Training network for research into bone Fragility In Diabetes in Europe – towards a personaLised medIcine apprOach

Project Information

FIDELIO

Grant agreement ID: 860898

DOI 10.3030/860898

Project closed

EC signature date 4 September 2019

Start date 1 October 2019

End date 31 March 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 3 810 146,38

EU contribution € 3 810 146,38

Coordinated by

TECHNISCHE UNIVERSITAET DRESDEN
Germany

Deliverables

Other (1)

ESR application pack

To be available to all applicants as a pdf file

Websites, patent fillings, videos etc. (3)

Communication plan and resource pack

Including protocols key messages logo templates and styles

Lay summaries of publications

including translation into +5 EU languages, for publication via the project website.

Report on project videos

One by each ESR plus one about FIDELIO in general, to be disseminated online.

Publications

Peer reviewed articles (30)

Sex- and Age Group-Specific Fracture Incidence Rates Trends for Type 1 and 2 Diabetes Mellitus

Author(s): Mohamad I Nasser, Annika Vestergaard Kvist, Peter Vestergaard, Richard Eastell, Andrea M Burden, Morten Frost
Published in: JBMR Plus, 2023, ISSN 2473-4039
Publisher: Wiley
DOI: 10.1002/jbm4.10836

Type 2 Diabetes Mellitus and Vertebral Fracture Risk

Author(s): Fjorda Koromani, Samuel Ghatan, Mandy van Hoek, M. Carola Zillikens, Edwin H. G. Oei, Fernando Rivadeneira & Ling Oei
Published in: Current Osteoporosis Reports, Issue 19, 2021, Page(s) 50-57, ISSN 1544-1873
Publisher: Current Science Inc.
DOI: 10.1007/s11914-020-00646-8

Bone fragility in diabetes: novel concepts and clinical implications

Author(s): Lorenz C Hofbauer, Björn Busse, Richard Eastell, Serge Ferrari, Morten Frost, Ralph Müller, Andrea M Burden, Fernando Rivadeneira, Nicola NapoliMartina Rauner
Published in: The Lancet Diabetes and Endocrinology, Issue 10, 3, 2022, Page(s) 207-220, ISSN 2213-8587
Publisher: Elsevier BV
DOI: 10.1016/s2213-8587(21)00347-8

Meta-analysis of Diabetes Mellitus-Associated Differences in Bone Structure Assessed by High-Resolution Peripheral Quantitative Computed Tomography

Author(s): Matthias Walle Danielle E Whittier, Morten Frost, Ralph Müller, Caitlyn J Collins
Published in: Current Osteoporosis Reports, Issue 15442241, 2022, ISSN 1544-2241
Publisher: Springer
DOI: 10.1007/s11914-022-00755-6

Mechanostat parameters estimated from time-lapsed in vivo micro-computed tomography data of mechanically driven bone adaptation are logarithmically dependent on loading frequency

Author(s): Francisco C Marques, Daniele Boaretti, Matthias Walle, Ariane C Scheuren, Friederike A Schulte, Ralph Müller
Published in: Frontiers in Bioengineering and Biotechnology, 2023, ISSN 2296-4185
Publisher: Frontiers Media SA
DOI: 10.3389/fbioe.2023.1140673

Effect of Anti-Osteoporotic Treatments on Circulating and Bone MicroRNA Patterns in Osteopenic ZDF Rats

Author(s): Carro Vázquez, D.; Emini, L.; Rauner, M.; Hofbauer, C.; Grillari, J.; Diendorfer, A.B.; Eastell, R.; Hofbauer, L.C.; Hackl, M.
Published in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23126534

Bone Mechanoregulation Allows Subject-Specific Load Estimation Based on Time-Lapsed Micro-CT and HR-pQCT in Vivo

Author(s): Matthias Walle, Francisco C. Marques, Nicholas Ohs, Michael Blauth, Ralph Müller, Caitlyn J. Collins
Published in: Frontiers in Bioengineering and Biotechnology, Issue 9, 2021, ISSN 2296-4185
Publisher: Frontiers
DOI: 10.3389/fbioe.2021.677985

Osteocyte apoptosis and cellular micropetrosis signify skeletal aging in type 1 diabetes

