Small-Molecule Drug Conjugates for Targeted Delivery in Tumor Therapy

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Pubblicazioni

A fast and sensitive absolute quantification assay for the detection of SARS-CoV-2 peptides using parallel reaction monitoring mass spectrometry

Autori: Akshada Gajbhiye, Atakan Nalbant, Tiaan Heunis, Frances Sidgwick, Andrew Porter, Yusri Taha, Matthias Trost
Pubblicato in: Journal of Proteomics, Numero Volume 265, 15 August 2022,, 2022, Pagina/e 104664, ISSN 1874-3919
Editore: Elsevier BV
DOI: 10.1016/j.jprot.2022.104664

Immunotherapy with immunocytokines and PD-1 blockade enhances the anticancer activity of Small Molecule-Drug Conjugates targeting Carbonic Anhydrase IX

Autori: Jacopo Millul; Christiane Krudewig; Aureliano Zana; Sheila Dakhel Plaza; Emanuele Puca; Alessandra Villa; Dario Neri; Samuele Cazzamalli
Pubblicato in: Millul, Jacopo; Krudewig, Christiane; Zana, Aureliano; Plaza, Sheila Dakhel; Puca, Emanuele; Villa, Alessandra; Neri, Dario; Cazzamalli, Samuele (2021). Immunotherapy with immunocytokines and PD-1 blockade enhances the anticancer activity of small molecule-drug conjugates targeting carbonic anhydrase IX. Molecular Cancer Therapeutics, 20(3):512-522., Numero 20(3), 2020, Pagina/e 512–522, ISSN 1535-7163
Editore: American Association for Cancer Research
DOI: 10.1158/1535-7163.mct-20-0361

Efficacy of selective histone deacetylase 6 inhibition in mouse models of Pseudomonasaeruginosa infection: A new glimpse for reducing inflammation and infection in cystic fibrosis.

Autori: Brindisi M, Barone S, Rossi A, Cassese E, Del Gaudio N, Feliz Morel ÁJ, Filocamo G, Alberico A, De Fino I, Gugliandolo D, Babaei M, Bove G, Croce M, Montesano C, Altucci L, Bragonzi A, Summa V
Pubblicato in: European Journal of Pharmacology, 2022, ISSN 1879-0712
Editore: Elsevier B.V. All
DOI: 10.1016/j.ejphar.2022.175349

Oxime-Linked Peptide–Daunomycin Conjugates as Good Tools for Selection of Suitable Homing Devices in Targeted Tumor Therapy: An Overview

Autori: Gábor Mezo, Jacopo Gomena, Ivan Randelovic, Endre Levente Dókus, Krisztina Kiss, Lilla Petho, Sabine Schuster, Balázs Vári, Diána Vári-Mezo, Eszter Lajkó, Lívia Polgár, László Kohidai, József Tóvári and Ildikó Szabó
Pubblicato in: International Journal of Molecular Sciences, Numero 25, 2024, Pagina/e 186, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25031864

Amine‐Carbamate Self‐Immolative Spacers Counterintuitively Release 3° Alcohol at Much Faster Rates than 1° Alcohol Payloads

Autori: Mattia Mason; Lydia Bisbal Lopez; Fazel Bashiri; Aurélie Herrero; Aurélien Baron; Raffaella Bucci; Luca Pignataro; Cesare Gennari; Alberto Dal Corso
Pubblicato in: ChemBioChem, Numero 3, 2024, Pagina/e e202400174, ISSN 1439-4227
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/cbic.202400174

Targeting the Gastrin-Releasing Peptide Receptor (GRP-R) in Cancer Therapy: Development of Bombesin-Based Peptide–Drug Conjugates

Autori: Jacopo Gomena, Balázs Vári, Rita Oláh-Szabó, Beáta Biri-Kovács, Szilvia Bősze, Adina Borbély, Ádám Soós, Ivan Ranđelović, József Tóvári and Gábor Mező
Pubblicato in: Int. J. Mol. Sci., Numero 24(4), 2023, Pagina/e 3400, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24043400

