Descrizione del progetto
Migliore comprensione del sistema dell’ubiquitina
Il sistema dell’ubiquitina è una promettente fonte di terapie per il trattamento di numerose malattie dell’uomo che rappresentano una sfida per la società. I brevi motivi lineari di interazione (SLiM, Short linear interaction motifs) sono importanti nei meccanismi che consentono l’uso del sistema dell’ubiquitina per il trattamento di alcune malattie, ma rimangono sottoutilizzati. Il progetto UBIMOTIF, finanziato dall’UE, mira a formare giovani ricercatori nella scienza degli SLiM utilizzando un approccio multidisciplinare e intersettoriale insieme a una tecnologia all’avanguardia. L’impatto di UBIMOTIF sarà senza precedenti, fornendo informazioni sul sistema dell’ubiquitina, nonché nuove opportunità terapeutiche e una forza lavoro qualificata in grado di riempire le pipeline esaurite delle aziende europee.
Obiettivo
A major challenge is the lack of therapeutic approaches for numerous human diseases, which poses a societal challenge. The ubiquitin system is a major promising source for novel therapeutic approaches but its potential has not been fully exploited due to limited insight and lack of researchers trained in understanding and identifying avenues to target the ubiquitin system. Ubiquitin ligases and deubiquitinating enzymes (DUBs) comprises enzymes that actively add or remove ubiquitin from proteins to regulate cell physiology. How these enzymes selectively recognize their substrates is largely unknown but an emerging theme is that a globular domain in the enzyme binds a short linear interaction motif (SLiM) in the substrate. SLiMs are short peptide motifs that constitute ideal entry points for understanding the ubiquitin system as they provide detailed insight into substrate selection and how this regulates the underlying biology. Further, SLiMs provide direct routes to therapeutic exploitation as they serve as peptide scaffolds for drug development and tools to highjack the ubiquitin system. The potential of SLiMs has not been capitalized upon because a method for efficient identification was missing, interactions between relevant partners were lacking and this has hampered training of young researchers. UBIMOTIF overcomes these barriers by exploiting novel technological advances to identify SLiMs and uniting outstanding complementary researchers and industrial partners with a common vision to provide outstanding training of early career scientist in SLiMs and the ubiquitin system. The UBIMOTIF topic provides ideal training of young researchers, as it requires a multidisciplinary and intersectorial approach providing training in multiple cutting-edge technologies. The impact of UBIMOTIF will be unprecedented insight into the ubiquitin system, novel therapeutic opportunities and a skilled workforce that can fill the exhausted pipelines of European companies.
Campo scientifico
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Meccanismo di finanziamento
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinatore
1165 Kobenhavn
Danimarca