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Multidisciplinary Training in Chronic Kidney Disease: from genetic modifiers to drug discovery

Project description

DEENESFRITPL

Stopping the rise of chronic kidney disease requires enhanced knowledge of mechanisms

According to the 2010 Global Burden of Disease study, chronic kidney disease (CKD) was ranked 27th on the list of causes of deaths worldwide in 1990 and rose to 18th in 2010. This drastic jump was second only to that for HIV and AIDs. Currently, the mechanisms of progression of the disease are not well understood including why CKD progresses faster in some people than others. TrainCKDis is supporting 15 young researchers working on research projects targeting key areas required to fill the gaps in CKD characterisation. Enhanced understanding will support the identification of biomarkers for early diagnosis of patients most at risk, for monitoring progression, as well as aid in development of treatments.

Objective

Chronic kidney disease (CKD) is recognized as an increasing global health problem. It currently affects 10-15% of the worldwide population, is associated with impaired quality of life and reduced life expectancy, and represents a significant burden for health care budgets.
CKD is characterized by the progressive decline of renal function. Little is known about the mechanisms underlying this progression and the genetic factors that predispose patients to different rate of progression. Even worse, there is no reliable biomarkers capable to identify patients at risk of fast progression and treatments able to halt CKD progression.
Understanding the physiopathology of CKD is therefore a prerequisite for the development of efficient preventive strategies and diagnostic tools.
With this goal in mind, TrainCKDis will provide an innovative, multidisciplinary, and intersectoral training programme, able to prepare top-level young scientists to develop creative solutions for CKD. The proposed 15 research projects will address key challenges: i) the identification of genetic and epigenetic modifiers that predispose patients to CKD progression, ii) the identification of pathways and biomarkers for monitoring CKD progression and iii) the identification of novel therapeutic targets to improve the limited treatments for CKD.
TrainCKDis gathers top European laboratories, companies, hospitals, and associations involved in the treatment of CKD.
Early Stage Researchers (ESRs) will thus benefit from an outstanding interdisciplinary platform integrating nephrology, epidemiology, genetics, cell biology, high-throughput screening, system biology, and metabolomics experts, as well as experimental animal models and unique human biobanks. Moreover, ESRs will be trained in disseminating results through modern channels of communication. Finally, TrainCKDis will provide ESRs with intersectoral and transferable training for efficient career development in both the academic and private sectors.

Fields of science

Programme(s)

Topic(s)

Call for proposal

H2020-MSCA-ITN-2019

See other projects for this call

Funding Scheme

MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)

Coordinator

UNIVERSITE PARIS CITE
Net EU contribution
€ 549 604,08
Address
85 bd saint germain
75006 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Higher or Secondary Education Establishments
Links
Other funding
€ 0,00

Participants (9)

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Last update: 9 December 2022

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Permalink: https://cordis.europa.eu/project/id/860977

European Union, 2023