Small-Molecule Drug Conjugates for Targeted Delivery in Tumor Therapy

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Publicaciones

A fast and sensitive absolute quantification assay for the detection of SARS-CoV-2 peptides using parallel reaction monitoring mass spectrometry

Autores: Akshada Gajbhiye, Atakan Nalbant, Tiaan Heunis, Frances Sidgwick, Andrew Porter, Yusri Taha, Matthias Trost
Publicado en: Journal of Proteomics, Edición Volume 265, 15 August 2022,, 2022, Página(s) 104664, ISSN 1874-3919
Editor: Elsevier BV
DOI: 10.1016/j.jprot.2022.104664

Immunotherapy with immunocytokines and PD-1 blockade enhances the anticancer activity of Small Molecule-Drug Conjugates targeting Carbonic Anhydrase IX

Autores: Jacopo Millul; Christiane Krudewig; Aureliano Zana; Sheila Dakhel Plaza; Emanuele Puca; Alessandra Villa; Dario Neri; Samuele Cazzamalli
Publicado en: Millul, Jacopo; Krudewig, Christiane; Zana, Aureliano; Plaza, Sheila Dakhel; Puca, Emanuele; Villa, Alessandra; Neri, Dario; Cazzamalli, Samuele (2021). Immunotherapy with immunocytokines and PD-1 blockade enhances the anticancer activity of small molecule-drug conjugates targeting carbonic anhydrase IX. Molecular Cancer Therapeutics, 20(3):512-522., Edición 20(3), 2020, Página(s) 512–522, ISSN 1535-7163
Editor: American Association for Cancer Research
DOI: 10.1158/1535-7163.mct-20-0361

Efficacy of selective histone deacetylase 6 inhibition in mouse models of Pseudomonasaeruginosa infection: A new glimpse for reducing inflammation and infection in cystic fibrosis.

Autores: Brindisi M, Barone S, Rossi A, Cassese E, Del Gaudio N, Feliz Morel ÁJ, Filocamo G, Alberico A, De Fino I, Gugliandolo D, Babaei M, Bove G, Croce M, Montesano C, Altucci L, Bragonzi A, Summa V
Publicado en: European Journal of Pharmacology, 2022, ISSN 1879-0712
Editor: Elsevier B.V. All
DOI: 10.1016/j.ejphar.2022.175349

Oxime-Linked Peptide–Daunomycin Conjugates as Good Tools for Selection of Suitable Homing Devices in Targeted Tumor Therapy: An Overview

Autores: Gábor Mezo, Jacopo Gomena, Ivan Randelovic, Endre Levente Dókus, Krisztina Kiss, Lilla Petho, Sabine Schuster, Balázs Vári, Diána Vári-Mezo, Eszter Lajkó, Lívia Polgár, László Kohidai, József Tóvári and Ildikó Szabó
Publicado en: International Journal of Molecular Sciences, Edición 25, 2024, Página(s) 186, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25031864

Amine‐Carbamate Self‐Immolative Spacers Counterintuitively Release 3° Alcohol at Much Faster Rates than 1° Alcohol Payloads

Autores: Mattia Mason; Lydia Bisbal Lopez; Fazel Bashiri; Aurélie Herrero; Aurélien Baron; Raffaella Bucci; Luca Pignataro; Cesare Gennari; Alberto Dal Corso
Publicado en: ChemBioChem, Edición 3, 2024, Página(s) e202400174, ISSN 1439-4227
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202400174

Targeting the Gastrin-Releasing Peptide Receptor (GRP-R) in Cancer Therapy: Development of Bombesin-Based Peptide–Drug Conjugates

Autores: Jacopo Gomena, Balázs Vári, Rita Oláh-Szabó, Beáta Biri-Kovács, Szilvia Bősze, Adina Borbély, Ádám Soós, Ivan Ranđelović, József Tóvári and Gábor Mező
Publicado en: Int. J. Mol. Sci., Edición 24(4), 2023, Página(s) 3400, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24043400

