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Antimicrobial Integrated Methodologies for orthopaedic applications

Project description

DEENESFRITPL

Reducing infection in orthopaedics

In orthopaedic implants, such as joint prostheses, postoperative infections by antibiotic-resistant bacteria are on the rise, representing a heavy burden for patients and healthcare systems. This is why the prevention of biofilm formation on the surface of the implants is important. The EU-funded AIMed project will develop a series of biomaterials with anti-bacterial properties. Laser processing will be used to make the biomaterials more resistant to the formation of biofilms. The project, which consists of a network of 12 beneficiaries and six partner institutions, will test the properties of the new materials to demonstrate that they are suitable for use in future implant interventions.

Objective

The AIMed network, consisting of 12 beneficiaries and 6 partner organisations, will develop a range of materials with anti-bacterial properties that are suitable for use on the surfaces of orthopaedic implants. This is in response to the increasing problem of post-operative infection by antibiotic-resistant bacteria. By combining several approaches to disrupt surface biofilm formation, the materials developed by the AIMed network will eventually result in fewer surgical infections, faster recovery of patients, and greatly reduced post-operative healthcare costs. The network will develop novel peptide sequences and ways of binding them to the surfaces of olymers, ceramics and metals. A complementary approach will be the developent of metal ion substituted calcium phosphate coatings which can be applied to implants by additive manufacturing techniques. The efficacy of these anti-bacterial surfaces will be further enhanced by laser processing of the material to make it unattractive to biofilms (by altering the roughness and wetting characteristics). The network will carry out a thorough investigation of the properties of the new materials to ensure that they are feasible for use in future implants. This work will include the evaluation of antibacterial action and biocompatibility using appropriate models. Training of the 15 ESR's appointed to the network will be multi-disciplinary and intersectoral, with an emphasis on the need for technology transfer from academic institutions to commercial users.

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Call for proposal

H2020-MSCA-ITN-2019

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Funding Scheme

MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)

Coordinator

THE UNIVERSITY OF BIRMINGHAM
Net EU contribution
€ 909 517,68
Address
Edgbaston
B15 2TT Birmingham
United Kingdom

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Region
West Midlands (England) West Midlands Birmingham
Activity type
Higher or Secondary Education Establishments
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Other funding
€ 0,00

Participants (11)

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EC signature date 17 January 2020
Last update: 11 September 2023

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Permalink: https://cordis.europa.eu/project/id/861138

European Union, 2023