The role of enhancers in the control of transcriptional precision during development
Despite the stochastic nature of transcription, during embryogenesis gene expression are implemented with great spatio-temporal precision. Scientists of the EU-funded PoisedLogic project are working under the hypothesis that a set of conserved cis-regulatory elements known as poised enhancers (PEs) are essential to achieve transcriptional precision, particularly during the establishment of anterior neural identity. PEs display a unique genetic composition since, in addition to clusters of transcription factor binding sites, they also contain CpG islands. These CpG island might confer PE with privileged chromatin, topological and regulatory features that enable the precise induction of the PE target genes. To test these hypotheses, the scientists will use embryonic stem cells as a model system in order to dissect the contribution of the different PE elements in the establishment of gene expression programmes during vertebrate embryogenesis.
Field of science
- /medical and health sciences/medical biotechnology/cells technologies/stem cells
- /natural sciences/biological sciences/biochemistry/biomolecules/proteins
- /medical and health sciences/medical biotechnology/genetic engineering
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