CORDIS - Risultati della ricerca dell’UE

Proton transport and proton-coupled transport

Risultati finali

Researcher Declarations on Conformity

Personal data and data related to the project allowances of the recruited PhD students are declared

Ranking of different surface structures/intraluminal transporter structures according to their ability to conduct protons

We measure proton fluxes along different surfaces in vitro and in silico and compare the specific conductances

PROTON vacancies published

The PhD positions are advertised

Websites (external and internal)

A website for the proton consortium is designed and mounted

Time lapse movies of traveling proton fronts along the hydration shells of lipid bilayers

Timedependent changes of proton concentration gradients on top of a lipid bilayer are imaged

Overall recruitment

Recruitment of 15 ESRs and their enrolment in a Doctoral Program


Protons at bio-interfaces

Autori: Ana-Nicoleta Bondar; Mihail Barboiu
Pubblicato in: Crossref, Numero 1, 2023, ISSN 0005-2736
Editore: Elsevier BV
DOI: 10.1016/j.bbamem.2023.184139

Size dependence of second-harmonic scattering from nanoparticles: Disentangling surface and electrostatic contributions

Autori: Bingxin Chu; Arianna Marchioro; Sylvie Roke
Pubblicato in: Crossref, Numero 5, 2023, ISSN 0021-9606
Editore: American Institute of Physics
DOI: 10.1063/5.0135157

Imaging Cu 2+ binding to charged phospholipid membranes by high-throughput second harmonic wide-field microscopy

Autori: Seonwoo Lee, David Roesel, Sylvie Roke
Pubblicato in: The Journal of Chemical Physics, Numero 155/18, 2021, Pagina/e 184704, ISSN 0021-9606
Editore: American Institute of Physics
DOI: 10.1063/5.0063362

Fluorescence Cross-Correlation Spectroscopy Yields True Affinity and Binding Kinetics of Plasmodium Lactate Transport Inhibitors

Autori: Iga Jakobowska, Frank Becker, Stefano Minguzzi, Kerrin Hansen, Björn Henke, Nathan Hugo Epalle, Eric Beitz, Stefan Hannus
Pubblicato in: Pharmaceuticals, Numero 14/8, 2021, Pagina/e 757, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14080757

Biomimetic Artificial Proton Channels

Autori: Andrei I-M, Barboiu M.
Pubblicato in: Biomolecules, Numero 2218273X, 2022, Pagina/e 1473, ISSN 2218-273X
Editore: MDPI
DOI: 10.3390/biom12101473

Basigin drives intracellular accumulation of l-lactate by harvesting protons and substrate anions

Autori: Anna-Lena Köpnick, Annika Jansen, Katharina Geistlinger, Nathan Hugo Epalle, Eric Beitz
Pubblicato in: PLOS ONE, Numero 16/3, 2021, Pagina/e e0249110, ISSN 1932-6203
Editore: Public Library of Science
DOI: 10.1371/journal.pone.0249110

Local Attraction of Substrates and Co-Substrates Enhances Weak Acid and Base Transmembrane Transport

Autori: Epalle, N. H. Beitz, E.
Pubblicato in: Biomolecules, 2022, ISSN 2218-273x
Editore: MDPI
DOI: 10.3390/biom12121794

Dissecting the mechanisms of environment sensitivity of smart probes for quantitative assessment of membrane properties

Autori: Franziska Ragaller, Luca Andronico, Jan Sykora, Waldemar Kulig, Tomasz Rog†, Yagmur Balim Urem, Abhinav, Dmytro I. Danylchuk, Martin Hof, Andrey Klymchenko, Mariana Amaro, Ilpo Vattulainen and Erdinc Sezgin
Pubblicato in: Open Biology, 2022, ISSN 2046-2441
Editore: Royal Society Publishing
DOI: 10.1098/rsob.220175

Modulation of Anionic Lipid Bilayers by Specific Interplay of Protons and Calcium Ions

