Proton transport and proton-coupled transport

Deliverables

Documents, reports (2)

Researcher Declarations on Conformity

Personal data and data related to the project allowances of the recruited PhD students are declared

Ranking of different surface structures/intraluminal transporter structures according to their ability to conduct protons

We measure proton fluxes along different surfaces in vitro and in silico and compare the specific conductances

Other (4)

PROTON vacancies published

The PhD positions are advertised

Websites (external and internal)

A website for the proton consortium is designed and mounted

Time lapse movies of traveling proton fronts along the hydration shells of lipid bilayers

Timedependent changes of proton concentration gradients on top of a lipid bilayer are imaged

Overall recruitment

Recruitment of 15 ESRs and their enrolment in a Doctoral Program

Publications

Peer reviewed articles (6)

Imaging Cu 2+ binding to charged phospholipid membranes by high-throughput second harmonic wide-field microscopy

Author(s): Seonwoo Lee, David Roesel, Sylvie Roke
Published in: The Journal of Chemical Physics, 155/18, 2021, Page(s) 184704, ISSN 0021-9606
Publisher: American Institute of Physics
DOI: 10.1063/5.0063362

Fluorescence Cross-Correlation Spectroscopy Yields True Affinity and Binding Kinetics of Plasmodium Lactate Transport Inhibitors

Author(s): Iga Jakobowska, Frank Becker, Stefano Minguzzi, Kerrin Hansen, Björn Henke, Nathan Hugo Epalle, Eric Beitz, Stefan Hannus
Published in: Pharmaceuticals, 14/8, 2021, Page(s) 757, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14080757

Basigin drives intracellular accumulation of l-lactate by harvesting protons and substrate anions

Author(s): Anna-Lena Köpnick, Annika Jansen, Katharina Geistlinger, Nathan Hugo Epalle, Eric Beitz
Published in: PLOS ONE, 16/3, 2021, Page(s) e0249110, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0249110

Discovery and Development of Inhibitors of the Plasmodial FNT-Type Lactate Transporter as Novel Antimalarials

Author(s): Cornelius Nerlich, Nathan H. Epalle, Philip Seick, Eric Beitz
Published in: Pharmaceuticals, 14/11, 2021, Page(s) 1191, ISSN 1424-8247
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14111191

Self-Assembled H-Bonding Superstructures for Alkali Cation and Proton Transport

Author(s): Erol Licsandru, Iuliana-Marilena Andrei, Arie van der Lee, Mihail Barboiu
Published in: Frontiers in Chemistry, 9, 2021, ISSN 2296-2646
Publisher: frontiers in chemistry
DOI: 10.3389/fchem.2021.678962

Mitochondrial Uncoupling Proteins (UCP1-UCP3) and Adenine Nucleotide Translocase (ANT1) Enhance the Protonophoric Action of 2,4-Dinitrophenol in Mitochondria and Planar Bilayer Membranes

Author(s): Kristina Žuna, Olga Jovanović, Ljudmila S Khailova, Sanja Škulj , Zlatko Brkljača , Jürgen Kreiter, Elena A Kotova , Mario Vazdar , Yuri N Antonenko, Elena E Pohl
Published in: Biomolecules, 11/8, 2021, Page(s) 1178, ISSN 2218-273X
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom11081178