The Medical Digital Twin for Aneurysm Prevention and Treatment

Project Information

MeDiTATe

Grant agreement ID: 859836

DOI

10.3030/859836

Project closed

EC signature date 11 September 2019

Start date 1 January 2020

End date 30 June 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 750 403,86

EU contribution

€ 3 750 403,86

Coordinated by

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Book chapters (1)

Advanced Radial Basis Functions Mesh Morphing for High Fidelity Fluid-Structure Interaction with Known Movement of the Walls: Simulation of an Aortic Valve

Author(s): Leonardo Geronzi, Emanuele Gasparotti, Katia Capellini, Ubaldo Cella, Corrado Groth, Stefano Porziani, Andrea Chiappa, Simona Celi, Marco Evangelos Biancolini
Published in: Lecture Notes in Computer Science, Computational Science – ICCS 2020, 2024, Page(s) 280-293
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-50433-5_22

Peer reviewed articles (30)

The Hemodynamic Effect of Modified Blalock–Taussig Shunt Morphologies: A Computational Analysis Based on Reduced Order Modeling

Author(s): Eirini Kardampiki; Emanuele Vignali; Dorela Haxhiademi; Duccio Federici; Edoardo Ferrante; Stefano Porziani; Andrea Chiappa; Corrado Groth; Margherita Cioffi; Marco Evangelos Biancolini; Emiliano Costa; Simona Celi
Published in: Electronics; Volume 11; Issue 13; Pages: 1930, Issue 5, 2022, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/electronics11131930

Fast interactive CFD evaluation of hemodynamics assisted by RBF mesh morphing and reduced order models: the case of aTAA modelling

Author(s): Marco Evangelos Biancolini; Katia Capellini; Emiliano Costa; Corrado Groth; Simona Celi
Published in: International Journal on Interactive Design and Manufacturing (IJIDeM), Issue 14, 2020, Page(s) 1227–1238, ISSN 1955-2513
Publisher: Springer Verlag
DOI: 10.1007/s12008-020-00694-5

Fabrication of Compliant and Transparent Hollow Cerebral Vascular Phantoms for In Vitro Studies Using 3D Printing and Spin–Dip Coating

Author(s): Beatrice Bisighini, Pierluigi Di Giovanni Alba Scerrati ,Federica Trovalusci and Silvia Vesco
Published in: Materials 2023, 16(1), 166, 2023, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma16010166

Segmentation of the aorta in systolic phase from 4D flow MRI: multi-atlas vs. deep learning

Author(s): Diana M Marin-Castrillon Leonardo Geronzi Arnaud Boucher Siyu Lin Marie-Catherine Morgant Alexandre Cochet Michel Rochette Sarah Leclerc Khalid Ambarki Ning Jin Ludwig Serge Aho Glele Alain Lalande Olivier Bouchot Benoît Presles
Published in: MAGMA . 2023 Oct;36(5):687-700, 2023, ISSN 0968-5243
Publisher: Springer Verlag
DOI: 10.1007/s10334-023-01066-2

Machine learning and reduced order modelling for the simulation of braided stent deployment

Author(s): Beatrice Bisighini; Beatrice Bisighini; Beatrice Bisighini; Miquel Aguirre; Miquel Aguirre; Miquel Aguirre; Marco Evangelos Biancolini; Federica Trovalusci; David Perrin; Stéphane Avril; Baptiste Pierrat
Published in: Frontiers in Physiology, Vol 14 (2023), Issue 1, 2023, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2023.1148540

Calibration of the Mechanical Boundary Conditions for a Patient-Specific Thoracic Aorta Model Including the Heart Motion Effect

Author(s): Leonardo Geronzi, Aline Bel-Brunon, Antonio Martinez, Michel Rochette, Marco Sensale, Olivier Bouchot, Alain Lalande, Siyu Lin, Pier Paolo Valentini, Marco Evangelos Biancolini
Published in: IEEE Trans Biomed Eng . 2023 Nov;70(11):3248-3259., 2023, ISSN 0018-9294
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2023.3287680

Computational Comparison of the Mechanical Behavior of Aortic Stent-Grafts Derived from Auxetic Unit Cells

Author(s): Rahul Vellaparambil; Woo-Suck Han; Pierluigi Di Giovanni; Stéphane Avril
Published in: Cardiovascular Engineering and Technology (2024) 15:199–210, Issue 1, 2024, ISSN 1869-408X
Publisher: Springer Pub. Co.,
DOI: 10.1007/s13239-023-00706-x

