Short linear interaction motifs as specificity determinants in the ubiquitin system – discovery, mechanisms and therapeutic opportunities

Información del proyecto

UBIMOTIF

Identificador del acuerdo de subvención: 860517

DOI

10.3030/860517

Proyecto cerrado

Fecha de la firma de la CE 9 Agosto 2019

Fecha de inicio 1 Diciembre 2019

Fecha de finalización 31 Mayo 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 4 143 173,11

Aportación de la UE

€ 4 143 173,11

Coordinado por

KOBENHAVNS UNIVERSITET
Denmark

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (6)

UBIMOTIF newsletter 3
UBIMOTIF newsletter 2
UBIMOTIF newsletter 4
UBIMOTIF newsletter 1
Open access publications from ESR projects
Joint publication form JC work

Joint publication form JC work3UCPHPDEPU48

Websites, patent fillings, videos etc. (1)

Website, LinkedIn, twitter, facebook accounts for network

Other (3)

Advertisement of positions
Presentation of results at meetings

Presentation of results at meetings3UCPHPDEPU42

Online open access SLiM resources

Publicaciones

Peer reviewed articles (14)

On the Effects of Disordered Tails, Supertertiary Structure and Quinary Interactions on the Folding and Function of Protein Domains

Autores: Francesca Malagrinò, Valeria Pennacchietti, Daniele Santorelli, Livia Pagano, Caterina Nardella, Awa Diop, Angelo Toto, Stefano Gianni
Publicado en: Biomolecules, 2022, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom12020209

Folding and Binding Mechanisms of the SH2 Domain from Crkl

Autores: Caterina Nardella, Angelo Toto, Daniele Santorelli, Livia Pagano, Awa Diop, Valeria Pennacchietti, Paola Pietrangeli, Lucia Marcocci, Francesca Malagrinò, Stefano Gianni
Publicado en: Biomolecules, 2022, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom12081014

The human GID complex engages two independent modules for substrate recruitment

Autores: Mohamed, Weaam I.; Park, Sophia L.; Rabl, Julius; id_orcid0000-0001-6375-852X; Leitner, Alexander; Boehringer, Daniel; Peter, Matthias; peter, matthias
Publicado en: EMBO Reports, 22 (11), Edición 1, 2021, ISSN 1469-221X
Editor: Nature Publishing Group
DOI: 10.3929/ethz-b-000511960

Unveiling induced folding of intrinsically disordered proteins – Protein engineering, frustration and emerging themes

Autores: Francesca Malagrinò, Awa Diop, Livia Pagano, Caterina Nardella, Angelo Toto, Stefano Gianni
Publicado en: Current Opinion in Structural Biology, 2022, ISSN 1879-033X
Editor: Elsevier
DOI: 10.1016/j.sbi.2021.11.004

Who Binds Better? Let Alphafold2 Decide!

Autores: Julia K. Varga, Ora Schueler-Furman
Publicado en: Angewandte Chemie, 2023, ISSN 1521-3773
Editor: Wiley-VCH GmbH
DOI: 10.1002/anie.202303526

Exploring the effect of tethered domains on the folding of Grb2 protein

Autores: Livia Pagano, Valeria Pennacchietti, Awa Diop, Daniele Santorelli, Paola Pietrangeli, Lucia Marcocci, Caterina Nardella, Francesca Malagrino, Angelo Toto, Stefano Gianni
Publicado en: Archives of Biochemistry and Biophysics, 2022, ISSN 0003-9861
Editor: Academic Press
DOI: 10.1016/j.abb.2022.109444

xProtCAS: A Toolkit for Extracting Conserved Accessible Surfaces from Protein Structures

Autores: Hazem M. Kotb, Norman E. Davey
Publicado en: Biomolecules, 2023, ISSN 2218-273X
Editor: MDPI
DOI: 10.3390/biom13060906

Matching protein surface structural patches for high-resolution blind peptide docking

Autores: Alisa Khramushin, Ziv Ben-Aharon, Tomer Tsaban, Julia K. Varga, Orly Avraham, Ora Schueler-Furman
Publicado en: PNAS, 2022, ISSN 1091-6490
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2121153119

Structure-Based Prediction of KDAC6 Substrates Validated by Enzymatic Assay Reveals Determinants of Promiscuity and Detects New Potential Substrates

Autores: Julia Varga; Kelsey Diffley; Katherine R. Welker Leng; Carol A. Fierke; Ora Schueler-Furman
Publicado en: Scientific Reports, 2022, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-022-05681-2

SH2 Domains: Folding, Binding and Therapeutical Approaches

Autores: Awa Diop, Daniele Santorelli, Francesca Malagrinò, Caterina Nardella, Valeria Pennacchietti, Livia Pagano, Lucia Marcocci, Paola Pietrangeli, Stefano Gianni, Angelo Toto
Publicado en: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232415944

Harnessing protein folding neural networks for peptide–protein docking

Autores: Tsaban, Tomer; Varga, Julia K.; Avraham, Orly; Ben-Aharon, Ziv; Khramushin, Alisa; Schueler-Furman, Ora
Publicado en: Nature Communications, Edición 1, 2022, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-021-27838-9

Biophysical Characterization of the Binding Mechanism between the MATH Domain of SPOP and Its Physiological Partners

Autores: Awa Diop, Paola Pietrangeli, Caterina Nardella, Valeria Pennacchietti, Livia Pagano, Angelo Toto, Mariana Di Felice, Sara Di Matteo, Lucia Marcocci, Francesca Malagrinò, Stefano Gianni
Publicado en: International Journal of Molecular Sciences, 2023, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241210138

Characterization of early and late transition states of the folding pathway of a SH2 domain

Autores: Angelo Toto; Francesca Malagrinò; Caterina Nardella; Valeria Pennacchietti; Livia Pagano; Daniele Santorelli; Awa Diop; Stefano Gianni
Publicado en: Protein Science, 2022, ISSN 1469-896X
Editor: Wiley
DOI: 10.1002/pro.4332

Profiling ubiquitin signalling with UBIMAX reveals DNA damage- and SCFβ-Trcp1-dependent ubiquitylation of the actin-organizing protein Dbn1

Autores: Camilla S. Colding-Christensen, Ellen S. Kakulidis, Javier Arroyo-Gomez, Ivo A. Hendriks, Connor Arkinson, Zita Fábián, Agnieszka Gambus, Niels Mailand, Julien P. Duxin & Michael L. Nielsen
Publicado en: Nature Communications, 2023, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-023-43873-0

Book chapters (1)

A Mass Spectrometry-Based Strategy for Mapping Modification Sites for the Ubiquitin-Like Modifier NEDD8

Autores: Oliveira, C.A.B., Isaakova, E., Beli, P., Xirodimas, D.P.
Publicado en: The Ubiquitin Code. Methods in Molecular Biology, vol 2602., 2022, ISBN 978-1-0716-2859-1
Editor: Humana
DOI: 10.1007/978-1-0716-2859-1_10