Objective
The Snail gene family of transcription factors plays important roles during embryonic development in processes that imply profound cell movements. These functions are essentially mediated by the triggering of the epithelial-mesenchymal transition (EMT), a phenotypic change that renders epithelial cells migratory and invasive. EMT is also a well-known process that occurs in the acquisition of invasive and migratory properties during tumour progression. Indeed, Snail genes have been coopted for the acquisition of malignant properties in epithelial tumours. It is well known that EMT can be triggered by different growth factors, including FGF, TGF-beta, HGF, etc. and recent results from several laboratories including the host lab indicate that all of them induce Snail expression concomitant with the induction of EMT. Thus, Snail may be a point of convergence of the signalling pathways triggered by these growth factors, and thus, located at the crossroads of the EMT.
Interestingly, unpublished data from the host l ab indicate that Snail also protects from cell death, leading to the idea that the process of EMT may be associated to cell survival through Snail. This link is of high interest due to the fact that tumour cells are indeed more resistant to cell death than their normal counterparts. The aim of my postdoctoral period in the team of Angela Nieto is to check the hypothesis of Snail being a central point during the triggering of EMT both in physiology and pathology. I will take advantage of my previous knowledge in Cell Biology and in the culture of cells and organs and particularly, of my background in the analysis of cell death both in vitro and in vivo. In addition to analyse the effects of growth factors on epithelial cells regarding the induction of EMT and Snail, I will use different cell lines with constitutive or inducible Snail expression, RNA interference strategies and a mouse transgenic model generated in the host lab with inducible Snail expression.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology
- natural sciences biological sciences developmental biology
- medical and health sciences basic medicine pathology
- medical and health sciences basic medicine physiology
- natural sciences biological sciences genetics RNA
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.