Project description
The role of enhancers in the control of transcriptional precision during development
Despite the stochastic nature of transcription, during embryogenesis gene expression are implemented with great spatio-temporal precision. Scientists of the EU-funded PoisedLogic project are working under the hypothesis that a set of conserved cis-regulatory elements known as poised enhancers (PEs) are essential to achieve transcriptional precision, particularly during the establishment of anterior neural identity. PEs display a unique genetic composition since, in addition to clusters of transcription factor binding sites, they also contain CpG islands. These CpG island might confer PE with privileged chromatin, topological and regulatory features that enable the precise induction of the PE target genes. To test these hypotheses, the scientists will use embryonic stem cells as a model system in order to dissect the contribution of the different PE elements in the establishment of gene expression programmes during vertebrate embryogenesis.
Fields of science
- natural sciencesbiological sciencesgeneticsDNA
- medical and health sciencesmedical biotechnologygenetic engineering
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- natural sciencesbiological sciencesdevelopmental biology
- medical and health sciencesmedical biotechnologycells technologiesstem cells
Programme(s)
Funding Scheme
ERC-COG - Consolidator Grant
Host institution
39005 Santander
Spain
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Beneficiaries (2)
39005 Santander
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
28006 Madrid
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