Autori: Abhinav, Jurkiewicz P, Hof M, Allolio C, Sýkora J.
Pubblicato in: Biomolecules, 2022, ISSN 2218-273X
Editore: mdpi
DOI: 10.3390/biom12121894

Discovery and Development of Inhibitors of the Plasmodial FNT-Type Lactate Transporter as Novel Antimalarials

Autori: Cornelius Nerlich, Nathan H. Epalle, Philip Seick, Eric Beitz
Pubblicato in: Pharmaceuticals, Numero 14/11, 2021, Pagina/e 1191, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph14111191

Self-Assembled H-Bonding Superstructures for Alkali Cation and Proton Transport.

Autori: Erol Licsandru; Iuliana-Marilena Andrei; Arie van der Lee; Mihail Barboiu
Pubblicato in:, Numero 4, 2021, ISSN 2296-2646
Editore: Front Chem
DOI: 10.3389/fchem.2021.678962

Cysteine 159 delineates a hinge region of the alternating access monocarboxylate transporter 1 and is targeted by cysteine-modifying inhibitors.

Autori: Anna-Lena Köpnick; Katharina Geistlinger; Eric Beitz
Pubblicato in: The FEBS Journal, Numero 2, 2021, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.16024

Lactic Acid Permeability of Aquaporin-9 Enables Cytoplasmic Lactate Accumulation via an Ion Trap

Autori: Katharina Geistlinger; Jana D. R. Schmidt; Eric Beitz
Pubblicato in: Life; Volume 12; Numero 1; Pages: 120, Numero 2, 2022, ISSN 2075-1729
Editore: life
DOI: 10.3390/life12010120

Self-Assembled H-Bonding Superstructures for Alkali Cation and Proton Transport

Autori: Erol Licsandru, Iuliana-Marilena Andrei, Arie van der Lee, Mihail Barboiu
Pubblicato in: Frontiers in Chemistry, Numero 9, 2021, ISSN 2296-2646
Editore: frontiers in chemistry
DOI: 10.3389/fchem.2021.678962

Mitochondrial Uncoupling Proteins (UCP1-UCP3) and Adenine Nucleotide Translocase (ANT1) Enhance the Protonophoric Action of 2,4-Dinitrophenol in Mitochondria and Planar Bilayer Membranes

Autori: Kristina Žuna, Olga Jovanović, Ljudmila S Khailova, Sanja Škulj , Zlatko Brkljača , Jürgen Kreiter, Elena A Kotova , Mario Vazdar , Yuri N Antonenko, Elena E Pohl
Pubblicato in: Biomolecules, Numero 11/8, 2021, Pagina/e 1178, ISSN 2218-273X
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/biom11081178

Protons taken hostage: Dynamic H-bond networks of the pH-sensing GPR68

Autori: Kapur, B.; Baldessari, F.; Lazaratos, M.; Nar, H.; Schnapp, G.; Giorgetti, A.; Bondar, A.-N.
Pubblicato in: Computational and Structural Biotechnology Journal, Numero 21, 2023, Pagina/e 4370-4384, ISSN 2001-0370
Editore: Elsevier
DOI: 10.1016/j.csbj.2023.08.034

Mechanisms of long-distance allosteric couplings in proton-binding membrane transporters

Autori: Ana-Nicoleta Bondar
Pubblicato in: Crossref, Numero 3, 2022, ISSN 1876-1623
Editore: Adv Protein Chem Struct Biol
DOI: 10.1016/bs.apcsb.2021.09.002

Dynamics and Hydration of Proteins Viewed by Fluorescence Methods: Investigations for Protein Engineering and Synthetic Biology

Autori: Sykora, J., Prokop, Z., Damborsky, J., Abhinav, Hof, M., Amaro, M.
Pubblicato in: Springer Series on Fluorescence, 2023
Editore: Springer
DOI: 10.1007/4243_2022_40

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