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Dissecting the regulatory logic of poised enhancers

Project description

The role of enhancers in the control of transcriptional precision during development

Despite the stochastic nature of transcription, during embryogenesis gene expression are implemented with great spatio-temporal precision. Scientists of the EU-funded PoisedLogic project are working under the hypothesis that a set of conserved cis-regulatory elements known as poised enhancers (PEs) are essential to achieve transcriptional precision, particularly during the establishment of anterior neural identity. PEs display a unique genetic composition since, in addition to clusters of transcription factor binding sites, they also contain CpG islands. These CpG island might confer PE with privileged chromatin, topological and regulatory features that enable the precise induction of the PE target genes. To test these hypotheses, the scientists will use embryonic stem cells as a model system in order to dissect the contribution of the different PE elements in the establishment of gene expression programmes during vertebrate embryogenesis.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /medical and health sciences/medical biotechnology/genetic engineering

Call for proposal

ERC-2019-COG
See other projects for this call

Funding Scheme

ERC-COG - Consolidator Grant

Host institution

UNIVERSIDAD DE CANTABRIA
Address
Avenida De Los Castros S/n
39005 Santander
Spain
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 997 662

Beneficiaries (1)

UNIVERSIDAD DE CANTABRIA
Spain
EU contribution
€ 1 997 662
Address
Avenida De Los Castros S/n
39005 Santander
Activity type
Higher or Secondary Education Establishments