Author(s): Dragoun Kolibová S, Wölfel EM, Hemmatian H, Milovanovic P, Mushumba H, Wulff B, Neidhardt M, Püschel K, Failla AV, Vlug A, Schlaefer A, Ondruschka B, Amling M, Hofbauer LC, Rauner M, Busse B, Jähn-Rickert K.
Published in: Acta Biomaterialia, Issue 162, 2023, Page(s) 254-265, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2023.02.037

Human tibial cortical bone with high porosity in type 2 diabetes mellitus is accompanied by distinctive bone material properties

Author(s): Wölfel EM, Fiedler IAK, Dragoun Kolibova S, Krug J, Lin MC, Yazigi B, Siebels AK, Mushumba H, Wulff B, Ondruschka B, Püschel K, Glüer CC, Jähn-Rickert K, Busse B
Published in: Bone, Issue 165, 2022, Page(s) 116546, ISSN 8756-3282
Publisher: Elsevier BV
DOI: 10.1016/j.bone.2022.116546

The Gut Microbiome: a New Frontier in Musculoskeletal Research

Author(s): R. Li; C. G. Boer; L. Oei; Carolina Medina-Gomez
Published in: Current Osteoporosis Reports, Issue 19, 2021, Page(s) 347–357, ISSN 1544-2241
Publisher: Springer Nature
DOI: 10.1007/s11914-021-00675-x

A multi-stack registration technique to improve measurement accuracy and precision across longitudinal HR-pQCT scans

Author(s): Whittier DE, Walle M, Schenk D, Atkins PR, Collins CJ, Zysset P, Lippuner K, Müller R.
Published in: Bone, Issue 176, 2023, ISSN 8756-3282
Publisher: Elsevier BV
DOI: 10.1016/j.bone.2023.116893

Precision of bone mechanoregulation assessment in humans using longitudinal high-resolution peripheral quantitative computed tomography in vivo

Author(s): Matthias Walle, Danielle E Whittier, Denis Schenk, Penny R Atkins, Michael Blauth, Philippe Zysset, Kurt Lippuner, Ralph Müller, Caitlyn J Collins
Published in: Bone, 2023, ISSN 8756-3282
Publisher: Elsevier BV
DOI: 10.1016/j.bone.2023.116780

Motion grading of high-resolution quantitative computed tomography supported by deep convolutional neural networks

Author(s): Matthias Walle; Dominic Eggemann; Penny R. Atkins; Jack J. Kendall; Kerstin Stock; Ralph Müller; Caitlyn J. Collins
Published in: Bone, 166, Issue 7, 2023, ISSN 8756-3282
Publisher: Elsevier BV
DOI: 10.3929/ethz-b-000581859

Low Bone Turnover Associates With Lower Insulin Sensitivity in Newly Diagnosed Drug-Naïve Persons With Type 2 Diabetes

Author(s): Mohamad Nasser, Jacob V Stidsen, Kurt Højlund, Jens Steen Nielsen, Richard Eastell, Morten Frost
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue dgad043, 2023, ISSN 1945-7197
Publisher: The Endocrine Society (United States)
DOI: 10.1210/clinem/dgad043

The Treatment Gap in Osteoporosis

Author(s): Nazia Ayub ,Malak Faraj ,Sam Ghatan ,Joannes A. A. Reijers, Nicola Napoli and Ling Oei
Published in: Journal of Clinical Medicine, Issue 10, 2021, Page(s) 3002, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10133002

Utility and Limitations of TALLYHO/JngJ as a Model for Type 2 Diabetes-Induced Bone Disease

Author(s): Emini L, Salbach-Hirsch J, Krug J, Jähn-Rickert K, Busse B, Rauner M, Hofbauer LC
Published in: JBMR Plus, Issue JBMR Plus.2023 Nov17;7(12):e10843., 2023
Publisher: Wiley
DOI: 10.1002/jbm4.10843

Microvascular Disease Associates with Larger Osteocyte Lacunae in Cortical Bone in Type 2 Diabetes Mellitus

