DOI: 10.3390/diagnostics13132311

Accumulation of 3-aminopropylphosphonate in the ex vivo brain observed by phosphorus-31 nuclear magnetic resonance

Autorzy: David Shaul, Benjamin Grieb, Naama Lev-Cohain, Jacob Sosna, J. Moshe Gomori, Rachel Katz-Brull
Opublikowane w: NMR in Biomedicine, 2022, Strona(/y) e4721, ISSN 0952-3480
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4721

ParaHydrogen Polarized Ethyl-[1-13 C]pyruvate in Water, a Key Substrate for Fostering the PHIP-SAH Approach to Metabolic Imaging.

Autorzy: Carla Carrera; Eleonora Cavallari; Giuseppe Digilio; Oksana Bondar; Silvio Aime; Francesca Reineri
Opublikowane w: Chemphyschem, Numer Vol 22, Iss 11, 2021, Strona(/y) 1042-1048, ISSN 1439-4235
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/cphc.202100062

Genetic algorithm‐based optimization of pulse sequences

Autorzy: Vencel Somai; Felix Kreis; Adam Gaunt; Anastasia Tsyben; Ming Li Chia; Friederike Hesse; Alan J. Wright; Kevin M. Brindle
Opublikowane w: Magnetic Resonance in Medicine, Numer Vol 87, Iss 5, 2022, Strona(/y) 2130–2144, ISSN 0740-3194
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/mrm.29110

Germanium iodide mediated synthesis of nanodiamonds from adamantane “seeds” under moderate high-pressure high-temperature conditions

Autorzy: Jiaxu Liang, Christopher P. Ender, Todd Zapata, Anna Ermakova, Manfred Wagner, Tanja Weil
Opublikowane w: Diamond and Related Materials, Numer 108, 2020, Strona(/y) 108000, ISSN 0925-9635
Wydawca: Elsevier BV
DOI: 10.1016/j.diamond.2020.108000

Directly Bound Deuterons Increase X-Nuclei Hyperpolarization using Dynamic Nuclear Polarization

Autorzy: Catriona H. E. Rooney, Dr. Ayelet Gamliel, David Shaul, Prof. Damian J. Tyler, Dr. James T. Grist, Prof. Rachel Katz-Brull
Opublikowane w: ChemPhysChem, 2023, ISSN 1439-4235
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/cphc.202300144

RF coil design for accurate parallel imaging on 13C MRSI using 23Na sensitivity profiles

Autorzy: Juan D. Sanchez-Heredia, Rie B. Olin, James T. Grist, Wenjun Wang, Nikolaj Bøgh, Vitaliy Zhurbenko, Esben S. Hansen, Rolf F. Schulte, Damian Tyler, Christoffer Laustsen, Jan H. Ardenkjær-Larsen
Opublikowane w: Magnetic Resonance in Medicine, 2022, ISSN 0740-3194
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/mrm.29259

Hydrogenative-PHIP polarized metabolites for biological studies

Autorzy: Francesca Reineri, Eleonora Cavallari, Carla Carrera, Silvio Aime
Opublikowane w: Magnetic Resonance Materials in Physics, Biology and Medicine, Numer Vol 34, Iss 1, 2021, Strona(/y) 25-47, ISSN 1352-8661
Wydawca: Springer Nature
DOI: 10.1007/s10334-020-00904-x

Tolerance of Rodents to an Intravenous Bolus Injection of Sodium Nitrate in a High Concentration

Autorzy: Rachel Katz-Brull
Opublikowane w: Biology, Numer 11-5, 2022, Strona(/y) 794, ISSN 2079-7737
Wydawca: MDPI
DOI: 10.3390/biology11050794

Fluorescent Nanodiamond–Nanogels for Nanoscale Sensing and Photodynamic Applications

Autorzy: Yingke Wu, Md Noor A Alam, Priyadharshini Balasubramanian, Pia Winterwerber, Anna Ermakova, Michael Müller, Manfred Wagner, Fedor Jelezko, Marco Raabe, Tanja Weil
Opublikowane w: Advanced NanoBiomed Research, Numer Vol 1, Iss 7, 2021, Strona(/y) 2000101, ISSN 2699-9307
Wydawca: Wiley-VCH GmbH
DOI: 10.1002/anbr.202000101

Effect of the hydrogenation solvent in the PHIP-SAH hyperpolarization of [1-13C]pyruvate

Autorzy: O.Bondar, E.Cavallari, C.Carrera, S.Aime, F.Reineri
Opublikowane w: Catalysis Today, 2021, ISSN 0920-5861
Wydawca: Elsevier BV
DOI: 10.1016/j.cattod.2021.11.030

Design and Analysis of Field-of-View Independent k-Space Trajectories for Magnetic Resonance Imaging

Autorzy: Tobias Speidel, Patrick Metze, Kilian Stumpf, Thomas Hüfken, Volker Rasche
Opublikowane w: Sec. Medical Physics and Imaging, 2022, ISSN 2296-424X
Wydawca: Frontiers
DOI: 10.3389/fphy.2022.867676

Hyperpolarized 13 C magnetic resonance imaging for noninvasive assessment of tissue inflammation.