A novel dimeric FAP-targeting small molecule-radio conjugate with high and prolonged tumour uptake

Autores: Andrea Galbiati, Aureliano Zana, Matilde Bocci, Jacopo Millul, Abdullah Elsayed, Jacqueline Mock, Dario Neri, Samuele Cazzamalli
Publicado en: Journal of Nuclear Medicine, Edición Vol. 64, Edición 8, 2022, Página(s) jnumed.122.264036, ISSN 0097-9058
Editor: Society of Nuclear Medicine and Molecular Imaging (SNMMI)
DOI: 10.2967/jnumed.122.264036

Highly pure DNA-encoded chemical libraries by dual-linker solid-phase synthesis

Autores: Michelle Keller, Dimitar Petrov, Andreas Gloger, Bastien Dietschi, Kilian Jobin, Timon Gradinger, Adriano Martinelli, Louise Plais, Yuichi Onda, Dario Neri, Jörg Scheuermann
Publicado en: Science, Edición 384, 2024, Página(s) 1259-1265, ISSN 1095-9203
Editor: American Association for the Advancement of Science
DOI: 10.1126/science.adn3412

Optimizing the enzymatic release of MMAE from isoDGR-based small molecule drug conjugate by incorporation of a GPLG-PABC enzymatically cleavable linker

Autores: Marco Zambra; Ivan Ranđelović; Francesco Talarico; Adina Borbély; Laura Svajda; Laura Svajda; József Tóvári; Gábor Mező; Gábor Mező; Lizeth Bodero; Sveva Colombo; Sveva Colombo; Federico Arrigoni; Elettra Fasola; Silvia Gazzola; Umberto Piarulli
Publicado en: Frontiers in Pharmacology, Vol 14 (2023), Edición 14, 2023, Página(s) 1215694, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1215694

Impact of DNA-Encoded Chemical Library Technology on Drug Discovery

Autores: Michelle Keller, Kristina Schira, Jörg Scheuermann
Publicado en: Chimia, Edición 76, 2022, Página(s) 388, ISSN 2673-2424
Editor: Swiss Chemical Society
DOI: 10.2533/chimia.2022.388

Targeting the Melanocortin 1 Receptor in Melanoma: Biological Activity of α-MSH–Peptide Conjugates

Autores: Ildikó Szabó, Beáta Biri-Kovács, Balázs Vári, Ivan Randelovic, Diána Vári-Mezo, Éva Juhász, Gábor Halmos, Szilvia Bosze, József Tóvári and Gábor Mezo
Publicado en: International Journal of Molecular Sciences, Edición 25, 2024, Página(s) 1095, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25021095

Ex vivo mass spectrometry-based biodistribution analysis of an antibody-Resiquimod conjugate bearing a protease-cleavable and acid-labile linker

Autores: Lydia Bisbal Lopez; Domenico Ravazza; Matilde Bocci; Aureliano Zana; Lucrezia Principi; Sheila Dakhel Plaza; Andrea Galbiati; Ettore Gilardoni; Jörg Scheuermann; Dario Neri; Dario Neri; Dario Neri; Luca Pignataro; Cesare Gennari; Samuele Cazzamalli; Alberto Dal Corso
Publicado en: Frontiers in Pharmacology, Vol 14 (2023), Edición 4, 2023, Página(s) 1320524, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1320524

Universal encoding of next generation DNA-encoded chemical libraries

Autores: Louise Plais; Alice Lessing; Michelle Keller; Adriano Martinelli; Sebastian Oehler; Gabriele Bassi; Dario Neri; Jörg Scheuermann
Publicado en: Chemical Science, 13 (4), Edición 2, 2022, Página(s) 967-974, ISSN 2633-0679
Editor: Royal Society of Chemistry
DOI: 10.3929/ethz-b-000526396