Aortic roadmapping during EVAR: a combined FEM–EM tracking feasibility study

Author(s): Monica Emendi, Geir A. Tangen, Pierluigi Di Giovanni, Håvard Ulsaker, Reidar Brekken, Frode Manstad-Hulaas, Victorien Prot, Aline Bel-Brunon, Karen H. Støverud
Published in: International Journal of Computer Assisted Radiology and Surgery, Issue 19, 2024, Page(s) 2239-2247, ISSN 1861-6429
Publisher: Springer
DOI: 10.1007/s11548-024-03187-y

Uncertainty Quantification in the In Vivo Image-Based Estimation of Local Elastic Properties of Vascular Walls

Author(s): Benigno Marco Fanni; Maria Nicole Antonuccio; Alessandra Pizzuto; Sergio Berti; Giuseppe Santoro; Simona Celi
Published in: Journal of Cardiovascular Development and Disease; Volume 10; Issue 3; Pages: 109, Issue 1, 2023, ISSN 2078-2489
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcdd10030109

Patient-specific computational modelling of endovascular treatment for intracranial aneurysms”

Author(s): Beatrice Bisighini, Miquel Aguirre, Baptiste Pierrat Stéphane Avril
Published in: Brain Multiphysics Volume 5, December 2023, 100079, 2023, ISSN 0346-251X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.brain.2023.100079

Towards a reduced order model for EVAR planning and intra-operative navigation

Author(s): Monica Emendi, Eirini Kardampiki, Karen-Helene Støverud, Antonio Martinez Pascual, Leonardo Geronzi, Sigrid Kaarstad Dahl, Victorien Prot, Paal Skjetne, Marco Evangelos Biancolini
Published in: Medical Engineering & Physics, Issue 131, 2024, Page(s) 104229, ISSN 1350-4533
Publisher: Elsevier BV
DOI: 10.1016/j.medengphy.2024.104229

An image-based approach for the estimation of arterial local stiffness in vivo

Author(s): Simona Celi; Emanuele Gasparotti; Katia Capellini; Francesco Bardi; Francesco Bardi; Martino Andrea Scarpolini; Martino Andrea Scarpolini; Carlo Cavaliere; Filippo Cademartiri; Emanuele Vignali
Published in: Frontiers in Bioengineering and Biotechnology, Vol 11 (2023), Issue 1, 2023, ISSN 2296-4185
Publisher: Pubmed
DOI: 10.3389/fbioe.2023.1096196

Fast strain mapping in abdominal aortic aneurysm wall reveals heterogeneous patterns

Author(s): Marta Irene Bracco; Marta Irene Bracco; Magdalena Broda; Ulver Spangsberg Lorenzen; Mateusz Cezary Florkow; Oudom Somphone; Stephane Avril; Marco Evangelos Biancolini; Laurence Rouet
Published in: Frontiers in Physiology, Vol 14 (2023), Issue 1, 2023, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2023.1163204

Numerical simulation of aortic coarctations of different grades of severity: Flow features and importance of outlet boundary conditions

Author(s): Mariotti A.; Antonuccio M. N.; Morello M.; Salvetti M. V.; Celi S.
Published in: Computers & Fluids Volume 266, 15 November 2023, 106043, Issue 1, 2023, ISSN 0346-251X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compfluid.2023.106043

Enabling supra-aortic vessels inclusion in statistical shape models of the aorta: a novel non-rigid registration method

Author(s): Martino Andrea Scarpolini,Marilena Mazzoli,Simona Celi
Published in: Front. Physiol., 10 August 2023 Sec. Computational Physiology and Medicine Volume 14 - 2023 |, 2023, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2023.1211461

An RBF Meshless Approach to Evaluate Strain Due to Large Displacements in Flexible Printed Circuit Boards

Author(s): Groth C.; Chiappa A.; Porziani S.; Salvini P.; Biancolini M. E.
Published in: Micromachines, Vol 13, Iss 8, p 1163 (2022), Issue 1, 2022, ISSN 2072-666X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/mi13081163

Prediction of guidewire-induced aortic deformations during EVAR: a finite element and in vitro study

Author(s): Monica Emendi; Monica Emendi; Karen H. Støverud; Geir A. Tangen; Håvard Ulsaker; Frode Manstad-H; Frode Manstad-H; Pierluigi Di Giovanni; Sigrid K. Dahl; Thomas Langø; Victorien Prot
Published in: Frontiers in Physiology, Vol 14 (2023), Issue 1, 2023, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2023.1098867

