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Validation of a novel class of cyclophilin inhibitors for the treatment of non-alcoholic steatohepatitis

Project description

The first oral drug for a common liver disease may be on the horizon

Non-alcoholic steatohepatitis (NASH), a type of non-alcoholic fatty liver disease, refers to inflammation and damage of the liver caused by a build-up of fat. If NASH gets worse, it can cause scarring of the liver and cirrhosis. Weight loss is recommended in cases of obesity, but there are no medicines to treat it. Cyclophilins are a family of proteins that includes cyclophilin D. Inhibitors of cyclophilin D have been implicated as potential therapeutics but selective, oral agents have been elusive. CYPNASH has discovered a new family of small molecules that inhibit cyclophilins. With expertise in business, pharmaceuticals, and basic research, the team plans to streamline discovery and testing of a suitable NASH therapeutic.

Host institution

THE UNIVERSITY OF EDINBURGH
Net EU contribution
€ 150 000,00
Address
Old College, South Bridge
EH8 9YL Edinburgh
United Kingdom

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Region
Eastern Scotland Edinburgh
Activity type
Higher or Secondary Education Establishments
Other funding
No data

Beneficiaries (1)

THE UNIVERSITY OF EDINBURGH
United Kingdom
Net EU contribution
€ 150 000,00
Address
Old College, South Bridge
EH8 9YL Edinburgh

See on map

Region
Eastern Scotland Edinburgh
Activity type
Higher or Secondary Education Establishments
Other funding
No data