Recent Advances and Trends in Chemical CPP–Drug Conjugation Techniques

Autores: Ines Neundorf; Félix Gayraud; Merlin Jan Klußmann
Publicado en: Molecules, Edición 26(6), 2021, Página(s) 1591, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26061591

An ultra-high-affinity small organic ligand of fibroblast activation protein for tumor-targeting applications

Autores: Jacopo Millul; Gabriele Bassi; Jacqueline Mock; Abdullah Elsayed; Christian Pellegrino; Aureliano Zana; Sheila Dakhel Plaza; Lisa Nadal; Andreas Gloger; Eleonore Schmidt; Ilaria Biancofiore; Etienne J. Donckele; Florent Samain; Dario Neri; Samuele Cazzamalli
Publicado en: Proc Natl Acad Sci U S A, Edición 118 (16), 2021, Página(s) e2101852118, ISSN 0027-8424
Editor: National Academy of Sciences
DOI: 10.1073/pnas.2101852118

SREKA-targeted liposomes for highly metastatic breast cancer therapy

Autores: Balázs Vári, Levente Dókus, Adina Borbély, Anikó Gaál, Diána Vári-Mező, Ivan Ranđelović, Anna Sólyom-Tisza, Zoltán Varga, Norbert Szoboszlai, Gábor Mező, József Tóvári
Publicado en: Drug Delivery, Edición Volume 30, 2023 - Edición 1, 2023, Página(s) 2174210, ISSN 1470-1200
Editor: Taylor & Francis
DOI: 10.1080/10717544.2023.2174210

Fibroblast Activation Protein Triggers Release of Drug Payload from Non-internalizing Small Molecule Drug Conjugates in Solid Tumors

Autores: Aureliano Zana; Andrea Galbiati; Ettore Gilardoni; Matilde Bocci; Jacopo Millul; Theo Sturm; Riccardo Stucchi; Abdullah Elsayed; Lisa Nadal; Martina Cirillo; Wolfgang Roll; Lars Stegger; Inga Asmus; Philipp Backhaus; Michael Schäfers; Dario Neri; Samuele Cazzamalli
Publicado en: Clinical Cancer Research, 28 (24), Edición 1, 2022, Página(s) 5440–5454, ISSN 1557-3265
Editor: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-1788

Mass Spectrometry-Based Method for the Determination of the Biodistribution of Tumor-Targeting Small Molecule–Metal Conjugates

Autores: Ettore Gilardoni, Aureliano Zana, Andrea Galbiati, Theo Sturm, Jacopo Millul, Samuele Cazzamalli, Dario Neri, and Riccardo Stucchi
Publicado en: Anal. Chem., Edición 94, 30, 2022, Página(s) 10715–10721, ISSN 1520-6882
Editor: American Chemical Society
DOI: 10.1021/acs.analchem.2c01104

Ph.D. Journeys Abroad – And so the Adventure Has Begun …

Autores: Sveva Colombo
Publicado en: Chemistry Views, Edición October 4, 2022, 2022, ISSN 2190-3735
Editor: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200083

Ph.D. Journeys Abroad – Be Kind to Yourself

Autores: Daniela Carraturo
Publicado en: Chemistry Views, Edición November 1, 2022, 2022, ISSN 2190-3735
Editor: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200094

Ph.D. Journeys Abroad – Creating a Second Home

Autores: Tine Haesen
Publicado en: Chemistry Views, Edición December 6, 2022, 2022, ISSN 2190-3735
Editor: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200099

Ph.D. Journeys Abroad – Overcoming Impostor Syndrome: Why Did I Feel Like It Was Just Me?

Autores: Lieke van Gijzel
Publicado en: Chemistry Views, Edición January 3, 2023, 2023, ISSN 2190-3735
Editor: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200100

Ph.D. Journeys Abroad – The Challenges of Starting a New Life Far from Home

Autores: Ana Ferrari
Publicado en: Chemistry Views, Edición February 7, 2023, 2023, ISSN 2190-3735
Editor: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200101

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