Projektbeschreibung
Forschung an Biomarkern für Osteoporose bei Typ-2-Diabetes
Die Zahl der Diabeteserkrankungen hat sich in den letzten vierzig Jahren fast vervierfacht und liegt nun bei fast 425 Millionen. Bei etwa 90 % der Fälle handelt es sich um Typ-2-Diabetes, was trotz höherer Knochenmineraldichte ein unabhängiger Risikofaktor für Knochenbrüchigkeit und osteoporosebedingte Frakturen sein könnte, wie neue Studien vermuten. Da dies von den klassischen Risikofaktoren für Osteoporose abweicht, müssen die Krankheitsmechanismen genauer erforscht werden, um bessere Methoden für Prävention, Diagnose und Behandlung zu entwickeln. Zusammen mit Nachwuchsforscherinnen und -forschern stellt sich nun das Partnerschaftsprojekt FIDELIO dieser Herausforderung und wird neue Erkenntnisse zum Osteoporoserisiko bei Typ-2-Diabetes liefern, um Biomarker für die Diagnostik und Therapieplanung zu entwickeln.
Ziel
Diabetes mellitus has emerged as a novel risk factor for fragility fractures. While in type 1 diabetes the 3-fold overall relative risk for fractures may mostly derive from low bone mineral density (BMD) likely due to the lack of the bone-anabolic hormones, in type 2 diabetes, the fracture risk is increased about 2-fold, despite a normal or even higher BMD. This suggests that bone fragility in each form of diabetes develops by distinct mechanisms that to date remain largely unknown and may require an individualized approach for effective treatment. As the diabetes epidemic is increasing worldwide with aging, and the fractures that are associated with diabetes cause an increase in morbidity, mortality, and healthcare costs, diabetes-induced osteoporosis imposes a significant burden on our society and our healthcare system.
FIDELIO offers a comprehensive, multidisciplinary training program for Early Stage Researchers (ESRs) in this emerging field, unravelling i) the biological mechanisms that contribute to altered bone quality parameters with subsequent bone fragility in diabetes, ii) identify predictive markers for patient stratification and individualized interventions, and iii) develop novel imaging techniques to determine bone quality aspects. The research will employ well-defined patient cohorts, preclinical models of diabetic bone disease, in vitro studies, genetic databases, artificial intelligence, and cutting-edge imaging technologies in a highly collaborative and interdisciplinary environment. ESRs will be trained through individual research projects, secondments, residential courses, and webinars provided by a broad range of experts, including bone biologists, clinicians, epidemiologists, geneticists, engineers and entrepreneurs, as well as companies supporting this important area of research. The joint training programme will also develop transferable and entrepreneurial skills to help the ESRs succeed in their choice of professional future.
Wissenschaftliches Gebiet
- natural sciencescomputer and information sciencesartificial intelligence
- social sciencessociologydemographymortality
- social scienceseconomics and businessbusiness and managemententrepreneurship
- medical and health sciencesclinical medicineendocrinologydiabetes
- medical and health scienceshealth sciencespersonalized medicine
Schlüsselbegriffe
Programm/Programme
Thema/Themen
Aufforderung zur Vorschlagseinreichung
Andere Projekte für diesen Aufruf anzeigenFinanzierungsplan
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Koordinator
01069 Dresden
Deutschland