Assessment of shape-based features ability to predict the ascending aortic aneurysm growth

Author(s): Leonardo Geronzi; Leonardo Geronzi; Pascal Haigron; Antonio Martinez; Antonio Martinez; Kexin Yan; Kexin Yan; Michel Rochette; Aline Bel-Brunon; Jean Porterie; Siyu Lin; Siyu Lin; Diana Marcela Marin-Castrillon; Diana Marcela Marin-Castrillon; Alain Lalande; Alain Lalande; Olivier Bouchot; Morgan Daniel; Pierre Escrig; Jacques Tomasi; Pier Paolo Valentini; Marco Evangelos Biancolini
Published in: Frontiers in Physiology, Vol 14 (2023), Issue 1, 2023, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2023.1125931

A Hybrid Mock Circulatory Loop for Fluid Dynamic Characterization of 3D Anatomical Phantoms

Author(s): Francesco Bardi; Emanuele Gasparotti; Emanuele Vignali; Stéphane Avril; Simona Celi
Published in: IEEE Transactions on Biomedical Engineering ( Volume: 70, Issue: 5, May 2023), 2023, ISSN 0018-9294
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tbme.2022.3224581

Computer-aided shape features extraction and regression models for predicting the ascending aortic aneurysm growth rate

Author(s): Leonardo Geronzi a b, Antonio Martinez a b, Michel Rochette b, Kexin Yan b c, Aline Bel-Brunon c, Pascal Haigron d, Pierre Escrig d, Jacques Tomasi d, Morgan Daniel d, Alain Lalande e f, Siyu Lin e f, Diana Marcela Marin-Castrillon e f, Olivier Bouchot g, Jean Porterie h, Pier Paolo Valentini a, Marco Evangelos Biancolini a
Published in: Computers in Biology and Medicine Volume 162, August 2023, 107052, 2023, ISSN 0010-4825
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.compbiomed.2023.107052

EndoBeams.jl: A Julia finite element package for beam-to-surface contact problems in cardiovascular mechanics

Author(s): Beatrice Bisighini; Miquel Aguirre; Baptiste Pierrat; David Perrin; Stéphane Avril
Published in: Advances in Engineering Software Volume 171, September 2022, 103173, Issue 1, 2022, ISSN 0965-9978
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.advengsoft.2022.103173

Ultrasound Probe Pressure Affects Aortic Wall Stiffness: A Patient-Specific Computational Study in Abdominal Aortic Aneurysms

Author(s): Marta Irene Bracco, Ali Akbar Karkhaneh Yousefi, Laurence Rouet, Stéphane Avril
Published in: Annals of Biomedical Engineering, Issue 53, 2025, Page(s) 71-82, ISSN 0090-6964
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10439-024-03608-8

Coupling synthetic and real-world data for a deep learning-based segmentation process of 4D flow MRI

Author(s): Simone Garzia; Martino Andrea Scarpolini; Marilena Mazzoli; Katia Capellini; Angelo Monteleone; Filippo Cademartiri; Vincenzo Positano; Simona Celi
Published in: Computer Methods and Programs in Biomedicine Volume 242, December 2023, 107790, Issue 1, 2023, ISSN 0346-251X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.cmpb.2023.107790

High fidelity fluid-structure interaction by radial basis functions mesh adaption of moving walls: A workflow applied to an aortic valve

Author(s): Leonardo Geronzi, Emanuele Gasparotti, Katia Capellini, Ubaldo Cella, Corrado Groth, Stefano Porziani, Andrea Chiappa, Simona Celi, Marco Evangelos Biancolini
Published in: Journal of Computational Science, Issue Volume 51, 2021, ISSN 1877-7503
Publisher: Elsevier BV
DOI: 10.1016/j.jocs.2021.101327

Experimental validation of auxetic stent designs: three-point bending of 3D printed Titanium prototypes

Author(s): Rahul Vellaparambil,Woo-Suck Han Pierluigi Di Giovanni Stéphane Avril
Published in: Front. Med. Technol., 06 May 2024 Sec. Cardiovascular Medtech Volume 6 - 2024 |, 2024, ISSN 2673-3129
Publisher: Frontiers in Medical Technology
DOI: 10.3389/fmedt.2024.1388207

Fabrication of deformable patient-specific AAA models by material casting techniques

