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Quantifying the spread of P. falciparum malaria

Deliverables

Publications

The effect of anticoagulants in blood collection tubes on Plasmodium falciparum transmission in direct membrane feeding assays

Author(s): Wouter Graumans, Kjerstin Lanke, Geert-Jan van Gemert, Manon Alkema, Marga van de Vegte-Bolmer, Teun Bousema, Katharine A Collins
Published in: Transactions of The Royal Society of Tropical Medicine and Hygiene, 2021, ISSN 0035-9203
Publisher: Royal Society of Tropical Medicine and Hygiene
DOI: 10.1093/trstmh/trab095

Naturally acquired antibodies to gametocyte antigens are associated with reduced transmission of Plasmodium vivax gametocytes to Anopheles arabiensis mosquitoes

Author(s): Tebeje SK, Chali W, Hailemeskel E, Ramjith J, Gashaw A, Ashine T, Nebret D, Esayas E, Emiru T, Tsegaye T, Teelen K, Lanke K, Takashima E, Tsuboi T, Salinas ND, Tolia NH, Narum D, Drakeley C, Witkowski B, Vantaux A, Jore MM, Stone WJR, Hansen IS, Tadesse FG, Bousema T.
Published in: Front Cell Infect Microbiol, 2023, ISSN 2235-2988
Publisher: Frontiers Media S. A.
DOI: 10.3389/fcimb.2022.1106369

Pyronaridine–artesunate or dihydroartemisinin–piperaquine combined with single low-dose primaquine to prevent Plasmodium falciparum malaria transmission in Ouélessébougou, Mali: a four-arm, single-blind, phase 2/3, randomised trial

Author(s): Stone W, Mahamar A, Sanogo K, Sinaba Y, Niambele SM, Sacko A, Keita S, Youssouf A, Diallo M, Soumare HM, Kaur H, Lanke K, Ter Heine R, Bradley J, Issiaka D, Diawara H, Traore SF, Bousema T, Drakeley C, Dicko A.
Published in: Lancet Microbe, 2022, ISSN 2666-5247
Publisher: The Lancet Publishing Group
DOI: 10.1016/s2666-5247(21)00192-0

Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment.

Author(s): Abdi AI, Achcar F, Sollelis L, Silva-Filho JL, Mwikali K, Muthui M, Mwangi S, Kimingi HW, Orindi B, Andisi Kivisi C, Alkema M, Chandrasekar A, Bull PC, Bejon P, Modrzynska K, Bousema T, Marti M.
Published in: Elife, 2023, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.85140

Safety, tolerability, and Plasmodium falciparum transmission-reducing activity of monoclonal antibody TB31F: a single-centre, open-label, first-in-human, dose-escalation, phase 1 trial in healthy malaria-naive adults.

Author(s): van der Boor SC, Smit MJ, van Beek SW, Ramjith J, Teelen K, van de Vegte-Bolmer M, van Gemert GJ, Pickkers P, Wu Y, Locke E, Lee SM, Aponte J, King CR, Birkett AJ, Miura K, Ayorinde MA, Sauerwein RW, Ter Heine R, Ockenhouse CF, Bousema T, Jore MM, McCall MBB.
Published in: Lancet Infect Dis, 2022, ISSN 1473-3099
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(22)00428-5

Flexible time-to-event models for double-interval-censored infectious disease data with clearance of the infection as a competing risk

Author(s): Ramjith, J.; Andolina, C.; Bousema, T.; Jonker, M.A.
Published in: Frontiers in Applied Mathematics and Statistics, 2022, ISSN 2297-4687
Publisher: Frontiers Media S.A.
DOI: 10.3389/fams.2022.1035393

Asymptomatic School-Aged Children Are Important Drivers of Malaria Transmission in a High Endemicity Setting in Uganda

Author(s): Rek J, Blanken SL, Okoth J, Ayo D, Onyige I, Musasizi E, Ramjith J, Andolina C, Lanke K, Arinaitwe E, Olwoch P, Collins KA, Kamya MR, Dorsey G, Drakeley C, Staedke SG, Bousema T, Conrad MD.
Published in: The Journal of Infectious Diseases, 2022, ISSN 0022-1899
Publisher: University of Chicago Press
DOI: 10.1093/infdis/jiac169

Comparative analysis of glass and Hemotek membrane feeding systems for malaria transmission research

Author(s): Graumans W, Schinkel M, van Gemert GJ, Spitzen J, Bousema T, Miesen P.
Published in: Transactions of The Royal Society of Tropical Medicine and Hygiene, 2023, ISSN 0035-9203
Publisher: Royal Society of Tropical Medicine and Hygiene
DOI: 10.1093/trstmh/trac135

Monoclonal antibodies block transmission of genetically diverse Plasmodium falciparum strains to mosquitoes

Author(s): Roos M. de Jong, Lisette Meerstein-Kessel, Dari F. Da, Sandrine Nsango, Joseph D. Challenger, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Elias Duarte, Noam Teyssier, Robert W. Sauerwein, Thomas S. Churcher, Roch K. Dabire, Isabelle Morlais, Emily Locke, Martijn A. Huynen, Teun Bousema & Matthijs M. Jore
Published in: npj Vaccines, 2021, ISSN 2059-0105
Publisher: Springer Nature
DOI: 10.1038/s41541-021-00366-9

Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230.