Author(s): Sebastian Zanner, Elliott Goff, Samuel Ghatan, Eva Maria Wölfel, Charlotte Ejersted, Gisela Kuhn, Ralph Müller, Morten Frost
Published in: JBMR Plus, 2023, ISSN 2473-4039
Publisher: Wiley
DOI: 10.1002/jbm4.10832

MiR-144-5p and miR-21-5p do not drive bone disease in a mouse model of type 1 diabetes mellitus

Author(s): Daamouch S, Blüher M, Vázquez DC, Hackl M, Hofbauer LC, Rauner M.
Published in: JBMR Plus, 2024
Publisher: Oxford Academics
DOI: 10.1093/jbmrpl/ziae036

The Polygenic and Monogenic Basis of Paediatric Fractures

Author(s): S. Ghatan, A. Costantini, R. Li, C. De Bruin, N. M. Appelman-Dijkstra, E. M. Winter, L. Oei & Carolina Medina-Gomez
Published in: Current Osteoporosis Reports, Issue 19, 2021, Page(s) 481–493, ISSN 1544-2241
Publisher: Springer Nature
DOI: 10.1007/s11914-021-00680-0

When Cortical Bone Matrix Properties Are Indiscernible between Elderly Men with and without Type 2 Diabetes, Fracture Resistance Follows Suit

Author(s): Eva M. Wölfel, Benjamin Bartsch, Jasmin Koldehoff, Imke A. K. Fiedler, Sofie Dragoun-Kolibova, Felix N. Schmidt, Johannes Krug, Mei-Chun Lin, Klaus Püschel, Benjamin Ondruschka, Elizabeth A. Zimmermann, Hans Jelitto, Gerold Schneider, Bernd Gludovatz, Björn Busse
Published in: Journal of Bone and Mineral Research Plus, Issue 7(12), 2023, Page(s) e10839, ISSN 2473-4039
Publisher: Oxford University Press
DOI: 10.1002/jbm4.10839

Site-Specific Fracture Incidence Rates Among Patients With Type 1 Diabetes, Type 2 Diabetes, or Without Diabetes in Denmark (1997–2017)

Author(s): Annika Vestergaard Kvist;Mohamad I. Nasser; Peter Vestergaard; Morten Frost; Andrea M. Burden
Published in: Diabetes Care, Issue 46(3), 2023, Page(s) 633–642, ISSN 1935-5548
Publisher: American Diabetes Association (United States)
DOI: 10.2337/dc22-1004

MicroRNA and Diabetic Bone Disease

Author(s): Souad, Daamouch; Lejla, Emini; Martina, Rauner; Lorenz C, Hofbauer
Published in: Curr Osteoporos Rep, Issue 5, 2022, Page(s) 194-201
Publisher: Springer
DOI: 10.1007/s11914-022-00731-0

Circulating miRNAs Respond to Denosumab Treatment After 2 Years in Postmenopausal Women With Osteoporosis—the MiDeTe study

Author(s): Zora Messner, David Carro Vázquez, Judith Haschka, Johannes Grillari, Heinrich Resch, Christian Muschitz, Peter Pietschmann, Jochen Zwerina, Matthias Hackl, Roland Kocijan
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue Volume 108, Issue 5, 2022, Page(s) 1154–1165, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgac667

Bone remodeling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus

Author(s): Matthias Walle, Ankita Duseja, Danielle E Whittier, Tatiane Vilaca, Margaret Paggiosi, Richard Eastell, Ralph Müller, Caitlyn J Collins
Published in: Journal of Bone and Mineral Research, Issue 39(2), 2024, Page(s) 85-94, ISSN 0884-0431
Publisher: American Society for Bone and Mineral Research
DOI: 10.1093/jbmr/zjad014

Evaluating the relationship between glycemic control and bone fragility within the UK Biobank: observational and one-sample Mendelian randomization analyses

Author(s): Samuel Ghatan, Fjorda Koromani, Katerina Trajanoska, Evert F S van Velsen, Maryam Kavousi, M Carola Zillikens, Carolina Medina-Gomez, Ling Oei, Fernando Rivadeneira
Published in: JBMR Plus, Issue 8, 2024, Page(s) ziae126, ISSN 2473-4039
Publisher: Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research
DOI: 10.1093/jbmrpl/ziae126

