Small-Molecule Drug Conjugates for Targeted Delivery in Tumor Therapy

Project Information

Magicbullet Reloaded

Grant agreement ID: 861316

DOI

10.3030/861316

Project closed

EC signature date 11 September 2019

Start date 1 November 2019

End date 30 April 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 915 902,88

EU contribution

€ 3 915 902,88

Coordinated by

UNIVERSITAET BIELEFELD
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (2)

Completion of Website and Social Media Accounts
Videos on ETN activities published

Documents, reports (4)

Special Issue published in a scientific journal
Four network meetings held
Total of seven network meetings (including skill workshops) given
Feature article published in a popular science journal

Publications

Peer reviewed articles (15)

A fast and sensitive absolute quantification assay for the detection of SARS-CoV-2 peptides using parallel reaction monitoring mass spectrometry

Author(s): Akshada Gajbhiye, Atakan Nalbant, Tiaan Heunis, Frances Sidgwick, Andrew Porter, Yusri Taha, Matthias Trost
Published in: Journal of Proteomics, Issue Volume 265, 15 August 2022,, 2022, Page(s) 104664, ISSN 1874-3919
Publisher: Elsevier BV
DOI: 10.1016/j.jprot.2022.104664

Immunotherapy with immunocytokines and PD-1 blockade enhances the anticancer activity of Small Molecule-Drug Conjugates targeting Carbonic Anhydrase IX

Author(s): Jacopo Millul; Christiane Krudewig; Aureliano Zana; Sheila Dakhel Plaza; Emanuele Puca; Alessandra Villa; Dario Neri; Samuele Cazzamalli
Published in: Millul, Jacopo; Krudewig, Christiane; Zana, Aureliano; Plaza, Sheila Dakhel; Puca, Emanuele; Villa, Alessandra; Neri, Dario; Cazzamalli, Samuele (2021). Immunotherapy with immunocytokines and PD-1 blockade enhances the anticancer activity of small molecule-drug conjugates targeting carbonic anhydrase IX. Molecular Cancer Therapeutics, 20(3):512-522., Issue 20(3), 2020, Page(s) 512–522, ISSN 1535-7163
Publisher: American Association for Cancer Research
DOI: 10.1158/1535-7163.mct-20-0361

Oxime-Linked Peptide–Daunomycin Conjugates as Good Tools for Selection of Suitable Homing Devices in Targeted Tumor Therapy: An Overview

Author(s): Gábor Mezo, Jacopo Gomena, Ivan Randelovic, Endre Levente Dókus, Krisztina Kiss, Lilla Petho, Sabine Schuster, Balázs Vári, Diána Vári-Mezo, Eszter Lajkó, Lívia Polgár, László Kohidai, József Tóvári and Ildikó Szabó
Published in: International Journal of Molecular Sciences, Issue 25, 2024, Page(s) 186, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25031864

Amine‐Carbamate Self‐Immolative Spacers Counterintuitively Release 3° Alcohol at Much Faster Rates than 1° Alcohol Payloads

Author(s): Mattia Mason; Lydia Bisbal Lopez; Fazel Bashiri; Aurélie Herrero; Aurélien Baron; Raffaella Bucci; Luca Pignataro; Cesare Gennari; Alberto Dal Corso
Published in: ChemBioChem, Issue 3, 2024, Page(s) e202400174, ISSN 1439-4227
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202400174

Targeting the Gastrin-Releasing Peptide Receptor (GRP-R) in Cancer Therapy: Development of Bombesin-Based Peptide–Drug Conjugates

Author(s): Jacopo Gomena, Balázs Vári, Rita Oláh-Szabó, Beáta Biri-Kovács, Szilvia Bősze, Adina Borbély, Ádám Soós, Ivan Ranđelović, József Tóvári and Gábor Mező
Published in: International Journal of Molecular Sciences, Issue 24(4), 2023, Page(s) 3400, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24043400

Highly pure DNA-encoded chemical libraries by dual-linker solid-phase synthesis

Author(s): Michelle Keller, Dimitar Petrov, Andreas Gloger, Bastien Dietschi, Kilian Jobin, Timon Gradinger, Adriano Martinelli, Louise Plais, Yuichi Onda, Dario Neri, Jörg Scheuermann
Published in: Science, Issue 384, 2024, Page(s) 1259-1265, ISSN 1095-9203
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adn3412

Optimizing the enzymatic release of MMAE from isoDGR-based small molecule drug conjugate by incorporation of a GPLG-PABC enzymatically cleavable linker

Author(s): Marco Zambra; Ivan Ranđelović; Francesco Talarico; Adina Borbély; Laura Svajda; Laura Svajda; József Tóvári; Gábor Mező; Gábor Mező; Lizeth Bodero; Sveva Colombo; Sveva Colombo; Federico Arrigoni; Elettra Fasola; Silvia Gazzola; Umberto Piarulli
Published in: Frontiers in Pharmacology, Vol 14 (2023), Issue 14, 2023, Page(s) 1215694, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1215694

Impact of DNA-Encoded Chemical Library Technology on Drug Discovery

Author(s): Michelle Keller, Kristina Schira, Jörg Scheuermann
Published in: Chimia, Issue 76, 2022, Page(s) 388, ISSN 2673-2424
Publisher: Swiss Chemical Society
DOI: 10.2533/chimia.2022.388

