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CORDIS - Risultati della ricerca dell’UE
CORDIS

Training network for research into bone Fragility In Diabetes in Europe – towards a personaLised medIcine apprOach

Risultati finali

ESR application pack

To be available to all applicants as a pdf file

Communication plan and resource pack

Including protocols key messages logo templates and styles

Lay summaries of publications

including translation into +5 EU languages, for publication via the project website.

Report on project videos

One by each ESR plus one about FIDELIO in general, to be disseminated online.

Pubblicazioni

Sex- and Age Group-Specific Fracture Incidence Rates Trends for Type 1 and 2 Diabetes Mellitus

Autori: Mohamad I Nasser, Annika Vestergaard Kvist, Peter Vestergaard, Richard Eastell, Andrea M Burden, Morten Frost
Pubblicato in: JBMR Plus, 2023, ISSN 2473-4039
Editore: Wiley
DOI: 10.1002/jbm4.10836

Type 2 Diabetes Mellitus and Vertebral Fracture Risk

Autori: Fjorda Koromani, Samuel Ghatan, Mandy van Hoek, M. Carola Zillikens, Edwin H. G. Oei, Fernando Rivadeneira & Ling Oei
Pubblicato in: Current Osteoporosis Reports, Numero 19, 2021, Pagina/e 50-57, ISSN 1544-1873
Editore: Current Science Inc.
DOI: 10.1007/s11914-020-00646-8

Bone fragility in diabetes: novel concepts and clinical implications

Autori: Lorenz C Hofbauer, Björn Busse, Richard Eastell, Serge Ferrari, Morten Frost, Ralph Müller, Andrea M Burden, Fernando Rivadeneira, Nicola NapoliMartina Rauner
Pubblicato in: The Lancet Diabetes and Endocrinology, Numero 10, 3, 2022, Pagina/e 207-220, ISSN 2213-8587
Editore: Elsevier BV
DOI: 10.1016/s2213-8587(21)00347-8

Meta-analysis of Diabetes Mellitus-Associated Differences in Bone Structure Assessed by High-Resolution Peripheral Quantitative Computed Tomography

Autori: Matthias Walle Danielle E Whittier, Morten Frost, Ralph Müller, Caitlyn J Collins
Pubblicato in: Current Osteoporosis Reports, Numero 15442241, 2022, ISSN 1544-2241
Editore: Springer
DOI: 10.1007/s11914-022-00755-6

Mechanostat parameters estimated from time-lapsed in vivo micro-computed tomography data of mechanically driven bone adaptation are logarithmically dependent on loading frequency

Autori: Francisco C Marques, Daniele Boaretti, Matthias Walle, Ariane C Scheuren, Friederike A Schulte, Ralph Müller
Pubblicato in: Frontiers in Bioengineering and Biotechnology, 2023, ISSN 2296-4185
Editore: Frontiers Media SA
DOI: 10.3389/fbioe.2023.1140673

Effect of Anti-Osteoporotic Treatments on Circulating and Bone MicroRNA Patterns in Osteopenic ZDF Rats

Autori: Carro Vázquez, D.; Emini, L.; Rauner, M.; Hofbauer, C.; Grillari, J.; Diendorfer, A.B.; Eastell, R.; Hofbauer, L.C.; Hackl, M.
Pubblicato in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23126534

Bone Mechanoregulation Allows Subject-Specific Load Estimation Based on Time-Lapsed Micro-CT and HR-pQCT in Vivo

Autori: Matthias Walle, Francisco C. Marques, Nicholas Ohs, Michael Blauth, Ralph Müller, Caitlyn J. Collins
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 9, 2021, ISSN 2296-4185
Editore: Frontiers
DOI: 10.3389/fbioe.2021.677985

Osteocyte apoptosis and cellular micropetrosis signify skeletal aging in type 1 diabetes

Autori: Dragoun Kolibová S, Wölfel EM, Hemmatian H, Milovanovic P, Mushumba H, Wulff B, Neidhardt M, Püschel K, Failla AV, Vlug A, Schlaefer A, Ondruschka B, Amling M, Hofbauer LC, Rauner M, Busse B, Jähn-Rickert K.
Pubblicato in: Acta Biomaterialia, Numero 162, 2023, Pagina/e 254-265, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2023.02.037

Human tibial cortical bone with high porosity in type 2 diabetes mellitus is accompanied by distinctive bone material properties

Autori: Wölfel EM, Fiedler IAK, Dragoun Kolibova S, Krug J, Lin MC, Yazigi B, Siebels AK, Mushumba H, Wulff B, Ondruschka B, Püschel K, Glüer CC, Jähn-Rickert K, Busse B
Pubblicato in: Bone, Numero 165, 2022, Pagina/e 116546, ISSN 8756-3282
Editore: Elsevier BV
DOI: 10.1016/j.bone.2022.116546