A novel dimeric FAP-targeting small molecule-radio conjugate with high and prolonged tumour uptake

Autori: Andrea Galbiati, Aureliano Zana, Matilde Bocci, Jacopo Millul, Abdullah Elsayed, Jacqueline Mock, Dario Neri, Samuele Cazzamalli
Pubblicato in: Journal of Nuclear Medicine, Numero Vol. 64, Numero 8, 2022, Pagina/e jnumed.122.264036, ISSN 0097-9058
Editore: Society of Nuclear Medicine and Molecular Imaging (SNMMI)
DOI: 10.2967/jnumed.122.264036

Highly pure DNA-encoded chemical libraries by dual-linker solid-phase synthesis

Autori: Michelle Keller, Dimitar Petrov, Andreas Gloger, Bastien Dietschi, Kilian Jobin, Timon Gradinger, Adriano Martinelli, Louise Plais, Yuichi Onda, Dario Neri, Jörg Scheuermann
Pubblicato in: Science, Numero 384, 2024, Pagina/e 1259-1265, ISSN 1095-9203
Editore: American Association for the Advancement of Science
DOI: 10.1126/science.adn3412

Optimizing the enzymatic release of MMAE from isoDGR-based small molecule drug conjugate by incorporation of a GPLG-PABC enzymatically cleavable linker

Autori: Marco Zambra; Ivan Ranđelović; Francesco Talarico; Adina Borbély; Laura Svajda; Laura Svajda; József Tóvári; Gábor Mező; Gábor Mező; Lizeth Bodero; Sveva Colombo; Sveva Colombo; Federico Arrigoni; Elettra Fasola; Silvia Gazzola; Umberto Piarulli
Pubblicato in: Frontiers in Pharmacology, Vol 14 (2023), Numero 14, 2023, Pagina/e 1215694, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1215694

Impact of DNA-Encoded Chemical Library Technology on Drug Discovery

Autori: Michelle Keller, Kristina Schira, Jörg Scheuermann
Pubblicato in: Chimia, Numero 76, 2022, Pagina/e 388, ISSN 2673-2424
Editore: Swiss Chemical Society
DOI: 10.2533/chimia.2022.388

Targeting the Melanocortin 1 Receptor in Melanoma: Biological Activity of α-MSH–Peptide Conjugates

Autori: Ildikó Szabó, Beáta Biri-Kovács, Balázs Vári, Ivan Randelovic, Diána Vári-Mezo, Éva Juhász, Gábor Halmos, Szilvia Bosze, József Tóvári and Gábor Mezo
Pubblicato in: International Journal of Molecular Sciences, Numero 25, 2024, Pagina/e 1095, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25021095

Ex vivo mass spectrometry-based biodistribution analysis of an antibody-Resiquimod conjugate bearing a protease-cleavable and acid-labile linker

Autori: Lydia Bisbal Lopez; Domenico Ravazza; Matilde Bocci; Aureliano Zana; Lucrezia Principi; Sheila Dakhel Plaza; Andrea Galbiati; Ettore Gilardoni; Jörg Scheuermann; Dario Neri; Dario Neri; Dario Neri; Luca Pignataro; Cesare Gennari; Samuele Cazzamalli; Alberto Dal Corso
Pubblicato in: Frontiers in Pharmacology, Vol 14 (2023), Numero 4, 2023, Pagina/e 1320524, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2023.1320524

Universal encoding of next generation DNA-encoded chemical libraries

Autori: Louise Plais; Alice Lessing; Michelle Keller; Adriano Martinelli; Sebastian Oehler; Gabriele Bassi; Dario Neri; Jörg Scheuermann
Pubblicato in: Chemical Science, 13 (4), Numero 2, 2022, Pagina/e 967-974, ISSN 2633-0679
Editore: Royal Society of Chemistry
DOI: 10.3929/ethz-b-000526396