Autorzy: Stephanie Anderson; James T. Grist; James T. Grist; Andrew Lewis; Damian J. Tyler
Opublikowane w: Nmr in Biomedicine, Numer 3, 2021, Strona(/y) e4460, ISSN 0952-3480
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4460

Singlet-Contrast Magnetic Resonance Imaging: Unlocking Hyperpolarization with Metabolism**

Autorzy: Dr. J. Eills, Dr. E. Cavallari, R. Kircher, G. Di Matteo, Dr. C. Carrera, Dr. L. Dagys, Prof. M. H. Levitt, K. L. Ivanov, Prof. S. Aime, Dr. F. Reineri, Dr. K. Münnemann, Prof. D. Budker, Prof. G. Buntkowsky, Dr. S. Knecht
Opublikowane w: Angewandte Chemie, 2021, ISSN 1433-7851
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202014933

Design and Testing of Diagnostic MRI/MRS Applications Based On Signal Enhancement by Parahydrogen-Induced Polarization

Autorzy: Francesca Reineri
Opublikowane w: Analysis & Sensing, 2022, ISSN 2629-2742
Wydawca: Wiley-VCH GmbH
DOI: 10.1002/anse.202200028

Rapid hyperpolarization and purification of the metabolite fumarate in aqueous solution.

Autorzy: Stephan Knecht; John W. Blanchard; Danila A. Barskiy; Eleonora Cavallari; Laurynas Dagys; Erik van Dyke; Maksim Tsukanov; Bea Bliemel; Kerstin Münnemann; Silvio Aime; Francesca Reineri; Malcolm H. Levitt; Gerd Buntkowsky; Alexander Pines; Peter Blümler; Dmitry Budker; James Eills
Opublikowane w: Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 13, Numer 9, 2021, ISSN 1091-6490
Wydawca: National Academy of Sciences
DOI: 10.15120/gsi-2021-01203

Instrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization Techniques

Autorzy: Andreas B. Schmidt, C. Russell Bowers, Kai Buckenmaier, Eduard Y. Chekmenev, Henri de Maissin, James Eills, Frowin Ellermann, Stefan Glöggler, Jeremy W. Gordon, Stephan Knecht, Igor V. Koptyug, Jule Kuhn, Andrey N. Pravdivtsev, Francesca Reineri, Thomas Theis, Kolja Them, and Jan-Bernd Hövener
Opublikowane w: Analytical Chemistry, Numer Vol 94, Iss 1, 2022, Strona(/y) 479-502, ISSN 0003-2700
Wydawca: American Chemical Society
DOI: 10.1021/acs.analchem.1c04863

Laser-Synthesis of NV-Centers-Enriched Nanodiamonds: Effect of Different Nitrogen Sources

Autorzy: Luca Basso, Mirko Sacco, Nicola Bazzanella, Massimo Cazzanelli, Alessandro Barge, Michele Orlandi, Angelo Bifone, Antonio Miotello
Opublikowane w: Micromachines, Numer 11/6, 2020, Strona(/y) 579, ISSN 2072-666X
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi11060579

Increasing the sensitivity of hyperpolarized [ 15 N 2 ]urea detection by serial transfer of polarization to spin‐coupled protons

Autorzy: Felix Kreis, Alan J. Wright, Vencel Somai, Rachel Katz‐Brull, Kevin M. Brindle
Opublikowane w: Magnetic Resonance in Medicine, Numer 84/4, 2020, Strona(/y) 1844-1856, ISSN 0740-3194
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/mrm.28241

Hyperpolarized water through dissolution dynamic nuclear polarization with UV-generated radicals

Autorzy: Arthur C. Pinon, Andrea Capozzi, Jan Henrik Ardenkjær-Larsen
Opublikowane w: Communications Chemistry, Numer 3/1, 2020, ISSN 2399-3669
Wydawca: Springer Nature Limited
DOI: 10.1038/s42004-020-0301-6

Signal enhancement of hyperpolarized 15N sites in solution—increase in solid-state polarization at 3.35 T and prolongation of relaxation in deuterated water mixtures

Autorzy: Ayelet Gamliel, David Shaul, J. Moshe Gomori, Rachel Katz-Brull
Opublikowane w: NMR in biomedicine, 2022, ISSN 0952-3480
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/nbm.4787

Advances in Stabilization and Enrichment of Shallow Nitrogen-Vacancy Centers in Diamond for Biosensing and Spin-Polarization Transfer

Autorzy: Federico Gorrini, Angelo Bifone
Opublikowane w: Biosensors, 2023, ISSN 2079-6374
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/bios13070691

Developing a metabolic clearance rate framework as a translational analysis approach for hyperpolarized 13C magnetic resonance imaging

Autorzy: James T. Grist, Nikolaj Bøgh, Esben Søvsø Hansen, Anna M. Schneider, Richard Healicon, Vicky Ball, Jack J. J. J. Miller, Sean Smart, Yvonne Couch, Alastair M. Buchan, Damian J. Tyler & Christoffer Laustsen
Opublikowane w: Nature Scientific Reports, 2023, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-023-28643-8

