Exploiting the methylerythritol phosphate pathway as a source of drug targets for novel anti-infectives

Informacje na temat projektu

MepAnti

Identyfikator umowy o grant: 860816

DOI

10.3030/860816

Projekt został zamknięty

Data podpisania przez KE 12 Maja 2020

Data rozpoczęcia 1 Kwietnia 2020

Data zakończenia 30 Września 2024

Finansowanie w ramach

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Koszt całkowity

€ 3 174 724,80

Wkład UE

€ 3 174 724,80

Koordynowany przez

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Documents, reports (8)

ESR PhD theses

ESR PhD theses (months 4154)

Scientific publications

Scientific publications (months 1754)

Presentation at conferences

Presentation at conferences (months 1754)

LinkedIN/Facebook group

LinkedINFacebook group

Distribution of network course and workshop material (WP4)

Distribution of network course and workshop material months 8 14 22 28 34 40

Articles in the popular press, press release, interviews in TV and radio shows

Articles in the popular press, press release, interviews in TV and radio shows (months 1754)

Distribution of network course and workshop material (WP5)

Distribution of network course and workshop material (months 8, 14, 22, 28, 34, 40)

Dissemination of new teaching material for secondary and high schools

Other (3)

FameLab competition
PhD degree awarded

PhD degree awarded (months 4154)

ESRs recruitment

ESRs recruitment months 59

Websites, patent fillings, videos etc. (3)

MepAntI website
Patents

Patents (months 1748)

Transfer and licensing of patents

Transfer and licensing of patents (months 1154)

Publikacje

Peer reviewed articles (11)

Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate

Autorzy: Victor Oliveira Gawriljuk, Rick Oerlemans, Robin M. Gierse, Riya Jotwani, Anna K. H. Hirsch, Matthew R. Groves
Opublikowane w: Crystals, Numer 13, 2023, Strona(/y) 737, ISSN 2073-4352
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cryst13050737

Studying Target–Engagement of Anti-Infectives by Solvent-Induced Protein Precipitation and Quantitative Mass Spectrometry

Autorzy: Lorenzo Bizzarri, Dominik Steinbrunn, Thibaut Quennesson, Antoine Lacour, Gabriella Ines Bianchino, Patricia Bravo, Philippe Chaignon, Jonas Lohse, Pascal Mäser, Myriam Seemann, Serge Van Calenbergh, Anna K. H. Hirsch, Hannes Hahne
Opublikowane w: ACS Infectious Diseases, 2024, ISSN 2373-8227
Wydawca: American Chemical Society
DOI: 10.1021/acsinfecdis.4c00417

Targeting <i>Plasmodium falciparum</i> IspD in the Methyl-<scp>d</scp>-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity

Autorzy: Daan Willocx, Lorenzo Bizzarri, Alaa Alhayek, Deepika Kannan, Patricia Bravo, Boris Illarionov, Katharina Rox, Jonas Lohse, Markus Fischer, Andreas M. Kany, Hannes Hahne, Matthias Rottmann, Matthias Witschel, Audrey Odom John, Mostafa M. Hamed, Eleonora Diamanti, Anna K. H. Hirsch
Opublikowane w: Journal of Medicinal Chemistry, Numer 67, 2024, Strona(/y) 17070-17086, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.1021/acs.jmedchem.4c00212

Target-Directed Dynamic Combinatorial Chemistry Affords Binders of <i>Mycobacterium tuberculosis</i> IspE

Autorzy: Maria Braun-Cornejo, Camilla Ornago, Vidhisha Sonawane, Jörg Haupenthal, Andreas M. Kany, Eleonora Diamanti, Gwenaëlle Jézéquel, Norbert Reiling, Wulf Blankenfeldt, Peter Maas, Anna K. H. Hirsch
Opublikowane w: ACS Omega, Numer 9, 2024, Strona(/y) 38160-38168, ISSN 2470-1343
Wydawca: American Chemical Society
DOI: 10.1021/acsomega.4c05537

First crystal structures of 1‑deoxy‑d‑xylulose 5‑phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization

Autorzy: Robin M. Gierse, Rick Oerlemans, Eswar R. Reddem, Victor O. Gawriljuk, Alaa Alhayek, Dominik Baitinger, Harald Jakobi, Bernd Laber, Gudrun Lange, Anna K. H. Hirsch, Matthew R. Groves
Opublikowane w: Scientific Reports, 2022, ISSN 2045-2322
Wydawca: Nature Publishing Group
DOI: 10.1038/s41598-022-11205-9

The Reductive Dehydroxylation Catalyzed by IspH, a Source of Inspiration for the Development of Novel Anti-Infectives

Autorzy: Hannah Jobelius, Gabriella Ines Bianchino, Franck Borel, Philippe Chaignon, Myriam Seemann
Opublikowane w: Molecules, 2022, ISSN 1420-3049
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27030708

Targeting the IspD Enzyme in the MEP Pathway: Identification of a Novel Fragment Class

Autorzy: Eleonora Diamanti, Mostafa M. Hamed, Antoine Lacour, Patricia Bravo,Boris Illarionov, Markus Fischer, Matthias Rottmann, Matthias Witschel,Anna K. H. Hirsch
Opublikowane w: ChemMedChem, 2021, ISSN 1860-7187
Wydawca: Wiley-VCH
DOI: 10.1002/cmdc.202100679

Synthesis and kinetic evaluation of analogs of (E)-4-amino-3-methylbut-2-en-1-yl diphosphate, a potent inhibitor of the IspH metalloenzyme

Autorzy: Benoît Eric Petit, Hannah Jobelius, Gabriella Ines Bianchino, Mélina Guérin, Franck Borel, Philippe Chaignon, Myriam Seemann
Opublikowane w: Comptes Rendus. Chimie, Numer 26, 2024, Strona(/y) 1-14, ISSN 1878-1543
Wydawca: Academie des Sciences- Institut de France
DOI: 10.5802/crchim.254

Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain

Autorzy: Victor O. Gawriljuk, Andre S. Godoy, Rick Oerlemans, Luise A. T. Welker, Anna K. H. Hirsch, Matthew R. Groves
Opublikowane w: Nature Communications, Numer 15, 2024, ISSN 2041-1723
Wydawca: Nature Publishing Group
DOI: 10.1038/s41467-024-50671-9

Acyloxymethyl and alkoxycarbonyloxymethyl prodrugs of a fosmidomycin surrogate as antimalarial and antibacterial agents

Autorzy: Charlotte Courtens, Frits van Charante, Thibaut Quennesson, Martijn Risseeuw, Paul Cos, Guy Caljon, Tom Coenye, Serge Van Calenbergh
Opublikowane w: European Journal of Medicinal Chemistry, Numer 245, 2023, Strona(/y) 114924, ISSN 0223-5234
Wydawca: Elsevier BV
DOI: 10.1016/j.ejmech.2022.114924

On the hunt for metalloenzyme inhibitors: Investigating the presence of metal‐coordinating compounds in screening libraries and chemical spaces

Autorzy: Bruna Schuck, Ruth Brenk
Opublikowane w: Archiv der Pharmazie, Numer 357, 2024, ISSN 0365-6233
Wydawca: John Wiley & Sons Ltd.
DOI: 10.1002/ardp.202300648