Description du projet
Rendre l’analyse des nanosuspensions plus rapide et plus abordable
Les nanosuspensions sont un type de matériau que l’on trouve partout, des produits pharmaceutiques, des encres et des peintures aux matériaux pour la catalyse, les batteries et la fabrication de verre. La mesure précise des nanoparticules dispersées est essentielle pour mettre au point des processus efficaces de fabrication et, au final, pour produire des matériaux performants. Le projet PAT4Nano, financé par l’UE, entend développer des outils permettant de mesurer de manière continue, rapide et fiable les nanoparticules afin de parvenir à une fabrication plus efficace, précise et abordable des nanomatériaux. De nouvelles technologies d’analyse des processus destinés à la mesure et l’analyse en ligne de nanoparticules pertinentes pour l’industrie devraient améliorer la fiabilité et la répétabilité de la production de nanoparticules et permettraient d’économiser 3,2 millions d’EUR dans la production par produit pharmaceutique.
Objectif
PAT4Nano offers an integrated, end user-driven, approach to develop and deploy different, yet complementary particle size measurement technologies for in- and online real-time monitoring. These will quantify particle size distribution and chemical composition in nanosuspensions. With the consortium end user partners (Agfa-Gevaert, Janssen Pharmaceutica, and Johnson Matthey), PAT4Nano will focus on applications in pharmaceuticals, inks/pigments, and materials for catalysis, batteries, and glass manufacture. Continuous, rapid, and reliable real-time data from PAT4Nano tools will provide more comprehensive process information than current offline measurements enabling manufacturers to obtain insights into the fundamental dynamics of nanoparticle-based processes. Furthermore, this information can enable continuous process feedback, opening new opportunities to implement real-time process control and feed-forward loops to correct for process variances, leading to better end product consistency and higher process efficiencies. Multi-PAT solutions, where several complementary measurement methods are combined, together with advanced data processing, will further enhance capability by increasing the information that can be extracted from measurements, extending the application range further. PAT4Nano solutions will improve process control and efficiency, and the quality of nanosuspension products. The increased quantity and quality of the real-time data will enhance the efficiency and quality of nanomaterial production. Increased reliability and repeatability will result in more efficient R&D which can produce savings of €3.2M per nanomaterial pharmaceutical product development, for advanced materials it could bring annual savings of >€3M and help advance sustainability, while for Agfa the PAT4nano tools can facilitate new business opportunities leading to local investments (mostly employment) of ~€15 M within 10 years.
Champ scientifique
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs
- engineering and technologymaterials engineering
- natural scienceschemical sciencescatalysis
- engineering and technologynanotechnologynano-materials
- natural sciencescomputer and information sciencesdata sciencedata processing
Programme(s)
Régime de financement
RIA - Research and Innovation actionCoordinateur
2595 DA Den Haag
Pays-Bas