Author(s): Ivanochko D, Fabra-García A, Teelen K, van de Vegte-Bolmer M, van Gemert GJ, Newton J, Semesi A, de Bruijni M, Bolscher J, Ramjith J, Szabat M, Vogt S, Kraft L, Duncan S, Lee SM, Kamya MR, Feeney ME, Jagannathan P, Greenhouse B, Sauerwein RW, Richter King C, MacGill RS, Bousema T, Jore MM, Julien JP.
Published in: Immunity, 2023, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2023.01.013

Plasmodium falciparum gametocyte production in longitudinally monitored incident infections is associated with duration of infection and human host factors

Author(s): Chiara Andolina; Jordache Ramjith; John Rek; Kjerstin Lanke; Joseph Okoth; Lynn Grignard; Emmanuel Arinaitwe; Jessica Briggs; Jeffrey Bailey; Ozkan Aydemir; Moses R Kamya; Bryan Greenhouse; Grant Dorsey; Sarah G Staedke; Chris Drakeley; Marianne Jonker; Teun Bousema
Published in: Scientific Report, Issue 1, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.21203/rs.3.rs-2158355/v1

Plasmodium malariae infections as a cause of febrile disease in an area of high Plasmodium falciparum transmission intensity in Eastern Uganda

Author(s): Daniel Ayo, Bakar Odongo, Joseph Omara, Chiara Andolina, Ole Mulder, Sarah G. Staedke & Teun Bousema
Published in: Malaria Journal, 2021, ISSN 1475-2875
Publisher: BioMed Central
DOI: 10.1186/s12936-021-03962-1

Maintaining Plasmodium falciparum gametocyte infectivity during blood collection and transport for mosquito feeding assays in the field

Author(s): Harouna M. Soumare, Wamdaogo Moussa Guelbeogo, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Zongo Soumanaba, Alphonse Ouedraogo, Maurice S. Ouattara, Ahmad Abdullahi, Lamin Jadama, Muhammed M. Camara, Pa Modou Gaye, Michael Mendy, Nwakanma Davis, Alfred B. Tiono, Umberto D’Alessandro, Chris Drakeley, Teun Bousema, Marta Moreno, Katharine A. Collins
Published in: Malaria Journal, Issue 20/1, 2021, ISSN 1475-2875
Publisher: BioMed Central
DOI: 10.1186/s12936-021-03725-y

Assessment of the transmission blocking activity of antimalarial compounds by membrane feeding assays using natural Plasmodium falciparum gametocyte isolates from West-Africa.

Author(s): B Henry N, Soulama I, S Sermé S, Bolscher JM, T G Huijs T, S Coulibaly A, Sombié S, Ouédraogo N, Diarra A, Zongo S, Guelbéogo WM, Nébié I, Sirima SB, Tiono AB, Pietro A, Collins KA, Dechering KJ, Bousema T.
Published in: PLoS One, 2023, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0284751

A portfolio of geographically distinct laboratory-adapted Plasmodium falciparum clones with consistent infection rates in Anopheles mosquitoes

Author(s): van de Vegte-Bolmer M, Graumans W, Stoter R, van Gemert GJ, Sauerwein R, Collins KA, Bousema T.
Published in: Malar J., 2021, ISSN 1475-2875
Publisher: BioMed Central
DOI: 10.1186/s12936-021-03912-x

Quantifying Reductions in Plasmodium falciparum Infectivity to Mosquitos: A Sample Size Calculator to Inform Clinical Trials on Transmission-Reducing Interventions

Author(s): Ramjith J, Alkema M, Bradley J, Dicko A, Drakeley C, Stone W, Bousema T.
Published in: Front. Immunol., 2022, ISSN 1664-3224
Publisher: Frontiers Media S.A
DOI: 10.3389/fimmu.2022.899615

The acquisition of humoral immune responses targeting Plasmodium falciparum sexual stages in controlled human malaria infections.