The Gut Microbiome: a New Frontier in Musculoskeletal Research

Autori: R. Li; C. G. Boer; L. Oei; Carolina Medina-Gomez
Pubblicato in: Current Osteoporosis Reports, Numero 19, 2021, Pagina/e 347–357, ISSN 1544-2241
Editore: Springer Nature
DOI: 10.1007/s11914-021-00675-x

A multi-stack registration technique to improve measurement accuracy and precision across longitudinal HR-pQCT scans

Autori: Whittier DE, Walle M, Schenk D, Atkins PR, Collins CJ, Zysset P, Lippuner K, Müller R.
Pubblicato in: Bone, Numero 176, 2023, ISSN 8756-3282
Editore: Elsevier BV
DOI: 10.1016/j.bone.2023.116893

Precision of bone mechanoregulation assessment in humans using longitudinal high-resolution peripheral quantitative computed tomography in vivo

Autori: Matthias Walle, Danielle E Whittier, Denis Schenk, Penny R Atkins, Michael Blauth, Philippe Zysset, Kurt Lippuner, Ralph Müller, Caitlyn J Collins
Pubblicato in: Bone, 2023, ISSN 8756-3282
Editore: Elsevier BV
DOI: 10.1016/j.bone.2023.116780

Motion grading of high-resolution quantitative computed tomography supported by deep convolutional neural networks

Autori: Matthias Walle; Dominic Eggemann; Penny R. Atkins; Jack J. Kendall; Kerstin Stock; Ralph Müller; Caitlyn J. Collins
Pubblicato in: Bone, 166, Numero 7, 2023, ISSN 8756-3282
Editore: Elsevier BV
DOI: 10.3929/ethz-b-000581859

Low Bone Turnover Associates With Lower Insulin Sensitivity in Newly Diagnosed Drug-Naïve Persons With Type 2 Diabetes

Autori: Mohamad Nasser, Jacob V Stidsen, Kurt Højlund, Jens Steen Nielsen, Richard Eastell, Morten Frost
Pubblicato in: The Journal of Clinical Endocrinology & Metabolism, Numero dgad043, 2023, ISSN 1945-7197
Editore: The Endocrine Society (United States)
DOI: 10.1210/clinem/dgad043

The Treatment Gap in Osteoporosis

Autori: Nazia Ayub ,Malak Faraj ,Sam Ghatan ,Joannes A. A. Reijers, Nicola Napoli and Ling Oei
Pubblicato in: Journal of Clinical Medicine, Numero 10, 2021, Pagina/e 3002, ISSN 2077-0383
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10133002

Utility and Limitations of TALLYHO/JngJ as a Model for Type 2 Diabetes-Induced Bone Disease

Autori: Emini L, Salbach-Hirsch J, Krug J, Jähn-Rickert K, Busse B, Rauner M, Hofbauer LC
Pubblicato in: JBMR Plus, Numero JBMR Plus.2023 Nov17;7(12):e10843., 2023
Editore: Wiley
DOI: 10.1002/jbm4.10843

Microvascular Disease Associates with Larger Osteocyte Lacunae in Cortical Bone in Type 2 Diabetes Mellitus

Autori: Sebastian Zanner, Elliott Goff, Samuel Ghatan, Eva Maria Wölfel, Charlotte Ejersted, Gisela Kuhn, Ralph Müller, Morten Frost
Pubblicato in: JBMR Plus, 2023, ISSN 2473-4039
Editore: Wiley
DOI: 10.1002/jbm4.10832

The Polygenic and Monogenic Basis of Paediatric Fractures

Autori: S. Ghatan, A. Costantini, R. Li, C. De Bruin, N. M. Appelman-Dijkstra, E. M. Winter, L. Oei & Carolina Medina-Gomez
Pubblicato in: Current Osteoporosis Reports, Numero 19, 2021, Pagina/e 481–493, ISSN 1544-2241
Editore: Springer Nature
DOI: 10.1007/s11914-021-00680-0

When Cortical Bone Matrix Properties Are Indiscernible between Elderly Men with and without Type 2 Diabetes, Fracture Resistance Follows Suit

Autori: Eva M. Wölfel, Benjamin Bartsch, Jasmin Koldehoff, Imke A. K. Fiedler, Sofie Dragoun-Kolibova, Felix N. Schmidt, Johannes Krug, Mei-Chun Lin, Klaus Püschel, Benjamin Ondruschka, Elizabeth A. Zimmermann, Hans Jelitto, Gerold Schneider, Bernd Gludovatz, Björn Busse
Pubblicato in: Journal of Bone and Mineral Research Plus, Numero 7(12), 2023, Pagina/e e10839, ISSN 2473-4039
Editore: Oxford University Press
DOI: 10.1002/jbm4.10839

