Deciphering the principles governing robust targeting of proteins to organelles

Project Information

OnTarget

Grant agreement ID: 864068

DOI

10.3030/864068

Project closed

EC signature date 12 December 2019

Start date 1 September 2020

End date 31 August 2025

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (19)

A Similarity-Based Method for Predicting Enzymatic Functions in Yeast Uncovers a New AMP Hydrolase

Author(s): Nir Cohen Amit Kahana MayaSchuldiner
Published in: Journal of Molecular Biology, 2022, Page(s) 167478, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2022.167478

Pls1 Is a Peroxisomal Matrix Protein with a Role in Regulating Lysine Biosynthesis

Author(s): Yotam David; Inês Gomes Castro; Eden Yifrach; Chen Bibi; Enas Katawi; Dekel Yahav Har-Shai; Sagie Brodsky; Naama Barkai; Tommer Ravid; Miriam Eisenstein; Shmuel Pietrokovski; Maya Schuldiner; Einat Zalckvar
Published in: Cells; Volume 11; Issue 9; Pages: 1426, Issue 1, 2022, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells11091426

ER-SURF: Riding the Endoplasmic Reticulum Surface to Mitochondria

Author(s): Christian Koch; Maya Schuldiner; Johannes Herrmann
Published in: International Journal of Molecular Sciences, 2021, Page(s) 9655, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22179655

Beyond rare disorders: A new era for peroxisomal pathophysiology

Author(s): Einat Zalckvar; Maya Schuldiner
Published in: Molecular Cell, Issue 1, 2022, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2022.05.028

Phosphorylation of the receptor protein Pex5p modulates import of proteins into peroxisomes

Author(s): Sven Fischer, Jérôme Bürgi, Shiran Gabay-Maskit, Renate Maier, Thomas Mastalski, Eden Yifrach, Agnieszka Obarska-Kosinska, Markus Rudowitz, Ralf Erdmann, Harald W Platta, Matthias Wilmanns, Maya Schuldiner, Einat Zalckvar, Silke Oeljeklaus, Friedel Drepper, Bettina Warscheid
Published in: Biological Chemistry, 2022, ISSN 1431-6730
Publisher: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/hsz-2022-0168

An avoidance segment resolves a lethal nuclear–mitochondrial targeting conflict during ribosome assembly

Author(s): Michaela Oborská-Oplová, Alexander Gregor Geiger, Erich Michel, Purnima Klingauf-Nerurkar, Sven Dennerlein, Yury S. Bykov, Simona Amodeo, André Schneider, Maya Schuldiner, Peter Rehling, Vikram Govind Panse
Published in: Nature Cell Biology, Issue 27, 2025, Page(s) 336-346, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-024-01588-4

Systematic Approaches to Study Eclipsed Targeting of Proteins Uncover a New Family of Mitochondrial Proteins

Author(s): Mark M, Klein O, Zhang Y, Das K, Elbaz A, Hazan RN, Lichtenstein M, Lehming N, Schuldiner M, Pines O
Published in: Cells, Issue 12(11), 2023, Page(s) 1550, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells12111550

Peroxisome function relies on organelle-associated mRNA translation

Author(s): Noa Dahan, Yury S Bykov, Elizabeth A Boydston, Amir Fadel, Zohar Gazi, Hodaya Hochberg-Laufer, James Martenson, Vlad Denic, Yaron Shav-Tal , Jonathan S Weissman, Naama Aviram, Einat Zalckvar, Maya Schuldiner
Published in: Science Advances, 2022, Page(s) eabk2141, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.abk2141

Sec61 channel subunit Sbh1/Sec61β promotes ER translocation of proteins with suboptimal targeting sequences and is fine-tuned by phosphorylation

Author(s): Guido Barbieri, Julien Simon, Cristina R Lupusella, Fabio Pereira, Francesco Elia, Hadar Meyer, Maya Schuldiner, Steven D Hanes, Duy Nguyen, Volkhard Helms, Karin Römisch
Published in: Journal of Biological Chemistry, 2023, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2023.102895

Mpf1 affects the dual distribution of tail-anchored proteins between mitochondria and peroxisomes

