Antimicrobial Integrated Methodologies for orthopaedic applications

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Award of PhD degree

D8.8 Award of PhD degree (after M42

Recruitment completed

D9.4 Recruitment completed (M12)

Research papers

D7.8 Research papers (M41)

Article in Materials Today

D7.7 Article in Materials Today (M40);

Birmingham Science Festival

D7.4 Birmingham Science Festival (M30

Vacancies advertisement

D9.2 Vacancies advertisement (M1

European Society for Biomaterials 2022

D7.6 European Society for Biomaterials 2022 (M36);

Operational network website and internet communication

D9.5 Operational network website and internet communication live (M2);

Bioceramics 32

D7.2 Bioceramics 32 (M12);

Outreach at UoB START

D7.3 Outreach at UoB START (M17);

Data management plan

A data management plan will be in place that will ensure all metadata accessible via UoB.

Open report on sterilization study

D6.4 Open report on sterilization study (M41);

Open report on drug release study

D6.5 Open report on drug release study (M41)

Publications

Concept of a Cyber–Physical System for Control of a Self-Cleaning Aquaponic Unit

Author(s): Kristiyan Dimitrov, Nayden Chivarov, Stefan Chivarov, Tsvetelina Paunova-Krasteva, Emil Filipov, Albena Daskalova
Published in: AgriEngineering, Issue 6, 2025, Page(s) 3843-3874, ISSN 2624-7402
Publisher: MDPI AG
DOI: 10.3390/agriengineering6040219

Materials derived from the human elastin-like polypeptide fusion with an antimicrobial peptide strongly promote cell adhesion

Author(s): Laura Colomina-Alfaro, Paola Sist, Paola D’Andrea, Ranieri Urbani, Silvia Marchesan, Artemis Stamboulis, Antonella Bandiera
Published in: Journal of Materials Chemistry B, Issue 12, 2024, Page(s) 8966-8976, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4tb00319e

Development of Femtosecond Laser-Engineered beta-Tricalcium Phosphate (beta-TCP) Biomimetic Templates for Orthopaedic Tissue Engineering

Author(s): Daskalova, A (Daskalova, Albena) [1] ; Angelova, L (Angelova, Liliya) [1] ; Trifonov, A (Trifonov, Anton) [2] ; Lasgorceix, M (Lasgorceix, Marie) [3] , [4] , [5] ; Hocquet, S (Hocquet, Stephane) [4] , [5] , [6] ; Minne, M (Minne, Mendy) [7] ; Declercq, H (Declercq, Heidi) [7] ; Leriche, A (Leriche, Anne) [3] , [4] , [5] ; Aceti, D (Aceti, Dante) [1] ; Buchvarov, I (Buchvarov, Ivan) [2]
Published in: Applied Science, 2021, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app11062565

Surface structuring of β-TCP and transition to α-TCP induced by femtosecond laser processing

Author(s): DM Aceti, E Filipov, L Sotelo, M Lasgorceix, A Leriche, I Buchvarov, A Daskalova
Published in: Journal of Physics: Conference Series, 2022, ISSN 1742-6588
Publisher: Institute of Physics
DOI: 10.1088/1742-6596/2487/1/012043

Binding Kinetics of Self-Assembled Monolayers of Fluorinated Phosphate Ester on Metal Oxides for Underwater Aerophilicity

Author(s): Anca Mazare, Mahmut Hakan Ulubas, Hyesung Kim, Iana Fomicheva, George Sarau, Silke H. Christiansen, Wolfgang H. Goldmann, Alexander B. Tesler
Published in: Langmuir, Issue 41, 2025, Page(s) 1868-1875, ISSN 0743-7463
Publisher: American Chemical Society
DOI: 10.1021/acs.langmuir.4c04320

Addressing data scarcity in nanomaterial segmentation networks with differentiable rendering and generative modeling

