Training network for research into bone Fragility In Diabetes in Europe – towards a personaLised medIcine apprOach | FIDELIO | Project | Results | H2020 | CORDIS

Resultado final

ESR application pack

To be available to all applicants as a pdf file

Communication plan and resource pack

Including protocols key messages logo templates and styles

Lay summaries of publications

including translation into +5 EU languages, for publication via the project website.

Report on project videos

One by each ESR plus one about FIDELIO in general, to be disseminated online.

Publicaciones

Sex- and Age Group-Specific Fracture Incidence Rates Trends for Type 1 and 2 Diabetes Mellitus

Autores: Mohamad I Nasser, Annika Vestergaard Kvist, Peter Vestergaard, Richard Eastell, Andrea M Burden, Morten Frost
Publicado en: JBMR Plus, 2023, ISSN 2473-4039
Editor: Wiley
DOI: 10.1002/jbm4.10836

Type 2 Diabetes Mellitus and Vertebral Fracture Risk

Autores: Fjorda Koromani, Samuel Ghatan, Mandy van Hoek, M. Carola Zillikens, Edwin H. G. Oei, Fernando Rivadeneira & Ling Oei
Publicado en: Current Osteoporosis Reports, Edición 19, 2021, Página(s) 50-57, ISSN 1544-1873
Editor: Current Science Inc.
DOI: 10.1007/s11914-020-00646-8

Bone fragility in diabetes: novel concepts and clinical implications

Autores: Lorenz C Hofbauer, Björn Busse, Richard Eastell, Serge Ferrari, Morten Frost, Ralph Müller, Andrea M Burden, Fernando Rivadeneira, Nicola NapoliMartina Rauner
Publicado en: The Lancet Diabetes and Endocrinology, Edición 10, 3, 2022, Página(s) 207-220, ISSN 2213-8587
Editor: Elsevier BV
DOI: 10.1016/s2213-8587(21)00347-8

Meta-analysis of Diabetes Mellitus-Associated Differences in Bone Structure Assessed by High-Resolution Peripheral Quantitative Computed Tomography

Autores: Matthias Walle Danielle E Whittier, Morten Frost, Ralph Müller, Caitlyn J Collins
Publicado en: Current Osteoporosis Reports, Edición 15442241, 2022, ISSN 1544-2241
Editor: Springer
DOI: 10.1007/s11914-022-00755-6

Mechanostat parameters estimated from time-lapsed in vivo micro-computed tomography data of mechanically driven bone adaptation are logarithmically dependent on loading frequency

Autores: Francisco C Marques, Daniele Boaretti, Matthias Walle, Ariane C Scheuren, Friederike A Schulte, Ralph Müller
Publicado en: Frontiers in Bioengineering and Biotechnology, 2023, ISSN 2296-4185
Editor: Frontiers Media SA
DOI: 10.3389/fbioe.2023.1140673

Effect of Anti-Osteoporotic Treatments on Circulating and Bone MicroRNA Patterns in Osteopenic ZDF Rats

Autores: Carro Vázquez, D.; Emini, L.; Rauner, M.; Hofbauer, C.; Grillari, J.; Diendorfer, A.B.; Eastell, R.; Hofbauer, L.C.; Hackl, M.
Publicado en: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23126534

Bone Mechanoregulation Allows Subject-Specific Load Estimation Based on Time-Lapsed Micro-CT and HR-pQCT in Vivo

Autores: Matthias Walle, Francisco C. Marques, Nicholas Ohs, Michael Blauth, Ralph Müller, Caitlyn J. Collins
Publicado en: Frontiers in Bioengineering and Biotechnology, Edición 9, 2021, ISSN 2296-4185
Editor: Frontiers
DOI: 10.3389/fbioe.2021.677985

Osteocyte apoptosis and cellular micropetrosis signify skeletal aging in type 1 diabetes

Autores: Dragoun Kolibová S, Wölfel EM, Hemmatian H, Milovanovic P, Mushumba H, Wulff B, Neidhardt M, Püschel K, Failla AV, Vlug A, Schlaefer A, Ondruschka B, Amling M, Hofbauer LC, Rauner M, Busse B, Jähn-Rickert K.
Publicado en: Acta Biomaterialia, Edición 162, 2023, Página(s) 254-265, ISSN 1742-7061
Editor: Elsevier BV
DOI: 10.1016/j.actbio.2023.02.037

Human tibial cortical bone with high porosity in type 2 diabetes mellitus is accompanied by distinctive bone material properties

Autores: Wölfel EM, Fiedler IAK, Dragoun Kolibova S, Krug J, Lin MC, Yazigi B, Siebels AK, Mushumba H, Wulff B, Ondruschka B, Püschel K, Glüer CC, Jähn-Rickert K, Busse B
Publicado en: Bone, Edición 165, 2022, Página(s) 116546, ISSN 8756-3282
Editor: Elsevier BV
DOI: 10.1016/j.bone.2022.116546