Author(s): Maria Nicole Antonuccio Emanuele Gasparotti , Francesco Bardi Angelo Monteleone , Alexandre This Laurence Rouet Stéphane Avril , Simona Celi
Published in: Front Cardiovasc Med . 2023 Sep 11:10:1141623., 2023, ISSN 2813-5911
Publisher: Lausanne: Frontiers Media S.A.
DOI: 10.3389/fcvm.2023.1141623

A novel formulation for the study of the ascending aortic fluid dynamics with in vivo data

Author(s): Katia Capellini, Emanuele Gasparotti, Ubaldo Cella, Emiliano Costa, Benigno Marco Fanni, Corrado Groth, Stefano Porziani, Marco Evangelos Biancolini, Simona Celi
Published in: Medical Engineering & Physics, Issue Volume 91, 2021, Page(s) 68-78, ISSN 1350-4533
Publisher: Elsevier BV
DOI: 10.1016/j.medengphy.2020.09.005

Potential of Auxetic Designs in Endovascular Aortic Repair: A Computational Study of Their Mechanical Performance

Author(s): Rahul Vellaparambil; Woo-Suck Han; Pierluigi Di Giovanni; Stéphane Avril
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 1, 2023, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.2139/ssrn.4258753

HPC+ in the medical field: Overview and current examples

Author(s): Koch, Miriam; Arlandini, Claudio; Antonopoulos, Gregory; Baretta, Alessia; Beaujean, Pierre; BEX, Geert Jan; Biancolini, Marco Evangelos; Celi, Simona; Costa, Emiliano; Drescher, Lukas; Eleftheriadis, Vasileios; Fadel, Nur A.; Fink, Andreas; Galbiati, Federica; Hatzakis, Ilias; Hompis, Georgios; Lewandowski, Natalie; Memmolo, Antonio; Mensch, Carl; Obrist, Dominik; Paneta, Valentina; Papadimitroul
Published in: Technology and Health Care 31 (2023) 1509–1523, Issue 2, 2023, ISSN 0928-7329
Publisher: IOS Press
DOI: 10.3233/thc-229015

Towards the 2D velocity reconstruction in abdominal aorta from Color-Doppler Ultrasound

Author(s): Maria Nicole Antonuccio; Hernan G. Morales; Alexandre This; Katia Capellini; Stéphane Avril; Simona Celi; Laurence Rouet
Published in: Medical Engineering & Physics Volume 107, September 2022, 103873, Issue 1, 2022, ISSN 1350-4533
Publisher: Elsevier BV
DOI: 10.1016/j.medengphy.2022.103873

Other (3)

Aortic Wall Stiffness Depends on Ultrasound Probe Pressure

Author(s): Bracco, Marta, Irene; Eiberg, Jonas, Peter; Lorenzen, Ulver, Spangsberg; Avril, Stephane; Rouet, Laurence
Published in: Medical Physics (physics.med-ph) arXiv:2312.07980 [physics.med-ph], Issue 1, 2023
Publisher: Medical Physics
DOI: 10.48550/arxiv.2312.07980

Impact of the Spatial Velocity Inlet Distribution on the Hemodynamics of the Thoracic Aorta

Author(s): Mariotti A.; Celi S.; Antonuccio M. N.; Salvetti M. V.
Published in: Cardiovascular Engineering and Technology,2023 Oct;14(5):713-725., Issue 1, 2023, ISSN 1539-3704
Publisher: Pubmed
DOI: 10.1007/s13239-023-00682-2

Effect of turbulence and viscosity models on wall shear stress derived biomarkers for aorta simulations

Author(s): Martínez A.; Hoeijmakers M.; Geronzi L.; Morgenthaler V.; Tomasi J.; Rochette M.; Biancolini M. E.
Published in: "Computers in Biology and Medicine, 2023, Computers in Biology and Medicine, 167, pp.107603. ⟨10.1016/j.compbiomed.2023.107603⟩", Issue 1, 2023
Publisher: https://hal.science/
DOI: 10.1016/j.compbiomed.2023.107603

Intellectual Property Rights

Patent (3)

METHOD FOR SIMULATING A DEVICE DEPLOYMENT

Application/Publication number: 22 305140
Date: 2022-02-09
Applicant(s): PREDISURGE

METHOD FOR SIMULATING A DEVICE DEPLOYMENT

Application/Publication number: 22 305140
Date: 2022-02-09
Applicant(s): ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS

AORTIC ABDOMINAL ANEURYSM BIOMARKERS

Application/Publication number: 21 290095
Date: 2021-12-21
Applicant(s): PHILIPS FRANCE