Descripción del proyecto
Una plataforma proteómica rápida, barata y efectiva podría transformar la medicina personalizada
El genoma incluye todos nuestros genes, que son las instrucciones para la síntesis de todas las proteínas que hace nuestro cuerpo (el proteoma) para que realicen multitud de funciones. El genoma humano codifica cerca de 20 000 proteínas diferentes, pero las variaciones en el corte pueden ampliar inmensamente este número. Al ser tan omnipresentes y tener un papel crítico en las enfermedades, las proteínas e incluso los trozos de ellas (los péptidos) son biomarcadores importantes de las enfermedades, así como dianas terapéuticas. La proteómica tiene un enorme potencial para la medicina personalizada, pero se enfrenta a retos en cuanto a la variedad de dianas y, en consecuencia, a la especificidad, la sensibilidad, el rendimiento y el coste. ElectroMed crea una plataforma que podría superar todos estos problemas y ofrece un salto cualitativo en materia de proteómica para la medicina personalizada y mucho más.
Objetivo
The uptake of proteomics for precision or personalised medicine applications requires the development of an effective screening instrument capable of detecting proteins at the low concentrations they are found in biological conditions while addressing their large chemical variability.
The ElectroMed project's objective is to build and validate a proof-of-concept prototype of a programmable high-throughput peptide microarray technology. It is based on the radical vision of integrating electrochemical synthesis of peptide bioreceptors to enable programmable in situ protein detection with nano-functionalised FinFET sensors for high-performance data acquisition within a microfluidic-driven multiplexed platform for parallel screening.
The project will undertake the research and innovation work required to 1) demonstrate multiplexed electrochemical peptide synthesis (EPS), 2) develop new FinFET sensors and 3) integrate EPS and the FinFET sensors in a single cost-effective prototype that we will validate in laboratory-relevant conditions.
The ElectroMed project will achieve a technology breakthrough of the first fully-programmable in situ protein screening instrument. This prototype small-size single instrument will come as a faster, cheaper, and more efficient technology than current protein screening instruments. The potential impact is to significantly ease and reduce the price of protein screening to trigger an uptake of protein detection in healthcare (our primary focus) as well as in the food sector (food authenticity and traceability, allergens, GMOs or toxins detection all along food the value chain), environmental remediation or defense (detection of biological warfare agents).
Electromed has also engaged to investigate COVID19 related peptide biomarkers and technology for the diagnosis of the infection and the relevant peptide protein iterations.
Ámbito científico
- natural scienceschemical scienceselectrochemistry
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors
- medical and health scienceshealth sciencespersonalized medicine
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-FETOPEN-2018-2019-2020-01
Régimen de financiación
RIA - Research and Innovation actionCoordinador
4362 Esch Sur Alzette
Luxemburgo