The Gut Microbiome: a New Frontier in Musculoskeletal Research

Autores: R. Li; C. G. Boer; L. Oei; Carolina Medina-Gomez
Publicado en: Current Osteoporosis Reports, Edición 19, 2021, Página(s) 347–357, ISSN 1544-2241
Editor: Springer Nature
DOI: 10.1007/s11914-021-00675-x

A multi-stack registration technique to improve measurement accuracy and precision across longitudinal HR-pQCT scans

Autores: Whittier DE, Walle M, Schenk D, Atkins PR, Collins CJ, Zysset P, Lippuner K, Müller R.
Publicado en: Bone, Edición 176, 2023, ISSN 8756-3282
Editor: Elsevier BV
DOI: 10.1016/j.bone.2023.116893

Precision of bone mechanoregulation assessment in humans using longitudinal high-resolution peripheral quantitative computed tomography in vivo

Autores: Matthias Walle, Danielle E Whittier, Denis Schenk, Penny R Atkins, Michael Blauth, Philippe Zysset, Kurt Lippuner, Ralph Müller, Caitlyn J Collins
Publicado en: Bone, 2023, ISSN 8756-3282
Editor: Elsevier BV
DOI: 10.1016/j.bone.2023.116780

Motion grading of high-resolution quantitative computed tomography supported by deep convolutional neural networks

Autores: Matthias Walle; Dominic Eggemann; Penny R. Atkins; Jack J. Kendall; Kerstin Stock; Ralph Müller; Caitlyn J. Collins
Publicado en: Bone, 166, Edición 7, 2023, ISSN 8756-3282
Editor: Elsevier BV
DOI: 10.3929/ethz-b-000581859

Low Bone Turnover Associates With Lower Insulin Sensitivity in Newly Diagnosed Drug-Naïve Persons With Type 2 Diabetes

Autores: Mohamad Nasser, Jacob V Stidsen, Kurt Højlund, Jens Steen Nielsen, Richard Eastell, Morten Frost
Publicado en: The Journal of Clinical Endocrinology & Metabolism, Edición dgad043, 2023, ISSN 1945-7197
Editor: The Endocrine Society (United States)
DOI: 10.1210/clinem/dgad043

The Treatment Gap in Osteoporosis

Autores: Nazia Ayub ,Malak Faraj ,Sam Ghatan ,Joannes A. A. Reijers, Nicola Napoli and Ling Oei
Publicado en: Journal of Clinical Medicine, Edición 10, 2021, Página(s) 3002, ISSN 2077-0383
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm10133002

Utility and Limitations of TALLYHO/JngJ as a Model for Type 2 Diabetes-Induced Bone Disease

Autores: Emini L, Salbach-Hirsch J, Krug J, Jähn-Rickert K, Busse B, Rauner M, Hofbauer LC
Publicado en: JBMR Plus, Edición JBMR Plus.2023 Nov17;7(12):e10843., 2023
Editor: Wiley
DOI: 10.1002/jbm4.10843

Microvascular Disease Associates with Larger Osteocyte Lacunae in Cortical Bone in Type 2 Diabetes Mellitus

Autores: Sebastian Zanner, Elliott Goff, Samuel Ghatan, Eva Maria Wölfel, Charlotte Ejersted, Gisela Kuhn, Ralph Müller, Morten Frost
Publicado en: JBMR Plus, 2023, ISSN 2473-4039
Editor: Wiley
DOI: 10.1002/jbm4.10832

The Polygenic and Monogenic Basis of Paediatric Fractures

Autores: S. Ghatan, A. Costantini, R. Li, C. De Bruin, N. M. Appelman-Dijkstra, E. M. Winter, L. Oei & Carolina Medina-Gomez
Publicado en: Current Osteoporosis Reports, Edición 19, 2021, Página(s) 481–493, ISSN 1544-2241
Editor: Springer Nature
DOI: 10.1007/s11914-021-00680-0

When Cortical Bone Matrix Properties Are Indiscernible between Elderly Men with and without Type 2 Diabetes, Fracture Resistance Follows Suit

Autores: Eva M. Wölfel, Benjamin Bartsch, Jasmin Koldehoff, Imke A. K. Fiedler, Sofie Dragoun-Kolibova, Felix N. Schmidt, Johannes Krug, Mei-Chun Lin, Klaus Püschel, Benjamin Ondruschka, Elizabeth A. Zimmermann, Hans Jelitto, Gerold Schneider, Bernd Gludovatz, Björn Busse
Publicado en: Journal of Bone and Mineral Research Plus, Edición 7(12), 2023, Página(s) e10839, ISSN 2473-4039
Editor: Oxford University Press
DOI: 10.1002/jbm4.10839

