Descrizione del progetto
Proteostasi e neurodegenerazione
Le malattie neurodegenerative tendono ad essere più rilevanti nelle società europee che invecchiano. I disturbi neurodegenerativi sono spesso caratterizzati da cambiamenti nella proteostasi (squilibrio tra produzione, smistamento e degradazione delle proteine). È necessario formare una nuova generazione di ricercatori in grado di studiare i meccanismi pertinenti della regolazione della proteostasi per una conversione di successo verso i moderni approcci, al fine di combattere la minaccia in crescita dei disordini neurodegenerativi. La rete di formazione finanziata dall’UE riunisce 22 partner da 12 paesi all’interno di un consorzio che rappresenta gli esperti di spicco nell’ambito della regolazione della proteostasi (autofagia, secrezione) e della neurodegenerazione dal mondo accademico e dall’industria. La rete del progetto sarà in grado di creare un quadro per la formazione professionale di specialisti con un alto livello di efficienza attraverso risorse comuni provenienti da modelli biomedici e banche dati elettronici.
Obiettivo
Neurodegenerative disorders are among the leading causes of mortality and will become more relevant in our continuously aging societies. Most neurodegenerative disorders exhibit alterations in proteostasis, i.e. an imbalance between protein production, sorting and degradation. The secretory and the autophagic pathways are two major regulators of cellular proteostasis and their crosstalk is likely to be relevant for neurodegeneration. Thus, there is a need to train a new generation of early stage researchers that will exploit and translate the fundamental biology principles of autophagy, secretion and their crosstalk in human diseases. Our ETN will explore the links between Secretion, Autophagy and their role in NeuroDegeneration (SAND) and will consolidate the position of Europe as a leader in this field by: (i) providing a framework for training and supervision of students to provide them with a repertoire of transferrable and scientific skills that will equip them for careers in academia and industry. (ii) bringing together leading experts in the fields of autophagy, secretion and neurodegeneration from academia and industry into a consortium that involves 22 participants from 12 countries (12 academic beneficiaries from 13 institutions, 3 industry beneficiaries, 4 non-academic partners and 3 academic partner institutions) (iii) using a unifying strategy such as a common stock of cell lines for screening and a common electronic custom-made database tailored to the needs of our consortium (iv) combining complementary expertise such as systems biology, chemical biology, model organisms (zebrafish, drosophila and mouse models), cellular models (neuronal cell lines, primary neurons and patient-derived iPSC neurons) and techniques (e.g. EM, intravital imaging, proteomics, microfluidics) (v) exploiting the translational potential because the network contains three clinically active neurologists, non-academic partners interested in development of drugs and diagnost
Campo scientifico
- natural sciencesbiological sciencesneurobiology
- natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidics
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- social sciencessociologydemographymortality
- natural sciencescomputer and information sciencesdatabases
Parole chiave
Programma(i)
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Meccanismo di finanziamento
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinatore
0313 Oslo
Norvegia