Advanced imaging will visualise metabolism in action in miniature organ systems
Dynamic nuclear polarisation (DNP) of labelled metabolites is a process that dramatically enhances signal detection with magnetic resonance (MR) spectroscopy. Not only does this amplify the amount of information one can obtain but it can also significantly reduce the time to do so. DNP-MR is gaining attention for use in biomolecular research, material science, and pharmaceuticals, and recently was used to enable non-invasive assessment of metabolism in vivo and in real time in humans. The EU-funded BLOC project is now applying cutting-edge DNP-MR technology to organ-on-a-chip (OOC) devices. Even better, the researchers plan to use the technology to evaluate a biomimetic multi-organ system critical to whole-body metabolism, liver spheroids and pancreatic islets.
Field of science
- /engineering and technology/other engineering and technologies/microtechnology/organ on a chip
Call for proposal
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Funding SchemeRIA - Research and Innovation action
OX13 5QX Abingdon