Site-Specific Fracture Incidence Rates Among Patients With Type 1 Diabetes, Type 2 Diabetes, or Without Diabetes in Denmark (1997–2017)

Autores: Annika Vestergaard Kvist;Mohamad I. Nasser; Peter Vestergaard; Morten Frost; Andrea M. Burden
Publicado en: Diabetes Care, Edición 46(3), 2023, Página(s) 633–642, ISSN 1935-5548
Editor: American Diabetes Association (United States)
DOI: 10.2337/dc22-1004

MicroRNA and Diabetic Bone Disease

Autores: Souad, Daamouch; Lejla, Emini; Martina, Rauner; Lorenz C, Hofbauer
Publicado en: Curr Osteoporos Rep, Edición 5, 2022, Página(s) 194-201
Editor: Springer
DOI: 10.1007/s11914-022-00731-0

Circulating miRNAs Respond to Denosumab Treatment After 2 Years in Postmenopausal Women With Osteoporosis—the MiDeTe study

Autores: Zora Messner, David Carro Vázquez, Judith Haschka, Johannes Grillari, Heinrich Resch, Christian Muschitz, Peter Pietschmann, Jochen Zwerina, Matthias Hackl, Roland Kocijan
Publicado en: The Journal of Clinical Endocrinology & Metabolism, Edición Volume 108, Edición 5, 2022, Página(s) 1154–1165, ISSN 0021-972X
Editor: The Endocrine Society
DOI: 10.1210/clinem/dgac667

Bone remodeling and responsiveness to mechanical stimuli in individuals with type 1 diabetes mellitus

Autores: Matthias Walle, Ankita Duseja, Danielle E Whittier, Tatiane Vilaca, Margaret Paggiosi, Richard Eastell, Ralph Müller, Caitlyn J Collins
Publicado en: Journal of Bone and Mineral Research, Edición 39(2), 2024, Página(s) 85-94, ISSN 0884-0431
Editor: American Society for Bone and Mineral Research
DOI: 10.1093/jbmr/zjad014

Circulating miRNAs in bone health and disease

Autores: Johannes Grillari, Riikka E. Mäkitie, Roland Kocijan, Judith Haschka, David Carro Vázquez, Elisabeth Semmelrock, Matthias Hackl
Publicado en: Bone, Edición 145, 2021, Página(s) 115787, ISSN 1873-2763
Editor: Elsevier
DOI: 10.1016/j.bone.2020.115787

Bi-Directional Interactions between Glucose-Lowering Medications and Gut Microbiome in Patients with Type 2 Diabetes Mellitus: A Systematic Review

Autores: Ruolin Li, Fereshteh Shokri, Alejandro Lopez Rincon, Fernando Rivadeneira, Carolina Medina-Gomez & Fariba Ahmadizar
Publicado en: Genes, Edición 14(8), 1572, 2023, ISSN 2073-4425
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes14081572

Effects of adipocyte-specific Dkk1 deletion on bone homeostasis and obesity-induced bone loss in male mice

Autores: Daamouch S, Thiele S, Hofbauer L, Rauner M
Publicado en: Endocrine Connections, Edición Endocr Connect. 2023 Sep 27;12(11), 2023, ISSN 2049-3614
Editor: BioScientifica Ltd.
DOI: 10.1530/ec-23-0251

Down-to-Earth Studies of the Gut Microbiome in Bone Health and Disease

Autores: Ruolin Li, Carolina Medina-Gomez, Fernando Rivadeneira
Publicado en: Journal of Bone and Mineral Research, Edición 37, 2022, Página(s) 595-596, ISSN 1523-4681
Editor: Wiley
DOI: 10.1002/jbmr.4547

Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations

Autores: Samuel Ghatan, Jeroen van Rooij, Mandy van Hoek, Cindy G. Boer, Janine F. Felix, Maryam Kavousi, Vincent W. Jaddoe, Eric J. G. Sijbrands, Carolina Medina-Gomez, Fernando Rivadeneira & Ling Oei
Publicado en: Genome Medicine, Edición Volume 16, article number 10, 2024, ISSN 1756-994X
Editor: BioMed Central
DOI: 10.1186/s13073-023-01255-7

Type 2 diabetes clusters indicate diabetes duration key in fracture risk

Autores: Samuel Ghatan, Fariba Ahmadizar, Ruolin Li, M. Carola Zillikens, Carolina Medina-Gomez, Fernando Rivadenira, Maryam Kavousi, Ling Oei.
Publicado en: Endocrine Abstracts, Edición 73, 2021, Página(s) ea0073pep2.2, ISSN 1479-6848
Editor: Bioscientifica
DOI: 10.1530/endoabs.73.pep2.2

