Description du projet
Comprendre la régulation des cellules embryonnaires pourrait mettre en lumière de nombreuses pathologies
Les cellules de la crête neurale sont un groupe transitoire de cellules embryonnaires qui migrent à maintes reprises, donnant naissance non seulement à la plupart des éléments du système nerveux périphérique, mais aussi aux cellules de la glande surrénale, aux cellules musculaires lisses du système cardiovasculaire, aux cellules pigmentaires de la peau, ainsi qu’aux os craniofaciaux, au cartilage et aux tissus conjonctifs. Les neurocristopathies (NCP) sont provoquées par des anomalies chez les cellules de la crête neurale, et des cancers comme le mélanome et le neuroblastome y sont associés. Toutefois, il s’avère difficile d’identifier l’origine des pathologies dans les mutations spécifiques de ces cellules. NEUcrest exploite le pouvoir des chercheurs en début de carrière pour déceler les aspects complexes de la formation de cellules neuronales et de tumeurs et, de manière plus générale, de la régulation du tissu cellulaire neuronal dans la santé humaine.
Objectif
Neurocristopathies caused by defects in the neural crest (NC) encompass a broad group of diseases from birth defects (cleftvpalate) to complex syndromes affecting systems such as heart, gut and adrenals. Because NC derivatives are diverse, mutations affecting this lineage can lead to pleiotropic phenotypes making it difficult to understand the causative events. Furthermore, NC-derived cancers, (e.g. melanoma and neuroblastoma) reactivate embryonic programs during tumour initiation. Our aim is to create a unique interdisciplinary network of scientists and clinicians partners from academia, healthcare, industry and the public sector with experience in gene discovery, genetics, functional studies and in vivo phenotyping aimed at training creative and innovative ESRs to study the overall genetic, molecular and environmental regulation of NC tissue in human health. To study each of complex aspects of NC and tumour formation, NEUcrest provides a synergistic framework for comprehensive analysis of candidate genes and biological processes, from patients to model systems to pharma and back to the clinic. With the aim to develop a unified strategy to identify new genetic and environmental factors that contribute to disease and to develop new drug targets for therapeutics, ESRs will address following scientific challenges: undertake novel gene discovery approaches; establish cellular/animal models of disease; establish integrative strategies for understanding neurocristopathies; optimise computational modelling of NC gene networks; establish translational strategies for drug screening in NC-related diseases; improve clinical management strategies of NC-disease and interface with patients and the public. Our training program takes into account training through research as well as multidisciplinary partnerships and networking opportunities. All together, this will improve our understanding of the fundamentals of neurocristopathy and contribute to improvements in healthcare.
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MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinateur
75231 Paris
France