Author(s): Dennis Possart, Leonid Mill, Florian Vollnhals, Tor Hildebrand, Peter Suter, Mathis Hoffmann, Jonas Utz, Daniel Augsburger, Mareike Thies, Mingxuan Gu, Fabian Wagner, George Sarau, Silke Christiansen,
Published in: npj Computational Materials, Issue 11, 2025, ISSN 2057-3960
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41524-025-01702-6

Analysis of femtosecond microstructured Poly Lactic Acid temporary cell scaffolds, spin-coated with Chitosan or Hydroxyapatite

Author(s): L. Angelova; A. Daskalova; E. Filipov; R. Mincheva; X. Carette; D. Miano; D. Aceti; A. Trifonov; I. Buchvarov
Published in: Optical and Quantum Electronics, 2022, ISSN 0306-8919
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s11082-022-03970-8

Ultra-short laser structuring of 3D-microfabricated non-resorbable polystyrene polymer to anchor cellular adhesion

Author(s): L Angelova, E Filipov, DM Aceti, Al Zhelyazkova, I Buchvarov, A Daskalova
Published in: Journal of Physics: Conference Series, 2023, ISSN 1742-6588
Publisher: Institute of Physics
DOI: 10.1088/1742-6596/2487/1/012001

Effect of Ag and Cu doping on the properties of ZnO magnetron sputtered thin films for biomedical applications

Author(s): Ana-Marija Milisav, Maja Mičetić, Pavo Dubček, Lamborghini Sotelo, Cristina Cantallops-Vilà, Ina Erceg, Tommaso Fontanot, Krunoslav Bojanić, Željka Fiket, Maja Ivanić, George Sarau, Silke Chris
Published in: Applied Surface Science, Issue 690, 2025, Page(s) 162623, ISSN 0169-4332
Publisher: Elsevier BV
DOI: 10.1016/j.apsusc.2025.162623

Predicting plastron thermodynamic stability for underwater superhydrophobicity

Author(s): Alexander B. Tesler, Heikki A. Nurmi, Stefan Kolle, Lucia H. Prado, Bhuvaneshwari Karunakaran, Anca Mazare, Ina Erceg, Íris de Brito Soares, George Sarau, Silke Christiansen, Shane Stafslien, Jack Al
Published in: Communications Materials, Issue 5, 2024, ISSN 2662-4443
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s43246-024-00555-8

Processing and interpretation of core-electron XPS spectra o complex plasma-treated polyethylene-based surfaces using a theoretical peak model

Author(s): Bruggeman, M (Bruggeman, Marc) [1] ; Zelzer, M (Zelzer, Mischa) [2] ; Dong, HS (Dong, Hanshan) [3] ; Stamboulis, A (Stamboulis, Artemis) [1]
Published in: Surface and Interface Analysis, 2022, ISSN 1096-9918
Publisher: Wiley
DOI: 10.1002/sia.7125

Comparison of the activity of two elastin-like recombinant carriers fused to the antimicrobial peptide indolicidin

Author(s): Laura Colomina-Alfaro, Paola Sist, Angela Ivask, Brenda Raid, Hanna Ainelo, Abeer Shaalan, Lucy Di Silvio, Ranieri Urbani, Artemis Stamboulis, Antonella Bandiera
Published in: International Journal of Biological Macromolecules, Issue 283, 2024, Page(s) 137682, ISSN 0141-8130
Publisher: Elsevier BV
DOI: 10.1016/j.ijbiomac.2024.137682

Optimised amine density via plasma treatment for covalent immobilisation of AMPs to promote osteoblasts and enhance antimicrobial activity

Author(s): Mohadeseh Zare, Bogdan Butoi, Corneliu Porosnicu, Ion N. Mihailescu, David Grossin, Sarah A. Kuehne, Zubair Ahmed, Artemis Stamboulis
Published in: Colloids and Surfaces B: Biointerfaces, Issue 257, 2025, Page(s) 115188, ISSN 0927-7765
Publisher: Elsevier BV
DOI: 10.1016/j.colsurfb.2025.115188

Immobilization of KR-12 on a Titanium Alloy Surface Using Linking Arms Improves Antimicrobial Activity and Supports Osteoblast Cytocompatibility

Author(s): Mohadeseh Zare, Laura Colomina Alfaro, Antonella Bandiera, Esra Cansever Mutlu, David Grossin, Fernando Albericio, Sarah A. Kuehne, Zubair Ahmed, Artemis Stamboulis
Published in: ACS Applied Bio Materials, Issue 8, 2025, Page(s) 2899-2915, ISSN 2576-6422
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acsabm.4c01731

Self-Assembly of Homo- and Hetero-Chiral Cyclodipeptides into Supramolecular Polymers towards Antimicrobial Gels

Author(s): Beatrice Rosetti; Erica Scarel; Laura Colomina-Alfaro; Simone Adorinni; Giovanni Pierri; Ottavia Bellotto; Kevin Mamprin; Maurizio Polentarutti; Antonella Bandiera; Consiglia Tedesco; Silvia Marchesan
Published in: Polymers; Volume 14; Issue 21; Pages: 4554, 2022, Page(s) 4554, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym14214554

Biomimetic Hierarchical Structuring of PLA by Ultra-Short Laser Pulses for Processing of Tissue Engineered Matrices: Study of Cellular and Antibacterial Behavior.

Author(s): A. Daskalova; L. Angelova; Emil Filipov; Dante Aceti; Rosica Mincheva; Xavier Carrete; Halima Kerdjoudj; Marie Dubus; Julie Chevrier; A. Trifonov; Ivan Buchvarov
Published in: Polymers, Issue 13(15), 2021, Page(s) 2577, ISSN 2073-4360
Publisher: MDPI
DOI: 10.48550/arxiv.2112.05026

Femtosecond Laser-Engineered β-TCP Scaffolds: A Comparative Study of Green-Synthesized AgNPs vs. Ion Doping Against S. aureus for Bone Regeneration

Author(s): Marco Oliveira, Liliya Angelova, Georgi Avdeev, Liliana Grenho, Maria Helena Fernandes, Albena Daskalova
Published in: International Journal of Molecular Sciences, Issue 26, 2025, Page(s) 4888, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms26104888

A Versatile Elastin‐Like Carrier for Bioactive Antimicrobial Peptide Production and Delivery

Author(s): Laura ColominaAlfaro, Paola Sist, Silvia Marchesan, Ranieri Urbani, Artemis Stamboulis, Antonella Bandiera
Published in: Macromolecular Bioscience. Wiley, 2023, ISSN 1616-5187
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/mabi.202300236

Silicone-Based Lubricant-Infused Slippery Coating Covalently Bound to Aluminum Substrates for Underwater Applications

Author(s): Lucia H. Prado, David Böhringer, Anca Mazare, Lamborghini Sotelo, George Sarau, Silke Christiansen, Ben Fabry, Patrik Schmuki, Sannakaisa Virtanen, Wolfgang H. Goldmann, Alexander B. Tesler
Published in: ACS Applied Materials & Interfaces, Issue 15, 2024, Page(s) 31776-31786, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.3c04508

Bone Cell Exosomes and Emerging Strategies in Bone Engineering

Author(s): Vig, S (Vig, Sanjana) [1] , [2] ; Fernandes, MH (Fernandes, Maria Helena) [1] , [2]
Published in: Biomedicines, 2022, ISSN 2227-9059
Publisher: MDPI
DOI: 10.3390/biomedicines10040767

Design of Laser Activated Antimicrobial Porous Tricalcium Phosphate-Hydroxyapatite Scaffolds for Orthopedic Applications

Author(s): Emil Filipov, Ridvan Yildiz, Anna Dikovska, Lamborghini Sotelo, Tharun Soma, Georgi Avdeev, Penka Terziyska, Silke Christiansen, Anne Leriche, Maria Helena Fernandes, Albena Daskalova
Published in: Journal of Functional Biomaterials, Issue 15, 2025, Page(s) 36, ISSN 2079-4983
Publisher: MDPI AG
DOI: 10.3390/jfb15020036

Tunable Double-Network GelMA/Alginate Hydrogels for Platelet Lysate-Derived Protein Delivery

Author(s): Andrea Marfoglia, Fahd Tibourtine, Ludovic Pilloux, Sophie Cazalbou
Published in: Bioengineering, Issue 10, 2025, Page(s) 1044, ISSN 2306-5354
Publisher: MDPI AG
DOI: 10.3390/bioengineering10091044

Single-Step Process for Titanium Surface Micro- and Nano-Structuring and In Situ Silver Nanoparticles Formation by Ultra-Short Laser Patterning

Author(s): Aceti, DM (Aceti, Dante Maria) [1] ; Filipov, E (Filipov, Emil) [1] ; Angelova, L (Angelova, Liliya) [1] ; Sotelo, L (Sotelo, Lamborghini) [2] , [3] ; Fontanot, T (Fontanot, Tommaso) [4] ; Yousefi, P (Yousefi, Peyman) [2] , [4] ; Christiansen, S (Christiansen, Silke) [3] , [4] ; Leuchs, G (Leuchs, Gerd) [2] , [5] ; Stanimirov, S (Stanimirov, Stanislav) [6] ; Trifonov, A (Trifonov, Anton) [7] ; Buc
Published in: Materials, 2022, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma15134670

Corrosion behaviour of electropolished magnesium materials

Author(s): Jessica Kloiber, Ulrich Schultheiß, Lamborghini Sotelo, George Sarau, Silke Christiansen, Sarkis Gavras, Norbert Hort, Helga Hornberger
Published in: Materials Today Communications, Issue 38, 2024, Page(s) 107983, ISSN 2352-4928
Publisher: Elsevier BV
DOI: 10.1016/j.mtcomm.2023.107983

Optimization of titanium and titanium alloy surface properties by ultra-short laser processing for improved antibacterial characteristics

Author(s): DM Aceti, A Daskalova, L Angelova, E Filipov, L Sotelo, A Andreeva, A Trifonov, I Buchvarov
Published in: Journal of Physics: Conference Series, 2022, ISSN 1742-6588
Publisher: Institute of Physics
DOI: 10.1088/1742-6596/2240/1/012040

In Vitro Analysis of Human Cartilage Infiltrated by Hydrogels and Hydrogel-Encapsulated Chondrocytes

Author(s): Hannah Köck, Birgit Striegl, Annalena Kraus, Magdalena Zborilova, Silke Christiansen, Nicole Schäfer, Susanne Grässel, Helga Hornberger
Published in: Bioengineering, Issue 10, 2025, Page(s) 767, ISSN 2306-5354
Publisher: MDPI AG
DOI: 10.3390/bioengineering10070767

Investigation of Thin Silicone Films on Opaque Solid Surfaces Using Coherent Raman Scattering Imaging

Author(s): Julian Naser, George Sarau, Jan Wrege, Silke Christiansen
Published in: Applied Spectroscopy, Issue 79, 2025, Page(s) 1508-1517, ISSN 0003-7028
Publisher: Society for Applied Spectroscopy
DOI: 10.1177/00037028251339495

Optimizing the Surface Structural and Morphological Properties of Silk Thin Films via Ultra-Short Laser Texturing for Creation of Muscle Cell Matrix Model

Author(s): Angelova, L (Angelova, Liliya) [1] ; Daskalova, A (Daskalova, Albena) [1] ; Filipov, E (Filipov, Emil) [1] ; Vila, XM (Vila, Xavier Monforte) [2] , [3] ; Tomasch, J (Tomasch, Janine) [2] , [3] ; Avdeev, G (Avdeev, Georgi) [4] ; Teuschl-Woller, AH (Teuschl-Woller, Andreas H.) [2] , [3] ; Buchvarov, I (Buchvarov, Ivan) [5]
Published in: Polymers, 2022, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym14132584

Smart tools for antimicrobial peptides expression and application: The elastic perspective

