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System omics to unravel the gut-kidney axis in Chronic Kidney Disease.

Description du projet

Un réseau de formation à la recherche sur l’insuffisance rénale chronique

L’insuffisance rénale chronique (IRC) est la perte de la fonction rénale dans le temps. Des millions de personnes souffrent d’IRC, qui est également corrélée avec un risque élevé de maladies cardiovasculaires (MCV). Le projet STRATEGY-CKD, financé par l’UE, créera un programme de formation axé sur l’axe intestin-rein et le rôle du microbiome intestinal dans la genèse et l’évolution des MCV dans les IRC. Le programme comprendra 10 universitaires multidisciplinaires et 2 chercheurs industriels avec leurs équipes. Ils offriront une formation aux compétences scientifiques et technologiques, couvrant les études moléculaires et fonctionnelles bactériennes et animales, l’omique de pointe, la bio-informatique et la biologie des systèmes pour générer des informations sur la pathogenèse et le traitement des maladies cardiovasculaires liées à l’IRC. Les stagiaires seront exposés à des environnements universitaires et industriels pour soutenir la future traduction des résultats de la recherche en thérapies innovantes.

Objectif

System omics to unravel the gut-kidney axis in Chronic Kidney Disease:
There is a great need for multi-disciplinary and methodologically well trained scientists in order to unravel complex diseases. Chronic kidney disease (CKD), which is more prevalent in women, and its high risk for cardiovascular disease (CVD) with nearly 50% of all deaths in CKD patients caused by CVD, is such a complex disease and its socio-economic burden is extremely high. STRATEGY-CKD will in this context focus on the gut-kidney axis and the role of the intestinal microbiome as important contributor to the genesis and evolution of CVD in CKD and as possible therapeutic target to improve outcome of CKD patients. For this purpose, 10 leading multidisciplinary academic and 3 industrial investigators and their teams will train young researchers in (1) excellent scientific skills, integrating technological skills [in vitro, bacterial and animals molecular and functional studies, state-of-the-art omic (cultur-, microbi, peptid-, prote-, metabolomics) approaches, bioinformatics, systems biology] in clinical/mechanistic knowledge to generate innovative insights triggering the pathogenesis and treatment of CKD related CVD; (2) Excellent complementary skills in personal and career development as well as business training required to extend beyond scientific research; and (3) exposure to both academic and non-academic environments, required to build bridges between researchers and entrepreneurs and support the future translation of research findings in innovative therapies and services.
STRATEGY-CKD builds on already available advanced technology, models and patient samples, and established collaborations. STRATEGY-CKD links to ongoing European programs among partners of the consortium. STRATEGY-CKD will stimulate the development of young, broadly-trained scientists able to successfully link basic to clinical research in academia as well as in industry unravelling complex diseases such as CVD-CKD.

Coordinateur

UNIVERSITEIT GENT
Contribution nette de l'UE
€ 256 320,00
Adresse
SINT PIETERSNIEUWSTRAAT 25
9000 Gent
Belgique

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Région
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
Type d’activité
Higher or Secondary Education Establishments
Liens
Coût total
€ 256 320,00

Participants (11)