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BENCHTOP NMR FOR LAB-ON-CHIP

Project description

Advanced imaging will visualise metabolism in action in miniature organ systems

Dynamic nuclear polarisation (DNP) of labelled metabolites is a process that dramatically enhances signal detection with magnetic resonance (MR) spectroscopy. Not only does this amplify the amount of information one can obtain but it can also significantly reduce the time to do so. DNP-MR is gaining attention for use in biomolecular research, material science, and pharmaceuticals, and recently was used to enable non-invasive assessment of metabolism in vivo and in real time in humans. The EU-funded BLOC project is now applying cutting-edge DNP-MR technology to organ-on-a-chip (OOC) devices. Even better, the researchers plan to use the technology to evaluate a biomimetic multi-organ system critical to whole-body metabolism, liver spheroids and pancreatic islets.

Objective

Organ-on-a-chip (OOC) devices offer new approaches to metabolic disease modelling and drug discovery by providing biologically relevant models of tissues and organs in vitro integrated with sensing technology. As such, OOC devices have the potential to revolutionise the pharmaceutical industry by enabling reliable and high predictive in vitro testing of drug candidates. The capability to miniaturise microfluidic systems and advanced tissue fabrication procedures have enabled researchers to create multiple tissues on a chip with a high degree of control over experimental variables for high-content screening applications. The objective of this project is to develop a new technology based on magnetic resonance spectroscopy and imaging using dynamic nuclear polarisation (DNP-MR) integrated with OOC devices to monitor disease and evaluate drug response in OOC models. As a proof-of-concept, this project will fabricate a biomimetic multi OOC integrated device composed of liver spheroids and pancreatic islets and develop the necessary DNP-MR hardware and software to study metabolic diseases and for future drug screening applications.

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Topic(s)

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RIA - Research and Innovation action

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Call for proposal

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(opens in new window) H2020-FETOPEN-2018-2020

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Coordinator

FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 116 208,75
Address
CARRER BALDIRI REIXAC PLANTA 2A 10-12
08028 Barcelona
Spain

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Links
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 1 116 208,75

Participants (4)

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