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Proton transport and proton-coupled transport

Project description

DEENESFRITPL

Training for proton transport

Nature always seems to have a solution for everything. Emulating nature for sustainable human innovations provides for biomimetic solutions. Such options are limited for the development of new biofuel cells because knowledge of proton transfer reactions remains incomplete. The EU-funded PROTON project aims to train 15 PhD students, who will acquire a solid state-of-the-art multidisciplinary scientific training in all kinds of proton migration/reaction systems. The training will enable them to resolve the molecular details of proton driven processes in all kinds of settings, enabling the improvement of biomimetic applications.

Objective

Secure, competitive, and sustainable energy production is a major challenge facing human societies. Biomimetic solutions such as the development of new biofuel cells are hampered by our thus far incomplete understanding of proton transfer reactions. The same holds for health threats to humanity: Curing diseases like cancer, obesity, chronic gastritis, gastric and duodenal ulcers, requires to pharmacologically interfere - in their molecular details - with yet unresolved proton transfer reactions.
Here we aim at clarifying the molecular reaction mechanism in the confines of interfacial water layers and proteinaceous cavities with
emphasis on arrangement and mobility of proton relay moieties. Achieving this requires an interdisciplinary, multi-level approach comprising cutting edge technologies like second harmonic imaging, single molecule and time resolved fluorescence microscopy and spectroscopy, advanced calculations of proton transfer, bioengineering of membrane channel and transporter containing systems, synthetic design of biomimetic proton channels, solving protein structures and rational drug design.

PROTON will train 15 PhD students, who will acquire a solid state-of-the-art multidisciplinary scientific training in all kinds of proton migration/reaction systems, covering from basic science to industrial applications, thus preparing them to generate new scientific knowledge of the highest impact. In addition, practical training on transferable skills will increase their employability and qualify them for responsible positions in private and public sectors. Cross-disciplinary strategies and close collaboration with industry will enable them to resolve the molecular details of proton driven processes in all kinds of settings - enabling the improvement of biomimetic applications – up to fuel cells - and to identify lead substances which may serve to pharmacologically interfere with proton transport through membrane channels and transporters.

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Programme(s)

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Call for proposal

H2020-MSCA-ITN-2019

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Funding Scheme

MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)

Coordinator

UNIVERSITAT LINZ
Net EU contribution
€ 528 414,48
Address
Altenberger strasse 69
4040 Linz
Austria

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Region
Westösterreich Oberösterreich Linz-Wels
Activity type
Higher or Secondary Education Establishments
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Other funding
€ 0,00

Participants (12)

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EC signature date 9 August 2019
Last update: 17 July 2023

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Permalink: https://cordis.europa.eu/project/id/860592

European Union, 2023