Description du projet
Améliorer les connaissances sur les mécanismes de la maladie rénale chronique pour l’enrayer
Selon l’étude sur la charge mondiale de morbidité de 2010, la maladie rénale chronique (MRC) était classée au 27e rang de la liste de causes de décès à l’échelle internationale en 1990 et a atteint le 18e rang en 2010. Cette nette progression est la deuxième plus importante après celle du VIH et du sida. Actuellement, les mécanismes d’évolution de la maladie sont mal compris, notamment la raison de l’évolution de la MRC plus rapide chez certaines personnes. TrainCKDis soutient 15 jeunes chercheurs travaillant dans des projets de recherche qui ciblent des domaines clés nécessaires pour combler les lacunes dans la caractérisation de la MRC. Améliorer la compréhension permettra d’identifier des biomarqueurs pour un diagnostic précoce des patients présentant le risque le plus élevé, surveiller l’évolution et aider au développement de traitements.
Objectif
Chronic kidney disease (CKD) is recognized as an increasing global health problem. It currently affects 10-15% of the worldwide population, is associated with impaired quality of life and reduced life expectancy, and represents a significant burden for health care budgets.
CKD is characterized by the progressive decline of renal function. Little is known about the mechanisms underlying this progression and the genetic factors that predispose patients to different rate of progression. Even worse, there is no reliable biomarkers capable to identify patients at risk of fast progression and treatments able to halt CKD progression.
Understanding the physiopathology of CKD is therefore a prerequisite for the development of efficient preventive strategies and diagnostic tools.
With this goal in mind, TrainCKDis will provide an innovative, multidisciplinary, and intersectoral training programme, able to prepare top-level young scientists to develop creative solutions for CKD. The proposed 15 research projects will address key challenges: i) the identification of genetic and epigenetic modifiers that predispose patients to CKD progression, ii) the identification of pathways and biomarkers for monitoring CKD progression and iii) the identification of novel therapeutic targets to improve the limited treatments for CKD.
TrainCKDis gathers top European laboratories, companies, hospitals, and associations involved in the treatment of CKD.
Early Stage Researchers (ESRs) will thus benefit from an outstanding interdisciplinary platform integrating nephrology, epidemiology, genetics, cell biology, high-throughput screening, system biology, and metabolomics experts, as well as experimental animal models and unique human biobanks. Moreover, ESRs will be trained in disseminating results through modern channels of communication. Finally, TrainCKDis will provide ESRs with intersectoral and transferable training for efficient career development in both the academic and private sectors.
Champ scientifique
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- natural sciencesbiological sciencesgenetics
- medical and health scienceshealth sciencespublic healthepidemiology
- natural sciencesbiological sciencescell biology
- medical and health sciencesclinical medicinenephrologykidney diseases
Mots‑clés
Programme(s)
Régime de financement
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinateur
75006 Paris
France