Deciphering the principles governing robust targeting of proteins to organelles

Informazioni relative al progetto

OnTarget

ID dell’accordo di sovvenzione: 864068

DOI

10.3030/864068

Progetto chiuso

Data della firma CE 12 Dicembre 2019

Data di avvio 1 Settembre 2020

Data di completamento 31 Agosto 2025

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale

€ 2 000 000,00

Contributo UE

€ 2 000 000,00

Coordinato da

WEIZMANN INSTITUTE OF SCIENCE
Israel

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (19)

A Similarity-Based Method for Predicting Enzymatic Functions in Yeast Uncovers a New AMP Hydrolase

Autori: Nir Cohen Amit Kahana MayaSchuldiner
Pubblicato in: Journal of Molecular Biology, 2022, Pagina/e 167478, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2022.167478

Pls1 Is a Peroxisomal Matrix Protein with a Role in Regulating Lysine Biosynthesis

Autori: Yotam David; Inês Gomes Castro; Eden Yifrach; Chen Bibi; Enas Katawi; Dekel Yahav Har-Shai; Sagie Brodsky; Naama Barkai; Tommer Ravid; Miriam Eisenstein; Shmuel Pietrokovski; Maya Schuldiner; Einat Zalckvar
Pubblicato in: Cells; Volume 11; Numero 9; Pages: 1426, Numero 1, 2022, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells11091426

ER-SURF: Riding the Endoplasmic Reticulum Surface to Mitochondria

Autori: Christian Koch; Maya Schuldiner; Johannes Herrmann
Pubblicato in: International Journal of Molecular Sciences, 2021, Pagina/e 9655, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22179655

Beyond rare disorders: A new era for peroxisomal pathophysiology

Autori: Einat Zalckvar; Maya Schuldiner
Pubblicato in: Molecular Cell, Numero 1, 2022, ISSN 1097-2765
Editore: Cell Press
DOI: 10.1016/j.molcel.2022.05.028

Phosphorylation of the receptor protein Pex5p modulates import of proteins into peroxisomes

Autori: Sven Fischer, Jérôme Bürgi, Shiran Gabay-Maskit, Renate Maier, Thomas Mastalski, Eden Yifrach, Agnieszka Obarska-Kosinska, Markus Rudowitz, Ralf Erdmann, Harald W Platta, Matthias Wilmanns, Maya Schuldiner, Einat Zalckvar, Silke Oeljeklaus, Friedel Drepper, Bettina Warscheid
Pubblicato in: Biological Chemistry, 2022, ISSN 1431-6730
Editore: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/hsz-2022-0168

An avoidance segment resolves a lethal nuclear–mitochondrial targeting conflict during ribosome assembly

Autori: Michaela Oborská-Oplová, Alexander Gregor Geiger, Erich Michel, Purnima Klingauf-Nerurkar, Sven Dennerlein, Yury S. Bykov, Simona Amodeo, André Schneider, Maya Schuldiner, Peter Rehling, Vikram Govind Panse
Pubblicato in: Nature Cell Biology, Numero 27, 2025, Pagina/e 336-346, ISSN 1465-7392
Editore: Nature Publishing Group
DOI: 10.1038/s41556-024-01588-4

Systematic Approaches to Study Eclipsed Targeting of Proteins Uncover a New Family of Mitochondrial Proteins

Autori: Mark M, Klein O, Zhang Y, Das K, Elbaz A, Hazan RN, Lichtenstein M, Lehming N, Schuldiner M, Pines O
Pubblicato in: Cells, Numero 12(11), 2023, Pagina/e 1550, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells12111550

Peroxisome function relies on organelle-associated mRNA translation

Autori: Noa Dahan, Yury S Bykov, Elizabeth A Boydston, Amir Fadel, Zohar Gazi, Hodaya Hochberg-Laufer, James Martenson, Vlad Denic, Yaron Shav-Tal , Jonathan S Weissman, Naama Aviram, Einat Zalckvar, Maya Schuldiner
Pubblicato in: Science Advances, 2022, Pagina/e eabk2141, ISSN 2375-2548
Editore: AAAS
DOI: 10.1126/sciadv.abk2141

Sec61 channel subunit Sbh1/Sec61β promotes ER translocation of proteins with suboptimal targeting sequences and is fine-tuned by phosphorylation

Autori: Guido Barbieri, Julien Simon, Cristina R Lupusella, Fabio Pereira, Francesco Elia, Hadar Meyer, Maya Schuldiner, Steven D Hanes, Duy Nguyen, Volkhard Helms, Karin Römisch
Pubblicato in: Journal of Biological Chemistry, 2023, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2023.102895

