Dissecting the regulatory logic of poised enhancers

Project Information

PoisedLogic

Grant agreement ID: 862022

DOI

10.3030/862022

Project closed

EC signature date 21 April 2020

Start date 1 September 2020

End date 31 August 2026

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 997 662,00

EU contribution

€ 1 997 662,00

Coordinated by

UNIVERSIDAD DE CANTABRIA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Thesis and dissertations (3)

Predicción de los mecanismos patogénicos de largo alcance de las variantes estructurales en enfermedades humanas congénitas

Author(s): Sánchez Gaya, Víctor
Published in: reponame:UCrea Repositorio Abierto de la Universidad de Cantabria, Issue 1, 2024
Publisher: UCrea (open repsoitory of the University of Cantabria)

Caracterización genómica y mecanística de la función de ZIC2 durante la inducción neural in vitro

Author(s): María Mariner Faulí
Published in: reponame:UCrea Repositorio Abierto de la Universidad de Cantabria, 2024
Publisher: UCrea (open repository of the University of Cantabria)

Modelización in vitro de la holoprosencefalia relacionada con ZIC2 en humanos revela genes diana sensibles a la dosis de ZIC2

Author(s): Robert, Sarah Malika
Published in: reponame:UCrea Repositorio Abierto de la Universidad de Cantabria, Issue 1, 2025
Publisher: UCrea (open repository of the University of Cantabria)

Other (2)

Synthetic engineering demonstrates that synergy among enhancers involves an increase in transcriptionally productive enhancer-gene contacts

Author(s): Endika Haro, Marianna Iliadou, Shyam Ramasamy, Thais Ealo, Victor M. Campa, Tomas Pachano, A. Marieke Oudelaar, Alvaro Rada-Iglesias
Published in: bioRxiv, 2026
Publisher: openRxiv
DOI: 10.1101/2025.08.08.669284

MLL2 facilitates long-range gene regulation through LINE1 elements

Author(s): Lara Zorro Shahidian, Lucio Di Filippo, Sarah Malika Robert, Alvaro Rada-Iglesias
Published in: bioRxiv, 2026
Publisher: openRxiv
DOI: 10.1101/2025.08.10.669526

Peer reviewed articles (8)

Changes in PRC1 activity during interphase modulate lineage transition in pluripotent cells

Author(s): Helena G. Asenjo, María Alcazar-Fabra, Mencía Espinosa-Martínez, Lourdes Lopez-Onieva, Amador Gallardo, Emilia Dimitrova, Angelika Feldmann, Tomas Pachano, Jordi Martorell-Marugán, Pedro Carmona-Sáez, Antonio Sanchez-Pozo, Álvaro Rada-Iglesias, Robert J. Klose, David Landeira
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-35859-9

POSTRE: a tool to predict the pathological effects of human structural variants

Author(s): Víctor Sánchez-Gaya, Álvaro Rada-Iglesias
Published in: Nucleic Acids Research, 2026, ISSN 1362-4962
Publisher: Oxford University Press
DOI: 10.1101/2022.06.20.496902

The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo

Author(s): Giuliano Crispatzu, Rizwan Rehimi, Tomas Pachano, Tore Bleckwehl, Sara Cruz-Molina, Cally Xiao , Esther Mahabir, Hisham Bazzi, Alvaro Rada-Iglesias
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24641-4

Protocol to study sufficiency of cis-regulatory elements in mouse embryonic stem cells using a CRISPR-mediated knockin approach

Author(s): Tomas Pachano, Alvaro Rada-Iglesias
Published in: STAR Protocols, 2022, ISSN 2666-1667
Publisher: New York: Cell Press Elsevier Inc.
DOI: 10.1016/j.xpro.2022.101492

Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness

Author(s): Tomas Pachano, Víctor Sánchez-Gaya, Thais Ealo, Maria Mariner-Faulí, Tore Bleckwehl, Helena G Asenjo, Patricia Respuela, Sara Cruz-Molina, María Muñoz-San Martín , Endika Haro, Wilfred F J van IJcken, David Landeira, Alvaro Rada-Iglesias
Published in: Nature Genetics, 2021, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-021-00888-x

Enhancer-associated H3K4 methylation safeguards in vitro germline competence

Author(s): Tore Bleckwehl, Giuliano Crispatzu, Kaitlin Schaaf, Patricia Respuela, Michaela Bartusel, Laura Benson, Stephen J. Clark, Kristel M. Dorighi, Antonio Barral, Magdalena Laugsch, Wilfred F. J. van IJcken, Miguel Manzanares, Joanna Wysocka, Wolf Reik & Álvaro Rada-Iglesias
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26065-6

Enhancer-gene specificity in development and disease.

Author(s): Tomás Pachano , Endika Haro, Alvaro Rada-Iglesias
Published in: Development, 2022, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.186536

Cooperative insulation of regulatory domains by CTCF-dependent physical insulation and promoter competition

Author(s): Thais Ealo, Victor Sanchez-Gaya, Patricia Respuela, María Muñoz-San Martín, Elva Martin-Batista, Endika Haro, Alvaro Rada-Iglesias
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-51602-4