Superconducting Mass Spectrometry and Molecule Analysis

Informations projet

SuperMaMa

N° de convention de subvention: 860713

DOI

10.3030/860713

Projet clôturé

Date de signature de la CE 30 Août 2019

Date de début 1 Janvier 2020

Date de fin 30 Juin 2023

Financé au titre de

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coût total

€ 2 841 418,75

Contribution de l’UE

€ 2 841 418,75

Coordonné par

UNIVERSITAT WIEN
Austria

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (16)

Iterated SNWD design, specification, fabrication, delivery

Iterated SNWD design specification fabrication delivery

Optimized ion steering and Chip cleaning in cryochamber

Optimized ion steering and Chip cleaning in cryochamber

SNWD sensitivity to internal molecular energy

Report on SNWD sensitivity to internal molecular energy

Validation 5: Peptides with green PCTs synthesized and validated
Validation 3: peptides/proteins detected by 8-pixel SNWA prototype

Validation 3 peptidesproteins detected by 8pixel SNWA prototype

Validation 9: Preparation of a mass selected neutral protein beam

Validation 9 Preparation of a mass selected neutral protein beam

128-pixel array prototype, shipped Vienna

128pixel packaged array prototype shipped to Vienna

Report on reliability in UHV, thermal cycling, molecular irradiation

Report on reliability in UHV thermal cycling molecular irradiation

Strategies for increasing density and collimation of neutral protein beams
Validation 2: Optimized SNWD tested with proteins

Validation 2 Optimized SNWD tested with proteins

Validation 11: SNWD assisted detection of absorption in neutral macromolecules

Validation 11 SNWD assisted detection of absorption in neutral macromolecules

Validation 6: Peptides with blue PCTs synthesized and validated

Validation 6 Peptides with blue PCTs synthesized and validated

Complete mass spectrometer design: selectors, optics zones, cryogenic chamber
8-pixel packaged array prototype, shipped to Vienna

8pixel packaged array prototype shipped to Vienna

Validation 8: SNWD detection of singly-charged mass selected 100 kDa proteins

Validation 8 SNWD detection of singlycharged mass selected 100 kDa proteins

Validation 10: SNWD assisted detection of absorption in biopolymer ions

Validation 10 SNWD assisted detection of absorption in biopolymer ions

Websites, patent fillings, videos etc. (1)

Project website

Up-to date information on the project

Publications

Peer reviewed articles (5)

A 0.32 × 0.12 mm^2 Cryogenic BiCMOS 0.1–8.8 GHz Low Noise Amplifier Achieving 4 K Noise Temperature for SNWD Readout

Auteurs: Y. Peng, J. Benserhir, M. Castaneda, A. Fognini, C. Bruschini and E. Charbon
Publié dans: IEEE Transactions on Microwave Theory and Techniques, 2024, ISSN 1557-9670
Éditeur: IEEE
DOI: 10.1109/tmtt.2024.3354828

Highly sensitive single-molecule detection in slow protein ion beams

Auteurs: M. Strauß, A. Shayeghi, M.F.X. Mauser, P. Geyer, T. Kostersitz, J. Salapa, O. Dobrovolskiy, S. Daly, J. Commandeur, Y. Hua, V. Köhler, M. Mayor, J. Benserhir, C. Bruschini, E. Charbon, M. Castaneda, M. Gevers, R. Gourgues, N. Kalhor, A. Fognini, and M. Arndt
Publié dans: Science Advances, Numéro 9, 2023, Page(s) 48, ISSN 2375-2548
Éditeur: American Society Association for the Advancement of Science
DOI: 10.1126/sciadv.adj2801

Giving the Green Light to Photochemical Uncaging of Large Biomolecules in High Vacuum

Auteurs: Yong Hua, Marcel Strauss, Sergey Fisher, Martin F. X. Mauser, Pierre Manchet, Martina Smacchia, Philipp Geyer, Armin Shayeghi, Michael Pfeffer, Tim Henri Eggenweiler, Steven Daly, Jan Commandeur, Marcel Mayor, Markus Arndt, Tomáš Šolomek, and Valentin Köhler
Publié dans: JACS, 2023, ISSN 2691-3704
Éditeur: ACS Publications
DOI: 10.1021/jacsau.3c00351

Neutralization of an Oxytocin Derivative by 355 nm Photocleavage in High Vacuum

Auteurs: Yong Hua, Daniel Häussinger, Marcel Mayor, Valentin Köhler, Marcel Strauss, Martin F. X. Mauser, Tim Kostersitz, Philipp Geyer, Markus Arndt
Publié dans: Helvetica Chimica Acta, Numéro 108, 2025, ISSN 0018-019X
Éditeur: Verlag Helvetica Chimica Acta
DOI: 10.1002/hlca.202400167

Superconducting Nanowire Detection of Neutral Atoms and Molecules via Their Internal and Kinetic Energy in the eV Range

Auteurs: M. Strauß, R. Gourgues, M. F. X. Mauser, L. Kulman, M. Castaneda, A. Fognini, A. Shayeghi, P. Geyer, M. Arndt
Publié dans: Advanced Physics Research, Numéro 4, 2025, ISSN 2751-1200
Éditeur: Wiley
DOI: 10.1002/apxr.202400133

Other (2)

Giving the green light to photochemical uncaging of large biomolecules in high vacuum

Auteurs: Yong Hua, Marcel Strauss, Sergey Fisher, Martin F. X. Mauser , Pierre Manchet, Martina Smacchia, Philipp Geyer, Armin Shayeghi, Michael Pfeffer, Tim Henri Eggenweiler, Steven Daly, Jan Commandeur, Marcel Mayor, Markus Arndt, Tomáš Šolomek, Valentin Köhler
Publié dans: 2023
Éditeur: -
DOI: 10.26434/chemrxiv-2023-mgqg3

Click, Lock & Dye: a chromogenic handle for selective cysteine modification

Auteurs: Yong Hua, Zhi Zou, Alessandro Prescimone,Thomas R. Ward, Marcel Mayor, Valentin Köhler
Publié dans: 2023
Éditeur: ChemRxiv

Conference proceedings (1)

Superconducting quantum detectors and single photon charge control for mass spectrometry

Auteurs: Marcel Strauß, Armin Shayeghi, Martin Mauser, Pierre Manchet, Martina Smacchia, Julia Salapa, Tim Kostersitz, Philipp Geyer, Steven Daly, Jan Commandeur, Yong Hua, Alfredo Di Silvestro, Marcel Mayor, Valentin Köhler, Jad Benserhir, Claudio Bruschini, Edoardo Charbon, Mario Castaneda, Monique Gevers, Ronan Gourgues, Nima Kalhor, Andreas Fognini, Markus Arndt
Publié dans: Proceedings of SPIE - Proceedings Volume 12447, Quantum Sensing, Imaging, and Precision Metrology; 124470I (2023), 2023, Page(s) 124470I-1 to 124470I-7
Éditeur: Proceedings of SPIE
DOI: 10.1117/12.2657258