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Quantifying the spread of P. falciparum malaria

Project information

Grant agreement ID: 864180

Status

Ongoing project

  • Start date

    1 July 2020

  • End date

    30 June 2025

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 2 000 000

  • EU contribution

    € 2 000 000

Hosted by:

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

Objective

Background: A major challenge for malaria elimination is its phenomenally efficient spread through sexual stage parasites (gametocytes). Many individuals in endemic settings harbour low but transmissible gametocyte densities. It is currently unclear how gametocyte density translates into the likelihood that an infected mosquito gives rise to secondary infections, who drive malaria transmission at population level and how anti-gametocyte immunity affects gametocyte production and infectivity.

I hypothesize that secondary infections can arise from low-density infections but that higher gametocyte densities result in comparatively more infectious mosquitoes and an increased number of secondary infections. I further hypothesize that malaria transmission efficiency and changes therein can only be accurately predicted if anti-gametocyte immunity is thoroughly understood and that the rapid loss of gametocyte immunity during effective control results in increased transmission efficiency.

Aims and approach: I will perform the first-ever direct assessment of numbers of malaria parasites ejected by mosquitoes in relation to natural gametocyte densities. Using novel genotyping approaches, longitudinal sampling of infections at unsurpassed resolution and state-of-the art analytical approaches, I will perform the most comprehensive molecular evaluation of malaria transmission in a real community ever performed. Lastly, I will quantify the impact of immune responses that reduce gametocyte density and infectivity by novel immune-profiling approaches and mathematical transmission models.

Importance and innovation: this project will profoundly improve understanding of the production and infectivity of gametocytes and the epidemiological impact of human immune responses that influence these processes. The work in different African settings will provide a major leap forward in understanding the human infectious reservoir for malaria and has direct implications for elimination

Host institution

STICHTING KATHOLIEKE UNIVERSITEIT

Address

Geert Grooteplein Noord 9
6525 Ez Nijmegen

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 851 250

Beneficiaries (2)

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

EU Contribution

€ 1 851 250

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

United States

EU Contribution

€ 148 750

Project information

Grant agreement ID: 864180

Status

Ongoing project

  • Start date

    1 July 2020

  • End date

    30 June 2025

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 2 000 000

  • EU contribution

    € 2 000 000

Hosted by:

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands