Description du projet
Réduire les infections dans l’orthopédie
Les infections post-opératoires par des bactéries résistantes aux antibiotiques sont en hausse pour les implants orthopédiques, tels que les prothèses articulaires, ce qui constitue un lourd fardeau pour les patients comme pour les systèmes de soins de santé. C’est la raison pour laquelle il est important d’empêcher la formation de biofilms à la surface des implants. Le projet AIMed, financé par l’UE, va mettre au point une série de biomatériaux disposant de propriétés antibactériennes. Un traitement au laser sera utilisé, afin de rendre les biomatériaux plus résistants à la formation de biofilms. Le projet, qui consiste en un réseau de 12 bénéficiaires et de 6 institutions partenaires, va tester les propriétés des nouveaux matériaux afin de prouver leur efficacité dans le cadre d’une utilisation pour de futures interventions implantaires.
Objectif
The AIMed network, consisting of 12 beneficiaries and 6 partner organisations, will develop a range of materials with anti-bacterial properties that are suitable for use on the surfaces of orthopaedic implants. This is in response to the increasing problem of post-operative infection by antibiotic-resistant bacteria. By combining several approaches to disrupt surface biofilm formation, the materials developed by the AIMed network will eventually result in fewer surgical infections, faster recovery of patients, and greatly reduced post-operative healthcare costs. The network will develop novel peptide sequences and ways of binding them to the surfaces of olymers, ceramics and metals. A complementary approach will be the developent of metal ion substituted calcium phosphate coatings which can be applied to implants by additive manufacturing techniques. The efficacy of these anti-bacterial surfaces will be further enhanced by laser processing of the material to make it unattractive to biofilms (by altering the roughness and wetting characteristics). The network will carry out a thorough investigation of the properties of the new materials to ensure that they are feasible for use in future implants. This work will include the evaluation of antibacterial action and biocompatibility using appropriate models. Training of the 15 ESR's appointed to the network will be multi-disciplinary and intersectoral, with an emphasis on the need for technology transfer from academic institutions to commercial users.
Champ scientifique
- engineering and technologymaterials engineeringcoating and films
- medical and health sciencesclinical medicineorthopaedics
- engineering and technologymechanical engineeringmanufacturing engineeringadditive manufacturing
- medical and health sciencesmedical biotechnologyimplants
- engineering and technologymaterials engineeringceramics
Mots‑clés
Programme(s)
Régime de financement
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinateur
B15 2TT Birmingham
Royaume-Uni