Assessing the effect of anesthetic gas mixtures on hyperpolarized 13C pyruvate metabolism in the rat brain

Autorzy: Richard Healicon, Catriona H. E. Rooney, Vicky Ball, Ayaka Shinozaki, Jack J. Miller, Sean Smart, Daniel Radford-Smith, Daniel Anthony, Damian J. Tyler, James T. Grist
Opublikowane w: Magnetic Resonance in Medicine, 2022, ISSN 0740-3194
Wydawca: John Wiley & Sons Inc.
DOI: 10.1002/mrm.29274

Nanodiamond Theranostic for Light-Controlled Intracellular Heating and Nanoscale Temperature Sensing.

Autorzy: Yingke Wu; Noor A Alam; Noor A Alam; Priyadharshini Balasubramanian; Anna Ermakova; Anna Ermakova; Stephan Fischer; Holger Barth; Manfred Wagner; Marco Raabe; Marco Raabe; Fedor Jelezko; Tanja Weil; Tanja Weil
Opublikowane w: Nano Letters, Numer Vol 21, Iss 9, 2021, Strona(/y) 3780-3788, ISSN 1530-6984
Wydawca: American Chemical Society
DOI: 10.1021/acs.nanolett.1c00043

Long-Lived Ensembles of Shallow NV- Centers in Flat and Nanostructured Diamonds by Photoconversion.

Autorzy: Federico Gorrini; Federico Gorrini; C. Dorigoni; Domingo Olivares-Postigo; Domingo Olivares-Postigo; Rakshyakar Giri; Pietro Aprà; Federico Picollo; Angelo Bifone; Angelo Bifone
Opublikowane w: ACS Applied Materials & Interfaces, Numer Vol 13, Iss 36, 2021, Strona(/y) 43221-43232, ISSN 1944-8244
Wydawca: American Chemical Society
DOI: 10.1021/acsami.1c09825

Metabolic imaging with deuterium labeled substrates

Autorzy: Jacob Chen Ming Low, Alan J Wright, Friederike Hesse, Jianbo Cao, Kevin M Brindle
Opublikowane w: Progress in Nuclear Magnetic Resonance Spectroscopy, 2023, ISSN 0079-6565
Wydawca: Elsevier BV
DOI: 10.1016/j.pnmrs.2023.02.002

Other (3)

Photoconversion of shallow nitrogen-vacancy centers in flat and nanostructured diamond under high-power laser irradiation

Autorzy: Federico Gorrini, Carla Dorigoni, Domingo Olivares-Postigo, Rakshyakar Giri, Pietro Aprà, Federico Picollo, Angelo Bifone
Opublikowane w: 2021
Wydawca: arXiv
DOI: 10.48550/arxiv.2105.04939

Divergent effects of laser irradiation on ensembles of nitrogen-vacancy centers in bulk and nano-diamonds: implications for biosensing

Autorzy: Domingo Olivares-Postigo, Federico Gorrini, Valeria Bitonto, Johannes Ackermann, Rakshyakar Giri, Anke Krueger, Angelo Bifone
Opublikowane w: 2021
Wydawca: arXiv
DOI: 10.48550/arxiv.2110.02955

Rapid Hyperpolarization and Purification of the Metabolite Fumarate in Aqueous Solution

Autorzy: Stephan Knecht, John W. Blanchard, Danila Barskiy, Eleonora Cavallari, Laurynas Dagys, Erik van Dyke, Maksim Tsukanov, Bea Bliemel, Kerstin Münnemann, Silvio Aime, Francesca Reineri, Malcolm H. Levitt, Gerd Buntkowsky, Alexander Pines, Peter Blümler, Dmitry Budker, James Eills
Opublikowane w: chemRxiv, 2020
Wydawca: ChemRxiv
DOI: 10.26434/chemrxiv.12909989.v1

Non-peer reviewed articles (2)

Metabolic Reactions Studied by Zero- and Low-Field Nuclear Magnetic Resonance

Autorzy: James Eills, Román Picazo-Frutos, Oksana Bondar, Eleonora Cavallari, Carla Carrera, Sylwia J. Barker, Marcel Utz, Silvio Aime, Francesca Reineri, Dmitry Budker, John W. Blanchard
Opublikowane w: arXiv, 2022, ISSN 2331-8422
Wydawca: arXiv
DOI: 10.48550/arxiv.2205.12380

High Pressure Induced Formation of Carbon Nanorods from Tetracosane

Autorzy: Jiaxu Liang, Christopher P. Ender, Pascal Rohrbeck, Robert Graf, Ingo Lieberwirth, Manfred Wagner, Stefan A. L. Weber, Klaus Müllen and Tanja Weil
Opublikowane w: ChemRxiv: Nanoscience, 2022, ISSN 2573-2293
Wydawca: ChemRxiv
DOI: 10.26434/chemrxiv-2022-2g6dl