Author(s): de Jong RM, Alkema M, Oulton T, Dumont E, Teelen K, Nakajima R, de Assis RR, Press KWD, Ngotho P, Tetteh KKA, Felgner P, Marti M, Collins KA, Drakeley C, Bousema T, Stone WJR.
Published in: Front Immunol., 2022, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/fimmu.2022.930956

Entomological impact of mass administration of ivermectin and dihydroartemisinin-piperaquine in The Gambia: a cluster-randomized controlled trial

Author(s): Soumare, H.M., Dabira, E.D., Camara, M.M. et al.
Published in: Parasites Vectors, 2022, ISSN 1756-3305
Publisher: BioMed Central
DOI: 10.1186/s13071-022-05557-4

Single low-dose tafenoquine combined with dihydroartemisinin–piperaquine to reduce Plasmodium falciparum transmission in Ouelessebougou, Mali: a phase 2, single-blind, randomised clinical trial

Author(s): Stone W, Mahamar A, Smit MJ, Sanogo K, Sinaba Y, Niambele SM, Sacko A, Keita S, Dicko OM, Diallo M, Maguiraga SO, Samake S, Attaher O, Lanke K, Ter Heine R, Bradley J, McCall MBB, Issiaka D, Traore SF, Bousema T, Drakeley C, Dicko A
Published in: Lancet Microbe, 2022, ISSN 2666-5247
Publisher: The Lancet Publishing Group
DOI: 10.1016/s2666-5247(21)00356-6

Sources of persistent malaria transmission in a setting with effective malaria control in eastern Uganda: a longitudinal, observational cohort study

Author(s): Andolina C, Rek JC, Briggs J, Okoth J, Musiime A, Ramjith J, Teyssier N, Conrad M, Nankabirwa JI, Lanke K, Rodriguez-Barraquer I, Meerstein-Kessel L, Arinaitwe E, Olwoch P, Rosenthal PJ, Kamya MR, Dorsey G, Greenhouse B, Drakeley C, Staedke SG, Bousema T.
Published in: Lancet Infect Dis., 2021, ISSN 1473-3099
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1473-3099(21)00072

Plasmodium falciparum gametocyte carriage in longitudinally monitored incident infections is associated with duration of infection and human host factors.

Author(s): Andolina C, Ramjith J, Rek J, Lanke K, Okoth J, Grignard L, Arinaitwe E, Briggs J, Bailey J, Aydemir O, Kamya MR, Greenhouse B, Dorsey G, Staedke SG, Drakeley C, Jonker M, Bousema T
Published in: Scientific Reports, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-33657-3

Improved Detectability of Plasmodium falciparum Clones with Repeated Sampling in Incident and Chronic Infections in Burkina Faso

Author(s): Barry A, Awandu S S, Tiono A B, Grignard L, Bousema T, Collins K A
Published in: Am J Trop Med Hyg ., 2021, ISSN 1476-1645
Publisher: Journal of the American Society of Tropical Medicine and Hygeine
DOI: 10.4269/ajtmh.21-0493

Modeling the Impact of a Highly Potent Plasmodium falciparum Transmission-Blocking Monoclonal Antibody in Areas of Seasonal Malaria Transmission

Author(s): Challenger JD, van Beek SW, Ter Heine R, van der Boor SC, Charles GD, Smit MJ, Ockenhouse C, Aponte JJ, McCall MBB, Jore MM, Churcher TS, Bousema T.
Published in: The Journal of Infectious Diseases, 2023, ISSN 1537-6613
Publisher: Oxfrd University Press
DOI: 10.1093/infdis/jiad101

The acquisition of humoral immune responses targeting Plasmodium falciparum sexual stages in controlled human malaria infections

Author(s): de Jong RM, Alkema M, Oulton T, Dumont E, Teelen K, Nakajima R, de Assis RR, Press KWD, Ngotho P, Tetteh KKA, Felgner P, Marti M, Collins KA, Drakeley C, Bousema T, Stone WJR. The
Published in: Front Immunol, 2022, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.930956.ecollection2022

Heterologous Expression and Evaluation of Novel Plasmodium falciparum Transmission Blocking Vaccine Candidates

Author(s): de Jong RM, Singh SK, Teelen K, van de Vegte-Bolmer M, van Gemert GJ, Stone WJR, Locke E, Plieskatt J, Theisen M, Bousema T, Jore MM.
Published in: Front. Immunol, 2022, ISSN 1664-3224
Publisher: Frontiers Media S.A.
DOI: 10.3389/fimmu.2022.909060

Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes.

Author(s): Fabra-García A, Hailemariam S, de Jong RM, Janssen K, Teelen K, van de Vegte-Bolmer M, van Gemert GJ, Ivanochko D, Semesi A, McLeod B, Vos MW, de Bruijni MHC, Bolscher JM, Szabat M, Vogt S, Kraft L, Duncan S, Kamya MR, Feeney ME, Jagannathan P, Greenhouse B, Dechering KJ, Sauerwein RW, King CR, MacGill RS, Bousema T, Julien JP, Jore MM.
Published in: Immunity, 2023, ISSN 1074-7613
Publisher: Cell Press
DOI: 10.1016/j.immuni.2023.01.009

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