Dissecting the regulatory logic of poised enhancers

Project Information

PoisedLogic

Grant agreement ID: 862022

DOI 10.3030/862022

EC signature date 21 April 2020

Start date 1 September 2020

End date 31 August 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 997 662,00

EU contribution € 1 997 662,00

Coordinated by

UNIVERSIDAD DE CANTABRIA
Spain

Publications

Peer reviewed articles (5)

The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo

Author(s): Giuliano Crispatzu, Rizwan Rehimi, Tomas Pachano, Tore Bleckwehl, Sara Cruz-Molina, Cally Xiao , Esther Mahabir, Hisham Bazzi, Alvaro Rada-Iglesias
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24641-4

Protocol to study sufficiency of cis-regulatory elements in mouse embryonic stem cells using a CRISPR-mediated knockin approach

Author(s): Tomas Pachano, Alvaro Rada-Iglesias
Published in: STAR Protocols, 2022, ISSN 2666-1667
Publisher: New York: Cell Press Elsevier Inc.
DOI: 10.1016/j.xpro.2022.101492

Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness

Author(s): Tomas Pachano, Víctor Sánchez-Gaya, Thais Ealo, Maria Mariner-Faulí, Tore Bleckwehl, Helena G Asenjo, Patricia Respuela, Sara Cruz-Molina, María Muñoz-San Martín , Endika Haro, Wilfred F J van IJcken, David Landeira, Alvaro Rada-Iglesias
Published in: Nature Genetics, 2021, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-021-00888-x

Enhancer-associated H3K4 methylation safeguards in vitro germline competence

Author(s): Tore Bleckwehl, Giuliano Crispatzu, Kaitlin Schaaf, Patricia Respuela, Michaela Bartusel, Laura Benson, Stephen J. Clark, Kristel M. Dorighi, Antonio Barral, Magdalena Laugsch, Wilfred F. J. van IJcken, Miguel Manzanares, Joanna Wysocka, Wolf Reik & Álvaro Rada-Iglesias
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26065-6

Enhancer-gene specificity in development and disease.

Author(s): Tomás Pachano , Endika Haro, Alvaro Rada-Iglesias
Published in: Development, 2022, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.186536