Author(s): Nitya Aravindan, Daniela G Vitali, Julia Breuer, Jessica Oberst, Einat Zalckvar, Maya Schuldiner, Doron Rapaport
Published in: EMBO Reports, 2025, ISSN 1469-3178
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s44319-025-00440-6

A toolbox for systematic discovery of stable and transient protein interactors in baker's yeast

Author(s): Nir Cohen; Zohar Gazi; Emma Fenech; Meital Kupervaser; Maya Schuldiner
Published in: Molecular Systems Biology, Issue 1, 2023, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.15252/msb.202211084

Novel targeting assay uncovers targeting information within peroxisomal ABC transporter Pxa1

Author(s): Renate L.M. Jansen, Marco van den Noort, Arjen M. Krikken, Chen Bibi, Astrid Böhm, Maya Schuldiner, Einat Zalckvar, Ida J. van der Klei
Published in: BBA- Molecular Cell Research, 2023, ISSN 0167-4889
Publisher: Elsevier BV
DOI: 10.1016/j.bbamcr.2023.119471

Determining the targeting specificity of the selective peroxisomal targeting factor Pex9

Author(s): Eden Yifrach, Markus Rudowitz, Luis Daniel Cruz-Zaragoza, Asa Tirosh, Zohar Gazi, Yoav Peleg, Markus Kunze, Miriam Eisenstein, Wolfgang Schliebs, Maya Schuldiner, Ralf Erdmann, Einat Zalckvar
Published in: Biological Chemistry, 2022, ISSN 1431-6730
Publisher: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/hsz-2022-0116

Widespread use of unconventional targeting signals in mitochondrial ribosome proteins.

Author(s): Yury S. Bykov; Tamara Flohr; Felix Boos; Naama Zung; Johannes M. Herrmann; Maya Schuldiner
Published in: The EMBO Journal, Issue 1, 2022, Page(s) e109519, ISSN 1460-2075
Publisher: EMBO Press
DOI: 10.15252/embj.2021109519

Proteins that carry dual targeting signals can act as tethers between peroxisomes and partner organelles

Author(s): Elena Bittner, Thorsten Stehlik, Jason Lam, Lazar Dimitrov, Thomas Heimerl, Isabelle Schöck, Jannik Harberding, Anita Dornes, Nikola Heymons, Gert Bange, Maya Schuldiner, Einat Zalckvar, Michael Bölker, Randy Schekman, Johannes Freitag
Published in: PLOS Biology, Issue 22, 2024, Page(s) e3002508, ISSN 1545-7885
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/journal.pbio.3002508

A systematic proximity ligation approach to studying protein-substrate specificity identifies the substrate spectrum of the Ssh1 translocon

Author(s): Nir Cohen, Naama Aviram, Maya Schuldiner
Published in: EMBO Journal, 2023, ISSN 1460-2075
Publisher: EMBO Press
DOI: 10.15252/embj.2022113385

The Fast and the Furious: Golgi Contact Sites

Author(s): Yotam David, Ines Castro, Maya Schuldiner
Published in: Contact, 2021, Page(s) 1-15, ISSN 2515-2564
Publisher: SAGE publishing
DOI: 10.1177/25152564211034424

Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions

Author(s): Eden Yifrach, Duncan Holbrook-Smith, Jérôme Bürgi, Alaa Othman, Miriam Eisenstein, Carlo Wt van Roermund, Wouter Visser, Asa Tirosh, Markus Rudowitz, Chen Bibi, Shahar Galor, Uri Weill, Amir Fadel, Yoav Peleg, Ralf Erdmann, Hans R Waterham, Ronald J A Wanders, Matthias Wilmanns, Nicola Zamboni, Maya Schuldiner, Einat Zalckvar
Published in: Molecular Systems Biology, 2022, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.15252/msb.202211186

A proteome-wide yeast degron collection for the dynamic study of protein function

Author(s): Rosario Valenti, Yotam David, Dunya Edilbi, Benjamin Dubreuil, Angela Boshnakovska, Yeynit Asraf, Tomer-Meir Salame, Ehud Sass, Peter Rehling, Maya Schuldiner
Published in: Journal of Cell Biology, Issue 224, 2024, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202409050