Descripción del proyecto
Red de formación en investigación sobre la insuficiencia renal crónica
La insuficiencia renal crónica o IRC (CKD, por sus siglas en inglés) es la pérdida de la función renal a lo largo del tiempo. Millones de personas en el mundo sufren IRC, la cual se correlaciona también con un alto riesgo de sufrir enfermedades cardiovasculares (ECV). El proyecto financiado con fondos europeos STRATEGY-CKD creará un programa de formación centrado en el eje intestino-riñón y en el papel del microbioma intestinal en la génesis y la evolución de las ECV en pacientes con IRC. El programa incluirá en sus respectivos equipos a dos investigadores de la industria y diez del ámbito académico, quienes ofrecerán formación sobre competencias científicas y tecnológicas que abarcarán aspectos como estudios funcionales y moleculares animales y bacterianos, estudios ómicos de vanguardia, bioinformática y biología de sistemas con el objetivo de obtener información nueva sobre la patogenia y el tratamiento de las ECV relacionadas con la IRC. Los alumnos participarán en entornos académicos e industriales para apoyar la futura traducción de los hallazgos de la investigación en tratamientos innovadores.
Objetivo
System omics to unravel the gut-kidney axis in Chronic Kidney Disease:
There is a great need for multi-disciplinary and methodologically well trained scientists in order to unravel complex diseases. Chronic kidney disease (CKD), which is more prevalent in women, and its high risk for cardiovascular disease (CVD) with nearly 50% of all deaths in CKD patients caused by CVD, is such a complex disease and its socio-economic burden is extremely high. STRATEGY-CKD will in this context focus on the gut-kidney axis and the role of the intestinal microbiome as important contributor to the genesis and evolution of CVD in CKD and as possible therapeutic target to improve outcome of CKD patients. For this purpose, 10 leading multidisciplinary academic and 3 industrial investigators and their teams will train young researchers in (1) excellent scientific skills, integrating technological skills [in vitro, bacterial and animals molecular and functional studies, state-of-the-art omic (cultur-, microbi, peptid-, prote-, metabolomics) approaches, bioinformatics, systems biology] in clinical/mechanistic knowledge to generate innovative insights triggering the pathogenesis and treatment of CKD related CVD; (2) Excellent complementary skills in personal and career development as well as business training required to extend beyond scientific research; and (3) exposure to both academic and non-academic environments, required to build bridges between researchers and entrepreneurs and support the future translation of research findings in innovative therapies and services.
STRATEGY-CKD builds on already available advanced technology, models and patient samples, and established collaborations. STRATEGY-CKD links to ongoing European programs among partners of the consortium. STRATEGY-CKD will stimulate the development of young, broadly-trained scientists able to successfully link basic to clinical research in academia as well as in industry unravelling complex diseases such as CVD-CKD.
Ámbito científico
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Régimen de financiación
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
9000 Gent
Bélgica