Mpf1 affects the dual distribution of tail-anchored proteins between mitochondria and peroxisomes

Autori: Nitya Aravindan, Daniela G Vitali, Julia Breuer, Jessica Oberst, Einat Zalckvar, Maya Schuldiner, Doron Rapaport
Pubblicato in: EMBO Reports, 2025, ISSN 1469-3178
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s44319-025-00440-6

A toolbox for systematic discovery of stable and transient protein interactors in baker's yeast

Autori: Nir Cohen; Zohar Gazi; Emma Fenech; Meital Kupervaser; Maya Schuldiner
Pubblicato in: Molecular Systems Biology, Numero 1, 2023, ISSN 1744-4292
Editore: Nature Publishing Group
DOI: 10.15252/msb.202211084

Novel targeting assay uncovers targeting information within peroxisomal ABC transporter Pxa1

Autori: Renate L.M. Jansen, Marco van den Noort, Arjen M. Krikken, Chen Bibi, Astrid Böhm, Maya Schuldiner, Einat Zalckvar, Ida J. van der Klei
Pubblicato in: BBA- Molecular Cell Research, 2023, ISSN 0167-4889
Editore: Elsevier BV
DOI: 10.1016/j.bbamcr.2023.119471

Determining the targeting specificity of the selective peroxisomal targeting factor Pex9

Autori: Eden Yifrach, Markus Rudowitz, Luis Daniel Cruz-Zaragoza, Asa Tirosh, Zohar Gazi, Yoav Peleg, Markus Kunze, Miriam Eisenstein, Wolfgang Schliebs, Maya Schuldiner, Ralf Erdmann, Einat Zalckvar
Pubblicato in: Biological Chemistry, 2022, ISSN 1431-6730
Editore: Walter de Gruyter GmbH & Co. KG
DOI: 10.1515/hsz-2022-0116

Widespread use of unconventional targeting signals in mitochondrial ribosome proteins.

Autori: Yury S. Bykov; Tamara Flohr; Felix Boos; Naama Zung; Johannes M. Herrmann; Maya Schuldiner
Pubblicato in: The EMBO Journal, Numero 1, 2022, Pagina/e e109519, ISSN 1460-2075
Editore: EMBO Press
DOI: 10.15252/embj.2021109519

Proteins that carry dual targeting signals can act as tethers between peroxisomes and partner organelles

Autori: Elena Bittner, Thorsten Stehlik, Jason Lam, Lazar Dimitrov, Thomas Heimerl, Isabelle Schöck, Jannik Harberding, Anita Dornes, Nikola Heymons, Gert Bange, Maya Schuldiner, Einat Zalckvar, Michael Bölker, Randy Schekman, Johannes Freitag
Pubblicato in: PLOS Biology, Numero 22, 2024, Pagina/e e3002508, ISSN 1545-7885
Editore: Public Library of Science (PLoS)
DOI: 10.1371/journal.pbio.3002508

A systematic proximity ligation approach to studying protein-substrate specificity identifies the substrate spectrum of the Ssh1 translocon

Autori: Nir Cohen, Naama Aviram, Maya Schuldiner
Pubblicato in: EMBO Journal, 2023, ISSN 1460-2075
Editore: EMBO Press
DOI: 10.15252/embj.2022113385

The Fast and the Furious: Golgi Contact Sites

Autori: Yotam David, Ines Castro, Maya Schuldiner
Pubblicato in: Contact, 2021, Pagina/e 1-15, ISSN 2515-2564
Editore: SAGE publishing
DOI: 10.1177/25152564211034424

Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions

Autori: Eden Yifrach, Duncan Holbrook-Smith, Jérôme Bürgi, Alaa Othman, Miriam Eisenstein, Carlo Wt van Roermund, Wouter Visser, Asa Tirosh, Markus Rudowitz, Chen Bibi, Shahar Galor, Uri Weill, Amir Fadel, Yoav Peleg, Ralf Erdmann, Hans R Waterham, Ronald J A Wanders, Matthias Wilmanns, Nicola Zamboni, Maya Schuldiner, Einat Zalckvar
Pubblicato in: Molecular Systems Biology, 2022, ISSN 1744-4292
Editore: Nature Publishing Group
DOI: 10.15252/msb.202211186

A proteome-wide yeast degron collection for the dynamic study of protein function

Autori: Rosario Valenti, Yotam David, Dunya Edilbi, Benjamin Dubreuil, Angela Boshnakovska, Yeynit Asraf, Tomer-Meir Salame, Ehud Sass, Peter Rehling, Maya Schuldiner
Pubblicato in: Journal of Cell Biology, Numero 224, 2024, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.202409050