Small-Molecule Drug Conjugates for Targeted Delivery in Tumor Therapy

Información del proyecto

Magicbullet Reloaded

Identificador del acuerdo de subvención: 861316

DOI

10.3030/861316

Proyecto cerrado

Fecha de la firma de la CE 11 Septiembre 2019

Fecha de inicio 1 Noviembre 2019

Fecha de finalización 30 Abril 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 915 902,88

Aportación de la UE

€ 3 915 902,88

Coordinado por

UNIVERSITAET BIELEFELD
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (2)

Completion of Website and Social Media Accounts
Videos on ETN activities published

Documents, reports (4)

Special Issue published in a scientific journal
Four network meetings held
Total of seven network meetings (including skill workshops) given
Feature article published in a popular science journal

Publicaciones

Peer reviewed articles (15)

A fast and sensitive absolute quantification assay for the detection of SARS-CoV-2 peptides using parallel reaction monitoring mass spectrometry

Autores: Akshada Gajbhiye, Atakan Nalbant, Tiaan Heunis, Frances Sidgwick, Andrew Porter, Yusri Taha, Matthias Trost
Publicado en: Journal of Proteomics, Edición Volume 265, 15 August 2022,, 2022, Página(s) 104664, ISSN 1874-3919
Editor: Elsevier BV
DOI: 10.1016/j.jprot.2022.104664

Immunotherapy with immunocytokines and PD-1 blockade enhances the anticancer activity of Small Molecule-Drug Conjugates targeting Carbonic Anhydrase IX

Autores: Jacopo Millul; Christiane Krudewig; Aureliano Zana; Sheila Dakhel Plaza; Emanuele Puca; Alessandra Villa; Dario Neri; Samuele Cazzamalli
Publicado en: Millul, Jacopo; Krudewig, Christiane; Zana, Aureliano; Plaza, Sheila Dakhel; Puca, Emanuele; Villa, Alessandra; Neri, Dario; Cazzamalli, Samuele (2021). Immunotherapy with immunocytokines and PD-1 blockade enhances the anticancer activity of small molecule-drug conjugates targeting carbonic anhydrase IX. Molecular Cancer Therapeutics, 20(3):512-522., Edición 20(3), 2020, Página(s) 512–522, ISSN 1535-7163
Editor: American Association for Cancer Research
DOI: 10.1158/1535-7163.mct-20-0361

Oxime-Linked Peptide–Daunomycin Conjugates as Good Tools for Selection of Suitable Homing Devices in Targeted Tumor Therapy: An Overview

Autores: Gábor Mezo, Jacopo Gomena, Ivan Randelovic, Endre Levente Dókus, Krisztina Kiss, Lilla Petho, Sabine Schuster, Balázs Vári, Diána Vári-Mezo, Eszter Lajkó, Lívia Polgár, László Kohidai, József Tóvári and Ildikó Szabó
Publicado en: International Journal of Molecular Sciences, Edición 25, 2024, Página(s) 186, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25031864

Amine‐Carbamate Self‐Immolative Spacers Counterintuitively Release 3° Alcohol at Much Faster Rates than 1° Alcohol Payloads

Autores: Mattia Mason; Lydia Bisbal Lopez; Fazel Bashiri; Aurélie Herrero; Aurélien Baron; Raffaella Bucci; Luca Pignataro; Cesare Gennari; Alberto Dal Corso
Publicado en: ChemBioChem, Edición 3, 2024, Página(s) e202400174, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202400174

Targeting the Gastrin-Releasing Peptide Receptor (GRP-R) in Cancer Therapy: Development of Bombesin-Based Peptide–Drug Conjugates

Autores: Jacopo Gomena, Balázs Vári, Rita Oláh-Szabó, Beáta Biri-Kovács, Szilvia Bősze, Adina Borbély, Ádám Soós, Ivan Ranđelović, József Tóvári and Gábor Mező
Publicado en: International Journal of Molecular Sciences, Edición 24(4), 2023, Página(s) 3400, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24043400

Highly pure DNA-encoded chemical libraries by dual-linker solid-phase synthesis

Autores: Michelle Keller, Dimitar Petrov, Andreas Gloger, Bastien Dietschi, Kilian Jobin, Timon Gradinger, Adriano Martinelli, Louise Plais, Yuichi Onda, Dario Neri, Jörg Scheuermann
Publicado en: Science, Edición 384, 2024, Página(s) 1259-1265, ISSN 1095-9203
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.adn3412

Optimizing the enzymatic release of MMAE from isoDGR-based small molecule drug conjugate by incorporation of a GPLG-PABC enzymatically cleavable linker

Autores: Marco Zambra; Ivan Ranđelović; Francesco Talarico; Adina Borbély; Laura Svajda; Laura Svajda; József Tóvári; Gábor Mező; Gábor Mező; Lizeth Bodero; Sveva Colombo; Sveva Colombo; Federico Arrigoni; Elettra Fasola; Silvia Gazzola; Umberto Piarulli
Publicado en: Frontiers in Pharmacology, Vol 14 (2023), Edición 14, 2023, Página(s) 1215694, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1215694

