Project description DEENESFRITPL Advanced imaging will visualise metabolism in action in miniature organ systems Dynamic nuclear polarisation (DNP) of labelled metabolites is a process that dramatically enhances signal detection with magnetic resonance (MR) spectroscopy. Not only does this amplify the amount of information one can obtain but it can also significantly reduce the time to do so. DNP-MR is gaining attention for use in biomolecular research, material science, and pharmaceuticals, and recently was used to enable non-invasive assessment of metabolism in vivo and in real time in humans. The EU-funded BLOC project is now applying cutting-edge DNP-MR technology to organ-on-a-chip (OOC) devices. Even better, the researchers plan to use the technology to evaluate a biomimetic multi-organ system critical to whole-body metabolism, liver spheroids and pancreatic islets. Show the project objective Hide the project objective Objective Organ-on-a-chip (OOC) devices offer new approaches to metabolic disease modelling and drug discovery by providing biologically relevant models of tissues and organs in vitro integrated with sensing technology. As such, OOC devices have the potential to revolutionise the pharmaceutical industry by enabling reliable and high predictive in vitro testing of drug candidates. The capability to miniaturise microfluidic systems and advanced tissue fabrication procedures have enabled researchers to create multiple tissues on a chip with a high degree of control over experimental variables for high-content screening applications. The objective of this project is to develop a new technology based on magnetic resonance spectroscopy and imaging using dynamic nuclear polarisation (DNP-MR) integrated with OOC devices to monitor disease and evaluate drug response in OOC models. As a proof-of-concept, this project will fabricate a biomimetic multi OOC integrated device composed of liver spheroids and pancreatic islets and develop the necessary DNP-MR hardware and software to study metabolic diseases and for future drug screening applications. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencescomputer and information sciencessoftwareengineering and technologyother engineering and technologiesmicrotechnologylab on a chipengineering and technologyother engineering and technologiesmicrotechnologyorgan on a chipnatural sciencesphysical sciencesopticsspectroscopy Keywords hyperpolarisation microfluidics organs-on-a-chip radiofrequency engineering magnetic resonance spectroscopy (MRS) Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Topic(s) FETOPEN-01-2018-2019-2020 - FET-Open Challenging Current Thinking Call for proposal H2020-FETOPEN-2018-2020 See other projects for this call Sub call H2020-FETOPEN-2018-2019-2020-01 Funding Scheme RIA - Research and Innovation action Coordinator FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA Net EU contribution € 1 116 208,75 Address CARRER BALDIRI REIXAC PLANTA 2A 10-12 08028 Barcelona Spain See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 116 208,75 Participants (4) Sort alphabetically Sort by Net EU contribution Expand all Collapse all OXFORD INSTRUMENTS INDUSTRIAL PRODUCTS LIMITED United Kingdom Net EU contribution € 404 601,25 Address TUBNEY WOODS OX13 5QX Abingdon See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 404 601,25 MULTIWAVE TECHNOLOGIES AG Switzerland Net EU contribution € 472 625,00 Address 34 ROUTE DE LA GALAISE 1228 Plan-Les-Ouates See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 901 646,25 Third-party Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure. MULTIWAVE TECHNOLOGIES France Net EU contribution € 429 021,25 Address 2 MARC DONADILLE HOTEL TECHNOPTIC 13453 Marseille See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 429 021,25 FUNDACIO DE RECERCA CLINIC BARCELONA-INSTITUT D INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Spain Net EU contribution € 489 323,75 Address CARRER ROSSELLO 149 08036 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 489 323,75