Descripción del proyecto
Proteóstasis y neurodegeneración
Las enfermedades neurodegenerativas tienden a adquirir una mayor importancia en las sociedades europeas en proceso de envejecimiento. Estos trastornos suelen caracterizarse por cambios en la proteóstasis (desequilibrio entre la producción, la clasificación y la degradación de las proteínas). Existe la necesidad de formar a una nueva generación de investigadores que sean capaces de investigar mecanismos relevantes de regulación de la proteóstasis para lograr convertirlos en nuevos enfoques que permitan luchar contra la creciente amenaza que supone este tipo de trastornos. La red de formación financiada con fondos europeos reúne a veintidós socios de doce países en un consorcio de líderes en el campo de la regulación de la proteóstasis (autofagia, secreción) y la neurodegeneración procedentes del mundo académico y de la industria. La red del proyecto permitirá crear un marco de formación profesional de especialistas con un alto nivel de eficiencia utilizando un conjunto común de modelos biomédicos y bases de datos electrónicas.
Objetivo
Neurodegenerative disorders are among the leading causes of mortality and will become more relevant in our continuously aging societies. Most neurodegenerative disorders exhibit alterations in proteostasis, i.e. an imbalance between protein production, sorting and degradation. The secretory and the autophagic pathways are two major regulators of cellular proteostasis and their crosstalk is likely to be relevant for neurodegeneration. Thus, there is a need to train a new generation of early stage researchers that will exploit and translate the fundamental biology principles of autophagy, secretion and their crosstalk in human diseases. Our ETN will explore the links between Secretion, Autophagy and their role in NeuroDegeneration (SAND) and will consolidate the position of Europe as a leader in this field by: (i) providing a framework for training and supervision of students to provide them with a repertoire of transferrable and scientific skills that will equip them for careers in academia and industry. (ii) bringing together leading experts in the fields of autophagy, secretion and neurodegeneration from academia and industry into a consortium that involves 22 participants from 12 countries (12 academic beneficiaries from 13 institutions, 3 industry beneficiaries, 4 non-academic partners and 3 academic partner institutions) (iii) using a unifying strategy such as a common stock of cell lines for screening and a common electronic custom-made database tailored to the needs of our consortium (iv) combining complementary expertise such as systems biology, chemical biology, model organisms (zebrafish, drosophila and mouse models), cellular models (neuronal cell lines, primary neurons and patient-derived iPSC neurons) and techniques (e.g. EM, intravital imaging, proteomics, microfluidics) (v) exploiting the translational potential because the network contains three clinically active neurologists, non-academic partners interested in development of drugs and diagnost
Ámbito científico
- natural sciencesbiological sciencesneurobiology
- natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidics
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- social sciencessociologydemographymortality
- natural sciencescomputer and information sciencesdatabases
Palabras clave
Programa(s)
Régimen de financiación
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
0313 Oslo
Noruega