Impact of DNA-Encoded Chemical Library Technology on Drug Discovery

Autores: Michelle Keller, Kristina Schira, Jörg Scheuermann
Publicado en: Chimia, Edición 76, 2022, Página(s) 388, ISSN 2673-2424
Editor: Swiss Chemical Society
DOI: 10.2533/chimia.2022.388

Targeting the Melanocortin 1 Receptor in Melanoma: Biological Activity of α-MSH–Peptide Conjugates

Autores: Ildikó Szabó, Beáta Biri-Kovács, Balázs Vári, Ivan Randelovic, Diána Vári-Mezo, Éva Juhász, Gábor Halmos, Szilvia Bosze, József Tóvári and Gábor Mezo
Publicado en: International Journal of Molecular Sciences, Edición 25, 2024, Página(s) 1095, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25021095

Ex vivo mass spectrometry-based biodistribution analysis of an antibody-Resiquimod conjugate bearing a protease-cleavable and acid-labile linker

Autores: Lydia Bisbal Lopez; Domenico Ravazza; Matilde Bocci; Aureliano Zana; Lucrezia Principi; Sheila Dakhel Plaza; Andrea Galbiati; Ettore Gilardoni; Jörg Scheuermann; Dario Neri; Dario Neri; Dario Neri; Luca Pignataro; Cesare Gennari; Samuele Cazzamalli; Alberto Dal Corso
Publicado en: Frontiers in Pharmacology, Vol 14 (2023), Edición 4, 2023, Página(s) 1320524, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1320524

Universal encoding of next generation DNA-encoded chemical libraries

Autores: Louise Plais; Alice Lessing; Michelle Keller; Adriano Martinelli; Sebastian Oehler; Gabriele Bassi; Dario Neri; Jörg Scheuermann
Publicado en: Chemical Science, 13 (4), Edición 2, 2022, Página(s) 967-974, ISSN 2633-0679
Editor: Royal Society of Chemistry
DOI: 10.3929/ethz-b-000526396

Recent Advances and Trends in Chemical CPP–Drug Conjugation Techniques

Autores: Ines Neundorf; Félix Gayraud; Merlin Jan Klußmann
Publicado en: Molecules, Edición 26(6), 2021, Página(s) 1591, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26061591

An ultra-high-affinity small organic ligand of fibroblast activation protein for tumor-targeting applications

Autores: Jacopo Millul; Gabriele Bassi; Jacqueline Mock; Abdullah Elsayed; Christian Pellegrino; Aureliano Zana; Sheila Dakhel Plaza; Lisa Nadal; Andreas Gloger; Eleonore Schmidt; Ilaria Biancofiore; Etienne J. Donckele; Florent Samain; Dario Neri; Samuele Cazzamalli
Publicado en: Proc Natl Acad Sci U S A, Edición 118 (16), 2021, Página(s) e2101852118, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2101852118

SREKA-targeted liposomes for highly metastatic breast cancer therapy

Autores: Balázs Vári, Levente Dókus, Adina Borbély, Anikó Gaál, Diána Vári-Mező, Ivan Ranđelović, Anna Sólyom-Tisza, Zoltán Varga, Norbert Szoboszlai, Gábor Mező, József Tóvári
Publicado en: Drug Delivery, Edición Volume 30, 2023 - Edición 1, 2023, Página(s) 2174210, ISSN 1470-1200
Editor: Taylor & Francis
DOI: 10.1080/10717544.2023.2174210

Fibroblast Activation Protein Triggers Release of Drug Payload from Non-internalizing Small Molecule Drug Conjugates in Solid Tumors

Autores: Aureliano Zana; Andrea Galbiati; Ettore Gilardoni; Matilde Bocci; Jacopo Millul; Theo Sturm; Riccardo Stucchi; Abdullah Elsayed; Lisa Nadal; Martina Cirillo; Wolfgang Roll; Lars Stegger; Inga Asmus; Philipp Backhaus; Michael Schäfers; Dario Neri; Samuele Cazzamalli
Publicado en: Clinical Cancer Research, 28 (24), Edición 1, 2022, Página(s) 5440–5454, ISSN 1557-3265
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-1788

Non-peer reviewed articles (5)

Ph.D. Journeys Abroad – And so the Adventure Has Begun …

Autores: Sveva Colombo
Publicado en: Chemistry Views, Edición October 4, 2022, 2022, ISSN 2190-3735
Editor: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200083

Ph.D. Journeys Abroad – Be Kind to Yourself

Autores: Daniela Carraturo
Publicado en: Chemistry Views, Edición November 1, 2022, 2022, ISSN 2190-3735
Editor: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200094

Ph.D. Journeys Abroad – Creating a Second Home

Autores: Tine Haesen
Publicado en: Chemistry Views, Edición December 6, 2022, 2022, ISSN 2190-3735
Editor: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200099

Ph.D. Journeys Abroad – Overcoming Impostor Syndrome: Why Did I Feel Like It Was Just Me?

Autores: Lieke van Gijzel
Publicado en: Chemistry Views, Edición January 3, 2023, 2023, ISSN 2190-3735
Editor: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200100

Ph.D. Journeys Abroad – The Challenges of Starting a New Life Far from Home

Autores: Ana Ferrari
Publicado en: Chemistry Views, Edición February 7, 2023, 2023, ISSN 2190-3735
Editor: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200101