Exploiting the methylerythritol phosphate pathway as a source of drug targets for novel anti-infectives

Informations projet

MepAnti

N° de convention de subvention: 860816

DOI

10.3030/860816

Projet clôturé

Date de signature de la CE 12 Mai 2020

Date de début 1 Avril 2020

Date de fin 30 Septembre 2024

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total

€ 3 174 724,80

Contribution de l’UE

€ 3 174 724,80

Coordonné par

HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (8)

ESR PhD theses

ESR PhD theses (months 4154)

Scientific publications

Scientific publications (months 1754)

Presentation at conferences

Presentation at conferences (months 1754)

LinkedIN/Facebook group

LinkedINFacebook group

Distribution of network course and workshop material (WP4)

Distribution of network course and workshop material months 8 14 22 28 34 40

Articles in the popular press, press release, interviews in TV and radio shows

Articles in the popular press, press release, interviews in TV and radio shows (months 1754)

Distribution of network course and workshop material (WP5)

Distribution of network course and workshop material (months 8, 14, 22, 28, 34, 40)

Dissemination of new teaching material for secondary and high schools

Other (3)

FameLab competition
PhD degree awarded

PhD degree awarded (months 4154)

ESRs recruitment

ESRs recruitment months 59

Websites, patent fillings, videos etc. (3)

MepAntI website
Patents

Patents (months 1748)

Transfer and licensing of patents

Transfer and licensing of patents (months 1154)

Publications

Peer reviewed articles (11)

Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate

Auteurs: Victor Oliveira Gawriljuk, Rick Oerlemans, Robin M. Gierse, Riya Jotwani, Anna K. H. Hirsch, Matthew R. Groves
Publié dans: Crystals, Numéro 13, 2023, Page(s) 737, ISSN 2073-4352
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cryst13050737

Studying Target–Engagement of Anti-Infectives by Solvent-Induced Protein Precipitation and Quantitative Mass Spectrometry

Auteurs: Lorenzo Bizzarri, Dominik Steinbrunn, Thibaut Quennesson, Antoine Lacour, Gabriella Ines Bianchino, Patricia Bravo, Philippe Chaignon, Jonas Lohse, Pascal Mäser, Myriam Seemann, Serge Van Calenbergh, Anna K. H. Hirsch, Hannes Hahne
Publié dans: ACS Infectious Diseases, 2024, ISSN 2373-8227
Éditeur: American Chemical Society
DOI: 10.1021/acsinfecdis.4c00417

Targeting <i>Plasmodium falciparum</i> IspD in the Methyl-<scp>d</scp>-erythritol Phosphate Pathway: Urea-Based Compounds with Nanomolar Potency on Target and Low-Micromolar Whole-Cell Activity

Auteurs: Daan Willocx, Lorenzo Bizzarri, Alaa Alhayek, Deepika Kannan, Patricia Bravo, Boris Illarionov, Katharina Rox, Jonas Lohse, Markus Fischer, Andreas M. Kany, Hannes Hahne, Matthias Rottmann, Matthias Witschel, Audrey Odom John, Mostafa M. Hamed, Eleonora Diamanti, Anna K. H. Hirsch
Publié dans: Journal of Medicinal Chemistry, Numéro 67, 2024, Page(s) 17070-17086, ISSN 0022-2623
Éditeur: American Chemical Society
DOI: 10.1021/acs.jmedchem.4c00212

Target-Directed Dynamic Combinatorial Chemistry Affords Binders of <i>Mycobacterium tuberculosis</i> IspE

Auteurs: Maria Braun-Cornejo, Camilla Ornago, Vidhisha Sonawane, Jörg Haupenthal, Andreas M. Kany, Eleonora Diamanti, Gwenaëlle Jézéquel, Norbert Reiling, Wulf Blankenfeldt, Peter Maas, Anna K. H. Hirsch
Publié dans: ACS Omega, Numéro 9, 2024, Page(s) 38160-38168, ISSN 2470-1343
Éditeur: American Chemical Society
DOI: 10.1021/acsomega.4c05537

First crystal structures of 1‑deoxy‑d‑xylulose 5‑phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization

Auteurs: Robin M. Gierse, Rick Oerlemans, Eswar R. Reddem, Victor O. Gawriljuk, Alaa Alhayek, Dominik Baitinger, Harald Jakobi, Bernd Laber, Gudrun Lange, Anna K. H. Hirsch, Matthew R. Groves
Publié dans: Scientific Reports, 2022, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-022-11205-9

The Reductive Dehydroxylation Catalyzed by IspH, a Source of Inspiration for the Development of Novel Anti-Infectives

Auteurs: Hannah Jobelius, Gabriella Ines Bianchino, Franck Borel, Philippe Chaignon, Myriam Seemann
Publié dans: Molecules, 2022, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27030708

Targeting the IspD Enzyme in the MEP Pathway: Identification of a Novel Fragment Class

Auteurs: Eleonora Diamanti, Mostafa M. Hamed, Antoine Lacour, Patricia Bravo,Boris Illarionov, Markus Fischer, Matthias Rottmann, Matthias Witschel,Anna K. H. Hirsch
Publié dans: ChemMedChem, 2021, ISSN 1860-7187
Éditeur: Wiley-VCH
DOI: 10.1002/cmdc.202100679

Synthesis and kinetic evaluation of analogs of (E)-4-amino-3-methylbut-2-en-1-yl diphosphate, a potent inhibitor of the IspH metalloenzyme

Auteurs: Benoît Eric Petit, Hannah Jobelius, Gabriella Ines Bianchino, Mélina Guérin, Franck Borel, Philippe Chaignon, Myriam Seemann
Publié dans: Comptes Rendus. Chimie, Numéro 26, 2024, Page(s) 1-14, ISSN 1878-1543
Éditeur: Academie des Sciences- Institut de France
DOI: 10.5802/crchim.254

Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain

Auteurs: Victor O. Gawriljuk, Andre S. Godoy, Rick Oerlemans, Luise A. T. Welker, Anna K. H. Hirsch, Matthew R. Groves
Publié dans: Nature Communications, Numéro 15, 2024, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-50671-9

Acyloxymethyl and alkoxycarbonyloxymethyl prodrugs of a fosmidomycin surrogate as antimalarial and antibacterial agents

Auteurs: Charlotte Courtens, Frits van Charante, Thibaut Quennesson, Martijn Risseeuw, Paul Cos, Guy Caljon, Tom Coenye, Serge Van Calenbergh
Publié dans: European Journal of Medicinal Chemistry, Numéro 245, 2023, Page(s) 114924, ISSN 0223-5234
Éditeur: Elsevier BV
DOI: 10.1016/j.ejmech.2022.114924

On the hunt for metalloenzyme inhibitors: Investigating the presence of metal‐coordinating compounds in screening libraries and chemical spaces

Auteurs: Bruna Schuck, Ruth Brenk
Publié dans: Archiv der Pharmazie, Numéro 357, 2024, ISSN 0365-6233
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/ardp.202300648