Circulating miRNAs in bone health and disease

Author(s): Johannes Grillari, Riikka E. Mäkitie, Roland Kocijan, Judith Haschka, David Carro Vázquez, Elisabeth Semmelrock, Matthias Hackl
Published in: Bone, Issue 145, 2021, Page(s) 115787, ISSN 1873-2763
Publisher: Elsevier
DOI: 10.1016/j.bone.2020.115787

Bi-Directional Interactions between Glucose-Lowering Medications and Gut Microbiome in Patients with Type 2 Diabetes Mellitus: A Systematic Review

Author(s): Ruolin Li, Fereshteh Shokri, Alejandro Lopez Rincon, Fernando Rivadeneira, Carolina Medina-Gomez & Fariba Ahmadizar
Published in: Genes, Issue 14(8), 1572, 2023, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes14081572

Effects of adipocyte-specific Dkk1 deletion on bone homeostasis and obesity-induced bone loss in male mice

Author(s): Daamouch S, Thiele S, Hofbauer L, Rauner M
Published in: Endocrine Connections, Issue Endocr Connect. 2023 Sep 27;12(11), 2023, ISSN 2049-3614
Publisher: BioScientifica Ltd.
DOI: 10.1530/ec-23-0251

Down-to-Earth Studies of the Gut Microbiome in Bone Health and Disease

Author(s): Ruolin Li, Carolina Medina-Gomez, Fernando Rivadeneira
Published in: Journal of Bone and Mineral Research, Issue 37, 2022, Page(s) 595-596, ISSN 1523-4681
Publisher: Wiley
DOI: 10.1002/jbmr.4547

Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations

Author(s): Samuel Ghatan, Jeroen van Rooij, Mandy van Hoek, Cindy G. Boer, Janine F. Felix, Maryam Kavousi, Vincent W. Jaddoe, Eric J. G. Sijbrands, Carolina Medina-Gomez, Fernando Rivadeneira & Ling Oei
Published in: Genome Medicine, Issue Volume 16, article number 10, 2024, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-023-01255-7

Conference proceedings (10)

Type 2 diabetes clusters indicate diabetes duration key in fracture risk

Author(s): Samuel Ghatan, Fariba Ahmadizar, Ruolin Li, M. Carola Zillikens, Carolina Medina-Gomez, Fernando Rivadenira, Maryam Kavousi, Ling Oei.
Published in: Endocrine Abstracts, Issue 73, 2021, Page(s) ea0073pep2.2, ISSN 1479-6848
Publisher: Bioscientifica
DOI: 10.1530/endoabs.73.pep2.2

Development of diabetes-sensitive fracture resistance analysis using finite element method to predict diabetic bone fragility and bone quality

Author(s): Cemre Yavuz, Eva Maria Wölfel, Katharina Jähn-Rickert, Herbert Mushumba, Birgit Wulff, Klaus Püschel, Bjoern Busse, Mahan Qwamizadeh
Published in: Bone Reports, Issue Volume 14, Supplement, 2021, Page(s) 100883, ISSN 2352-1872
Publisher: Elsevier
DOI: 10.1016/j.bonr.2021.100883

A 20-year comparison of sex-specific fracture incidence between Type 1 and Type 2 diabetics and non-diabetics in Denmark

Author(s): Mohamad Nasser, Annika Kvist, Morten Frost, Peter Vestergaard, Andrea M. Burden
Published in: Bone Reports, Issue Volume 14, Supplement, 2021, Page(s) 100822, ISSN 2352-1872
Publisher: Elsevier
DOI: 10.1016/j.bonr.2021.100771

MicroRNAs in diabetic bone disease: A systematic review

Author(s): Ankita Duseja, Lisa Dowling, Tatiane Vilaca, Patryk Zarecki, Richard Eastell, Matthias Hackl
Published in: Bone Reports, Issue Volume 14, Supplement, 2021, Page(s) 100876, ISSN 2352-1872
Publisher: Elsevier
DOI: 10.1016/j.bonr.2021.100876

Tissue-level mechanical stimuli drive bone formation and resorption in humans and mice