Author(s): Colomina-Alfaro, L (Colomina-Alfaro, Laura) [1] ; Marchesan, S (Marchesan, Silvia) [2] ; Stamboulis, A (Stamboulis, Artemis) [3] ; Bandiera, A (Bandiera, Antonella)
Published in: Biotechnology and Bioengineering, 2022, ISSN 1097-0290
Publisher: Wiley
DOI: 10.1002/bit.28283

Ultra-Short Laser Surface Properties Optimization of Biocompatibility Characteristics of 3D Poly-ε-Caprolactone and Hydroxyapatite Composite Scaffolds

Author(s): Albena Daskalova 1,*ORCID,Emil Filipov 1ORCID,Liliya Angelova 1ORCID,Radostin Stefanov 2,Dragomir Tatchev 3ORCID,Georgi Avdeev 3ORCID,Lamborghini Sotelo 4,5,Silke Christiansen 4,George Sarau 4,6ORCID,Gerd Leuchs 5,Ekaterina Iordanova 7 and Ivan Buchvarov 8
Published in: Materials, 2021, Page(s) 14(24) 7513, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma14247513

Influence of Initial Surface Roughness on LIPSS Formation and Its Consecutive Impact on Cell/Bacteria Attachment for TiAl6V4 Surfaces

Author(s): Lamborghini Sotelo, Tommaso Fontanot, Sanjana Vig, Patrick Herre, Peyman Yousefi, Maria Helena Fernandes, George Sarau, Gerd Leuchs, Silke Christiansen
Published in: Advanced Materials Technologies, Issue 8, 2025, ISSN 2365-709X
Publisher: Wiley
DOI: 10.1002/admt.202201802

Design of Surfaces with Persistent Antimicrobial Properties on Stainless Steel Developed Using Femtosecond Laser Texturing for Application in “High Traffic” Objects

Author(s): Albena Daskalova, Liliya Angelova
Published in: Nanomaterials, Issue 13, 2025, Page(s) 2396, ISSN 2079-4991
Publisher: MDPI AG
DOI: 10.3390/nano13172396

Improvement of Metal-Doped β-TCP Scaffolds for Active Bone Substitutes via Ultra-Short Laser Structuring

Author(s): Íris Soares, Lamborghini Sotelo, Ina Erceg, Florian Jean, Marie Lasgorceix, Anne Leriche, Maja Dutour Sikirić, Katarina Marušić, Silke Christiansen, Albena Daskalova
Published in: Bioengineering, Issue 10, 2025, Page(s) 1392, ISSN 2306-5354
Publisher: MDPI AG
DOI: 10.3390/bioengineering10121392

Physicochemical Characterization of a Biomimetic, Elastin-Inspired Polypeptide with Enhanced Thermoresponsive Properties and Improved Cell Adhesion

Author(s): Antonella Bandiera, Laura Colomina-Alfaro, Paola Sist, Giovanna Gomez d'Ayala, Federica Zuppardi, Pierfrancesco Cerruti, Ovidio Catanzano, Sabina Passamonti, Ranieri Urbani
Published in: American Chemical Society, 2023, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/acs.biomac.3c00782

Toward Smart Biomimetic Apatite-Based Bone Scaffolds with Spatially Controlled Ion Substitutions

Author(s): Cianflone, E.; Brouillet, F.; Grossin, D.; Soulié, J.; Josse, C.; Vig, S.; Fernandes, M.H.; Tenailleau, C.; Duployer, B.; Thouron, C.; Drouet, C.
Published in: Nanomaterials, Issue 13, 2023, Page(s) 519, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano13030519

Investigating Potential Effects of Ultra-Short Laser-Textured Porous Poly-epsilon-Caprolactone Scaffolds on Bacterial Adhesion and Bone Cell Metabolism

