Descrizione del progetto
Una piattaforma proteomica veloce, economica ed efficace potrebbe trasformare la medicina personalizzata
Il genoma comprende tutti i nostri geni e i nostri geni sono le istruzioni per la sintesi di tutte le proteine che il nostro corpo produce (proteoma) per svolgere la sua miriade di funzioni. Il genoma umano codifica per circa 20 000 proteine diverse ma variazioni nello splicing possono amplificare enormemente quel numero. Dal momento che sono onnipresenti e svolgono un ruolo fondamentale nella malattia, le proteine, come anche i loro frammenti (peptidi), rappresentano importanti biomarcatori e bersagli terapeutici di una malattia. La proteomica ha un enorme potenziale per la medicina personalizzata, ma deve affrontare sfide in termini di varietà di obiettivi e conseguenti specificità, sensibilità, produttività e costi. ElectroMed sta costruendo una piattaforma in grado di superare questi problemi, garantendo un gigantesco passo in avanti nella proteomica per la medicina personalizzata e molto altro.
Obiettivo
The uptake of proteomics for precision or personalised medicine applications requires the development of an effective screening instrument capable of detecting proteins at the low concentrations they are found in biological conditions while addressing their large chemical variability.
The ElectroMed project's objective is to build and validate a proof-of-concept prototype of a programmable high-throughput peptide microarray technology. It is based on the radical vision of integrating electrochemical synthesis of peptide bioreceptors to enable programmable in situ protein detection with nano-functionalised FinFET sensors for high-performance data acquisition within a microfluidic-driven multiplexed platform for parallel screening.
The project will undertake the research and innovation work required to 1) demonstrate multiplexed electrochemical peptide synthesis (EPS), 2) develop new FinFET sensors and 3) integrate EPS and the FinFET sensors in a single cost-effective prototype that we will validate in laboratory-relevant conditions.
The ElectroMed project will achieve a technology breakthrough of the first fully-programmable in situ protein screening instrument. This prototype small-size single instrument will come as a faster, cheaper, and more efficient technology than current protein screening instruments. The potential impact is to significantly ease and reduce the price of protein screening to trigger an uptake of protein detection in healthcare (our primary focus) as well as in the food sector (food authenticity and traceability, allergens, GMOs or toxins detection all along food the value chain), environmental remediation or defense (detection of biological warfare agents).
Electromed has also engaged to investigate COVID19 related peptide biomarkers and technology for the diagnosis of the infection and the relevant peptide protein iterations.
Campo scientifico
- natural scienceschemical scienceselectrochemistry
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors
- medical and health scienceshealth sciencespersonalized medicine
Parole chiave
Programma(i)
Invito a presentare proposte
Vedi altri progetti per questo bandoBando secondario
H2020-FETOPEN-2018-2019-2020-01
Meccanismo di finanziamento
RIA - Research and Innovation actionCoordinatore
4362 Esch Sur Alzette
Lussemburgo