Site-Specific Fracture Incidence Rates Among Patients With Type 1 Diabetes, Type 2 Diabetes, or Without Diabetes in Denmark (1997–2017)

Autori: Annika Vestergaard Kvist;Mohamad I. Nasser; Peter Vestergaard; Morten Frost; Andrea M. Burden
Pubblicato in: Diabetes Care, Numero 46(3), 2023, Pagina/e 633–642, ISSN 1935-5548
Editore: American Diabetes Association (United States)
DOI: 10.2337/dc22-1004

MicroRNA and Diabetic Bone Disease

Autori: Souad, Daamouch; Lejla, Emini; Martina, Rauner; Lorenz C, Hofbauer
Pubblicato in: Curr Osteoporos Rep, Numero 5, 2022, Pagina/e 194-201
Editore: Springer
DOI: 10.1007/s11914-022-00731-0

Circulating miRNAs Respond to Denosumab Treatment After 2 Years in Postmenopausal Women With Osteoporosis—the MiDeTe study

Autori: Zora Messner, David Carro Vázquez, Judith Haschka, Johannes Grillari, Heinrich Resch, Christian Muschitz, Peter Pietschmann, Jochen Zwerina, Matthias Hackl, Roland Kocijan
Pubblicato in: The Journal of Clinical Endocrinology & Metabolism, Numero Volume 108, Numero 5, 2022, Pagina/e 1154–1165, ISSN 0021-972X
Editore: The Endocrine Society
DOI: 10.1210/clinem/dgac667

Bone remodeling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus

Autori: Matthias Walle, Ankita Duseja, Danielle E Whittier, Tatiane Vilaca, Margaret Paggiosi, Richard Eastell, Ralph Müller, Caitlyn J Collins
Pubblicato in: Journal of Bone and Mineral Research, Numero 39(2), 2024, Pagina/e 85-94, ISSN 0884-0431
Editore: American Society for Bone and Mineral Research
DOI: 10.1093/jbmr/zjad014

Circulating miRNAs in bone health and disease

Autori: Johannes Grillari, Riikka E. Mäkitie, Roland Kocijan, Judith Haschka, David Carro Vázquez, Elisabeth Semmelrock, Matthias Hackl
Pubblicato in: Bone, Numero 145, 2021, Pagina/e 115787, ISSN 1873-2763
Editore: Elsevier
DOI: 10.1016/j.bone.2020.115787

Bi-Directional Interactions between Glucose-Lowering Medications and Gut Microbiome in Patients with Type 2 Diabetes Mellitus: A Systematic Review

Autori: Ruolin Li, Fereshteh Shokri, Alejandro Lopez Rincon, Fernando Rivadeneira, Carolina Medina-Gomez & Fariba Ahmadizar
Pubblicato in: Genes, Numero 14(8), 1572, 2023, ISSN 2073-4425
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes14081572

Effects of adipocyte-specific Dkk1 deletion on bone homeostasis and obesity-induced bone loss in male mice

Autori: Daamouch S, Thiele S, Hofbauer L, Rauner M
Pubblicato in: Endocrine Connections, Numero Endocr Connect. 2023 Sep 27;12(11), 2023, ISSN 2049-3614
Editore: BioScientifica Ltd.
DOI: 10.1530/ec-23-0251

Down-to-Earth Studies of the Gut Microbiome in Bone Health and Disease

Autori: Ruolin Li, Carolina Medina-Gomez, Fernando Rivadeneira
Pubblicato in: Journal of Bone and Mineral Research, Numero 37, 2022, Pagina/e 595-596, ISSN 1523-4681
Editore: Wiley
DOI: 10.1002/jbmr.4547

Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations

Autori: Samuel Ghatan, Jeroen van Rooij, Mandy van Hoek, Cindy G. Boer, Janine F. Felix, Maryam Kavousi, Vincent W. Jaddoe, Eric J. G. Sijbrands, Carolina Medina-Gomez, Fernando Rivadeneira & Ling Oei
Pubblicato in: Genome Medicine, Numero Volume 16, article number 10, 2024, ISSN 1756-994X
Editore: BioMed Central
DOI: 10.1186/s13073-023-01255-7

Type 2 diabetes clusters indicate diabetes duration key in fracture risk

Autori: Samuel Ghatan, Fariba Ahmadizar, Ruolin Li, M. Carola Zillikens, Carolina Medina-Gomez, Fernando Rivadenira, Maryam Kavousi, Ling Oei.
Pubblicato in: Endocrine Abstracts, Numero 73, 2021, Pagina/e ea0073pep2.2, ISSN 1479-6848
Editore: Bioscientifica
DOI: 10.1530/endoabs.73.pep2.2

