Project description
Advanced imaging will visualise metabolism in action in miniature organ systems
Dynamic nuclear polarisation (DNP) of labelled metabolites is a process that dramatically enhances signal detection with magnetic resonance (MR) spectroscopy. Not only does this amplify the amount of information one can obtain but it can also significantly reduce the time to do so. DNP-MR is gaining attention for use in biomolecular research, material science, and pharmaceuticals, and recently was used to enable non-invasive assessment of metabolism in vivo and in real time in humans. The EU-funded BLOC project is now applying cutting-edge DNP-MR technology to organ-on-a-chip (OOC) devices. Even better, the researchers plan to use the technology to evaluate a biomimetic multi-organ system critical to whole-body metabolism, liver spheroids and pancreatic islets.
Field of science
- /engineering and technology/other engineering and technologies/microtechnology/organ on a chip
Programme(s)
Call for proposal
H2020-FETOPEN-2018-2019-2020-01
See other projects for this call
Funding Scheme
RIA - Research and Innovation actionCoordinator
08028 Barcelona
Spain
Participants (3)
OX13 5QX Abingdon
1228 Geneva
08036 Barcelona