Author(s): Filipov, E (Filipov, Emil) [1] ; Angelova, L (Angelova, Liliya) [1] ; Vig, S (Vig, Sanjana) [2] , [3] ; Fernandes, MH (Fernandes, Maria Helena) [2] , [3] ; Moreau, G (Moreau, Gerard) [4] ; Lasgorceix, M (Lasgorceix, Marie) [4] ; Buchvarov, I (Buchvarov, Ivan) [5] ; Daskalova, A (Daskalova, Albena) [1]
Published in: Polymers, 2022, Page(s) 14(12) 2382, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym14122382

Dual-Function Femtosecond Laser: β-TCP Structuring and AgNP Synthesis via Photoreduction with Azorean Green Tea for Enhanced Osteointegration and Antibacterial Properties

Author(s): Marco Oliveira, Liliya Angelova, Liliana Grenho, Maria Helena Fernandes, Albena Daskalova
Published in: Materials, Issue 17, 2025, Page(s) 5057, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma17205057

Design of femtosecond microstructured poly lactic acid temporal scaffolds coated with hydroxyapatite by pulse laser deposition method for bone tissue regeneration

Author(s): L. Angelova, A. Daskalova, R. Mincheva, E. Filipov, A. Dikovska, M. H. Fernandes, S. Vig, I. Buchvarov
Published in: Optical and Quantum Electronics, Issue 56, 2024, ISSN 1572-817X
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s11082-024-06500-w

Poly(Amino Acid) LbL Multilayers With Embedded Silver and Copper Oxide Nanoparticles as Biocompatible Antibacterial Coatings

Author(s): Ana‐Marija Milisav, Lamborghini Sotelo, Cristina Cantallops‐Vilà, Tommaso Fontanot, Ina Erceg, Krunoslav Bojanić, Tomislav Vuletić, Željka Fiket, Maja Ivanić, Silke Christiansen, Edwige Meuri
Published in: Advanced Materials Interfaces, Issue 12, 2025, ISSN 2196-7350
Publisher: Wiley
DOI: 10.1002/admi.202400631

Ultra-short laser processing of 3D bioceramic, porous scaffolds designed by freeze foaming method for orthopedic applications

Author(s): Albena Daskalova, Matthias Ahlhelm, Liliya Angelova, Emil Filipov, Georgi Avdeev, Dragomir Tatchev, Maria-Helena Fernandes, Sanjana Vig, Ivan Buchvarov
Published in: Frontiers in Cell and Developmental Biology, Issue 12, 2024, ISSN 2296-634X
Publisher: Frontiers Media SA
DOI: 10.3389/fcell.2024.1447979

Different Strategies of Antimicrobial Peptides Production for Biomedical Applications

Author(s): Cristina Cantallops-Vilà, Laura Colomina-Alfaro, Pietro Riccio, Hanieh Ijakipour, Edwige Meurice, Antonella Bandiera, and Artemis Stamboulis
Published in: Proceedings of the 36th European Peptide Symposium, 2023, ISBN 979-8-9872140-0-8
Publisher: Proceedings of the 36th European Peptide Symposium
DOI: 10.17952/36eps.2022.039

Initial surface roughness influence on the generation of LIPSS on titanium and stainless steel and their effect on cell/bacteria viability

Author(s): Lamborghini Sotelo, Tommaso Fontanot, Sanjana Vig, Maria Helena Fernandes, George Sarau, Gerd Leuchs, Silke Christiansen
Published in: Photonics West SPIE Proceedings, 2023
Publisher: Photonics West SPIE Proceedings
DOI: 10.1117/12.2648921

Dynamics of development of laser-induced structures on the surface of a titanium alloy

Author(s): Iana Fomicheva, Petr Druzhinin, Hans Amler, Wolfgang Schuesslbauer, Silke Christiansen, Gerd Leuchs
Published in: 2023
Publisher: SPIE
DOI: 10.1117/12.2649015

Antimicrobial Bioceramics for Biomedical Applications.

Author(s): Pietro Riccio, Mohadeseh Zare, Diana Gomes, David Green, and Artemis Stamboulis.
Published in: Springer Series In Bio Materials, Science and Engineering, 2022
Publisher: Springer Nature

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