Development of diabetes-sensitive fracture resistance analysis using finite element method to predict diabetic bone fragility and bone quality

Autori: Cemre Yavuz, Eva Maria Wölfel, Katharina Jähn-Rickert, Herbert Mushumba, Birgit Wulff, Klaus Püschel, Bjoern Busse, Mahan Qwamizadeh
Pubblicato in: Bone Reports, Numero Volume 14, Supplement, 2021, Pagina/e 100883, ISSN 2352-1872
Editore: Elsevier
DOI: 10.1016/j.bonr.2021.100883

A 20-year comparison of sex-specific fracture incidence between Type 1 and Type 2 diabetics and non-diabetics in Denmark

Autori: Mohamad Nasser, Annika Kvist, Morten Frost, Peter Vestergaard, Andrea M. Burden
Pubblicato in: Bone Reports, Numero Volume 14, Supplement, 2021, Pagina/e 100822, ISSN 2352-1872
Editore: Elsevier
DOI: 10.1016/j.bonr.2021.100771

MicroRNAs in diabetic bone disease: A systematic review

Autori: Ankita Duseja, Lisa Dowling, Tatiane Vilaca, Patryk Zarecki, Richard Eastell, Matthias Hackl
Pubblicato in: Bone Reports, Numero Volume 14, Supplement, 2021, Pagina/e 100876, ISSN 2352-1872
Editore: Elsevier
DOI: 10.1016/j.bonr.2021.100876

Tissue-level mechanical stimuli drive bone formation and resorption in humans and mice

Autori: Matthias Walle, Francisco C. Marques, Nicholas Ohs, Michael Blauth, Ralph Müller, Caitlyn J. Collins
Pubblicato in: Bone Reports, Numero Volume 14, Supplement, 2021, Pagina/e 101032, ISSN 2352-1872
Editore: Eksevier
DOI: 10.1016/j.bonr.2021.101032

Type 2 diabetes clusters indicate diabetes duration key in fracture risk

Autori: Samuel Ghatan, Fariba Ahmadizar, Ruolin Li, M. Carola Zillikens, Carolina Medina-Gomez, Fernando Rivadenira, Maryam Kavousi, Ling Oei
Pubblicato in: Bone Reports, Numero Volume 14, Supplement, 2021, Pagina/e 100822, ISSN 2352-1872
Editore: Elsevier
DOI: 10.1016/j.bonr.2021.100822

3D physiological load estimation based on time-lapsed HR-pQCT images.

Autori: M. Walle, F. C. Marques, N. Ohs, R. Müller, and C. J. Collins
Pubblicato in: Journal of Bone and Mineral Research, Numero Volume 35, Numero S1, 2020, Pagina/e 143-144, ISSN 1523-4681
Editore: Wiley
DOI: 10.1002/jbmr.4206

Femur specimens from type 1 diabetes mellitus individuals presented with unaffected cortical bone matrix quality, but altered cellular histomorphometry

Autori: Sofie Kolibova, Eva Maria Wölfel, Haniyeh Hemmatian, Herbert Mushumba, Birgit Wulff, Klaus Püschel, Björn Busse, Katharina Jähn-Rickert
Pubblicato in: Bone Reports, Numero Volume 14, Supplement, 2021, Pagina/e 100886, ISSN 2352-1872
Editore: Elsevier
DOI: 10.1016/j.bonr.2021.100886

Circulating microRNA analysis in ZDF rats as a model for the identification of biomarkers and disease mechanisms in diabetic osteopathy

Autori: David Carro Vázquez, Christine Hofbauer, Lejla Emini, Martina Rauner, Johannes Grillari, Richard Eastell, Lorenz Hofbauer, Matthias Hackl
Pubblicato in: Bone Reports, Numero Volume 14, Supplement, 2021, Pagina/e 100803, ISSN 2352-1872
Editore: Elsevier
DOI: 10.1016/j.bonr.2021.100803

Type 2 Diabetes Clusters Indicate Diabetes Duration Key in Fracture Risk

Autori: Samuel Ghatan, Fariba Ahmadizar, Ruolin Li, M. Carola Zillikens, Carolina Medina-Gomez, Fernando Rivadenira, Maryam Kavousi, Ling Oei.
Pubblicato in: Journal of the Endocrine Society, Numero Volume 5, Supplement 1, 2021, Pagina/e A280–A281, ISSN 2472-1972
Editore: Oxford University Press
DOI: 10.1210/jendso/bvab048.570

Circulating miRNAs associated with diabetes mellitus and altered bone phenotype: a systematic review

Autori: Ankita Duseja, Lisa Dowling
Pubblicato in: PROSPERO International prospective register of systematic reviews, 2020, Pagina/e CRD42020212451
Editore: Centre for Reviews and Dissemination, University of York

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