Author(s): Matthias Walle, Francisco C. Marques, Nicholas Ohs, Michael Blauth, Ralph Müller, Caitlyn J. Collins
Published in: Bone Reports, Issue Volume 14, Supplement, 2021, Page(s) 101032, ISSN 2352-1872
Publisher: Eksevier
DOI: 10.1016/j.bonr.2021.101032

Type 2 diabetes clusters indicate diabetes duration key in fracture risk

Author(s): Samuel Ghatan, Fariba Ahmadizar, Ruolin Li, M. Carola Zillikens, Carolina Medina-Gomez, Fernando Rivadenira, Maryam Kavousi, Ling Oei
Published in: Bone Reports, Issue Volume 14, Supplement, 2021, Page(s) 100822, ISSN 2352-1872
Publisher: Elsevier
DOI: 10.1016/j.bonr.2021.100822

3D physiological load estimation based on time-lapsed HR-pQCT images.

Author(s): M. Walle, F. C. Marques, N. Ohs, R. Müller, and C. J. Collins
Published in: Journal of Bone and Mineral Research, Issue Volume 35, Issue S1, 2020, Page(s) 143-144, ISSN 1523-4681
Publisher: Wiley
DOI: 10.1002/jbmr.4206

Femur specimens from type 1 diabetes mellitus individuals presented with unaffected cortical bone matrix quality, but altered cellular histomorphometry

Author(s): Sofie Kolibova, Eva Maria Wölfel, Haniyeh Hemmatian, Herbert Mushumba, Birgit Wulff, Klaus Püschel, Björn Busse, Katharina Jähn-Rickert
Published in: Bone Reports, Issue Volume 14, Supplement, 2021, Page(s) 100886, ISSN 2352-1872
Publisher: Elsevier
DOI: 10.1016/j.bonr.2021.100886

Circulating microRNA analysis in ZDF rats as a model for the identification of biomarkers and disease mechanisms in diabetic osteopathy

Author(s): David Carro Vázquez, Christine Hofbauer, Lejla Emini, Martina Rauner, Johannes Grillari, Richard Eastell, Lorenz Hofbauer, Matthias Hackl
Published in: Bone Reports, Issue Volume 14, Supplement, 2021, Page(s) 100803, ISSN 2352-1872
Publisher: Elsevier
DOI: 10.1016/j.bonr.2021.100803

Type 2 Diabetes Clusters Indicate Diabetes Duration Key in Fracture Risk

Author(s): Samuel Ghatan, Fariba Ahmadizar, Ruolin Li, M. Carola Zillikens, Carolina Medina-Gomez, Fernando Rivadenira, Maryam Kavousi, Ling Oei.
Published in: Journal of the Endocrine Society, Issue Volume 5, Supplement 1, 2021, Page(s) A280–A281, ISSN 2472-1972
Publisher: Oxford University Press
DOI: 10.1210/jendso/bvab048.570

Thesis and dissertations (2)

Mechanoregulation of Bone Remodelling in Diabetes Mellitus using High-Resolution Peripheral Quantitative Computed Tomography In Vivo Patient Data

Author(s): Walle, Matthias
Published in: Issue 6, 2023
Publisher: ETH Zurich
DOI: 10.3929/ethz-b-000649478

Role of DKK-1 in bone fragility and miRNA crosstalk in T1D

Author(s): Souad Daamouch
Published in: 2023
Publisher: TU Dresden

Other (2)

Evaluating the relationship between glycemic control and bone fragility within the UK biobank: Observational and one-sample Mendelian randomization analyses.

Author(s): Samuel Ghatan, Fjorda Koromani, Katerina Trajanoska, Evert F.S. van Velsen, Maryam Kavousi, M Carola. Zillikens, Carolina Medina-Gomez, Ling Oei, Fernando Rivadeneira
Published in: 2023
Publisher: https://www.medrxiv.org
DOI: 10.1101/2023.12.25.23300434

Circulating miRNAs associated with diabetes mellitus and altered bone phenotype: a systematic review

Author(s): Ankita Duseja, Lisa Dowling
Published in: PROSPERO International prospective register of systematic reviews, 2020, Page(s) CRD42020212451
Publisher: Centre for Reviews and Dissemination, University of York