Descripción del proyecto
Reducir las infecciones en ortopedia
Las infecciones posoperatorias debidas a bacterias resistentes a antibióticos están aumentando en los implantes ortopédicos, como las prótesis articulares, lo que representa una carga pesada para los pacientes y los sistemas sanitarios. Por ello, es importante prevenir la formación de biopelículas en la superficie de los implantes. El proyecto AIMed, financiado con fondos europeos, desarrollará una serie de biomateriales con propiedades antibacterianas. Se utilizará el procesamiento láser para aumentar la resistencia de los biomateriales a la formación de biopelículas. El proyecto, que consiste en una red de doce beneficiarios y seis instituciones socias, probará las propiedades de los nuevos materiales para demostrar que son adecuados para su uso en futuras intervenciones de implantes.
Objetivo
The AIMed network, consisting of 12 beneficiaries and 6 partner organisations, will develop a range of materials with anti-bacterial properties that are suitable for use on the surfaces of orthopaedic implants. This is in response to the increasing problem of post-operative infection by antibiotic-resistant bacteria. By combining several approaches to disrupt surface biofilm formation, the materials developed by the AIMed network will eventually result in fewer surgical infections, faster recovery of patients, and greatly reduced post-operative healthcare costs. The network will develop novel peptide sequences and ways of binding them to the surfaces of olymers, ceramics and metals. A complementary approach will be the developent of metal ion substituted calcium phosphate coatings which can be applied to implants by additive manufacturing techniques. The efficacy of these anti-bacterial surfaces will be further enhanced by laser processing of the material to make it unattractive to biofilms (by altering the roughness and wetting characteristics). The network will carry out a thorough investigation of the properties of the new materials to ensure that they are feasible for use in future implants. This work will include the evaluation of antibacterial action and biocompatibility using appropriate models. Training of the 15 ESR's appointed to the network will be multi-disciplinary and intersectoral, with an emphasis on the need for technology transfer from academic institutions to commercial users.
Ámbito científico
- engineering and technologymaterials engineeringcoating and films
- medical and health sciencesclinical medicineorthopaedics
- engineering and technologymechanical engineeringmanufacturing engineeringadditive manufacturing
- medical and health sciencesmedical biotechnologyimplants
- engineering and technologymaterials engineeringceramics
Palabras clave
Programa(s)
Régimen de financiación
MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN)Coordinador
B15 2TT Birmingham
Reino Unido