Recent Advances and Trends in Chemical CPP–Drug Conjugation Techniques

Autori: Ines Neundorf; Félix Gayraud; Merlin Jan Klußmann
Pubblicato in: Molecules, Numero 26(6), 2021, Pagina/e 1591, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26061591

An ultra-high-affinity small organic ligand of fibroblast activation protein for tumor-targeting applications

Autori: Jacopo Millul; Gabriele Bassi; Jacqueline Mock; Abdullah Elsayed; Christian Pellegrino; Aureliano Zana; Sheila Dakhel Plaza; Lisa Nadal; Andreas Gloger; Eleonore Schmidt; Ilaria Biancofiore; Etienne J. Donckele; Florent Samain; Dario Neri; Samuele Cazzamalli
Pubblicato in: Proc Natl Acad Sci U S A, Numero 118 (16), 2021, Pagina/e e2101852118, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2101852118

SREKA-targeted liposomes for highly metastatic breast cancer therapy

Autori: Balázs Vári, Levente Dókus, Adina Borbély, Anikó Gaál, Diána Vári-Mező, Ivan Ranđelović, Anna Sólyom-Tisza, Zoltán Varga, Norbert Szoboszlai, Gábor Mező, József Tóvári
Pubblicato in: Drug Delivery, Numero Volume 30, 2023 - Numero 1, 2023, Pagina/e 2174210, ISSN 1470-1200
Editore: Taylor & Francis
DOI: 10.1080/10717544.2023.2174210

Fibroblast Activation Protein Triggers Release of Drug Payload from Non-internalizing Small Molecule Drug Conjugates in Solid Tumors

Autori: Aureliano Zana; Andrea Galbiati; Ettore Gilardoni; Matilde Bocci; Jacopo Millul; Theo Sturm; Riccardo Stucchi; Abdullah Elsayed; Lisa Nadal; Martina Cirillo; Wolfgang Roll; Lars Stegger; Inga Asmus; Philipp Backhaus; Michael Schäfers; Dario Neri; Samuele Cazzamalli
Pubblicato in: Clinical Cancer Research, 28 (24), Numero 1, 2022, Pagina/e 5440–5454, ISSN 1557-3265
Editore: American Association for Cancer Research
DOI: 10.1158/1078-0432.ccr-22-1788

Mass Spectrometry-Based Method for the Determination of the Biodistribution of Tumor-Targeting Small Molecule–Metal Conjugates

Autori: Ettore Gilardoni, Aureliano Zana, Andrea Galbiati, Theo Sturm, Jacopo Millul, Samuele Cazzamalli, Dario Neri, and Riccardo Stucchi
Pubblicato in: Anal. Chem., Numero 94, 30, 2022, Pagina/e 10715–10721, ISSN 1520-6882
Editore: American Chemical Society
DOI: 10.1021/acs.analchem.2c01104

Ph.D. Journeys Abroad – And so the Adventure Has Begun …

Autori: Sveva Colombo
Pubblicato in: Chemistry Views, Numero October 4, 2022, 2022, ISSN 2190-3735
Editore: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200083

Ph.D. Journeys Abroad – Be Kind to Yourself

Autori: Daniela Carraturo
Pubblicato in: Chemistry Views, Numero November 1, 2022, 2022, ISSN 2190-3735
Editore: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200094

Ph.D. Journeys Abroad – Creating a Second Home

Autori: Tine Haesen
Pubblicato in: Chemistry Views, Numero December 6, 2022, 2022, ISSN 2190-3735
Editore: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200099

Ph.D. Journeys Abroad – Overcoming Impostor Syndrome: Why Did I Feel Like It Was Just Me?

Autori: Lieke van Gijzel
Pubblicato in: Chemistry Views, Numero January 3, 2023, 2023, ISSN 2190-3735
Editore: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200100

Ph.D. Journeys Abroad – The Challenges of Starting a New Life Far from Home

Autori: Ana Ferrari
Pubblicato in: Chemistry Views, Numero February 7, 2023, 2023, ISSN 2190-3735
Editore: Wiley-VCH GmbH
DOI: 10.1002/chemv.202200101

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