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Dissecting the regulatory logic of poised enhancers

Publications

The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo

Author(s): Giuliano Crispatzu, Rizwan Rehimi, Tomas Pachano, Tore Bleckwehl, Sara Cruz-Molina, Cally Xiao , Esther Mahabir, Hisham Bazzi, Alvaro Rada-Iglesias
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24641-4

Protocol to study sufficiency of cis-regulatory elements in mouse embryonic stem cells using a CRISPR-mediated knockin approach

Author(s): Tomas Pachano, Alvaro Rada-Iglesias
Published in: STAR Protocols, 2022, ISSN 2666-1667
Publisher: New York: Cell Press Elsevier Inc.
DOI: 10.1016/j.xpro.2022.101492

Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness

Author(s): Tomas Pachano, Víctor Sánchez-Gaya, Thais Ealo, Maria Mariner-Faulí, Tore Bleckwehl, Helena G Asenjo, Patricia Respuela, Sara Cruz-Molina, María Muñoz-San Martín , Endika Haro, Wilfred F J van IJcken, David Landeira, Alvaro Rada-Iglesias
Published in: Nature Genetics, 2021, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-021-00888-x

Enhancer-associated H3K4 methylation safeguards in vitro germline competence

Author(s): Tore Bleckwehl, Giuliano Crispatzu, Kaitlin Schaaf, Patricia Respuela, Michaela Bartusel, Laura Benson, Stephen J. Clark, Kristel M. Dorighi, Antonio Barral, Magdalena Laugsch, Wilfred F. J. van IJcken, Miguel Manzanares, Joanna Wysocka, Wolf Reik & Álvaro Rada-Iglesias
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-26065-6

Enhancer-gene specificity in development and disease.

Author(s): Tomás Pachano , Endika Haro, Alvaro Rada-Iglesias
Published in: Development, 2022, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.186536

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