Exploiting the methylerythritol phosphate pathway as a source of drug targets for novel anti-infectives

Información del proyecto

MepAnti

Identificador del acuerdo de subvención: 860816

DOI

10.3030/860816

Proyecto cerrado

Fecha de la firma de la CE 12 Mayo 2020

Fecha de inicio 1 Abril 2020

Fecha de finalización 30 Septiembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 174 724,80

Aportación de la UE

€ 3 174 724,80

Coordinado por

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (8)

ESR PhD theses

ESR PhD theses (months 4154)

Scientific publications

Scientific publications (months 1754)

Presentation at conferences

Presentation at conferences (months 1754)

LinkedIN/Facebook group

LinkedINFacebook group

Distribution of network course and workshop material (WP4)

Distribution of network course and workshop material months 8 14 22 28 34 40

Articles in the popular press, press release, interviews in TV and radio shows

Articles in the popular press, press release, interviews in TV and radio shows (months 1754)

Distribution of network course and workshop material (WP5)

Distribution of network course and workshop material (months 8, 14, 22, 28, 34, 40)

Dissemination of new teaching material for secondary and high schools

Other (3)

FameLab competition
PhD degree awarded

PhD degree awarded (months 4154)

ESRs recruitment

ESRs recruitment months 59

Websites, patent fillings, videos etc. (3)

MepAntI website
Patents

Patents (months 1748)

Transfer and licensing of patents

Transfer and licensing of patents (months 1154)

Publicaciones

Peer reviewed articles (11)

Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate

Autores: Victor Oliveira Gawriljuk, Rick Oerlemans, Robin M. Gierse, Riya Jotwani, Anna K. H. Hirsch, Matthew R. Groves
Publicado en: Crystals, Edición 13, 2023, Página(s) 737, ISSN 2073-4352
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cryst13050737

Studying Target–Engagement of Anti-Infectives by Solvent-Induced Protein Precipitation and Quantitative Mass Spectrometry

Autores: Lorenzo Bizzarri, Dominik Steinbrunn, Thibaut Quennesson, Antoine Lacour, Gabriella Ines Bianchino, Patricia Bravo, Philippe Chaignon, Jonas Lohse, Pascal Mäser, Myriam Seemann, Serge Van Calenbergh, Anna K. H. Hirsch, Hannes Hahne
Publicado en: ACS Infectious Diseases, 2024, ISSN 2373-8227
Editor: American Chemical Society
DOI: 10.1021/acsinfecdis.4c00417

Targeting <i>Plasmodium falciparum</i> IspD in the Methyl-<scp>d</scp>-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity

Autores: Daan Willocx, Lorenzo Bizzarri, Alaa Alhayek, Deepika Kannan, Patricia Bravo, Boris Illarionov, Katharina Rox, Jonas Lohse, Markus Fischer, Andreas M. Kany, Hannes Hahne, Matthias Rottmann, Matthias Witschel, Audrey Odom John, Mostafa M. Hamed, Eleonora Diamanti, Anna K. H. Hirsch
Publicado en: Journal of Medicinal Chemistry, Edición 67, 2024, Página(s) 17070-17086, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.1021/acs.jmedchem.4c00212

Target-Directed Dynamic Combinatorial Chemistry Affords Binders of <i>Mycobacterium tuberculosis</i> IspE

Autores: Maria Braun-Cornejo, Camilla Ornago, Vidhisha Sonawane, Jörg Haupenthal, Andreas M. Kany, Eleonora Diamanti, Gwenaëlle Jézéquel, Norbert Reiling, Wulf Blankenfeldt, Peter Maas, Anna K. H. Hirsch
Publicado en: ACS Omega, Edición 9, 2024, Página(s) 38160-38168, ISSN 2470-1343
Editor: American Chemical Society
DOI: 10.1021/acsomega.4c05537

First crystal structures of 1‑deoxy‑d‑xylulose 5‑phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization

Autores: Robin M. Gierse, Rick Oerlemans, Eswar R. Reddem, Victor O. Gawriljuk, Alaa Alhayek, Dominik Baitinger, Harald Jakobi, Bernd Laber, Gudrun Lange, Anna K. H. Hirsch, Matthew R. Groves
Publicado en: Scientific Reports, 2022, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-022-11205-9

The Reductive Dehydroxylation Catalyzed by IspH, a Source of Inspiration for the Development of Novel Anti-Infectives

Autores: Hannah Jobelius, Gabriella Ines Bianchino, Franck Borel, Philippe Chaignon, Myriam Seemann
Publicado en: Molecules, 2022, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27030708

Targeting the IspD Enzyme in the MEP Pathway: Identification of a Novel Fragment Class

Autores: Eleonora Diamanti, Mostafa M. Hamed, Antoine Lacour, Patricia Bravo,Boris Illarionov, Markus Fischer, Matthias Rottmann, Matthias Witschel,Anna K. H. Hirsch
Publicado en: ChemMedChem, 2021, ISSN 1860-7187
Editor: Wiley-VCH
DOI: 10.1002/cmdc.202100679

Synthesis and kinetic evaluation of analogs of (E)-4-amino-3-methylbut-2-en-1-yl diphosphate, a potent inhibitor of the IspH metalloenzyme

Autores: Benoît Eric Petit, Hannah Jobelius, Gabriella Ines Bianchino, Mélina Guérin, Franck Borel, Philippe Chaignon, Myriam Seemann
Publicado en: Comptes Rendus. Chimie, Edición 26, 2024, Página(s) 1-14, ISSN 1878-1543
Editor: Academie des Sciences- Institut de France
DOI: 10.5802/crchim.254

Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain

Autores: Victor O. Gawriljuk, Andre S. Godoy, Rick Oerlemans, Luise A. T. Welker, Anna K. H. Hirsch, Matthew R. Groves
Publicado en: Nature Communications, Edición 15, 2024, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-024-50671-9

Acyloxymethyl and alkoxycarbonyloxymethyl prodrugs of a fosmidomycin surrogate as antimalarial and antibacterial agents

Autores: Charlotte Courtens, Frits van Charante, Thibaut Quennesson, Martijn Risseeuw, Paul Cos, Guy Caljon, Tom Coenye, Serge Van Calenbergh
Publicado en: European Journal of Medicinal Chemistry, Edición 245, 2023, Página(s) 114924, ISSN 0223-5234
Editor: Elsevier BV
DOI: 10.1016/j.ejmech.2022.114924

On the hunt for metalloenzyme inhibitors: Investigating the presence of metal‐coordinating compounds in screening libraries and chemical spaces

Autores: Bruna Schuck, Ruth Brenk
Publicado en: Archiv der Pharmazie, Edición 357, 2024, ISSN 0365-6233
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/ardp.202300648