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BENCHTOP NMR FOR LAB-ON-CHIP

Project description

Advanced imaging will visualise metabolism in action in miniature organ systems

Dynamic nuclear polarisation (DNP) of labelled metabolites is a process that dramatically enhances signal detection with magnetic resonance (MR) spectroscopy. Not only does this amplify the amount of information one can obtain but it can also significantly reduce the time to do so. DNP-MR is gaining attention for use in biomolecular research, material science, and pharmaceuticals, and recently was used to enable non-invasive assessment of metabolism in vivo and in real time in humans. The EU-funded BLOC project is now applying cutting-edge DNP-MR technology to organ-on-a-chip (OOC) devices. Even better, the researchers plan to use the technology to evaluate a biomimetic multi-organ system critical to whole-body metabolism, liver spheroids and pancreatic islets.

Field of science

  • /engineering and technology/other engineering and technologies/microtechnology/organ on a chip

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
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Funding Scheme

RIA - Research and Innovation action

Coordinator

FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Address
Carrer Baldiri Reixac Planta 2A 10-12
08028 Barcelona
Spain
Activity type
Research Organisations
EU contribution
€ 985 808,75

Participants (3)

OXFORD INSTRUMENTS INDUSTRIAL PRODUCTS LIMITED
United Kingdom
EU contribution
€ 575 000
Address
Tubney Woods
OX13 5QX Abingdon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MULTIWAVE TECHNOLOGIES AG
Switzerland
EU contribution
€ 901 646,25
Address
3 Chemin Du Pre Fleuri
1228 Geneva
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
EU contribution
€ 449 325
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Activity type
Other