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Heterogenous biocatalytic reaction cascades training network

Descrizione del progetto

DEENESFRITPL

I benefici industriali derivanti dalle cascate enzimatiche di reazioni catalitiche ispirate alla natura abbondano

La sintesi chimica è al centro di processi e prodotti industriali, dai prodotti farmaceutici ai polimeri, ai sensori e all’energia. Mentre il mondo si rivolge a metodi sintetici più sostenibili, i biocatalizzatori hanno rivendicato la pubblica attenzione. La biocatalisi eterogenea prevede l’uso di enzimi (catalizzatori proteici) immobilizzati su supporti solidi. Il confinamento degli enzimi nei materiali solidi si ispira all’organizzazione spaziale e alla compartimentazione delle vie metaboliche nelle cellule. Ora, INTERfaces sta estendendo questo concetto a cascate di reazioni biocatalitiche eterogenee. Approfittando dell’impulso fornito dai ricercatori all’inizio della carriera, il team prevede di progettare cascate a partire da due monomeri a base biologica che portano alla creazione di prodotti di rilevanza industriale. Il più promettente verrà preparato per l’implementazione commerciale.

Obiettivo

The INTERfaces program will train 14 ESRs within an EID network jointly designed by European academic and industry partners in innovative research projects dedicated to developing clean bioprocesses for the production of chemicals. The assembly of biocatalysts to reaction sequences allows avoiding steps for isolation and purification of intermediates and thus a significant improvement of the environmental footprint of catalytic processes. The main goal of INTERfaces is the extension of this concept towards multi-step biocatalytic reactions in immobilized form. These “Heterogeneous Biocatalytic Reaction Cascades” will greatly facilitate re-use of the catalysts and further simplify downstream-processing. INTERfaces combines material science and protein engineering to design tailored enzymes and (bio-based) materials that will complement each other to obtain optimized heterogeneous biocatalysts. These tools will be applied to solve synthetic challenges in the use of two biobased monomers as starting materials to synthesize products for application fields like antioxidants and biopolymers. Process optimization and up-scale in industry will reveal key factors for synthetic utilization of the biocatalysts. INTERfaces emphasizes particularly the engineering of the designed cascades in solid phase. This includes the design of reactors, use of computational modeling tools, application of the right operational modes, and reaction medium needed for desired space-time-yields and product titers. Commercial relevant processes will be up-scaled together with industry for technical implementation. 13 Non-academic partners ranging from high-tech SMEs to large producing companies and 9 academic institutions offer an intersectoral and interdisciplinary environment to provide 14 Ph.D. candidates with outstanding employability profiles for the European Biotech Sector. Dedicated workshops and well-balanced supervisory team aim at increasing the gender diversity in biotech research.

Campo scientifico

Parole chiave

Programma(i)

Argomento(i)

Invito a presentare proposte

H2020-MSCA-ITN-2019

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Meccanismo di finanziamento

MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)

Coordinatore

AARHUS UNIVERSITET
Contribution nette de l'UE
€ 595 044,00
Indirizzo
Nordre ringgade 1
8000 Aarhus c
Danimarca

Mostra sulla mappa
Regione
Danmark Midtjylland Østjylland
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Altri finanziamenti
€ 0,00

Partecipanti (17)

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Ultimo aggiornamento: 23 Giugno 2023

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Permalink: https://cordis.europa.eu/project/id/860414/it

European Union, 2023