Development of diabetes-sensitive fracture resistance analysis using finite element method to predict diabetic bone fragility and bone quality

Autores: Cemre Yavuz, Eva Maria Wölfel, Katharina Jähn-Rickert, Herbert Mushumba, Birgit Wulff, Klaus Püschel, Bjoern Busse, Mahan Qwamizadeh
Publicado en: Bone Reports, Edición Volume 14, Supplement, 2021, Página(s) 100883, ISSN 2352-1872
Editor: Elsevier
DOI: 10.1016/j.bonr.2021.100883

A 20-year comparison of sex-specific fracture incidence between Type 1 and Type 2 diabetics and non-diabetics in Denmark

Autores: Mohamad Nasser, Annika Kvist, Morten Frost, Peter Vestergaard, Andrea M. Burden
Publicado en: Bone Reports, Edición Volume 14, Supplement, 2021, Página(s) 100822, ISSN 2352-1872
Editor: Elsevier
DOI: 10.1016/j.bonr.2021.100771

MicroRNAs in diabetic bone disease: A systematic review

Autores: Ankita Duseja, Lisa Dowling, Tatiane Vilaca, Patryk Zarecki, Richard Eastell, Matthias Hackl
Publicado en: Bone Reports, Edición Volume 14, Supplement, 2021, Página(s) 100876, ISSN 2352-1872
Editor: Elsevier
DOI: 10.1016/j.bonr.2021.100876

Tissue-level mechanical stimuli drive bone formation and resorption in humans and mice

Autores: Matthias Walle, Francisco C. Marques, Nicholas Ohs, Michael Blauth, Ralph Müller, Caitlyn J. Collins
Publicado en: Bone Reports, Edición Volume 14, Supplement, 2021, Página(s) 101032, ISSN 2352-1872
Editor: Eksevier
DOI: 10.1016/j.bonr.2021.101032

Type 2 diabetes clusters indicate diabetes duration key in fracture risk

Autores: Samuel Ghatan, Fariba Ahmadizar, Ruolin Li, M. Carola Zillikens, Carolina Medina-Gomez, Fernando Rivadenira, Maryam Kavousi, Ling Oei
Publicado en: Bone Reports, Edición Volume 14, Supplement, 2021, Página(s) 100822, ISSN 2352-1872
Editor: Elsevier
DOI: 10.1016/j.bonr.2021.100822

3D physiological load estimation based on time-lapsed HR-pQCT images.

Autores: M. Walle, F. C. Marques, N. Ohs, R. Müller, and C. J. Collins
Publicado en: Journal of Bone and Mineral Research, Edición Volume 35, Edición S1, 2020, Página(s) 143-144, ISSN 1523-4681
Editor: Wiley
DOI: 10.1002/jbmr.4206

Femur specimens from type 1 diabetes mellitus individuals presented with unaffected cortical bone matrix quality, but altered cellular histomorphometry

Autores: Sofie Kolibova, Eva Maria Wölfel, Haniyeh Hemmatian, Herbert Mushumba, Birgit Wulff, Klaus Püschel, Björn Busse, Katharina Jähn-Rickert
Publicado en: Bone Reports, Edición Volume 14, Supplement, 2021, Página(s) 100886, ISSN 2352-1872
Editor: Elsevier
DOI: 10.1016/j.bonr.2021.100886

Circulating microRNA analysis in ZDF rats as a model for the identification of biomarkers and disease mechanisms in diabetic osteopathy

Autores: David Carro Vázquez, Christine Hofbauer, Lejla Emini, Martina Rauner, Johannes Grillari, Richard Eastell, Lorenz Hofbauer, Matthias Hackl
Publicado en: Bone Reports, Edición Volume 14, Supplement, 2021, Página(s) 100803, ISSN 2352-1872
Editor: Elsevier
DOI: 10.1016/j.bonr.2021.100803

Type 2 Diabetes Clusters Indicate Diabetes Duration Key in Fracture Risk

Autores: Samuel Ghatan, Fariba Ahmadizar, Ruolin Li, M. Carola Zillikens, Carolina Medina-Gomez, Fernando Rivadenira, Maryam Kavousi, Ling Oei.
Publicado en: Journal of the Endocrine Society, Edición Volume 5, Supplement 1, 2021, Página(s) A280–A281, ISSN 2472-1972
Editor: Oxford University Press
DOI: 10.1210/jendso/bvab048.570

Circulating miRNAs associated with diabetes mellitus and altered bone phenotype: a systematic review

Autores: Ankita Duseja, Lisa Dowling
Publicado en: PROSPERO International prospective register of systematic reviews, 2020, Página(s) CRD42020212451
Editor: Centre for Reviews and Dissemination, University of York

Training network for research into bone Fragility In Diabetes in Europe – towards a personaLised medIcine apprOach

Resultado final

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