Project description
The encore to a successful training network is honing in on new targets for cancer therapies
Proteins are ubiquitous but they are not all created equal. G-protein-coupled receptors (GPCRs) are the largest and most diverse proteins in the mammalian genome. They are a class of transmembrane proteins that transduce extracellular stimuli or messengers into intracellular signals through interaction of their intracellular domains with G-proteins. The chemokine receptors CXCR4 and ACKR3 are GPCRs that bind the chemokine CXCL12 and they have been implicated in cancer, inflammatory and autoimmune diseases. They are a major target of numerous drug discovery efforts yet their exact mechanisms and roles remain unclear. The ONCORENET2.0 initiative plans to find out more and target new therapies with the help of 15 early stage researchers and recent pioneering work in the field of GPCRs.
Fields of science
Programme(s)
Call for proposal
H2020-MSCA-ITN-2019
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Funding Scheme
MSCA-ITN-ETN - European Training NetworksCoordinator
1081 HV Amsterdam
Netherlands
Participants (9)
75794 Paris
13125 Berlin
07743 Jena
NG7 2RD Nottingham
28049 Madrid
75654 Paris
G12 8QQ Glasgow
3584 CL Utrecht
5234 Villingen