Targeting the Melanocortin 1 Receptor in Melanoma: Biological Activity of α-MSH–Peptide Conjugates

Author(s): Ildikó Szabó, Beáta Biri-Kovács, Balázs Vári, Ivan Randelovic, Diána Vári-Mezo, Éva Juhász, Gábor Halmos, Szilvia Bosze, József Tóvári and Gábor Mezo
Published in: International Journal of Molecular Sciences, Issue 25, 2024, Page(s) 1095, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25021095

Ex vivo mass spectrometry-based biodistribution analysis of an antibody-Resiquimod conjugate bearing a protease-cleavable and acid-labile linker

Author(s): Lydia Bisbal Lopez; Domenico Ravazza; Matilde Bocci; Aureliano Zana; Lucrezia Principi; Sheila Dakhel Plaza; Andrea Galbiati; Ettore Gilardoni; Jörg Scheuermann; Dario Neri; Dario Neri; Dario Neri; Luca Pignataro; Cesare Gennari; Samuele Cazzamalli; Alberto Dal Corso
Published in: Frontiers in Pharmacology, Vol 14 (2023), Issue 4, 2023, Page(s) 1320524, ISSN 1663-9812
Publisher: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1320524

Universal encoding of next generation DNA-encoded chemical libraries

Author(s): Louise Plais; Alice Lessing; Michelle Keller; Adriano Martinelli; Sebastian Oehler; Gabriele Bassi; Dario Neri; Jörg Scheuermann
Published in: Chemical Science, 13 (4), Issue 2, 2022, Page(s) 967-974, ISSN 2633-0679
Publisher: Royal Society of Chemistry
DOI: 10.3929/ethz-b-000526396

Recent Advances and Trends in Chemical CPP–Drug Conjugation Techniques

Author(s): Ines Neundorf; Félix Gayraud; Merlin Jan Klußmann
Published in: Molecules, Issue 26(6), 2021, Page(s) 1591, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26061591

An ultra-high-affinity small organic ligand of fibroblast activation protein for tumor-targeting applications

Author(s): Jacopo Millul; Gabriele Bassi; Jacqueline Mock; Abdullah Elsayed; Christian Pellegrino; Aureliano Zana; Sheila Dakhel Plaza; Lisa Nadal; Andreas Gloger; Eleonore Schmidt; Ilaria Biancofiore; Etienne J. Donckele; Florent Samain; Dario Neri; Samuele Cazzamalli
Published in: Proc Natl Acad Sci U S A, Issue 118 (16), 2021, Page(s) e2101852118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2101852118

SREKA-targeted liposomes for highly metastatic breast cancer therapy

Author(s): Balázs Vári, Levente Dókus, Adina Borbély, Anikó Gaál, Diána Vári-Mező, Ivan Ranđelović, Anna Sólyom-Tisza, Zoltán Varga, Norbert Szoboszlai, Gábor Mező, József Tóvári
Published in: Drug Delivery, Issue Volume 30, 2023 - Issue 1, 2023, Page(s) 2174210, ISSN 1470-1200
Publisher: Taylor & Francis
DOI: 10.1080/10717544.2023.2174210

Fibroblast Activation Protein Triggers Release of Drug Payload from Non-internalizing Small Molecule Drug Conjugates in Solid Tumors

Author(s): Aureliano Zana; Andrea Galbiati; Ettore Gilardoni; Matilde Bocci; Jacopo Millul; Theo Sturm; Riccardo Stucchi; Abdullah Elsayed; Lisa Nadal; Martina Cirillo; Wolfgang Roll; Lars Stegger; Inga Asmus; Philipp Backhaus; Michael Schäfers; Dario Neri; Samuele Cazzamalli
Published in: Clinical Cancer Research, 28 (24), Issue 1, 2022, Page(s) 5440–5454, ISSN 1557-3265
Publisher: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-1788

Non-peer reviewed articles (5)

Ph.D. Journeys Abroad – And so the Adventure Has Begun …

Author(s): Sveva Colombo
Published in: Chemistry Views, Issue October 4, 2022, 2022, ISSN 2190-3735
Publisher: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200083

Ph.D. Journeys Abroad – Be Kind to Yourself

Author(s): Daniela Carraturo
Published in: Chemistry Views, Issue November 1, 2022, 2022, ISSN 2190-3735
Publisher: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200094

Ph.D. Journeys Abroad – Creating a Second Home

Author(s): Tine Haesen
Published in: Chemistry Views, Issue December 6, 2022, 2022, ISSN 2190-3735
Publisher: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200099

Ph.D. Journeys Abroad – Overcoming Impostor Syndrome: Why Did I Feel Like It Was Just Me?

Author(s): Lieke van Gijzel
Published in: Chemistry Views, Issue January 3, 2023, 2023, ISSN 2190-3735
Publisher: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200100

Ph.D. Journeys Abroad – The Challenges of Starting a New Life Far from Home

Author(s): Ana Ferrari
Published in: Chemistry Views, Issue February 7, 2023, 2023, ISSN 2190-3735
Publisher: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200101